-
1
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
DOI 10.1200/JCO.20.1.110
-
Albanell J., Rojo F., Averbuch S., Feyereislova A., Mascaro J.M., Herbst R., LoRusso P., Rischin D., Sauleda S., Gee J., et al. (2002) Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition. J Clin Oncol 20:110-124. (Pubitemid 34032602)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.1
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
Feyereislova, A.4
Mascaro, J.M.5
Herbst, R.6
LoRusso, P.7
Rischin, D.8
Sauleda, S.9
Gee, J.10
Nicholson, R.I.11
Baselga, J.12
-
2
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
Bain J., Plater L., Elliott M., Shpiro N., Hastie C.J., McLauchlan H., Klevernic I., Arthur J.S., Alessi DR, and Cohen P. (2007) The selectivity of protein kinase inhibitors: A further update. Biochem J 408:297-315.
-
(2007)
Biochem J
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shpiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
3
-
-
63849151166
-
LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation
-
Belkina N.V., Liu Y., Hao J.J., Karasuyama H, and Shaw S. (2009) LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci USA 106:4707-4712.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4707-4712
-
-
Belkina, N.V.1
Liu, Y.2
Hao, J.J.3
Karasuyama, H.4
Shaw, S.5
-
4
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
DOI 10.1056/NEJMoa053422
-
Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., Jones C.U., Sur R., Raben D., Jassem J., et al. (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567-578. (Pubitemid 43209104)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.6
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
Jones, C.U.7
Sur, R.8
Raben, D.9
Jassem, J.10
Ove, R.11
Kies, M.S.12
Baselga, J.13
Youssoufian, H.14
Amellal, N.15
Rowinsky, E.K.16
Ang, K.K.17
-
5
-
-
48249149092
-
Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase
-
Burakov A.V., Zhapparova O.N., Kovalenko O.V., Zinovkina L.A., Potekhina E.S., Shanina N.A., Weiss D.G., Kuznetsov SA, and Nadezhdina E.S. (2008) Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. Mol Biol Cell 19:1952-1961.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 1952-1961
-
-
Burakov, A.V.1
Zhapparova, O.N.2
Kovalenko, O.V.3
Zinovkina, L.A.4
Potekhina, E.S.5
Shanina, N.A.6
Weiss, D.G.7
Kuznetsov, S.A.8
Nadezhdina, E.S.9
-
6
-
-
0035724536
-
Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
-
DOI 10.1046/j.1365-2133.2001.04226.x
-
Busam K.J., Capodieci P., Motzer R., Kiehn T., Phelan D, and Halpern A.C. (2001) Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol 144:1169-1176. (Pubitemid 34204207)
-
(2001)
British Journal of Dermatology
, vol.144
, Issue.6
, pp. 1169-1176
-
-
Busam, K.J.1
Capodieci, P.2
Motzer, R.3
Kiehn, T.4
Phelan, D.5
Halpern, A.C.6
-
7
-
-
0024328679
-
Mechanisms of T cell activation by the calcium ionophore ionomycin
-
Chatila T., Silverman L., Miller R, and Geha R. (1989) Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol 143:1283-1289. (Pubitemid 19211362)
-
(1989)
Journal of Immunology
, vol.143
, Issue.4
, pp. 1283-1289
-
-
Chatila, T.1
Silverman, L.2
Miller, R.3
Geha, R.4
-
8
-
-
0031788487
-
The Syk family of protein tyrosine kinases in T-cell activation and development
-
Chu D.H., Morita CT, and Weiss A. (1998) The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol Rev 165:167-180. (Pubitemid 28524211)
-
(1998)
Immunological Reviews
, vol.165
, pp. 167-180
-
-
Chu, D.H.1
Morita, C.T.2
Weiss, A.3
-
10
-
-
70350453927
-
Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: Insights from intravital imaging
-
Deane JA and Hickey M.J. (2009) Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging. Expert Rev Mol Med 11:e25.
-
(2009)
Expert Rev Mol Med
, vol.11
-
-
Deane, J.A.1
Hickey, M.J.2
-
11
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
DOI 10.1182/blood-2004-08-3097
-
Deininger M., Buchdunger E, and Druker B.J. (2005) The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 105:2640-2653. (Pubitemid 40446252)
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
12
-
-
0028208969
-
Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes
-
Franklin R.A., Tordai A., Patel H., Gardner A.M., Johnson GL, and Gelfand E.W. (1994) Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes. J Clin Invest 93:2134-2140. (Pubitemid 24143095)
-
(1994)
Journal of Clinical Investigation
, vol.93
, Issue.5
, pp. 2134-2140
-
-
Franklin, R.A.1
Tordai, A.2
Patel, H.3
Gardner, A.M.4
Johnson, G.L.5
Gelfand, E.W.6
-
13
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2003.10.038
-
Fukuoka M., Yano S., Giaccone G., Tamura T., Nakagawa K., Douillard J.Y., Nishiwaki Y., Vansteenkiste J., Kudoh S., Rischin D., et al. (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [published erratum appears in J Clin Oncol 22:4811, 2004]. J Clin Oncol 21:2237-2246. (Pubitemid 46621858)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.-Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
Macleod, A.17
Feyereislova, A.18
Dong, R.-P.19
Baselga, J.20
more..
-
14
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
DOI 10.1056/NEJMoa064320
-
Geyer C.E., Forster J., Lindquist D., Chan S., Romieu C.G., Pienkowski T., Jagiello-Gruszfeld A., Crown J., Chan A., Kaufman B., et al. (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355:2733-2743. (Pubitemid 46021510)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
15
-
-
77954216241
-
Characterisation of the cutaneous pathology in non-small cell lung cancer (NSCLC) patients treated with the EGFR tyrosine kinase inhibitor erlotinib
-
Guttman-Yassky E., Mita A., De Jonge M., Matthews L., McCarthy S., Iwata K.K., Verweij J., Rowinsky EK, and Krueger J.G. (2010) Characterisation of the cutaneous pathology in non-small cell lung cancer (NSCLC) patients treated with the EGFR tyrosine kinase inhibitor erlotinib. Eur J Cancer 46:2010-2019.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2010-2019
-
-
Guttman-Yassky, E.1
Mita, A.2
De Jonge, M.3
Matthews, L.4
McCarthy, S.5
Iwata, K.K.6
Verweij, J.7
Rowinsky, E.K.8
Krueger, J.G.9
-
16
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M., Siu L.L., Nemunaitis J., Rizzo J., Hammond L.A., Takimoto C., Eckhardt S.G., Tolcher A., Britten C.D., Denis L., et al. (2001) Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19:3267-3279. (Pubitemid 32591445)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.13
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
Rizzo, J.4
Hammond, L.A.5
Takimoto, C.6
Eckhardt, S.G.7
Tolcher, A.8
Britten, C.D.9
Denis, L.10
Ferrante, K.11
Von Hoff, D.D.12
Silberman, S.13
Rowinsky, E.K.14
-
17
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman M.W., Herrgard S., Treiber D.K., Gallant P., Atteridge C.E., Campbell B.T., Chan K.W., Ciceri P., Davis M.I., Edeen P.T., et al. (2008) A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26:127-132.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
-
18
-
-
0037229076
-
Targeting the epidermal growth factor receptor in cancer: Apoptosis takes center stage
-
Kari C., Chan T.O., Rocha de Quadros M, and Rodeck U. (2003) Targeting the epidermal growth factor receptor in cancer: Apoptosis takes center stage. Cancer Res 63:1-5. (Pubitemid 36070409)
-
(2003)
Cancer Research
, vol.63
, Issue.1
, pp. 1-5
-
-
Kari, C.1
Chan, T.O.2
Rocha De, Q.M.3
Rodeck, U.4
-
19
-
-
74049092701
-
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase
-
Kerkela R., Woulfe K.C., Durand J.B., Vagnozzi R., Kramer D., Chu T.F., Beahm C., Chen MH, and Force T. (2009) Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci 2:15-25.
-
(2009)
Clin Transl Sci
, vol.2
, pp. 15-25
-
-
Kerkela, R.1
Woulfe, K.C.2
Durand, J.B.3
Vagnozzi, R.4
Kramer, D.5
Chu, T.F.6
Beahm, C.7
Chen, M.H.8
Force, T.9
-
20
-
-
0142055937
-
Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients with Non-Small Cell Lung Cancer: A Randomized Trial
-
DOI 10.1001/jama.290.16.2149
-
Kris M.G., Natale R.B., Herbst R.S., Lynch T.J. Jr, Prager D., Belani C.P., Schiller J.H., Kelly K., Spiridonidis H., Sandler A., et al. (2003) Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 290:2149-2158. (Pubitemid 37432975)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
21
-
-
33749018219
-
Mechanisms of cutaneous toxicities to EGFR inhibitors
-
Lacouture M.E. (2006) Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer 6:803-812.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 803-812
-
-
Lacouture, M.E.1
-
23
-
-
33845680787
-
CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine kinase inhibitors
-
DOI 10.1093/jnci/djj466
-
Li J., Karlsson M.O., Brahmer J., Spitz A., Zhao M., Hidalgo M, and Baker S.D. (2006) CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine kinase inhibitors. J Natl Cancer Inst 98:1714-1723. (Pubitemid 44942709)
-
(2006)
Journal of the National Cancer Institute
, vol.98
, Issue.23
, pp. 1714-1723
-
-
Li, J.1
Karlsson, M.O.2
Brahmer, J.3
Spitz, A.4
Zhao, M.5
Hidalgo, M.6
Baker, S.D.7
-
24
-
-
34250694236
-
Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
-
DOI 10.1158/1078-0432.CCR-07-0088
-
Li J., Zhao M., He P., Hidalgo M, and Baker S.D. (2007) Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 13:3731-3737. (Pubitemid 46955138)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3731-3737
-
-
Li, J.1
Zhao, M.2
He, P.3
Hidalgo, M.4
Baker, S.D.5
-
25
-
-
53349099403
-
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice
-
Marchetti S., De Vries N.A., Buckle T., Bolijn M.J., Van Eijndhoven M.A., Beijnen J.H., Mazzanti R., Van Tellingen O, and Schellens J.H. (2008) Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice. Mol Cancer Ther 7:2280-2287.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2280-2287
-
-
Marchetti, S.1
De Vries, N.A.2
Buckle, T.3
Bolijn, M.J.4
Van Eijndhoven, M.A.5
Beijnen, J.H.6
Mazzanti, R.7
Van Tellingen, O.8
Schellens, J.H.9
-
26
-
-
0038306878
-
Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation
-
Mascia F., Mariani V., Girolomoni G, and Pastore S. (2003) Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation. Am J Pathol 163:303-312. (Pubitemid 36759615)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.1
, pp. 303-312
-
-
Mascia, F.1
Mariani, V.2
Girolomoni, G.3
Pastore, S.4
-
27
-
-
16244394037
-
Cytochrome P450-dependent metabolism of gefitinib
-
DOI 10.1080/00498250400026464
-
McKillop D., McCormick A.D., Millar A., Miles G.S., Phillips PJ, and HutchisonM.(2005) Cytochrome P450-dependent metabolism of gefitinib. Xenobiotica 35:39-50. (Pubitemid 40459216)
-
(2005)
Xenobiotica
, vol.35
, Issue.1
, pp. 39-50
-
-
McKillop, D.1
McCormick, A.D.2
Millar, A.3
Miles, G.S.4
Phillips, P.J.5
Hutchison, M.6
-
28
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer J.D., Barbacci E.G., Iwata K.K., Arnold L., Boman B., Cunningham A., DiOrio C., Doty J., Morin M.J., Moyer M.P., et al. (1997) Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 57:4838-4848. (Pubitemid 27468992)
-
(1997)
Cancer Research
, vol.57
, Issue.21
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
DiOrio, C.7
Doty, J.8
Morin, M.J.9
Moyer, M.P.10
Neveu, M.11
Pollack, V.A.12
Pustilnik, L.R.13
Reynolds, M.M.14
Sloan, D.15
Theleman, A.16
Miller, P.17
-
29
-
-
0037673681
-
Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors
-
DOI 10.1093/annonc/mdg250
-
Nakagawa K., Tamura T., Negoro S., Kudoh S., Yamamoto N., Yamamoto N., Takeda K., Swaisland H., Nakatani I., Hirose M., et al. (2003) Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors. Ann Oncol 14:922-930. (Pubitemid 36827209)
-
(2003)
Annals of Oncology
, vol.14
, Issue.6
, pp. 922-930
-
-
Nakagawa, K.1
Tamura, T.2
Negoro, S.3
Kudoh, S.4
Yamamoto, N.5
Takeda, K.6
Swaisland, H.7
Nakatani, I.8
Hirose, M.9
Dong, R.-P.10
Fukuoka, M.11
-
30
-
-
0038021580
-
ZD1839, a novel, oral epidermal growth factor receptor-tyrosine kinase inhibitor, as salvage treatment in patients with advanced non-small cell lung cancer. Experience from a single center participating in a compassionate use program
-
DOI 10.1016/S0169-5002(03)00079-5
-
Pallis A.G., Mavroudis D., Androulakis N., Souglakos J., Kouroussis C., Bozionelou V., Vlachonikolis IG, and Georgoulias V. (2003) ZD1839, a novel, oral epidermal growth factor receptor-tyrosine kinase inhibitor, as salvage treatment in patients with advanced non-small cell lung cancer. Experience from a single center participating in a compassionate use program. Lung Cancer 40:301-307. (Pubitemid 36627710)
-
(2003)
Lung Cancer
, vol.40
, Issue.3
, pp. 301-307
-
-
Pallis, A.G.1
Mavroudis, D.2
Androulakis, N.3
Souglakos, J.4
Kouroussis, C.5
Bozionelou, V.6
Vlachonikolis, I.G.7
Georgoulias, V.8
-
31
-
-
38049054403
-
The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (SimCYP) predicts in vivo metabolic inhibition
-
Rakhit A., Pantze M.P., Fettner S., Jones H.M., Charoin J.E., Riek M., Lum BL, and Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (SimCYP) predicts in vivo metabolic inhibition. Eur J Clin Pharmacol 64:31-41.
-
(2008)
Eur J Clin Pharmacol
, vol.64
, pp. 31-41
-
-
Rakhit, A.1
Pantze, M.P.2
Fettner, S.3
Jones, H.M.4
Charoin, J.E.5
Riek, M.6
Lum, B.L.7
Hamilton, M.8
-
32
-
-
68349152796
-
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
-
Roovers K., Wagner S., Storbeck C.J., O'Reilly P., Lo V., Northey J.J., Chmielecki J., Muller W.J., Siegel PM, and Sabourin L.A. (2009) The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene 28:2839-2848.
-
(2009)
Oncogene
, vol.28
, pp. 2839-2848
-
-
Roovers, K.1
Wagner, S.2
Storbeck, C.J.3
O'Reilly, P.4
Lo, V.5
Northey, J.J.6
Chmielecki, J.7
Muller, W.J.8
Siegel, P.M.9
Sabourin, L.A.10
-
33
-
-
41949140593
-
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
-
Rudin C.M., Liu W., Desai A., Karrison T., Jiang X., Janisch L., Das S., Ramirez J., Poonkuzhali B., Schuetz E., et al. (2008) Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. J Clin Oncol 26:1119-1127.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1119-1127
-
-
Rudin, C.M.1
Liu, W.2
Desai, A.3
Karrison, T.4
Jiang, X.5
Janisch, L.6
Das, S.7
Ramirez, J.8
Poonkuzhali, B.9
Schuetz, E.10
-
34
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak D.W., Lackey K., Affleck K., Wood E.R., Alligood K.J., Rhodes N., Keith B.R., Murray D.M., Knight W.B., Mullin R.J., et al. (2001) The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 1:85-94.
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
Wood, E.R.4
Alligood, K.J.5
Rhodes, N.6
Keith, B.R.7
Murray, D.M.8
Knight, W.B.9
Mullin, R.J.10
-
35
-
-
24044500971
-
Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
-
DOI 10.1093/annonc/mdi279
-
Segaert S and Van Cutsem E. (2005) Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann Oncol 16:1425-1433. (Pubitemid 41222414)
-
(2005)
Annals of Oncology
, vol.16
, Issue.9
, pp. 1425-1433
-
-
Segaert, S.1
Van Cutsem, E.2
-
36
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd F.A., Rodrigues Pereira J., Ciuleanu T., Tan E.H., Hirsh V., Thongprasert S., Campos D., Maoleekoonpiroj S., Smylie M., Martins R., et al. (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132. (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
37
-
-
43249124980
-
Dose selection in phase I studies: Why we should always go for the top
-
Sleijfer S and Wiemer E. (2008) Dose selection in phase I studies: Why we should always go for the top. J Clin Oncol 26:1576-1578.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1576-1578
-
-
Sleijfer, S.1
Wiemer, E.2
-
38
-
-
25144436285
-
Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol
-
DOI 10.2165/00003088-200544100-00005
-
Swaisland H.C., Ranson M., Smith R.P., Leadbetter J., Laight A., McKillop D, and Wild M.J. (2005) Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet 44:1067-1081. (Pubitemid 41356392)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.10
, pp. 1067-1081
-
-
Swaisland, H.C.1
Ranson, M.2
Smith, R.P.3
Leadbetter, J.4
Laight, A.5
McKillop, D.6
Wild, M.J.7
-
39
-
-
0036534469
-
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells
-
DOI 10.1042/0264-6021:3630175
-
Tao L., Wadsworth S., Mercer J., Mueller C., Lynn K., Siekierka J, and August A. (2002) Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. Biochem J 363:175-182. (Pubitemid 34280624)
-
(2002)
Biochemical Journal
, vol.363
, Issue.1
, pp. 175-182
-
-
Tao, L.1
Wadsworth, S.2
Mercer, J.3
Mueller, C.4
Lynn, K.5
Siekierka, J.6
August, A.7
-
40
-
-
68749095215
-
Population pharmacokinetics of erlotinib and its pharmacokinetic/ pharmacodynamic relationships in head and neck squamous cell carcinoma
-
Thomas F., Rochaix P., White-Koning M., Hennebelle I., Sarini J., Benlyazid A., Malard L., Lefebvre J.L., Chatelut E, and Delord J.P. (2009) Population pharmacokinetics of erlotinib and its pharmacokinetic/pharmacodynamic relationships in head and neck squamous cell carcinoma. Eur J Cancer 45:2316-2323.
-
(2009)
Eur J Cancer
, vol.45
, pp. 2316-2323
-
-
Thomas, F.1
Rochaix, P.2
White-Koning, M.3
Hennebelle, I.4
Sarini, J.5
Benlyazid, A.6
Malard, L.7
Lefebvre, J.L.8
Chatelut, E.9
Delord, J.P.10
-
41
-
-
70449517339
-
Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: Efficacy, safety, and biomarker results from Japanese patients phase II studies
-
Toi M., Iwata H., Fujiwara Y., Ito Y., Nakamura S., Tokuda Y., Taguchi T., Rai Y., Aogi K., Arai T., et al. (2009) Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: Efficacy, safety, and biomarker results from Japanese patients phase II studies. Br J Cancer 101:1676-1682.
-
(2009)
Br J Cancer
, vol.101
, pp. 1676-1682
-
-
Toi, M.1
Iwata, H.2
Fujiwara, Y.3
Ito, Y.4
Nakamura, S.5
Tokuda, Y.6
Taguchi, T.7
Rai, Y.8
Aogi, K.9
Arai, T.10
-
42
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
DOI 10.1200/JCO.2006.08.1620
-
Van Cutsem E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., Canon J.L., Van Laethem J.L., Maurel J., Richardson G., et al. (2007) Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 25:1658-1664. (Pubitemid 46797944)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.-L.7
Van Laethem, J.-L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
43
-
-
77949311903
-
Dysregulation of bone remodeling by imatinib mesylate
-
Vandyke K., Fitter S., Dewar A.L., Hughes TP, and Zannettino A.C. (2010) Dysregulation of bone remodeling by imatinib mesylate. Blood 115:766-774.
-
(2010)
Blood
, vol.115
, pp. 766-774
-
-
Vandyke, K.1
Fitter, S.2
Dewar, A.L.3
Hughes, T.P.4
Zannettino, A.C.5
-
44
-
-
0038381428
-
Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue
-
DOI 10.1074/jbc.M212556200
-
Walter S.A., Cutler R.E. Jr, Martinez R., Gishizky M, and Hill R.J. (2003) Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. J Biol Chem 278:18221-18228. (Pubitemid 36799439)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.20
, pp. 18221-18228
-
-
Walter, S.A.1
Cutler Jr., R.E.2
Martinez, R.3
Gishizky, M.4
Hill, R.J.5
-
45
-
-
39749131036
-
Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models
-
DOI 10.1158/1535-7163.MCT-07-2070
-
Wang S., Guo P., Wang X., Zhou Q, and Gallo J.M. (2008) Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models. Mol Cancer Ther 7:407-417. (Pubitemid 351302534)
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.2
, pp. 407-417
-
-
Wang, S.1
Guo, P.2
Wang, X.3
Zhou, Q.4
Gallo, J.M.5
-
46
-
-
0030067653
-
MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells
-
Whitehurst CE and Geppert T.D. (1996) MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J Immunol 156:1020-1029. (Pubitemid 26048095)
-
(1996)
Journal of Immunology
, vol.156
, Issue.3
, pp. 1020-1029
-
-
Whitehurst, C.E.1
Geppert, T.D.2
-
47
-
-
18044364483
-
Inhibition of the epidermal growth factor receptor increases epxression of genes that stimulate inflammation, apoptosis, and cell attachment
-
DOI 10.1158/1535-7163.MCT-04-0238
-
Woodworth C.D., Michael E., Marker D., Allen S., Smith L, and Nees M. (2005) Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment. Mol Cancer Ther 4:650-658. (Pubitemid 40601847)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.4
, pp. 650-658
-
-
Woodworth, C.D.1
Michael, E.2
Marker, D.3
Allen, S.4
Smith, L.5
Nees, M.6
-
48
-
-
0033961586
-
Molecular cloning and characterization of a novel human STE20-like kinase, hSLK
-
DOI 10.1016/S0167-4889(99)00164-0, PII S0167488999001640
-
Yamada E., Tsujikawa K., Itoh S., Kameda Y., Kohama Y, and Yamamoto H. (2000) Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. Biochim Biophys Acta 1495:250-262. (Pubitemid 30103546)
-
(2000)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1495
, Issue.3
, pp. 250-262
-
-
Yamada, E.1
Tsujikawa, K.2
Itoh, S.3
Kameda, Y.-I.4
Kohama, Y.5
Yamamoto, H.6
-
49
-
-
37249041552
-
Phase I dose-finding and pharmacokinetic study of the oral epidermal growth factor receptor tyrosine kinase inhibitor Ro50-8231 (erlotinib) in Japanese patients with solid tumors
-
DOI 10.1007/s00280-007-0494-8
-
Yamamoto N., Horiike A., Fujisaka Y., Murakami H., Shimoyama T., Yamada Y, and Tamura T. (2008) Phase I dose-finding and pharmacokinetic study of the oral epidermal growth factor receptor tyrosine kinase inhibitor Ro50-8231 (erlotinib) in Japanese patients with solid tumors. Cancer Chemother Pharmacol 61:489-496. (Pubitemid 350275984)
-
(2008)
Cancer Chemotherapy and Pharmacology
, vol.61
, Issue.3
, pp. 489-496
-
-
Yamamoto, N.1
Horiike, A.2
Fujisaka, Y.3
Murakami, H.4
Shimoyama, T.5
Yamada, Y.6
Tamura, T.7
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