A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1032, Issue , 2016, Pages 149-154

  Excoffier, Mélissa ^a   Janin Bussat, Marie Claire ^a   Beau Larvor, Charlotte ^a   Troncy, Lysiane ^a   Corvaia, Nathalie ^a   Beck, Alain ^a   Klinguer Hamour, Christine ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

ADC; DAR; De conjugation; ELISA; LC MS analysis; Stability in serum

Indexed keywords

ANTIGENS; BODY FLUIDS; MONOCLONAL ANTIBODIES; STABILITY; TOXICITY; TUMORS;

ANTIBODY-DRUG CONJUGATES; CYNOMOLGUS MONKEYS; DE-CONJUGATION; ELISA; IMMUNOPRECIPITATIONS; ORTHOGONAL METHOD; PRECLINICAL STUDIES; SYSTEMIC CIRCULATION;

POPULATION DISTRIBUTION;

DRUG ANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; MALEIMIDE; ANTIBODY CONJUGATE; MONOCLONAL ANTIBODY;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOPRECIPITATION; IN VITRO STUDY; MACACA FASCICULARIS; MASS SPECTROMETRY; MICHAEL ADDITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SERUM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; LIQUID CHROMATOGRAPHY; NUDE MOUSE; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOCONJUGATES; MACACA FASCICULARIS; MASS SPECTROMETRY; MICE; MICE, NUDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84971654989     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2016.05.037     Document Type: Article

References (29)

1. [1] Beck, A., Reichert, J.M., MAbs 6 (2014), 15–17.
2. [2] Beck, A., Terral, G., Debaene, F., Wagner-Rousset, E., Marcoux, J., Janin-Bussat, M.C., Colas, O., Van Dorsselaer, A., Cianferani, S., Expert. Rev. Proteomics, 2016, 1–27.
3. [3] Beck, A., Haeuw, J.F., Wurch, T., Goetsch, L., Bailly, C., Corvaia, N., Discov. Med. 10 (2010), 329–339.
4. [4] Wiggins, B., Liu-Shin, L., Yamaguchi, H., Ratnaswamy, G., J. Pharm. Sci. 104 (2015), 1362–1372.
5. [5] Chari, R.V., Miller, M.L., Widdison, W.C., Angew. Chem. Int. Ed. Engl. 53 (2014), 3796–3827.
6. [6] Klinguer-Hamour, C., Strop, P., Shah, D.K., Ducry, L., Xu, A., Beck, A., MAbs 6 (2014), 18–29.
7. [7] Valliere-Douglass, J.F., McFee, W.A., Salas-Solano, O., Anal. Chem. 84 (2012), 2843–2849.
8. [8] Debaene, F., Boeuf, A., Wagner-Rousset, E., Colas, O., Ayoub, D., Corvaia, N., Van Dorsselaer, A., Beck, A., Cianferani, S., Anal. Chem. 86 (2014), 10674–10683.
9. [9] Birdsall, R.E., McCarthy, S.M., Janin-Bussat, M.C., Perez, M., Haeuw, J.F., Chen, W., Beck, A., MAbs, 2015, 1.
10. [10] Wakankar, A., Chen, Y., Gokarn, Y., Jacobson, F.S., MAbs 3 (2011), 161–172.
11. [11] Janin-Bussat, M.C., Dillenbourg, M., Corvaia, N., Beck, A., Klinguer-Hamour, C., J.Chromatogr. B Analyt. Technol. Biomed. Life Sci. 981–982 (2015), 9–13.
12. [12] Beck, A., Wagner-Rousset, E., Ayoub, D., Van Dorsselaer, A., Sanglier-Cianferani, S., Anal. Chem. 85 (2013), 715–736.
13. [13] Tibbitts, J., Canter, D., Graff, R., Smith, A., Khawli, L.A., MAbs, 2015, 00.
14. [14] Marcoux, J., Champion, T., Colas, O., Wagner-Rousset, E., Corvaia, N., Van Dorsselaer, A., Beck, A., Cianferani, S., Protein Sci. 24 (2015), 1210–1223.
15. [15] Saber, H., Leighton, J.K., Regul. Toxicol. Pharmacol. 71 (2015), 444–452.
16. [16] Xu, K., Liu, L., Saad, O.M., Baudys, J., Williams, L., Leipold, D., Shen, B., Raab, H., Junutula, J.R., Kim, A., Kaur, S., Anal. Biochem. 412 (2011), 56–66.
17. [17] Hengel, S.M., Sanderson, R., Valliere-Douglass, J., Nicholas, N., Leiske, C., Alley, S.C., Anal. Chem. 86 (2014), 3420–3425.
18. [18] Sanderson, R.J., Nicholas, N.D., Baker Lee, C., Hengel, S.M., Lyon, R.P., Benjamin, D.R., Alley, S.C., Bioanalysis 8 (2015), 55–63.
19. [19] Liu, A., Kozhich, A., Passmore, D., Gu, H., Wong, R., Zambito, F., Rangan, V.S., Myler, H., Aubry, A.F., Arnold, M.E., Wang, J., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1002 (2015), 54–62, 10.1016/j.jchromb.2015.08.007 (Epub;%2015 Aug 12).
20. [20] Redman, E.A., Mellors, J.S., Starkey, J.A., Ramsey, J.M., Anal. Chem. 88 (2016), 2220–2226.
21. [21] Wagner-Rousset, E., Janin-Bussat, M.C., Colas, O., Excoffier, M., Ayoub, D., Haeuw, J.F., Rilatt, I., Perez, M., Corvaia, N., Beck, A., MAbs 6 (2014), 173–184.
22. [22] Kaur, S., Xu, K., Saad, O.M., Dere, R.C., Carrasco-Triguero, M., Bioanalysis 5 (2013), 201–226.
23. [23] Lyon, R.P., Meyer, D.L., Setter, J.R., Senter, P.D., Methods Enzymol. 502 (2012), 123–138, 10.1016/B978-0-12-416039-2 (00006-9 123–138).
24. [24] Shen, B.Q., Xu, K., Liu, L., Raab, H., Bhakta, S., Kenrick, M., Parsons-Reponte, K.L., Tien, J., Yu, S.F., Mai, E., Li, D., Tibbitts, J., Baudys, J., Saad, O.M., Scales, S.J., McDonald, P.J., Hass, P.E., Eigenbrot, C., Nguyen, T., Solis, W.A., Fuji, R.N., Flagella, K.M., Patel, D., Spencer, S.D., Khawli, L.A., Ebens, A., Wong, W.L., Vandlen, R., Kaur, S., Sliwkowski, M.X., Scheller, R.H., Polakis, P., Junutula, J.R., Nat. Biotechnol. 30 (2012), 184–189.
25. [25] Alley, S.C., Benjamin, D.R., Jeffrey, S.C., Okeley, N.M., Meyer, D.L., Sanderson, R.J., Senter, P.D., Bioconjugate Chem. 19 (2008), 759–765.
26. [26] Lyon, R.P., Setter, J.R., Bovee, T.D., Doronina, S.O., Hunter, J.H., Anderson, M.E., Balasubramanian, C.L., Duniho, S.M., Leiske, C.I., Li, F., Senter, P.D., Nat. Biotechnol 32 (2014), 1059–1062.
27. [27] Tumey, L.N., Charati, M., He, T., Sousa, E., Ma, D., Han, X., Clark, T., Casavant, J., Loganzo, F., Barletta, F., Lucas, J., Graziani, E.I., Bioconjugate Chem. 25 (2014), 1871–1880.
28. [28] Fontaine, S.D., Reid, R., Robinson, L., Ashley, G.W., Santi, D.V., Bioconjugate Chem. 26 (2015), 145–152.
29. [29] Xu, K., Liu, L., Dere, R., Mai, E., Erickson, R., Hendricks, A., Lin, K., Junutula, J.R., Kaur, S., Bioanalysis 5 (2013), 1057–1071.