-
1
-
-
77951586447
-
Strategies and challenges for the next generation of therapeutic antibodies
-
PMID:20414207
-
Beck A, Wurch T, Bailly C, Corvaia N. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol 2010; 10:345-52; PMID:20414207; http://dx.doi.org/10.1038/ nri2747
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 345-352
-
-
Beck, A.1
Wurch, T.2
Bailly, C.3
Corvaia, N.4
-
2
-
-
79952199443
-
The next generation of antibody-drug conjugates comes of age
-
PMID:21034674
-
Beck A, Haeuw JF, Wurch T, Goetsch L, Bailly C, Corvaïa N. The next generation of antibody-drug conjugates comes of age. Discov Med 2010; 10:329-39; PMID:21034674
-
(2010)
Discov Med
, vol.10
, pp. 329-339
-
-
Beck, A.1
Haeuw, J.F.2
Wurch, T.3
Goetsch, L.4
Bailly, C.5
Corvaïa, N.6
-
3
-
-
79960097846
-
-
Frankfurt, Germany. MAbs 2011; PMID:21691144
-
Beck A, Senter P, Chari R. World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, Germany. MAbs 2011; 3:331-7; PMID:21691144; http://dx.doi.org/10.4161/ mabs.3.4.16612
-
(2011)
World Antibody Drug Conjugate Summit Europe: February 21-23
, vol.3
, pp. 331-337
-
-
Beck, A.1
Senter, P.2
Chari, R.3
-
4
-
-
84869797748
-
-
Frankfurt, Germany. MAbs 2012; PMID:22909934
-
Beck A, Lambert J, Sun M, Lin K. Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany. MAbs 2012; 4:637-47; PMID:22909934; http://dx.doi. org/10.4161/mabs.21697
-
(2012)
Fourth World Antibody-Drug Conjugate Summit: February 29-March 1
, vol.4
, pp. 637-647
-
-
Beck, A.1
Lambert, J.2
Sun, M.3
Lin, K.4
-
5
-
-
84874300889
-
Location matters: Site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates
-
PMID:23438745
-
Strop P, Liu SH, Dorywalska M, Delaria K, Dushin RG, Tran TT, Ho WH, Farias S, Casas MG, Abdiche Y, et al. Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem Biol 2013; 20:161-7; PMID:23438745; http://dx.doi.org/10.1016/j. chembiol.2013.01.010
-
(2013)
Chem Biol
, vol.20
, pp. 161-167
-
-
Strop, P.1
Liu, S.H.2
Dorywalska, M.3
Delaria, K.4
Dushin, R.G.5
Tran, T.T.6
Ho, W.H.7
Farias, S.8
Casas, M.G.9
Abdiche, Y.10
-
6
-
-
78650297318
-
Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase
-
PMID:21110357
-
Jeger S, Zimmermann K, Blanc A, Grünberg J, Honer M, Hunziker P, Struthers H, Schibli R. Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase. Angew Chem Int Ed Engl 2010; 49:9995-7; PMID:21110357; http://dx.doi. org/10.1002/anie.201004243
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 9995-9997
-
-
Jeger, S.1
Zimmermann, K.2
Blanc, A.3
Grünberg, J.4
Honer, M.5
Hunziker, P.6
Struthers, H.7
Schibli, R.8
-
7
-
-
84892581066
-
Tumor uptake and efficacy of antibody drug conjugates using 89Zirconium immunoPET
-
World Molecular Imaging Congress, San Diego, California
-
Ogasawara AF, Vanderbilt J, Tinianow A, Gill J, Kan H. Tumor uptake and efficacy of antibody drug conjugates using 89Zirconium immunoPET. P822. 2011 World Molecular Imaging Congress, San Diego, California.
-
(2011)
P822
-
-
Ogasawara, A.F.1
Vanderbilt, J.2
Tinianow, A.3
Gill, J.4
Kan, H.5
-
8
-
-
22044451179
-
177Lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer
-
DOI 10.1200/JCO.2005.05.160
-
Bander NH, Milowsky MI, Nanus DM, Kostakoglu L, Vallabhajosula S, Goldsmith SJ. Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. J Clin Oncol 2005; 23:4591-601; PMID:15837970; http://dx.doi. org/10.1200/JCO.2005.05.160 (Pubitemid 46224061)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.21
, pp. 4591-4601
-
-
Bander, N.H.1
Milowsky, M.I.2
Nanus, D.M.3
Kostakoglu, L.4
Vallabhajosula, S.5
Goldsmith, S.J.6
-
9
-
-
84880733804
-
Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: A case study with brentuximab-vedotin
-
PMID:23151991
-
Shah DK, Haddish-Berhane N, Betts A. Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin. J Pharmacokinet Pharmacodyn 2012; 39:643-59; PMID:23151991; http://dx.doi.org/10.1007/s10928-012-9276-y
-
(2012)
J Pharmacokinet Pharmacodyn
, vol.39
, pp. 643-659
-
-
Shah, D.K.1
Haddish-Berhane, N.2
Betts, A.3
-
10
-
-
84861480783
-
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
-
PMID:22143261
-
Shah DK, Betts AM. Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human. J Pharmacokinet Pharmacodyn 2012; 39:67-86; PMID:22143261; http://dx.doi.org/10.1007/ s10928-011-9232-2
-
(2012)
J Pharmacokinet Pharmacodyn
, vol.39
, pp. 67-86
-
-
Shah, D.K.1
Betts, A.M.2
-
11
-
-
84866601281
-
Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer
-
PMID:22968044
-
Chudasama VL, Schaedeli Stark F, Harrold JM, Tibbitts J, Girish SR, Gupta M, Frey N, Mager DE. Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer. Clin Pharmacol Ther 2012; 92:520-7; PMID:22968044; http://dx.doi. org/10.1038/clpt.2012.153
-
(2012)
Clin Pharmacol Ther
, vol.92
, pp. 520-527
-
-
Chudasama, V.L.1
Schaedeli Stark, F.2
Harrold, J.M.3
Tibbitts, J.4
Girish, S.R.5
Gupta, M.6
Frey, N.7
De, M.8
-
12
-
-
84867571080
-
A population pharmacokinetic/ pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer
-
PMID:22886072
-
Bender BC, Schaedeli-Stark F, Koch R, Joshi A, Chu YW, Rugo H, Krop IE, Girish S, Friberg LE, Gupta M. A population pharmacokinetic/ pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Cancer Chemother Pharmacol 2012; 70:591-601; PMID:22886072; http://dx.doi.org/10.1007/s00280-012-1934-7
-
(2012)
Cancer Chemother Pharmacol
, vol.70
, pp. 591-601
-
-
Bender, B.C.1
Schaedeli-Stark, F.2
Koch, R.3
Joshi, A.4
Chu, Y.W.5
Rugo, H.6
Krop, I.E.7
Girish, S.8
Friberg, L.E.9
Gupta, M.10
-
13
-
-
84885643512
-
On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: A PK/PD approach
-
PMID:23933716
-
Haddish-Berhane N, Shah DK, Ma D, Leal M, Gerber HP, Sapra P, Barton HA, Betts AM. On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach. J Pharmacokinet Pharmacodyn 2013; 40:557-71; PMID:23933716; http://dx.doi. org/10.1007/s10928-013-9329-x
-
(2013)
J Pharmacokinet Pharmacodyn
, vol.40
, pp. 557-571
-
-
Haddish-Berhane, N.1
Shah, D.K.2
Ma, D.3
Leal, M.4
Gerber, H.P.5
Sapra, P.6
Barton, H.A.7
Betts, A.M.8
-
14
-
-
84877280582
-
Key bioanalytical measurements for antibody-drug conjugate development: PK/PD modelers' perspective
-
PMID:23641690
-
Shah DK, Barletta F, Betts A, Hansel S. Key bioanalytical measurements for antibody-drug conjugate development: PK/PD modelers' perspective. Bioanalysis 2013; 5:989-92; PMID:23641690; http://dx.doi.org/10.4155/bio.13.78
-
(2013)
Bioanalysis
, vol.5
, pp. 989-992
-
-
Shah, D.K.1
Barletta, F.2
Betts, A.3
Hansel, S.4
-
15
-
-
65549151884
-
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
-
PMID:19258515
-
Polson AG, Calemine-Fenaux J, Chan P, Chang W, Christensen E, Clark S, de Sauvage FJ, Eaton D, Elkins K, Elliott JM, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res 2009; 69:2358-64; PMID:19258515; http://dx.doi. org/10.1158/0008- 5472.CAN-08-2250
-
(2009)
Cancer Res
, vol.69
, pp. 2358-2364
-
-
Polson, A.G.1
Calemine-Fenaux, J.2
Chan, P.3
Chang, W.4
Christensen, E.5
Clark, S.6
De Sauvage, F.J.7
Eaton, D.8
Elkins, K.9
Elliott, J.M.10
-
16
-
-
49449087300
-
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
-
PMID:18641636
-
Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, Chen Y, Simpson M, Tsai SP, Dennis MS, et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol 2008; 26:925-32; PMID:18641636; http://dx.doi.org/10.1038/nbt.1480
-
(2008)
Nat Biotechnol
, vol.26
, pp. 925-932
-
-
Junutula, J.R.1
Raab, H.2
Clark, S.3
Bhakta, S.4
Leipold, D.D.5
Weir, S.6
Chen, Y.7
Simpson, M.8
Tsai, S.P.9
Dennis, M.S.10
-
17
-
-
0037440038
-
Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: A phase I, pharmacokinetic, and biologic correlative study
-
DOI 10.1200/JCO.2003.05.137
-
Tolcher AW, Ochoa L, Hammond LA, Patnaik A, Edwards T, Takimoto C, Smith L, de Bono J, Schwartz G, Mays T, et al. Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol 2003; 21:211-22; PMID:12525512; http://dx.doi.org/10.1200/ JCO.2003.05.137 (Pubitemid 46606149)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.2
, pp. 211-222
-
-
Tolcher, A.W.1
Ochoa, L.2
Hammond, L.A.3
Patnaik, A.4
Edwards, T.5
Takimoto, C.6
Smith, L.7
De Bono, J.8
Schwartz, G.9
Mays, T.10
Jonak, Z.L.11
Johnson, R.12
DeWitte, M.13
Martino, H.14
Audette, C.15
Maes, K.16
Chari, R.V.J.17
Lambert, J.M.18
Rowinsky, E.K.19
-
18
-
-
84892590004
-
Review of antibody-drug conjugates, methods in molecular biology series: A book edited by Laurent Ducry
-
in press
-
Beck A. Review of Antibody-Drug Conjugates, Methods in Molecular Biology series: A book edited by Laurent Ducry. MAbs. 2013; 6: in press.
-
(2013)
MAbs
, vol.6
-
-
Beck, A.1
-
19
-
-
34249076359
-
Introducing genetically encoded aldehydes into proteins
-
DOI 10.1038/nchembio878, PII NCHEMBIO878
-
Carrico IS, Carlson BL, Bertozzi CR. Introducing genetically encoded aldehydes into proteins. Nat Chem Biol 2007; 3:321-2; PMID:17450134; http:// dx.doi.org/10.1038/nchembio878 (Pubitemid 46789266)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.6
, pp. 321-322
-
-
Carrico, I.S.1
Carlson, B.L.2
Bertozzi, C.R.3
-
20
-
-
62549121136
-
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
-
PMID:19202059
-
Wu P, Shui W, Carlson BL, Hu N, Rabuka D, Lee J, Bertozzi CR. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A 2009; 106:3000-5; PMID:19202059; http://dx.doi.org/10.1073/ pnas.0807820106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3000-3005
-
-
Wu, P.1
Shui, W.2
Carlson, B.L.3
Hu, N.4
Rabuka, D.5
Lee, J.6
Bertozzi, C.R.7
-
21
-
-
78649810925
-
Chemoenzymatic methods for sitespecific protein modification
-
PMID:21030291
-
Rabuka D. Chemoenzymatic methods for sitespecific protein modification. Curr Opin Chem Biol 2010; 14:790-6; PMID:21030291; http://dx.doi. org/10.1016/j.cbpa.2010.09.020
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 790-796
-
-
Rabuka, D.1
-
22
-
-
84859992212
-
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag
-
PMID:22407566
-
Hudak JE, Barfield RM, de Hart GW, Grob P, Nogales E, Bertozzi CR, Rabuka D. Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl 2012; 51:4161-5; PMID:22407566; http://dx.doi.org/10.1002/anie.201108130
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 4161-4165
-
-
Hudak, J.E.1
Barfield, R.M.2
De Hart, G.W.3
Grob, P.4
Nogales, E.5
Bertozzi, C.R.6
Rabuka, D.7
-
23
-
-
84861034877
-
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
-
PMID:22576105
-
Rabuka D, Rush JS, deHart GW, Wu P, Bertozzi CR. Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc 2012; 7:1052-67; PMID:22576105; http://dx.doi. org/10.1038/nprot.2012.045
-
(2012)
Nat Protoc
, vol.7
, pp. 1052-1067
-
-
Rabuka, D.1
Rush, J.S.2
Dehart, G.W.3
Wu, P.4
Bertozzi, C.R.5
-
24
-
-
84879340492
-
Hydrazino-pictet-spengler ligation as a biocompatible method for the generation of stable protein conjugates
-
PMID:23731037
-
Agarwal P, Kudirka R, Albers AE, Barfield RM, de Hart GW, Drake PM, Jones LC, Rabuka D. Hydrazino-pictet-spengler ligation as a biocompatible method for the generation of stable protein conjugates. Bioconjug Chem 2013; 24:846-51; PMID:23731037; http://dx.doi.org/10.1021/bc400042a
-
(2013)
Bioconjug Chem
, vol.24
, pp. 846-851
-
-
Agarwal, P.1
Kudirka, R.2
Albers, A.E.3
Barfield, R.M.4
De Hart, G.W.5
Drake, P.M.6
Jones, L.C.7
Rabuka, D.8
|