Long-term stabilization of maleimide-thiol conjugates

Bioconjugate Chemistry

Volumn 26, Issue 1, 2015, Pages 145-152

  Fontaine, Shaun D ^a   Reid, Ralph ^a   Robinson, Louise ^a   Ashley, Gary W ^a   Santi, Daniel V ^a  

^a ProLynx   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; HYDROLYSIS;

'CURRENT; ANTIBODY-DRUG CONJUGATES; BIO-CONJUGATION; ELECTRONWITHDRAWING; IN-VIVO; MALEIMIDES; MICHAEL ADDITIONS; RING OPENING; RING-OPENED PRODUCTS; SUCCINIMIDE;

MONOCLONAL ANTIBODIES;

BRENTUXIMAB VEDOTIN; MALEIMIDE DERIVATIVE; SUCCINIMIDE; SULFIDE; THIOL DERIVATIVE; TRASTUZUMAB EMTANSINE; MALEIMIDE; SUCCINIMIDE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; DRUG CONJUGATION; DRUG STABILITY; ELECTRON; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MICHAEL ADDITION; RING OPENING; CHEMISTRY; ENZYME SPECIFICITY; KINETICS;

DRUG STABILITY; KINETICS; MALEIMIDES; SUBSTRATE SPECIFICITY; SUCCINIMIDES; SULFHYDRYL COMPOUNDS;

EID: 84921497726     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5005262     Document Type: Article

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