CC2D1a loss of function disrupts functional and morphological development in forebrain neurons leading to cognitive and social deficits

Cerebral Cortex

Volumn 27, Issue 2, 2017, Pages 1670-1685

  Oaks, Adam W ^a   Zamarbide, Marta ^a   Tambunan, Dimira E ^b,c   Santini, Emanuela ^d   Costanzo, Stefania Di ^a   Pond, Heather L ^a   Johnson, Mark W ^a   Lin, Jeff ^e   Gonzalez, Dilenny M ^b,c   Boehler, Jessica F ^a   Wu, Guangying K ^e   Klann, Eric ^d   Walsh, Christopher A ^b,c   Chiara Manzini, M ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Autism; Cognitive development; Dendritic spines; Intellectual disability; Long term plasticity

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; CRE RECOMBINASE; NESTIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; CC2D1A PROTEIN, HUMAN; DNA BINDING PROTEIN; FREUD-1 PROTEIN, MOUSE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; CC2D1A GENE; COGNITIVE DEFECT; DENDRITIC SPINE; FOREBRAIN; GENE; GENOTYPING TECHNIQUE; GROOMING; HIPPOCAMPAL SLICE; HYPERACTIVITY; IMMUNOBLOTTING; LOSS OF FUNCTION MUTATION; MENTAL DISEASE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SOCIAL INTERACTION; SPATIAL LEARNING; TISSUE SECTION; ANIMAL; AUTISM; CYTOLOGY; DEFICIENCY; DENDRITE; DISEASE MODEL; GENETICS; HUMAN; INTELLECTUAL IMPAIRMENT; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; AUTISM SPECTRUM DISORDER; DENDRITES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HUMANS; INTELLECTUAL DISABILITY; MICE, TRANSGENIC; NEURONAL PLASTICITY; NEURONS; PROSENCEPHALON; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84971647326     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhw009     Document Type: Article

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