Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 811, Issue , 2016, Pages 43-48

  Kyoya, Takahiro ^a   Hori, Masami ^a   Terada, Megumi ^a  

^a KUMIAI CHEMICAL INDUSTRY CO LTD   (Japan)

Author keywords

Flow cytometry; In vivo mutagenicity test; Non genotoxic carcinogen; Pig a mutation; Reticulocyte Pig a assay

Indexed keywords

ETHYLNITROSOUREA; MELAMINE; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN; TRIAZINE DERIVATIVE;

ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; ERYTHROCYTE PIG A ASSAY; FLOW CYTOMETER; GENOTOXICITY; GENOTOXICITY ASSAY; IN VIVO STUDY; MALE; MUTAGENICITY; MUTATION RATE; NONHUMAN; PIG A RETICULOCYTE ASSAY; PRIORITY JOURNAL; RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ERYTHROCYTE; EVALUATION STUDY; GENETICS; MUTAGEN TESTING; PROCEDURES; RETICULOCYTE; SPRAGUE DAWLEY RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; MEMBRANE PROTEINS; MUTAGENICITY TESTS; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; TRIAZINES;

EID: 84971634663     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2016.04.003     Document Type: Article

References (22)

1. [1] Dobrovolsky, V.N., Miura, D., Heflich, R.H., Dertinger, S.D., The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment. Environ. Mol. Mutagen. 51 (2010), 825–835.
2. [2] Miura, D., The in vivo Pig-a gene mutation assay. Genes Environ. 36 (2014), 169–173.
3. [3] Miura, D., Dobrovolsky, V.N., Kasahara, Y., Katsuura, Y., Heflich, R.H., Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. Environ. Mol. Mutagen. 49 (2008), 614–621.
4. [4] Miura, D., Dobrovolsky, V.N., Kimoto, T., Kasahara, Y., Heflich, R.H., Accumulation and persistence of Pig-A mutant peripheral red blood cells. Mutat. Res. 677 (2008), 86–92.
5. [5] Dobo, K.L., Fiedler, R.D., Gunther, W.C., Thiffeault, C.J., Cammerer, Z., Coffing, S.L., Shutsky, T., Schuler, M., Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in rats. Mutat. Res. 725 (2011), 13–21.
6. [6] Kimoto, T., Horibata, K., Chikura, S., Hashimoto, K., Itoh, S., Sanada, H., Muto, S., Uno, Y., Yamada, M., Honma, M., Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat. Res. 755 (2013), 126–134.
7. [7] Itoh, S., Nagata, M., Hattori, C., Takasaki, W., In vivo mutagenicity of ethyl methanesulfonate detected by Pig-a and PIGRET assays. Genes Environ. 36 (2014), 174–178.
8. [8] Sanada, H., Okamoto, M., Ohsumi, T., Nakamura, T., Evaluation for a mutagenicity of 4,4′ −methylenedianiline on hematopoietic cells by a Pig-a gene mutation assay in rats. Genes Environ. 36 (2014), 179–185.
9. [9] Muto, S., Yamada, K., Kato, T., Iwase, Y., Uno, Y., Pig-a gene mutation and micronucleus induction in rat peripheral blood by methyl methanesulfonate. Genes Environ. 36 (2014), 186–190.
10. [10] Kimoto, T., Chikura, S., Suzuki-Okada, K., Kobayashi, X., Itano, Y., Miura, D., Kasahara, Y., The rat Pig-a mutation assay in single and 28 day-repeated dose study of cyclophosphamide: the PIGRET assay can detect the in vivo mutagenicity earlier than the RBC Pig-a assay. Genes Environ. 36 (2014), 191–198.
11. [11] Melnick, R.L., Boorman, G.A., Haseman, J.K., Montali, R.J., Huff, J., Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol. Appl. Pharmacol. 72 (1984), 292–303.
12. [12] Ogasawara, H., Imaida, K., Ishiwata, H., Toyoda, K., Kawanishi, T., Uneyama, C., Hayashi, S., Takahashi, M., Hayashi, Y., Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis 16 (1995), 2773–2777.
13. [13] Hang, Q.X., Yang, G.Y., Li, J.T., Li, W.X., Zhang, B., Zhu, W., Melamine induces sperm DNA damage and abnormality, but not genetic toxicity. Regul. Toxicol. Pharmacol. 60 (2011), 144–150.
14. [14] Tu, H., Zhang, M., Zhou, C., Wang, Z., Huang, P., Ou, H., Chang, Y., Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays. Mutat. Res. 777 (2015), 62–67.
15. [15] Kimoto, T., et al. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: summary of the MMS/JEMS-collaborative study across 16 laboratoriesusing 24 chemicals. Mutat. Res. 811 (2016), 3–15.
16. [16] Wako Pure Chemical Industries, Ltd., Material Safety Data Sheet, Melamine (139-00945).
17. [17] OECD Guideline for the testing of chemicals #474: Mammalian erythrocyte micronucleus test, 26 September 2014.
18. [18] OECD Guideline for the testing of chemicals #489: In vivo mammalian alkaline comet assay, 26 September 2014.
19. [19] Horibata, K., Ukai, A., Honma, M., Evaluation of rats’ in vivo genotoxicity induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt assays. Genes and Environ 36 (2014), 199–202.
20. [20] Kimoto, T., Chikura, S., Suzuki-Okada, K., Kobayashi, X.-M., Itano, Y., Miura, D., Kasahara, Y., Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals. J. Toxicol. Sci. 37 (2012), 943–955.
21. [21] Kimoto, T., Chikura, S., Suzuki, K., Kobayashi, X.-M., Itano, Y., Horibata, K., Honma, M., Dobrovolsky, V.N., Heflich, R.H., Miura, D., Kasahara, Y., Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ. Mol. Mutagen. 52 (2011), 774–783.
22. [22] Terada, S., Suzuki, N., Uchide, K., Akasofu, K., Nishida, E., Effect of testosterone on the development of bladder tumors and calculi in female rats. Gynecol. Obstet. Invest. 34 (1992), 105–110.