Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 777, Issue , 2015, Pages 62-67

  Tu, Honggang ^a   Zhang, Min ^a   Zhou, Changhui ^a   Wang, Zheng ^a   Huang, Pengcheng ^a   Ou, Hongmei ^a   Chang, Yan ^a  

^a National Shanghai Center for New Drug Safety Evaluation and Research   (China)

Author keywords

Ames test; Flow cytometry; Melamine; MN test; Pig a gene mutation

Indexed keywords

MELAMINE; PIG A PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CD59 ANTIGEN; ETHYLNITROSOUREA; EXCIPIENT; RESIN; SESAME SEED OIL; TRIAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; CHO CELL LINE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GENE MUTATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; MALE; METABOLIC ACTIVATION; MICRONUCLEUS; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; RAT; RETICULOCYTE; REVERTANT; RISK ASSESSMENT; ANIMAL; CRICETULUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; ORAL DRUG ADMINISTRATION; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SPRAGUE DAWLEY RAT;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; RATTUS; SESAMUM INDICUM; SUIDAE;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD59; CHO CELLS; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; ETHYLNITROSOUREA; EXCIPIENTS; GENE EXPRESSION; MALE; MICRONUCLEUS TESTS; MUTATION; RATS; RATS, SPRAGUE-DAWLEY; RESINS, SYNTHETIC; RETICULOCYTES; SALMONELLA TYPHIMURIUM; SESAME OIL; TRIAZINES;

EID: 84919346614     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.12.001     Document Type: Article

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