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Volumn 36, Issue 4, 2014, Pages 191-198

The rat Pig-a mutation assay in single and 28 day-repeated dose study of cyclophosphamide: The PIGRET assay can detect the in vivo mutagenicity earlier than the RBC Pig-a assay

Author keywords

Flow cytometry; In vivo mutation assay; Peripheral blood; Pig a gene

Indexed keywords

CYCLOPHOSPHAMIDE;

EID: 84918795580     PISSN: 18807046     EISSN: 18807062     Source Type: Journal    
DOI: 10.3123/jemsge.2014.025     Document Type: Article
Times cited : (19)

References (18)
  • 1
    • 78349292149 scopus 로고    scopus 로고
    • The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment
    • Dobrovolsky VN, Miura D, Heflich RH, Dertinger SD. The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment. Environ Mol Mutagen. 2010; 51: 825-35.
    • (2010) Environ Mol Mutagen. , vol.51 , pp. 825-835
    • Dobrovolsky, V.N.1    Miura, D.2    Heflich, R.H.3    Dertinger, S.D.4
  • 2
    • 42949122947 scopus 로고    scopus 로고
    • In vivo mutation assay based on the endogenous Pig-a locus
    • Bryce SM, Bemis JC, Dertinger SD. In vivo mutation assay based on the endogenous Pig-a locus. Environ Mol Mutagen. 2008; 49: 256-64.
    • (2008) Environ Mol Mutagen. , vol.49 , pp. 256-264
    • Bryce, S.M.1    Bemis, J.C.2    Dertinger, S.D.3
  • 3
    • 54249128207 scopus 로고    scopus 로고
    • Development of an in vivo gene mutation assay using the endogenous Pig-a gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat
    • Miura D, Dobrovolsky VN, Kasahara Y, Katsuura Y, Heflich RH. Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. Environ Mol Mutagen. 2008; 49: 614-21.
    • (2008) Environ Mol Mutagen. , vol.49 , pp. 614-621
    • Miura, D.1    Dobrovolsky, V.N.2    Kasahara, Y.3    Katsuura, Y.4    Heflich, R.H.5
  • 4
    • 54249134721 scopus 로고    scopus 로고
    • Development of an in vivo gene mutation assay using the endogenous Pig-a gene: II. Selection of Pig-a mutant rat spleen T-cells with proaerolysin and sequencing Pig-a cDNA from the mutants
    • Miura D, Dobrovolsky VN, Mittelstaedt RA, Kasahara Y, Katsuura Y, Heflich RH. Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants. Environ Mol Mutagen. 2008; 49: 622-30.
    • (2008) Environ Mol Mutagen. , vol.49 , pp. 622-630
    • Miura, D.1    Dobrovolsky, V.N.2    Mittelstaedt, R.A.3    Kasahara, Y.4    Katsuura, Y.5    Heflich, R.H.6
  • 5
    • 80155178417 scopus 로고    scopus 로고
    • Need and potential value of the Pig-a in vivo mutation assay - A HESI perspective
    • Schuler M, Gollapudi BB, Thybaud V, Kim JH. Need and potential value of the Pig-a in vivo mutation assay - A HESI perspective, Environ Mol Mutagen. 2011; 52: 685-9.
    • (2011) Environ Mol Mutagen. , vol.52 , pp. 685-689
    • Schuler, M.1    Gollapudi, B.B.2    Thybaud, V.3    Kim, J.H.4
  • 6
    • 84869753046 scopus 로고    scopus 로고
    • Efficient monitoring of in vivo Pig-a gene mutation and chromosomal damage: Summary of 7 published studies and results from 11 new reference compounds
    • Dertinger SD, Phonethepswath S, Avlasevich S, Torous DK, Mereness J, Bryce SM, et al. Efficient monitoring of in vivo Pig-a gene mutation and chromosomal damage: Summary of 7 published studies and results from 11 new reference compounds, Toxicol Sci. 2012; 130: 328-48.
    • (2012) Toxicol Sci. , vol.130 , pp. 328-348
    • Dertinger, S.D.1    Phonethepswath, S.2    Avlasevich, S.3    Torous, D.K.4    Mereness, J.5    Bryce, S.M.6
  • 7
    • 77249096480 scopus 로고    scopus 로고
    • Flow cytometric detection of Pig-a mutant red blood cells using an erythroid-specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylpheni-date in adolescent rats
    • Dobrovolsky VN, Boctor SY, Twaddle NC, Doerge DR, Bishop ME, Manjanatha MG, et al. Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylpheni-date in adolescent rats, Environ Mol Mutagen. 2010; 51: 138-45.
    • (2010) Environ Mol Mutagen. , vol.51 , pp. 138-145
    • Dobrovolsky, V.N.1    Boctor, S.Y.2    Twaddle, N.C.3    Doerge, D.R.4    Bishop, M.E.5    Manjanatha, M.G.6
  • 8
    • 0028046590 scopus 로고
    • Molecular cloning of murine Pig-a, a gene for GPI-anchor biosynthesis, and demonstration of interspecies conservation of its structure, function, and genetic locus
    • Kawagoe K, Takeda J, Endo Y, Kinoshita T. Molecular cloning of murine Pig-a, a gene for GPI-anchor biosynthesis, and demonstration of interspecies conservation of its structure, function, and genetic locus. Genomics. 1994; 23: 566-74.
    • (1994) Genomics , vol.23 , pp. 566-574
    • Kawagoe, K.1    Takeda, J.2    Endo, Y.3    Kinoshita, T.4
  • 9
    • 0035801698 scopus 로고    scopus 로고
    • FES-cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow
    • Keller P, Payne JL, Tremml G, Greer PA, Gaboli M, Pandolfi PP, et al. FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow. J Exp Med. 2001; 194: 581-9.
    • (2001) J Exp Med. , vol.194 , pp. 581-589
    • Keller, P.1    Payne, J.L.2    Tremml, G.3    Greer, P.A.4    Gaboli, M.5    Pandolfi, P.P.6
  • 10
    • 56249145977 scopus 로고    scopus 로고
    • Erythrocyte-based Pig-a gene mutation assay: Demonstration of cross-species potential
    • Phonethepswath S, Bryce SM, Bemis JC, Dertinger SD. Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential. Mutat Res. 2008; 657: 122-6.
    • (2008) Mutat Res. , vol.657 , pp. 122-126
    • Phonethepswath, S.1    Bryce, S.M.2    Bemis, J.C.3    Dertinger, S.D.4
  • 12
    • 67650021207 scopus 로고    scopus 로고
    • Accumulation and persistence of Pig-a mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea
    • Miura D, Dobrovolsky VN, Kimoto T, Kasahara Y, Heflich RH. Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea. Mutat Res. 2009; 677: 86-92.
    • (2009) Mutat Res. , vol.677 , pp. 86-92
    • Miura, D.1    Dobrovolsky, V.N.2    Kimoto, T.3    Kasahara, Y.4    Heflich, R.H.5
  • 13
    • 77954067514 scopus 로고    scopus 로고
    • Integration of mutation and chromosomal damage endpoints into 28-day repeated dose toxicology studies
    • Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, et al. Integration of mutation and chromosomal damage endpoints into 28-day repeated dose toxicology studies. Toxicol Sci. 2010; 115: 401-11.
    • (2010) Toxicol Sci. , vol.115 , pp. 401-411
    • Dertinger, S.D.1    Phonethepswath, S.2    Franklin, D.3    Weller, P.4    Torous, D.K.5    Bryce, S.M.6
  • 14
    • 84881030430 scopus 로고    scopus 로고
    • Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody
    • Kimoto T, Horibata K, Chikura S, Hashimoto K, Itoh S, Sanada H, et al. Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat Res. 2013; 755: 126-34.
    • (2013) Mutat Res. , vol.755 , pp. 126-134
    • Kimoto, T.1    Horibata, K.2    Chikura, S.3    Hashimoto, K.4    Itoh, S.5    Sanada, H.6
  • 15
    • 84918783072 scopus 로고    scopus 로고
    • Document of Food and Drug Administration. Revised April 2012
    • Cyclophosphamide for Injection, USP/Cyclophosphamide Tablets, USP. Document of Food and Drug Administration. Revised April 2012. http://www.accessdata. fda.gov/drugsatfdadocs/label/2012/012141s089lbl.pdf
    • Cyclophosphamide for Injection, USP/Cyclophosphamide Tablets, USP
  • 16
    • 84881023095 scopus 로고    scopus 로고
    • Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
    • Bhalli JA, Shaddock JG, Pearce MG, Dobrovolsky VN. Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens. Mutagenesis. 2013; 28: 447-55.
    • (2013) Mutagenesis , vol.28 , pp. 447-455
    • Bhalli, J.A.1    Shaddock, J.G.2    Pearce, M.G.3    Dobrovolsky, V.N.4
  • 17
    • 2542566599 scopus 로고    scopus 로고
    • Hprt mutant frequencies in splenic T-cells of male F344 rats exposed by inhalation to propylene
    • Walker DM, Seilkop SK, Scott BR, Walker VE. Hprt mutant frequencies in splenic T-cells of male F344 rats exposed by inhalation to propylene. Environ Mol Mutagen. 2004; 43: 265-72.
    • (2004) Environ Mol Mutagen. , vol.43 , pp. 265-272
    • Walker, D.M.1    Seilkop, S.K.2    Scott, B.R.3    Walker, V.E.4
  • 18
    • 84867875271 scopus 로고    scopus 로고
    • Effective use of the Pig-a gene mutation assay for mutagenicity screening: Measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals
    • Kimoto T, Chikura S, Suzuki K, Kobayashi XM, Itano Y, Miura D, et al. Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals. J Toxicol Sci. 2012; 37: 943-55.
    • (2012) J Toxicol Sci. , vol.37 , pp. 943-955
    • Kimoto, T.1    Chikura, S.2    Suzuki, K.3    Kobayashi, X.M.4    Itano, Y.5    Miura, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.