메뉴 건너뛰기




Volumn 16, Issue 5, 2016, Pages 335-343

Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer

Author keywords

Clinical trials; Endocrine therapy; Pathways; Treatment strategies; Triple negative breast cancer

Indexed keywords

ABC TRANSPORTER SUBFAMILY B; BREAST CANCER RESISTANCE PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HORMONE RECEPTOR; MULTIDRUG RESISTANCE RELATED PROTEIN; PROTEIN; UNCLASSIFIED DRUG; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; ESTROGEN RECEPTOR; MULTIDRUG RESISTANCE PROTEIN; PROGESTERONE RECEPTOR;

EID: 84971602948     PISSN: 15268209     EISSN: 19380666     Source Type: Journal    
DOI: 10.1016/j.clbc.2016.05.012     Document Type: Review
Times cited : (208)

References (124)
  • 1
    • 85044267061 scopus 로고    scopus 로고
    • What are the key statistics about breast cancer? Available at: Accessed: February 4
    • American Cancer Society. What are the key statistics about breast cancer? Available at: http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-key-statistics. Accessed: February 4, 2015.
    • (2015)
  • 2
    • 84887842900 scopus 로고    scopus 로고
    • Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex
    • Giessrigl, B., Schmidt, W.M., Kalipciyan, M., et al. Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer 109 (2013), 2751–2762.
    • (2013) Br J Cancer , vol.109 , pp. 2751-2762
    • Giessrigl, B.1    Schmidt, W.M.2    Kalipciyan, M.3
  • 3
    • 84863715487 scopus 로고    scopus 로고
    • Chemotherapy-resistant metastatic breast cancer
    • Marquette, C., Nabell, L., Chemotherapy-resistant metastatic breast cancer. Curr Treat Options Oncol 13 (2012), 263–275.
    • (2012) Curr Treat Options Oncol , vol.13 , pp. 263-275
    • Marquette, C.1    Nabell, L.2
  • 4
    • 84921465766 scopus 로고    scopus 로고
    • Triple-negative breast cancer: new perspectives for targeted therapies
    • Tomao, F., Papa, A., Zaccarelli, E., et al. Triple-negative breast cancer: new perspectives for targeted therapies. Onco Targets Ther 8 (2015), 177–193.
    • (2015) Onco Targets Ther , vol.8 , pp. 177-193
    • Tomao, F.1    Papa, A.2    Zaccarelli, E.3
  • 5
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: causes and consequences
    • Marusyk, A., Polyak, K., Tumor heterogeneity: causes and consequences. Biochim Biophys Acta, 1805, 2010, 105.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105
    • Marusyk, A.1    Polyak, K.2
  • 6
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie, T., Perou, C.M., Tibshirani, R., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98 (2001), 10869–10874.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 7
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie, T., Tibshirani, R., Parker, J., et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 100 (2003), 8418–8423.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 8
    • 28344454000 scopus 로고    scopus 로고
    • Molecular classification and molecular forecasting of breast cancer: ready for clinical application?
    • Brenton, J.D., Carey, L.A., Ahmed, A.A., Caldas, C., Molecular classification and molecular forecasting of breast cancer: ready for clinical application?. J Clin Oncol 23 (2005), 7350–7360.
    • (2005) J Clin Oncol , vol.23 , pp. 7350-7360
    • Brenton, J.D.1    Carey, L.A.2    Ahmed, A.A.3    Caldas, C.4
  • 9
    • 37249012374 scopus 로고    scopus 로고
    • Expression profiling technology: its contribution to our understanding of breast cancer
    • Rakha, E.A., El-Sayed, M.E., Reis-Filho, J.S., Ellis, I.O., Expression profiling technology: its contribution to our understanding of breast cancer. Histopathology 52 (2008), 67–81.
    • (2008) Histopathology , vol.52 , pp. 67-81
    • Rakha, E.A.1    El-Sayed, M.E.2    Reis-Filho, J.S.3    Ellis, I.O.4
  • 10
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker, J.S., Mullins, M., Cheang, M.C., et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27 (2009), 1160–1167.
    • (2009) J Clin Oncol , vol.27 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 11
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou, C., Pusztai, L., Gene-expression signatures in breast cancer. N Engl J Med 360 (2009), 790–800.
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 12
    • 68349126950 scopus 로고    scopus 로고
    • Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet?
    • Correa Geyer, F., Reis-Filho, J.S., Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet?. Int J Surg Pathol 17 (2009), 285–302.
    • (2009) Int J Surg Pathol , vol.17 , pp. 285-302
    • Correa Geyer, F.1    Reis-Filho, J.S.2
  • 13
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann, B.D., Bauer, J.A., Chen, X., et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121 (2011), 2750–2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 14
    • 84886412350 scopus 로고    scopus 로고
    • Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes
    • Masuda, H., Baggerly, K.A., Wang, Y., et al. Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes. Clin Cancer Res 19 (2013), 5533–5540.
    • (2013) Clin Cancer Res , vol.19 , pp. 5533-5540
    • Masuda, H.1    Baggerly, K.A.2    Wang, Y.3
  • 15
    • 84874644584 scopus 로고    scopus 로고
    • The natural history of hormone receptor–positive breast cancer: attempting to decipher an intriguing concept
    • 700
    • Nagaraj, G., Ellis, M.J., Ma, C.X., The natural history of hormone receptor–positive breast cancer: attempting to decipher an intriguing concept. Oncology (Williston Park) 26 (2012), 696–697 700.
    • (2012) Oncology (Williston Park) , vol.26 , pp. 696-697
    • Nagaraj, G.1    Ellis, M.J.2    Ma, C.X.3
  • 16
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365 (2005), 1687–1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 17
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo, B.J., Korach, K.S., Estrogen receptors and human disease. J Clin Invest 116 (2006), 561–570.
    • (2006) J Clin Invest , vol.116 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 18
    • 85044266957 scopus 로고    scopus 로고
    • Aromatase inhibitors. Available at: Accessed: February 20
    • American Cancer Society. Aromatase inhibitors. Available at: http://www.cancer.org/cancer/breastcancer/moreinformation/medicinestoreducebreastcancer/medicines-to-reduce-breast-cancer-risk-aromatase-inhibitors. Accessed: February 20, 2015.
    • (2015)
  • 19
    • 31444447160 scopus 로고    scopus 로고
    • Extending survival with chemotherapy in metastatic breast cancer
    • O'Shaughnessy, J., Extending survival with chemotherapy in metastatic breast cancer. Oncologist 10:suppl 3 (2005), 20–29.
    • (2005) Oncologist , vol.10 , pp. 20-29
    • O'Shaughnessy, J.1
  • 20
    • 84887114555 scopus 로고    scopus 로고
    • The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy
    • Mitri, Z., Constantine, T., O'Regan, R., The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy. Chemother Res Pract, 2012, 2012, 743193.
    • (2012) Chemother Res Pract , vol.2012 , pp. 743193
    • Mitri, Z.1    Constantine, T.2    O'Regan, R.3
  • 21
    • 33645469844 scopus 로고    scopus 로고
    • Expression of MDR proteins in breast cancer and its correlation with some clinical and pathological parameters
    • Rybarova, S., Hodorova, I., Hajdukova, M., et al. Expression of MDR proteins in breast cancer and its correlation with some clinical and pathological parameters. Neoplasma 53 (2006), 128–135.
    • (2006) Neoplasma , vol.53 , pp. 128-135
    • Rybarova, S.1    Hodorova, I.2    Hajdukova, M.3
  • 22
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: clinical features and patterns of recurrence
    • Dent, R., Trudeau, M., Pritchard, K.I., et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13:15 pt 1 (2007), 4429–4434.
    • (2007) Clin Cancer Res , vol.13 , Issue.15 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 23
    • 56049103793 scopus 로고    scopus 로고
    • Understanding and treating triple-negative breast cancer
    • Anders, C., Carey, L.A., Understanding and treating triple-negative breast cancer. Oncology (Williston Park) 22 (2008), 1233–1239.
    • (2008) Oncology (Williston Park) , vol.22 , pp. 1233-1239
    • Anders, C.1    Carey, L.A.2
  • 25
    • 84866866082 scopus 로고    scopus 로고
    • Triple-negative breast cancer: are we making headway at least?
    • Arnedos, M., Bihan, C., Delaloge, S., Andre, F., Triple-negative breast cancer: are we making headway at least?. Ther Adv Med Oncol 4 (2012), 195–210.
    • (2012) Ther Adv Med Oncol , vol.4 , pp. 195-210
    • Arnedos, M.1    Bihan, C.2    Delaloge, S.3    Andre, F.4
  • 26
    • 85009728547 scopus 로고    scopus 로고
    • Androgen receptor expression and its relationship with clinicopathological parameters in an Iranian population with invasive breast carcinoma
    • Mohammadizadeh, F., Sajadieh, S., Sajjadieh, H., Kasaei, Z., Androgen receptor expression and its relationship with clinicopathological parameters in an Iranian population with invasive breast carcinoma. Adv Biomed Res, 3, 2014, 132.
    • (2014) Adv Biomed Res , vol.3 , pp. 132
    • Mohammadizadeh, F.1    Sajadieh, S.2    Sajjadieh, H.3    Kasaei, Z.4
  • 27
    • 79953315588 scopus 로고    scopus 로고
    • Androgen receptor expression and breast cancer survival in postmenopausal women
    • Hu, R., Dawood, S., Holmes, M.D., et al. Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res 17 (2011), 1867–1874.
    • (2011) Clin Cancer Res , vol.17 , pp. 1867-1874
    • Hu, R.1    Dawood, S.2    Holmes, M.D.3
  • 28
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • Musgrove, E.A., Sutherland, R.L., Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 9 (2009), 631–643.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 29
    • 85046982181 scopus 로고    scopus 로고
    • Endocrine resistance in breast cancer: from cellular signaling pathways to epigenetic mechanisms
    • Bianco, S., Gevry, N., Endocrine resistance in breast cancer: from cellular signaling pathways to epigenetic mechanisms. Transcription 3 (2012), 165–170.
    • (2012) Transcription , vol.3 , pp. 165-170
    • Bianco, S.1    Gevry, N.2
  • 30
    • 73349088416 scopus 로고    scopus 로고
    • Resistance to trastuzumab in breast cancer
    • Pohlmann, P.R., Mayer, I.A., Mernaugh, R., Resistance to trastuzumab in breast cancer. Clin Cancer Res 15 (2009), 7479–7491.
    • (2009) Clin Cancer Res , vol.15 , pp. 7479-7491
    • Pohlmann, P.R.1    Mayer, I.A.2    Mernaugh, R.3
  • 31
    • 84871229995 scopus 로고    scopus 로고
    • Trastuzumab: updated mechanisms of action and resistance in breast cancer
    • Vu, T., Claret, F.X., Trastuzumab: updated mechanisms of action and resistance in breast cancer. Front Oncol, 2, 2012, 62.
    • (2012) Front Oncol , vol.2 , pp. 62
    • Vu, T.1    Claret, F.X.2
  • 32
    • 84859376472 scopus 로고    scopus 로고
    • Molecular pathways: regulation and therapeutic implications of multidrug resistance
    • Chen, K.G., Sikic, B.I., Molecular pathways: regulation and therapeutic implications of multidrug resistance. Clin Cancer Res 18 (2012), 1863–1869.
    • (2012) Clin Cancer Res , vol.18 , pp. 1863-1869
    • Chen, K.G.1    Sikic, B.I.2
  • 33
    • 0036668995 scopus 로고    scopus 로고
    • Tamoxifen (“Nolvadex”): a review
    • Clemons, M., Danson, S., Howell, A., Tamoxifen (“Nolvadex”): a review. Cancer Treat Rev 28 (2002), 165–180.
    • (2002) Cancer Treat Rev , vol.28 , pp. 165-180
    • Clemons, M.1    Danson, S.2    Howell, A.3
  • 34
    • 11244296162 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance
    • Ring, A., Dowsett, M., Mechanisms of tamoxifen resistance. Endocr Relat Cancer 11 (2004), 643–658.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 643-658
    • Ring, A.1    Dowsett, M.2
  • 35
    • 84890252506 scopus 로고    scopus 로고
    • D538G mutation in estrogen receptor-alpha: a novel mechanism for acquired endocrine resistance in breast cancer
    • Merenbakh-Lamin, K., Ben-Baruch, N., Yeheskel, A., et al. D538G mutation in estrogen receptor-alpha: a novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res 73 (2013), 6856–6864.
    • (2013) Cancer Res , vol.73 , pp. 6856-6864
    • Merenbakh-Lamin, K.1    Ben-Baruch, N.2    Yeheskel, A.3
  • 36
    • 84952716241 scopus 로고    scopus 로고
    • Tamoxifen resistance: from cell culture experiments towards novel biomarkers
    • Nass, N., Kalinski, T., Tamoxifen resistance: from cell culture experiments towards novel biomarkers. Pathol Res Pract 211 (2015), 189–197.
    • (2015) Pathol Res Pract , vol.211 , pp. 189-197
    • Nass, N.1    Kalinski, T.2
  • 37
    • 84879946410 scopus 로고    scopus 로고
    • Efficacy of histone deacetylase and estrogen receptor inhibition in breast cancer cells due to concerted down regulation of Akt
    • Thomas, S., Thurn, K.T., Raha, P., Chen, S., Munster, P.N., Efficacy of histone deacetylase and estrogen receptor inhibition in breast cancer cells due to concerted down regulation of Akt. PLoS One, 8, 2013, e68973.
    • (2013) PLoS One , vol.8 , pp. e68973
    • Thomas, S.1    Thurn, K.T.2    Raha, P.3    Chen, S.4    Munster, P.N.5
  • 38
    • 84888381937 scopus 로고    scopus 로고
    • Activating ESR1 mutations in hormone-resistant metastatic breast cancer
    • Robinson, D.R., Wu, Y.M., Vats, P., et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet 45 (2013), 1446–1451.
    • (2013) Nat Genet , vol.45 , pp. 1446-1451
    • Robinson, D.R.1    Wu, Y.M.2    Vats, P.3
  • 39
    • 84884559238 scopus 로고    scopus 로고
    • Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer–derived xenografts
    • Li, S., Shen, D., Shao, J., et al. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer–derived xenografts. Cell Rep 4 (2013), 1116–1130.
    • (2013) Cell Rep , vol.4 , pp. 1116-1130
    • Li, S.1    Shen, D.2    Shao, J.3
  • 40
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li, J., Yen, C., Liaw, D., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275 (1997), 1943–1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 41
    • 66249119060 scopus 로고    scopus 로고
    • Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
    • Miller, T.W., Perez-Torres, M., Narasanna, A., et al. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res 69 (2009), 4192–4201.
    • (2009) Cancer Res , vol.69 , pp. 4192-4201
    • Miller, T.W.1    Perez-Torres, M.2    Narasanna, A.3
  • 42
    • 80052009896 scopus 로고    scopus 로고
    • Epigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance
    • Raha, P., Thomas, S., Munster, P.N., Epigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance. Epigenomics 3 (2011), 451–470.
    • (2011) Epigenomics , vol.3 , pp. 451-470
    • Raha, P.1    Thomas, S.2    Munster, P.N.3
  • 43
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor–positive advanced breast cancer
    • Baselga, J., Campone, M., Piccart, M., et al. Everolimus in postmenopausal hormone-receptor–positive advanced breast cancer. N Engl J Med 366 (2012), 520–529.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 44
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2–negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study
    • Bachelot, T., Bourgier, C., Cropet, C., et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2–negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J Clin Oncol 30 (2012), 2718–2724.
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 45
    • 84863697538 scopus 로고    scopus 로고
    • The BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor–positive advanced breast cancer
    • Beaver, J.A., Park, B.H., The BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor–positive advanced breast cancer. Future Oncol 8 (2012), 651–657.
    • (2012) Future Oncol , vol.8 , pp. 651-657
    • Beaver, J.A.1    Park, B.H.2
  • 46
    • 84937042338 scopus 로고    scopus 로고
    • Palbociclib in hormone-receptor–positive advanced breast cancer
    • Turner, N.C., Ro, J., Andre, F., et al. Palbociclib in hormone-receptor–positive advanced breast cancer. N Engl J Med 373 (2015), 209–219.
    • (2015) N Engl J Med , vol.373 , pp. 209-219
    • Turner, N.C.1    Ro, J.2    Andre, F.3
  • 47
    • 84959316268 scopus 로고    scopus 로고
    • Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial
    • Cristofanilli, M., Turner, N.C., Bondarenko, I., et al. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol 17 (2016), 425–439.
    • (2016) Lancet Oncol , vol.17 , pp. 425-439
    • Cristofanilli, M.1    Turner, N.C.2    Bondarenko, I.3
  • 48
    • 84879834815 scopus 로고    scopus 로고
    • Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
    • Yardley, D.A., Ismail-Khan, R.R., Melichar, B., et al. Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol 31 (2013), 2128–2135.
    • (2013) J Clin Oncol , vol.31 , pp. 2128-2135
    • Yardley, D.A.1    Ismail-Khan, R.R.2    Melichar, B.3
  • 49
    • 85044281604 scopus 로고    scopus 로고
    • +, aromatase inhibitor (AI)-resistant advanced or metastatic breast cancer—part 1 results. Paper presented at: San Antonio Breast Cancer Symposium; December 9-13; San Antonio, TX.
    • +, aromatase inhibitor (AI)-resistant advanced or metastatic breast cancer—part 1 results. Paper presented at: San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX.
    • (2014)
    • Krop, I.J.S.1    Mayer, I.A.2    Dickler, M.3
  • 50
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab—mechanism of action and use in clinical practice
    • Hudis, C.A., Trastuzumab—mechanism of action and use in clinical practice. N Engl J Med 357 (2007), 39–51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 51
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
    • Nagy, P., Friedlander, E., Tanner, M., et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 65 (2005), 473–482.
    • (2005) Cancer Res , vol.65 , pp. 473-482
    • Nagy, P.1    Friedlander, E.2    Tanner, M.3
  • 52
    • 35448969823 scopus 로고    scopus 로고
    • Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
    • Palyi-Krekk, Z., Barok, M., Isola, J., Tammi, M., Szollosi, J., Nagy, P., Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Eur J Cancer 43 (2007), 2423–2433.
    • (2007) Eur J Cancer , vol.43 , pp. 2423-2433
    • Palyi-Krekk, Z.1    Barok, M.2    Isola, J.3    Tammi, M.4    Szollosi, J.5    Nagy, P.6
  • 53
    • 33751344602 scopus 로고    scopus 로고
    • HER2 therapy: molecular mechanisms of trastuzumab resistance
    • Nahta, R., Esteva, F.J., HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res, 8, 2006, 215.
    • (2006) Breast Cancer Res , vol.8 , pp. 215
    • Nahta, R.1    Esteva, F.J.2
  • 54
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga, J., Gelmon, K.A., Verma, S., et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 28 (2010), 1138–1144.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 55
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal, L.H., Holm, K., Maurer, M., et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65 (2005), 2554–2559.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3
  • 56
    • 84899992665 scopus 로고    scopus 로고
    • Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial
    • Andre, F., O'Regan, R., Ozguroglu, M., et al. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 15 (2014), 580–591.
    • (2014) Lancet Oncol , vol.15 , pp. 580-591
    • Andre, F.1    O'Regan, R.2    Ozguroglu, M.3
  • 57
    • 84878038749 scopus 로고    scopus 로고
    • Role of mTOR inhibition in preventing resistance and restoring sensitivity to hormone-targeted and HER2-targeted therapies in breast cancer
    • Mayer, I., Role of mTOR inhibition in preventing resistance and restoring sensitivity to hormone-targeted and HER2-targeted therapies in breast cancer. Clin Adv Hematol Oncol 11 (2013), 217–224.
    • (2013) Clin Adv Hematol Oncol , vol.11 , pp. 217-224
    • Mayer, I.1
  • 58
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes, R.A., Towers, T.L., Presta, L.G., Ravetch, J.V., Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6 (2000), 443–446.
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 59
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • Musolino, A., Naldi, N., Bortesi, B., et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 26 (2008), 1789–1796.
    • (2008) J Clin Oncol , vol.26 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3
  • 60
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer, C.E., Forster, J., Lindquist, D., et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355 (2006), 2733–2743.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 61
    • 80053362290 scopus 로고    scopus 로고
    • Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
    • von Minckwitz, G., Schwedler, K., Schmidt, M., et al. Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer 47 (2011), 2273–2281.
    • (2011) Eur J Cancer , vol.47 , pp. 2273-2281
    • von Minckwitz, G.1    Schwedler, K.2    Schmidt, M.3
  • 62
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon, D.J., Leyland-Jones, B., Shak, S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344 (2001), 783–792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 63
    • 34447117507 scopus 로고    scopus 로고
    • Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy
    • Tacca, O., Penault-Llorca, F., Abrial, C., et al. Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy. Oncologist 12 (2007), 636–643.
    • (2007) Oncologist , vol.12 , pp. 636-643
    • Tacca, O.1    Penault-Llorca, F.2    Abrial, C.3
  • 64
    • 79960972539 scopus 로고    scopus 로고
    • Discordances in ER, PR and HER2 receptors after neoadjuvant chemotherapy in breast cancer
    • van de Ven, S., Smit, V.T., Dekker, T.J., Nortier, J.W., Kroep, J.R., Discordances in ER, PR and HER2 receptors after neoadjuvant chemotherapy in breast cancer. Cancer Treat Rev 37 (2011), 422–430.
    • (2011) Cancer Treat Rev , vol.37 , pp. 422-430
    • van de Ven, S.1    Smit, V.T.2    Dekker, T.J.3    Nortier, J.W.4    Kroep, J.R.5
  • 65
    • 70350675250 scopus 로고    scopus 로고
    • Change in the hormone receptor status following administration of neoadjuvant chemotherapy and its impact on the long-term outcome in patients with primary breast cancer
    • Hirata, T., Shimizu, C., Yonemori, K., et al. Change in the hormone receptor status following administration of neoadjuvant chemotherapy and its impact on the long-term outcome in patients with primary breast cancer. Br J Cancer 101 (2009), 1529–1536.
    • (2009) Br J Cancer , vol.101 , pp. 1529-1536
    • Hirata, T.1    Shimizu, C.2    Yonemori, K.3
  • 66
    • 84960496215 scopus 로고    scopus 로고
    • Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial
    • Harbeck, N., Huang, C.S., Hurvitz, S., et al. Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial. Lancet Oncol 17 (2016), 357–366.
    • (2016) Lancet Oncol , vol.17 , pp. 357-366
    • Harbeck, N.1    Huang, C.S.2    Hurvitz, S.3
  • 67
    • 84933564599 scopus 로고    scopus 로고
    • Lapatinib or trastuzumab plus taxane therapy for human epidermal growth factor receptor 2–positive advanced breast cancer: final results of NCIC CTG MA.31
    • Gelmon, K.A., Boyle, F.M., Kaufman, B., et al. Lapatinib or trastuzumab plus taxane therapy for human epidermal growth factor receptor 2–positive advanced breast cancer: final results of NCIC CTG MA.31. J Clin Oncol 33 (2015), 1574–1583.
    • (2015) J Clin Oncol , vol.33 , pp. 1574-1583
    • Gelmon, K.A.1    Boyle, F.M.2    Kaufman, B.3
  • 68
    • 84919342671 scopus 로고    scopus 로고
    • Management of patients with HER2-positive metastatic breast cancer: is there an optimal sequence of HER2-directed approaches?
    • Zelnak, A.B., Wisinski, K.B., Management of patients with HER2-positive metastatic breast cancer: is there an optimal sequence of HER2-directed approaches?. Cancer 121 (2015), 17–24.
    • (2015) Cancer , vol.121 , pp. 17-24
    • Zelnak, A.B.1    Wisinski, K.B.2
  • 69
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma, S., Miles, D., Gianni, L., et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 367 (2012), 1783–1791.
    • (2012) N Engl J Med , vol.367 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3
  • 70
    • 80054092983 scopus 로고    scopus 로고
    • Trastuzumab emtansine: a unique antibody–drug conjugate in development for human epidermal growth factor receptor 2–positive cancer
    • LoRusso, P.M., Weiss, D., Guardino, E., Girish, S., Sliwkowski, M.X., Trastuzumab emtansine: a unique antibody–drug conjugate in development for human epidermal growth factor receptor 2–positive cancer. Clin Cancer Res 17 (2011), 6437–6447.
    • (2011) Clin Cancer Res , vol.17 , pp. 6437-6447
    • LoRusso, P.M.1    Weiss, D.2    Guardino, E.3    Girish, S.4    Sliwkowski, M.X.5
  • 71
    • 84868595258 scopus 로고    scopus 로고
    • The promise of antibody–drug conjugates
    • Teicher, B.A., Doroshow, J.H., The promise of antibody–drug conjugates. N Engl J Med 367 (2012), 1847–1848.
    • (2012) N Engl J Med , vol.367 , pp. 1847-1848
    • Teicher, B.A.1    Doroshow, J.H.2
  • 72
    • 84867123853 scopus 로고    scopus 로고
    • Triple-negative breast cancer: epidemiological considerations and recommendations
    • Boyle, P., Triple-negative breast cancer: epidemiological considerations and recommendations. Ann Oncol 23:suppl 6 (2012), vi7–v12.
    • (2012) Ann Oncol , vol.23 , pp. vi7-v12
    • Boyle, P.1
  • 73
    • 79959503213 scopus 로고    scopus 로고
    • Triple-negative breast cancer: an unmet medical need
    • Hudis, C.A., Gianni, L., Triple-negative breast cancer: an unmet medical need. Oncologist 16:suppl 1 (2011), 1–11.
    • (2011) Oncologist , vol.16 , pp. 1-11
    • Hudis, C.A.1    Gianni, L.2
  • 74
    • 59449102796 scopus 로고    scopus 로고
    • Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer
    • Perez, E.A., Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer. Breast Cancer Res Treat 114 (2009), 195–201.
    • (2009) Breast Cancer Res Treat , vol.114 , pp. 195-201
    • Perez, E.A.1
  • 75
    • 84867757134 scopus 로고    scopus 로고
    • Multidrug resistance in breast cancer: from in vitro models to clinical studies
    • Wind, N.S., Holen, I., Multidrug resistance in breast cancer: from in vitro models to clinical studies. Int J Breast Cancer, 2011, 2011, 967419.
    • (2011) Int J Breast Cancer , vol.2011 , pp. 967419
    • Wind, N.S.1    Holen, I.2
  • 76
    • 28944432804 scopus 로고    scopus 로고
    • Multidrug resistance/P-glycoprotein and breast cancer: review and meta-analysis
    • Clarke, R., Leonessa, F., Trock, B., Multidrug resistance/P-glycoprotein and breast cancer: review and meta-analysis. Semin Oncol 32(6 suppl 7) (2005), S9–S15.
    • (2005) Semin Oncol , vol.326 suppl 7) , pp. S9-S15
    • Clarke, R.1    Leonessa, F.2    Trock, B.3
  • 77
    • 77951977594 scopus 로고    scopus 로고
    • Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology
    • Hutson, J.R., Koren, G., Matthews, S.G., Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology. Placenta 31 (2010), 351–357.
    • (2010) Placenta , vol.31 , pp. 351-357
    • Hutson, J.R.1    Koren, G.2    Matthews, S.G.3
  • 78
    • 0031158805 scopus 로고    scopus 로고
    • The physiological function of drug-transporting P-glycoproteins
    • Schinkel, A.H., The physiological function of drug-transporting P-glycoproteins. Semin Cancer Biol 8 (1997), 161–170.
    • (1997) Semin Cancer Biol , vol.8 , pp. 161-170
    • Schinkel, A.H.1
  • 79
    • 0033616684 scopus 로고    scopus 로고
    • Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance–associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier
    • Rao, V.V., Dahlheimer, J.L., Bardgett, M.E., et al. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance–associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci U S A 96 (1999), 3900–3905.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3900-3905
    • Rao, V.V.1    Dahlheimer, J.L.2    Bardgett, M.E.3
  • 80
    • 0037362355 scopus 로고    scopus 로고
    • ATP binding cassette transporters and drug resistance in breast cancer
    • Leonessa, F., Clarke, R., ATP binding cassette transporters and drug resistance in breast cancer. Endocr Relat Cancer 10 (2003), 43–73.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 43-73
    • Leonessa, F.1    Clarke, R.2
  • 81
    • 84929670601 scopus 로고    scopus 로고
    • Fast, stable induction of P-glycoprotein-mediated drug resistance in BT-474 breast cancer cells by stable transfection of ABCB1 gene
    • Tang, Y., Wang, Y., Deosarkar, S., Soroush, F., Kiani, M.F., Wang, B., Fast, stable induction of P-glycoprotein-mediated drug resistance in BT-474 breast cancer cells by stable transfection of ABCB1 gene. Anticancer Res 35 (2015), 2531–2538.
    • (2015) Anticancer Res , vol.35 , pp. 2531-2538
    • Tang, Y.1    Wang, Y.2    Deosarkar, S.3    Soroush, F.4    Kiani, M.F.5    Wang, B.6
  • 82
    • 0031427453 scopus 로고    scopus 로고
    • Biological and clinical significance of concurrent p53 gene alterations, MDR1 gene expression, and S-phase fraction analyses in breast cancer patients treated with primary chemotherapy or radiotherapy
    • Chevillard, S., Lebeau, J., Pouillart, P., et al. Biological and clinical significance of concurrent p53 gene alterations, MDR1 gene expression, and S-phase fraction analyses in breast cancer patients treated with primary chemotherapy or radiotherapy. Clin Cancer Res 3:12 pt 1 (1997), 2471–2478.
    • (1997) Clin Cancer Res , vol.3 , Issue.12 , pp. 2471-2478
    • Chevillard, S.1    Lebeau, J.2    Pouillart, P.3
  • 84
    • 0032457154 scopus 로고    scopus 로고
    • Integration of estrogen and progesterone receptors with pathological and molecular prognostic factors in breast cancer patients
    • Gago, F.E., Tello, O.M., Diblasi, A.M., Ciocca, D.R., Integration of estrogen and progesterone receptors with pathological and molecular prognostic factors in breast cancer patients. J Steroid Biochem Mol Biol 67 (1998), 431–437.
    • (1998) J Steroid Biochem Mol Biol , vol.67 , pp. 431-437
    • Gago, F.E.1    Tello, O.M.2    Diblasi, A.M.3    Ciocca, D.R.4
  • 85
    • 0029266368 scopus 로고
    • P-glycoprotein expression in primary breast cancer
    • He, L., Hao, C., Lin, B., Wang, Y., Gao, F., P-glycoprotein expression in primary breast cancer. Chin Med Sci J 10 (1995), 12–15.
    • (1995) Chin Med Sci J , vol.10 , pp. 12-15
    • He, L.1    Hao, C.2    Lin, B.3    Wang, Y.4    Gao, F.5
  • 86
    • 84907481394 scopus 로고    scopus 로고
    • The phenomenon of multi-drug resistance in the treatment of malignant tumors
    • Vtorushin, S.V., Khristenko, K.Y., Zavyalova, M.V., et al. The phenomenon of multi-drug resistance in the treatment of malignant tumors. Exp Oncol 36 (2014), 144–156.
    • (2014) Exp Oncol , vol.36 , pp. 144-156
    • Vtorushin, S.V.1    Khristenko, K.Y.2    Zavyalova, M.V.3
  • 87
    • 0027455027 scopus 로고
    • Randomized phase II study of single-agent epirubicin +/− verapamil in patients with advanced metastatic breast cancer. An AIO clinical trial. Arbeitsgemeinschaft Internistische Onkologie of the German Cancer Society
    • Mross, K., Bohn, C., Edler, L., et al. Randomized phase II study of single-agent epirubicin +/− verapamil in patients with advanced metastatic breast cancer. An AIO clinical trial. Arbeitsgemeinschaft Internistische Onkologie of the German Cancer Society. Ann Oncol 4 (1993), 45–50.
    • (1993) Ann Oncol , vol.4 , pp. 45-50
    • Mross, K.1    Bohn, C.2    Edler, L.3
  • 88
    • 0028567035 scopus 로고
    • The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
    • Zaman, G.J., Flens, M.J., van Leusden, M.R., et al. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A 91 (1994), 8822–8826.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8822-8826
    • Zaman, G.J.1    Flens, M.J.2    van Leusden, M.R.3
  • 89
    • 0028844581 scopus 로고
    • Expression of multidrug resistance–associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution
    • Breuninger, L.M., Paul, S., Gaughan, K., et al. Expression of multidrug resistance–associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res 55 (1995), 5342–5347.
    • (1995) Cancer Res , vol.55 , pp. 5342-5347
    • Breuninger, L.M.1    Paul, S.2    Gaughan, K.3
  • 90
    • 0029979819 scopus 로고    scopus 로고
    • ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter
    • Paul, S., Breuninger, L.M., Tew, K.D., et al. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. Proc Natl Acad Sci U S A 93 (1996), 6929–6934.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6929-6934
    • Paul, S.1    Breuninger, L.M.2    Tew, K.D.3
  • 91
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole, S.P., Sparks, K.E., Fraser, K., et al. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54 (1994), 5902–5910.
    • (1994) Cancer Res , vol.54 , pp. 5902-5910
    • Cole, S.P.1    Sparks, K.E.2    Fraser, K.3
  • 92
    • 33947397241 scopus 로고    scopus 로고
    • A molecular understanding of ATP-dependent solute transport by multidrug resistance–associated protein MRP1
    • Chang, X.B., A molecular understanding of ATP-dependent solute transport by multidrug resistance–associated protein MRP1. Cancer Metastasis Rev 26 (2007), 15–37.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 15-37
    • Chang, X.B.1
  • 93
    • 0028855891 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in human cancers
    • Nooter, K., Westerman, A.M., Flens, M.J., et al. Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin Cancer Res 1 (1995), 1301–1310.
    • (1995) Clin Cancer Res , vol.1 , pp. 1301-1310
    • Nooter, K.1    Westerman, A.M.2    Flens, M.J.3
  • 94
    • 0029157072 scopus 로고
    • Expression pattern of MRP in human tissues and adult solid tumor cell lines
    • Kruh, G.D., Gaughan, K.T., Godwin, A., Chan, A., Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst 87 (1995), 1256–1258.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1256-1258
    • Kruh, G.D.1    Gaughan, K.T.2    Godwin, A.3    Chan, A.4
  • 95
    • 33646772906 scopus 로고    scopus 로고
    • Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia
    • Huh, H.J., Park, C.J., Jang, S., et al. Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia. J Korean Med Sci 21 (2006), 253–258.
    • (2006) J Korean Med Sci , vol.21 , pp. 253-258
    • Huh, H.J.1    Park, C.J.2    Jang, S.3
  • 96
    • 8544241727 scopus 로고    scopus 로고
    • The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer
    • Nooter, K., Brutel de la Riviere, G., Look, M.P., et al. The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer. Br J Cancer 76 (1997), 486–493.
    • (1997) Br J Cancer , vol.76 , pp. 486-493
    • Nooter, K.1    Brutel de la Riviere, G.2    Look, M.P.3
  • 97
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: the multidrug resistance–associated proteins
    • Borst, P., Evers, R., Kool, M., Wijnholds, J., A family of drug transporters: the multidrug resistance–associated proteins. J Natl Cancer Inst 92 (2000), 1295–1302.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 98
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • Hooijberg, J.H., Broxterman, H.J., Kool, M., et al. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 59 (1999), 2532–2535.
    • (1999) Cancer Res , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3
  • 99
    • 0030009305 scopus 로고    scopus 로고
    • Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
    • Loe, D.W., Almquist, K.C., Deeley, R.G., Cole, S.P., Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem 271 (1996), 9675–9682.
    • (1996) J Biol Chem , vol.271 , pp. 9675-9682
    • Loe, D.W.1    Almquist, K.C.2    Deeley, R.G.3    Cole, S.P.4
  • 100
    • 80053436675 scopus 로고    scopus 로고
    • The ABCG family of membrane-associated transporters: you don't have to be big to be mighty
    • Kerr, I.D., Haider, A.J., Gelissen, I.C., The ABCG family of membrane-associated transporters: you don't have to be big to be mighty. Br J Pharmacol 164 (2011), 1767–1779.
    • (2011) Br J Pharmacol , vol.164 , pp. 1767-1779
    • Kerr, I.D.1    Haider, A.J.2    Gelissen, I.C.3
  • 101
    • 13044249156 scopus 로고    scopus 로고
    • A multidrug resistance transporter from human MCF-7 breast cancer cells
    • Doyle, L.A., Yang, W., Abruzzo, L.V., et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A 95 (1998), 15665–15670.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15665-15670
    • Doyle, L.A.1    Yang, W.2    Abruzzo, L.V.3
  • 102
    • 84903482229 scopus 로고    scopus 로고
    • Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics
    • Jani, M., Ambrus, C., Magnan, R., et al. Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics. Arch Toxicol 88 (2014), 1205–1248.
    • (2014) Arch Toxicol , vol.88 , pp. 1205-1248
    • Jani, M.1    Ambrus, C.2    Magnan, R.3
  • 103
    • 34547114499 scopus 로고    scopus 로고
    • Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution
    • Takenaka, K., Morgan, J.A., Scheffer, G.L., et al. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res 67 (2007), 6965–6972.
    • (2007) Cancer Res , vol.67 , pp. 6965-6972
    • Takenaka, K.1    Morgan, J.A.2    Scheffer, G.L.3
  • 104
    • 2142799057 scopus 로고    scopus 로고
    • Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy
    • Lockhart, A.C., Tirona, R.G., Kim, R.B., Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy. Mol Cancer Ther 2 (2003), 685–698.
    • (2003) Mol Cancer Ther , vol.2 , pp. 685-698
    • Lockhart, A.C.1    Tirona, R.G.2    Kim, R.B.3
  • 105
    • 80054093587 scopus 로고    scopus 로고
    • Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells
    • Selever, J., Gu, G., Lewis, M.T., et al. Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells. Clin Cancer Res 17 (2011), 6510–6521.
    • (2011) Clin Cancer Res , vol.17 , pp. 6510-6521
    • Selever, J.1    Gu, G.2    Lewis, M.T.3
  • 106
    • 84872725617 scopus 로고    scopus 로고
    • Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells
    • Wu, A.M., Dalvi, P., Lu, X., et al. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol 83 (2013), 377–388.
    • (2013) Mol Pharmacol , vol.83 , pp. 377-388
    • Wu, A.M.1    Dalvi, P.2    Lu, X.3
  • 107
    • 12444261717 scopus 로고    scopus 로고
    • Expression and functional analyses of breast cancer resistance protein in lung cancer
    • Kawabata, S., Oka, M., Soda, H., et al. Expression and functional analyses of breast cancer resistance protein in lung cancer. Clin Cancer Res 9 (2003), 3052–3057.
    • (2003) Clin Cancer Res , vol.9 , pp. 3052-3057
    • Kawabata, S.1    Oka, M.2    Soda, H.3
  • 109
    • 77958025244 scopus 로고    scopus 로고
    • Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)
    • Ni, Z., Bikadi, Z., Rosenberg, M.F., Mao, Q., Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab 11 (2010), 603–617.
    • (2010) Curr Drug Metab , vol.11 , pp. 603-617
    • Ni, Z.1    Bikadi, Z.2    Rosenberg, M.F.3    Mao, Q.4
  • 110
    • 71049156626 scopus 로고    scopus 로고
    • ABCG2: the key to chemoresistance in cancer stem cells?
    • An, Y., Ongkeko, W.M., ABCG2: the key to chemoresistance in cancer stem cells?. Expert Opin Drug Metab Toxicol 5 (2009), 1529–1542.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 1529-1542
    • An, Y.1    Ongkeko, W.M.2
  • 111
    • 84871668993 scopus 로고    scopus 로고
    • Synthesis and quantitative structure–activity relationships of selective BCRP inhibitors
    • Marighetti, F., Steggemann, K., Hanl, M., Wiese, M., Synthesis and quantitative structure–activity relationships of selective BCRP inhibitors. ChemMedChem 8 (2013), 125–135.
    • (2013) ChemMedChem , vol.8 , pp. 125-135
    • Marighetti, F.1    Steggemann, K.2    Hanl, M.3    Wiese, M.4
  • 112
    • 23644452472 scopus 로고    scopus 로고
    • Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma
    • Pusztai, L., Wagner, P., Ibrahim, N., et al. Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma. Cancer 104 (2005), 682–691.
    • (2005) Cancer , vol.104 , pp. 682-691
    • Pusztai, L.1    Wagner, P.2    Ibrahim, N.3
  • 113
    • 17644440990 scopus 로고    scopus 로고
    • Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen
    • Warner, E., Hedley, D., Andrulis, I., et al. Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. Clin Cancer Res 4 (1998), 1451–1457.
    • (1998) Clin Cancer Res , vol.4 , pp. 1451-1457
    • Warner, E.1    Hedley, D.2    Andrulis, I.3
  • 114
    • 84859708410 scopus 로고    scopus 로고
    • Investigational ABC transporter inhibitors
    • Falasca, M., Linton, K.J., Investigational ABC transporter inhibitors. Expert Opin Investig Drugs 21 (2012), 657–666.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 657-666
    • Falasca, M.1    Linton, K.J.2
  • 115
    • 84857939767 scopus 로고    scopus 로고
    • Reversing multidrug resistance by tyrosine kinase inhibitors
    • He, M., Wei, M.J., Reversing multidrug resistance by tyrosine kinase inhibitors. Chin J Cancer 31 (2012), 126–133.
    • (2012) Chin J Cancer , vol.31 , pp. 126-133
    • He, M.1    Wei, M.J.2
  • 116
    • 79956337181 scopus 로고    scopus 로고
    • Comparing cellular uptake and cytotoxicity of targeted drug carriers in cancer cell lines with different drug resistance mechanisms
    • Lei, T., Srinivasan, S., Tang, Y., et al. Comparing cellular uptake and cytotoxicity of targeted drug carriers in cancer cell lines with different drug resistance mechanisms. Nanomedicine 7 (2011), 324–332.
    • (2011) Nanomedicine , vol.7 , pp. 324-332
    • Lei, T.1    Srinivasan, S.2    Tang, Y.3
  • 117
    • 77957341466 scopus 로고    scopus 로고
    • Simultaneous delivery of chemotherapeutic and thermal-optical agents to cancer cells by a polymeric (PLGA) nanocarrier: an in vitro study
    • Tang, Y., Lei, T., Manchanda, R., et al. Simultaneous delivery of chemotherapeutic and thermal-optical agents to cancer cells by a polymeric (PLGA) nanocarrier: an in vitro study. Pharm Res 27 (2010), 2242–2253.
    • (2010) Pharm Res , vol.27 , pp. 2242-2253
    • Tang, Y.1    Lei, T.2    Manchanda, R.3
  • 118
    • 63949085116 scopus 로고    scopus 로고
    • Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors
    • Pattillo, C.B., Venegas, B., Donelson, F.J., et al. Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors. Pharm Res 26 (2009), 1093–1100.
    • (2009) Pharm Res , vol.26 , pp. 1093-1100
    • Pattillo, C.B.1    Venegas, B.2    Donelson, F.J.3
  • 119
    • 84928318557 scopus 로고    scopus 로고
    • + advanced breast cancer: phase II activity, safety, and predictive biomarker assessment
    • + advanced breast cancer: phase II activity, safety, and predictive biomarker assessment. Clin Cancer Res 21 (2015), 995–1001.
    • (2015) Clin Cancer Res , vol.21 , pp. 995-1001
    • DeMichele, A.1    Clark, A.S.2    Tan, K.S.3
  • 120
    • 84925500147 scopus 로고    scopus 로고
    • Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor
    • Juric, D., Castel, P., Griffith, M., et al. Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor. Nature 518 (2015), 240–244.
    • (2015) Nature , vol.518 , pp. 240-244
    • Juric, D.1    Castel, P.2    Griffith, M.3
  • 121
    • 54249157033 scopus 로고    scopus 로고
    • Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2
    • Dai, C.L., Tiwari, A.K., Wu, C.P., et al. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res 68 (2008), 7905–7914.
    • (2008) Cancer Res , vol.68 , pp. 7905-7914
    • Dai, C.L.1    Tiwari, A.K.2    Wu, C.P.3
  • 122
    • 51049091694 scopus 로고    scopus 로고
    • Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells
    • Zhang, D., Pal, A., Bornmann, W.G., et al. Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells. Mol Cancer Ther 7 (2008), 1846–1850.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1846-1850
    • Zhang, D.1    Pal, A.2    Bornmann, W.G.3
  • 124
    • 77957065782 scopus 로고    scopus 로고
    • Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer
    • Wang, B., Rosano, J.M., Cheheltani, R., Achary, M.P., Kiani, M.F., Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer. Expert Opin Drug Deliv 7 (2010), 1159–1173.
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 1159-1173
    • Wang, B.1    Rosano, J.M.2    Cheheltani, R.3    Achary, M.P.4    Kiani, M.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.