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Volumn 13, Issue 2, 2012, Pages 263-275

Chemotherapy-resistant metastatic breast cancer

Author keywords

Combinatorial regimens; Microtubulins; Treatment of resistant breast cancer

Indexed keywords

ABC TRANSPORTER; ANGIOGENESIS INHIBITOR; ANTHRACYCLINE DERIVATIVE; CARBOPLATIN; DOCETAXEL; ELACRIDAR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERIBULIN; EVEROLIMUS; EXEMESTANE; GEMCITABINE; IXABEPILONE; LAPATINIB; LAROTAXEL; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NAVELBINE; OLAPARIB; PERTUZUMAB; SUNITINIB; TANESPIMYCIN; TARIQUIDAR; TAXANE DERIVATIVE; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VINFLUNINE; ZOSUQUIDAR;

EID: 84863715487     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-012-0184-6     Document Type: Article
Times cited : (89)

References (67)
  • 1
    • 70349176240 scopus 로고    scopus 로고
    • Is resistance useless? Multidrug resistance and collateral sensitivity
    • Hall MD, Handley MD, Gottesman MM. Is resistance useless? Multidrug resistance and collateral sensitivity. Trend Pharmacol Sci. 2009;30 (10):546-56.
    • (2009) Trend Pharmacol Sci. , vol.30 , Issue.10 , pp. 546-556
    • Hall, M.D.1    Handley, M.D.2    Gottesman, M.M.3
  • 3
    • 0026584396 scopus 로고
    • Cyclosporins as drug resistance modifiers
    • Twentyman PR. Cyclosporins as drug resistance modifiers. Biochem Pharmacol. 1992;43:109-17.
    • (1992) Biochem Pharmacol. , vol.43 , pp. 109-117
    • Twentyman, P.R.1
  • 4
    • 78549238612 scopus 로고    scopus 로고
    • Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: A randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999
    • Cripe LD, Uno H, Paietta EM, et al. Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: A randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood. 2010;116:4077-85.
    • (2010) Blood. , vol.116 , pp. 4077-4085
    • Cripe, L.D.1    Uno, H.2    Paietta, E.M.3
  • 5
    • 68149149796 scopus 로고    scopus 로고
    • A randomized, placebocontrolled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen
    • Ruff P, Vorobiof DA, et al. A randomized, placebocontrolled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen. Canc Chemother Pharmacol. 2009;64 (4):763-8.
    • (2009) Canc Chemother Pharmacol. , vol.64 , Issue.4 , pp. 763-768
    • Ruff, P.1    Vorobiof, D.A.2
  • 6
    • 37449017239 scopus 로고    scopus 로고
    • Looking at drug resistance mechanisms for microtubule interacting drugs: Does TUBB3 work?
    • Ferlini C, Raspaglio G, Cicchillitti L, et al. Looking at drug resistance mechanisms for microtubule interacting drugs: Does TUBB3 work? Curr Cancer Drug Targets. 2007;7:704-12.
    • (2007) Curr Cancer Drug Targets. , vol.7 , pp. 704-712
    • Ferlini, C.1    Raspaglio, G.2    Cicchillitti, L.3
  • 7
    • 38549161093 scopus 로고    scopus 로고
    • Is class III β-Tubulin a predictive factor in patients receiving tubulin-binding agents?
    • Seve PS, Dumontet C. Is class III β-Tubulin a predictive factor in patients receiving tubulin-binding agents? Lancet Oncol. 2009;9:168-75.
    • (2009) Lancet Oncol. , vol.9 , pp. 168-175
    • Seve, P.S.1    Dumontet, C.2
  • 8
    • 57149135866 scopus 로고    scopus 로고
    • Preclinical efficacy spectrum and pharmacokinetics of ixabepilone
    • Lee FY, Smykla R, Johnston K, et al. Preclinical efficacy spectrum and pharmacokinetics of ixabepilone. Canc Chemother Pharmacol. 2009;63:201-12.
    • (2009) Canc Chemother Pharmacol. , vol.63 , pp. 201-212
    • Lee, F.Y.1    Smykla, R.2    Johnston, K.3
  • 9
    • 80053434629 scopus 로고    scopus 로고
    • Ixabepilone: Clinical role in metastatic breast cancer
    • Denduuluri N, Swain S. Ixabepilone: Clinical role in metastatic breast cancer. Clin Breast Cancer. 2011;3:139-45.
    • (2011) Clin Breast Cancer. , vol.3 , pp. 139-145
    • Denduuluri, N.1    Swain, S.2
  • 10
    • 77954752064 scopus 로고    scopus 로고
    • Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Sparano JA, Vrdoljak E, Rixe O, Xu B, et al. Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. JCO. 2010;28:3256-63.
    • (2010) JCO , vol.28 , pp. 3256-3263
    • Sparano, J.A.1    Vrdoljak, E.2    Rixe, O.3    Xu, B.4
  • 11
    • 84855712591 scopus 로고    scopus 로고
    • The paradox of triple negative breast cancer: Novel approaches to treatment
    • doi: 10.1111/j.1524-4741.2011.01175.x. Provides a succinct overview of approaches to a subgroup of breast cancer that epitomizes the improvements made in defining breast cancer at a molecular level
    • Fornier M, Fumoleau P. The paradox of triple negative breast cancer: Novel approaches to treatment. The Breast Journal 2011; doi: 10.1111/j.1524-4741.2011.01175.x. Provides a succinct overview of approaches to a subgroup of breast cancer that epitomizes the improvements made in defining breast cancer at a molecular level.
    • (2011) The Breast Journal
    • Fornier, M.1    Fumoleau, P.2
  • 12
    • 67449164588 scopus 로고    scopus 로고
    • Eribulin: Rediscovering tubulin as an anticancer target
    • Jimeno A. Eribulin: Rediscovering tubulin as an anticancer target. Clin Cancer Res. 2009;15:3903-5.
    • (2009) Clin Cancer Res. , vol.15 , pp. 3903-3905
    • Jimeno, A.1
  • 13
    • 23144433687 scopus 로고    scopus 로고
    • The primary antimitotic mechanism of action of the synthetic halichondrins E7389 is suppression of microtubule growth
    • Jordan MA, Kamath K, Manna T, et al. The primary antimitotic mechanism of action of the synthetic halichondrins E7389 is suppression of microtubule growth. Mol Cancer Ther. 2005;4:1086-95.
    • (2005) Mol Cancer Ther. , vol.4 , pp. 1086-1095
    • Jordan, M.A.1    Kamath, K.2    Manna, T.3
  • 14
    • 79952487463 scopus 로고    scopus 로고
    • Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): A phase 3 open-label randomised study
    • One of the newest agents approved for use in the treatment of metastatic breast cancer, this class of drugs demonstrates activity in taxane resistant breast cancer
    • Cortes, et al. Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): A phase 3 open-label randomised study Lancet. 2011;377:914-23. One of the newest agents approved for use in the treatment of metastatic breast cancer, this class of drugs demonstrates activity in taxane resistant breast cancer.
    • (2011) Lancet. , vol.377 , pp. 914-923
    • Cortes1
  • 15
    • 84857554191 scopus 로고    scopus 로고
    • Cytotoxic drugs for patients with breast cancer in the era of targeted treatment: Back to the future?
    • doi:10.1093/annonc/mdr382
    • Ribeiro JT, Macedo LT, Curigliano G, et al. Cytotoxic drugs for patients with breast cancer in the era of targeted treatment: Back to the future? Ann Oncol. 2011. doi:10.1093/annonc/mdr382.
    • (2011) Ann Oncol.
    • Ribeiro, J.T.1    Macedo, L.T.2    Curigliano, G.3
  • 16
    • 82555170343 scopus 로고    scopus 로고
    • Vinflunine: A new vision that may translate into antiangiogenic and antimetastatic activity
    • Jan
    • Anton Aparicio LM, Pulido EG, Gallego GA. Vinflunine: A new vision that may translate into antiangiogenic and antimetastatic activity. Anticancer Drugs 2012 Jan23(1):1-11.
    • (2012) Anticancer Drugs , vol.23 , Issue.1 , pp. 1-11
    • Anton Aparicio, L.M.1    Pulido, E.G.2    Gallego, G.A.3
  • 17
    • 33750457974 scopus 로고    scopus 로고
    • Vinflunine: A new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy
    • Capone, et al. Vinflunine: A new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy. Br J Cancer. 2006;95:1161-6.
    • (2006) Br J Cancer. , vol.95 , pp. 1161-1116
    • Capone1
  • 18
    • 69349085207 scopus 로고    scopus 로고
    • Phase 2 study of single-Agent IV vinflunine as thirdline treatment of metastatic breast cancer after failure of anthracycline/taxane-based chemotherapy
    • Fumoleau P, Cortes-Funes H, Taleb AB, Chan S, et al. Phase 2 study of single-Agent IV vinflunine as thirdline treatment of metastatic breast cancer after failure of anthracycline/taxane-based chemotherapy. Am J Clin Oncol. 2009;32(4):375-80.
    • (2009) Am J Clin Oncol. , vol.32 , Issue.4 , pp. 375-380
    • Fumoleau, P.1    Cortes-Funes, H.2    Taleb, A.B.3    Chan, S.4
  • 19
    • 84859802211 scopus 로고    scopus 로고
    • A phase I study of vinflunine in combination with capecitabine in patients with metastatic breast cancer previously treated with anthracyclines and taxanes
    • doi:10.1007/s00280-011-1767-9
    • Campone M, Isambert N, Bourbouloux E, et al. A phase I study of vinflunine in combination with capecitabine in patients with metastatic breast cancer previously treated with anthracyclines and taxanes. Canc Chemother Pharmacol. 2011. doi:10.1007/s00280-011-1767-9.
    • (2011) Canc Chemother Pharmacol.
    • Campone, M.1    Isambert, N.2    Bourbouloux, E.3
  • 20
    • 63049108452 scopus 로고    scopus 로고
    • Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
    • Venkitaraman AR. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol. 2009;4:461-87.
    • (2009) Annu Rev Pathol. , vol.4 , pp. 461-487
    • Venkitaraman, A.R.1
  • 21
    • 80355135233 scopus 로고    scopus 로고
    • PARP inhibitors in breast cancer: BRCA and beyond
    • Rios J, Puhalla S. PARP inhibitors in breast cancer: BRCA and beyond. Oncology. 2011;25(11):1014-25.
    • (2011) Oncology. , vol.25 , Issue.11 , pp. 1014-1025
    • Rios, J.1    Puhalla, S.2
  • 22
    • 45149094267 scopus 로고    scopus 로고
    • Basal-like breast cancer: A critical review
    • Rakha EA, Reis-Filho JS, Ellis IO. Basal-like breast cancer: A critical review. J Clin Oncol. 2008;26 (15):2568-81.
    • (2008) J Clin Oncol. , vol.26 , Issue.15 , pp. 2568-2581
    • Rakha, E.A.1    Reis-Filho, J.S.2    Ellis, I.O.3
  • 23
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADPribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, et al. Oral poly(ADPribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet. 2010;376:235-44.
    • (2010) Lancet. , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 24
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial. Lancet. 2010;376:245-51.
    • (2010) Lancet. , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 25
    • 77955877185 scopus 로고    scopus 로고
    • A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer
    • abstr 1019
    • Isakoff SJ, Overmoyer B, Tung NM, et al. A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. J Clin Oncol. 2010;28(suppl):118s. abstr 1019.
    • (2010) J Clin Oncol. , vol.28 , Issue.SUPPL.
    • Isakoff, S.J.1    Overmoyer, B.2    Tung, N.M.3
  • 26
    • 77958458006 scopus 로고    scopus 로고
    • First-inhuman trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers
    • abstr 3001
    • Sandhu SK, Wenham RM, Wilding G, et al. First-inhuman trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers. J Clin Oncol. 2010;28(suppl):233s. abstr 3001.
    • (2010) J Clin Oncol. , vol.28 , Issue.SUPPL.
    • Sandhu, S.K.1    Wenham, R.M.2    Wilding, G.3
  • 27
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer
    • abstr 1007
    • O'Shaughnessy J. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer. J Clin Oncol. 2011;29(suppl):81s. abstr 1007.
    • (2011) J Clin Oncol. , vol.29 , Issue.SUPPL.
    • O'Shaughnessy, J.1
  • 28
    • 77955770116 scopus 로고    scopus 로고
    • DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
    • Roderiguez AA, Makris A, Wu MF, et al. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat. 2010;123:189-96.
    • (2010) Breast Cancer Res Treat. , vol.123 , pp. 189-196
    • Roderiguez, A.A.1    Makris, A.2    Wu, M.F.3
  • 29
    • 84655162706 scopus 로고    scopus 로고
    • Treatment of HER2-positive breast cancer: Current status and future perspectives
    • Arteaga CL, Sliwkowski MX, Osborne CK, et al. Treatment of HER2-positive breast cancer: Current status and future perspectives. Nat Rev Clin Oncol. 2011;9(1):16-32.
    • (2011) Nat Rev Clin Oncol. , vol.9 , Issue.1 , pp. 16-32
    • Arteaga, C.L.1    Sliwkowski, M.X.2    Osborne, C.K.3
  • 30
    • 48649092620 scopus 로고    scopus 로고
    • A central role for HER3 in HER2-Amplified breast cancer: Implications for targeted therapy
    • Lee-Hoeflich ST, et al. A central role for HER3 in HER2-Amplified breast cancer: Implications for targeted therapy. Cancer Res. 2008;68:5878-87.
    • (2008) Cancer Res. , vol.68 , pp. 5878-5887
    • Lee-Hoeflich, S.T.1
  • 31
    • 77649095719 scopus 로고    scopus 로고
    • Her3 comes of age: New insights into its functions and role in signaling, tumor biology, and cancer therapy
    • Campbell MR, Amin D, Moasser MM. Her3 comes of age: New insights into its functions and role in signaling, tumor biology, and cancer therapy. Clin Cancer Res. 2010;16:1209-18.
    • (2010) Clin Cancer Res. , vol.16 , pp. 1209-1218
    • Campbell, M.R.1    Amin, D.2    Moasser, M.M.3
  • 32
    • 62549085622 scopus 로고    scopus 로고
    • Beyond trastuzumab: Overcoming resistance to targeted HER-2 therapy in breast cancer
    • Bedard PL, de Azambuja E, Cardoso F. Beyond trastuzumab: Overcoming resistance to targeted HER-2 therapy in breast cancer. Curr Cancer Drug Targets. 2009;9(2):148-62.
    • (2009) Curr Cancer Drug Targets. , vol.9 , Issue.2 , pp. 148-162
    • Bedard, P.L.1    De Azambuja, E.2    Cardoso, F.3
  • 33
    • 77949899466 scopus 로고    scopus 로고
    • Whither HER2-related therapeutics?
    • De P, Leyland-Jones B. Whither HER2-related therapeutics? J Clin Oncol. 2010;28(7):1091-6.
    • (2010) J Clin Oncol. , vol.28 , Issue.7 , pp. 1091-1096
    • De, P.1    Leyland-Jones, B.2
  • 34
    • 20244378677 scopus 로고    scopus 로고
    • Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
    • Agus, DB, Gordon MS, Taylor C, et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. JCO2005:2534-2543.
    • (2005) JCO , pp. 2534-2543
    • Agus, D.B.1    Gordon, M.S.2    Taylor, C.3
  • 35
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. JCO 2010:1138-1144.
    • (2010) JCO , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 36
    • 80054092983 scopus 로고    scopus 로고
    • Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
    • LoRusso PM, Weiss D, Guardino E, Girish S, Silwkowski MX. Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res. 2011;17 (20):6437-47.
    • (2011) Clin Cancer Res. , vol.17 , Issue.20 , pp. 6437-6447
    • LoRusso, P.M.1    Weiss, D.2    Guardino, E.3    Girish, S.4    Silwkowski, M.X.5
  • 37
    • 77950216941 scopus 로고    scopus 로고
    • An ErbB3 antibody, MM-121, is active in cancer with ligand-dependent activation
    • Schoeberl B, Faber AC, Li D, et al. An ErbB3 antibody, MM-121, is active in cancer with ligand-dependent activation. Cancer Res. 2010;70(6):2485-94.
    • (2010) Cancer Res. , vol.70 , Issue.6 , pp. 2485-2494
    • Schoeberl, B.1    Faber, A.C.2    Li, D.3
  • 38
    • 42049121934 scopus 로고    scopus 로고
    • Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family
    • Arpino G, Weichmann L, Osborne CK, et al. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family. Endocr Rev. 2008;29:217-33.
    • (2008) Endocr Rev. , vol.29 , pp. 217-233
    • Arpino, G.1    Weichmann, L.2    Osborne, C.K.3
  • 39
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen Jr J, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2010;27:5538-46.
    • (2010) J Clin Oncol. , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3
  • 40
    • 73549115638 scopus 로고    scopus 로고
    • Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways
    • Ghayad SE, Vendrell JA, Larbi SB, et al. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. Int J Cancer. 2010;126 (2):545-62.
    • (2010) Int J Cancer. , vol.126 , Issue.2 , pp. 545-562
    • Ghayad, S.E.1    Vendrell, J.A.2    Larbi, S.B.3
  • 41
    • 9244219598 scopus 로고    scopus 로고
    • Breast cancer: Loss of PTEN predicts resistance to treatment
    • Pandolfi PP. Breast cancer: Loss of PTEN predicts resistance to treatment. N Engl J Med. 2004;351:2337-8.
    • (2004) N Engl J Med. , vol.351 , pp. 2337-2338
    • Pandolfi, P.P.1
  • 42
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. JCO. 2011;29:3126-32.
    • (2011) JCO , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 43
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • Miller TW, Balko JM, Arteaga CL. Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. J Clin Oncol. 2011;29:4452-61.
    • (2011) J Clin Oncol. , vol.29 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 44
    • 84857100003 scopus 로고    scopus 로고
    • Everolimus in combination with exemestane for postmenopausal women with advanced breast cancer who are refractory to letrozole or anastrozole: Reports of the BOLERO-2 phase III trial
    • Abstact 9LBA
    • Baselga j, Campone M, Sahmoud T, et al. Everolimus in combination with exemestane for postmenopausal women with advanced breast cancer who are refractory to letrozole or anastrozole: Reports of the BOLERO-2 phase III trial. 2011 European Multidisciplinary Cancer Congress. Abstact 9LBA, 2011.
    • (2011) 2011 European Multidisciplinary Cancer Congress
    • Baselga, J.1    Campone, M.2    Sahmoud, T.3
  • 45
    • 84858689347 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor positive advanced breast cancer
    • Dec. (Epub ahead of print). Represents an early success story in the use of combining agents targeting intersecting pathways that are drivers for breast cancer proliferation
    • Baselga J, Campone M, Piccart M et al. Everolimus in postmenopausal hormone-receptor positive advanced breast cancer. N Engl J Med 2011 Dec (Epub ahead of print). Represents an early success story in the use of combining agents targeting intersecting pathways that are drivers for breast cancer proliferation.
    • (2011) N Engl J Med
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 46
    • 84855168056 scopus 로고    scopus 로고
    • Bevacizumab treatment for advanced breast cancer
    • Dec 6. Epub ahead of print
    • Alvarez RH, Guarneri V, et al. Bevacizumab treatment for advanced breast cancer. Oncologist 2011 Dec 6 Epub ahead of print.
    • (2011) Oncologist
    • Alvarez, R.H.1    Guarneri, V.2
  • 47
    • 73449097493 scopus 로고    scopus 로고
    • Bevacizumab in metastatic breast cancer: A meta-Analysis of randomized controlled trials
    • Valachis A, Polyzos NP, Patsopoulos NA, et al. Bevacizumab in metastatic breast cancer: A meta-Analysis of randomized controlled trials. Breast Cancer Res Treat. 2010;122(1):1-7.
    • (2010) Breast Cancer Res Treat. , vol.122 , Issue.1 , pp. 1-7
    • Valachis, A.1    Polyzos, N.P.2    Patsopoulos, N.A.3
  • 48
    • 83055197249 scopus 로고    scopus 로고
    • A phase II pilot trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node positive breast cancer: A trial coordinated by the Eastern Cooperative Oncology Group
    • Aug 4 (Epub ahead of print
    • Miller KD, O'Neill A, Perez EA, Seidman AD, Sledge GW. A phase II pilot trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node positive breast cancer: A trial coordinated by the Eastern Cooperative Oncology Group. Ann Oncol 2011 Aug 4 (Epub ahead of print).
    • (2011) Ann Oncol
    • Miller, K.D.1    O'Neill, A.2    Perez, E.A.3    Seidman, A.D.4    Sledge, G.W.5
  • 49
    • 77955628590 scopus 로고    scopus 로고
    • Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor-or progesterone receptor-positive breast cancer
    • Forero-Torres A, Salhe MN, Galleshaw, Jones CF, Shah JJ, Percent IJ, Nabell LM, Carpenter JC, et al. Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor-or progesterone receptor-positive breast cancer. Clin Breast Cancer. 2010;10(4):275-80.
    • (2010) Clin Breast Cancer. , vol.10 , Issue.4 , pp. 275-280
    • Forero-Torres, A.1    Salhe, M.N.2    Galleshaw Jones, C.F.3    Shah, J.J.4    Percent, I.J.5    Nabell, L.M.6    Carpenter, J.C.7
  • 50
    • 80053400728 scopus 로고    scopus 로고
    • Hormonal therapy plus bevacizumab in postmenopausal patients who have hormone recepor-positive metastatic breast cancer: A phase II trial of the Sarah Cannon Oncology Research Consortium
    • Yarkley DA, Burris HA, Clark BL, Shipley D, et al. Hormonal therapy plus bevacizumab in postmenopausal patients who have hormone recepor-positive metastatic breast cancer: A phase II trial of the Sarah Cannon Oncology Research Consortium. Clin Breast Cancer. 2011;11(3):146-52.
    • (2011) Clin Breast Cancer. , vol.11 , Issue.3 , pp. 146-152
    • Yarkley, D.A.1    Burris, H.A.2    Clark, B.L.3    Shipley, D.4
  • 51
    • 77955894152 scopus 로고    scopus 로고
    • Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC
    • abstr LBA1011
    • Crown J, et al. (2010) Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC) J Clin Oncol 28(suppl; abstr LBA1011):18 s.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Crown, J.1
  • 52
    • 80054864382 scopus 로고    scopus 로고
    • Reappraising antiangiogenic therapy for breast cancer
    • Kerbel RS. Reappraising antiangiogenic therapy for breast cancer.Breast 2011;Suppl3:S56-60.
    • (2011) Breast , Issue.SUPPL. 3
    • Kerbel, R.S.1
  • 53
  • 54
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E, Ginestier C, Iovino F, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 2009;69:1302-13.
    • (2009) Cancer Res. , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3
  • 55
    • 77957591579 scopus 로고    scopus 로고
    • Targeting breast cancer stem cells
    • Liu S, Wicha MS. Targeting Breast Cancer Stem Cells. J Clin Oncol. 2010;28:4006-12.
    • (2010) J Clin Oncol. , vol.28 , pp. 4006-4012
    • Liu, S.1    Wicha, M.S.2
  • 56
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya H, Paulson A, Iovino F, et al. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene. 2008;27:6120-30.
    • (2008) Oncogene. , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3
  • 57
    • 67649969473 scopus 로고    scopus 로고
    • Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    • Korkaya H, Paulson A, Charafe-Jauffret E, et al. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol. 2009;7:e1000121.
    • (2009) PLoS Biol. , vol.7
    • Korkaya, H.1    Paulson, A.2    Charafe-Jauffret, E.3
  • 58
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL
    • Ashkenazi A, Holland P, Eckhardt SG. Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). JCO. 2008;26:3621-30.
    • (2008) JCO , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 60
    • 84872209245 scopus 로고    scopus 로고
    • Basal-like breast cancer stem cells are sensitive to anti-DR5 mediated cytotoxicity
    • Sept (Epub ahead of print
    • Londono-Joshi AI, Oliver PG, Li Y, et al. Basal-like breast cancer stem cells are sensitive to anti-DR5 mediated cytotoxicity. Breast Cancer Res 2011 Sept (Epub ahead of print).
    • (2011) Breast Cancer Res
    • Londono-Joshi, A.I.1    Oliver, P.G.2    Li, Y.3
  • 61
    • 35848950227 scopus 로고    scopus 로고
    • The no trail to yes trail in cancer therapy (review
    • Lee JIY, Huerta-GYepez SH, Vega M, et al. The no trail to yes trail in cancer therapy (review). Int J of Oncology. 2007;31:685-91.
    • (2007) Int J of Oncology. , vol.31 , pp. 685-691
    • Lee, J.I.Y.1    Huerta-Gyepez, S.H.2    Vega, M.3
  • 62
    • 84863721324 scopus 로고    scopus 로고
    • WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis
    • Dec 20 (Epub ahead of print
    • Garimella SV, Rocca A, Lipkowitz S. WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis. Mol Cancer Res 2011 Dec 20 (Epub ahead of print).
    • (2011) Mol Cancer Res
    • Garimella, S.V.1    Rocca, A.2    Lipkowitz, S.3
  • 63
    • 80052662217 scopus 로고    scopus 로고
    • Suppression of apotosis inhibitor c-FLIP selectively eliminates breast cancer cell activity in response to the anticancer agent, TRAIL
    • Piggott, L, Omidvar N, Perez SM, et al. Suppression of apotosis inhibitor c-FLIP selectively eliminates breast cancer cell activity in response to the anticancer agent, TRAIL. Breast Cancer Res 2011;13(5):
    • (2011) Breast Cancer Res , vol.13 , Issue.5
    • Piggott, L.1    Omidvar, N.2    Perez, S.M.3
  • 64
    • 58149237789 scopus 로고    scopus 로고
    • TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype
    • Rahman M, Davis SR, Pumphrey JG, et al. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype. Breast Cancer Res Treat. 2009;113:217-30.
    • (2009) Breast Cancer Res Treat. , vol.113 , pp. 217-230
    • Rahman, M.1    Davis, S.R.2    Pumphrey, J.G.3
  • 65
    • 77649301860 scopus 로고    scopus 로고
    • Phase I trial of weekly tigatuzumab, an agonistic humanized monoclonal antibody targeting death receptor 5 (DR5
    • Forero-Torres A, Shah J, Wood T, Posey J, et al. Phase I trial of weekly tigatuzumab, an agonistic humanized monoclonal antibody targeting death receptor 5 (DR5). Cancer Biother Radiopharm. 2010;1:13-9.
    • (2010) Cancer Biother Radiopharm. , vol.1 , pp. 13-19
    • Forero-Torres, A.1    Shah, J.2    Wood, T.3    Posey, J.4
  • 66
    • 51349083634 scopus 로고    scopus 로고
    • The heat shock protein 90 chaperone complex: An evolving therapeutic target
    • Barginear MF, v Poznak C, Rosen N, et al. The heat shock protein 90 chaperone complex: An evolving therapeutic target. Curr Cancer Drug Targets. 2008;6:522-32.
    • (2008) Curr Cancer Drug Targets. , vol.6 , pp. 522-532
    • Barginear, M.F.1    V. Poznak, C.2    Rosen, N.3
  • 67
    • 79960985354 scopus 로고    scopus 로고
    • HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck A, Linden H, et al. HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res. 2011;17 (15):5132-9.
    • (2011) Clin Cancer Res. , vol.17 , Issue.15 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.2    Linden, H.3


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