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Volumn 114, Issue 2, 2009, Pages 195-201

Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer

Author keywords

Tubulin; Chemotherapy resistant; Drug efflux proteins; Ixabepilone; Metastatic breast cancer; P gp

Indexed keywords

9,10 DIDEHYDROEPOTHILONE D; ABJ 879; ALBUMIN; ANTHRACYCLINE DERIVATIVE; BETA TUBULIN; CAPECITABINE; CARBOPLATIN; CARMOFUR; CISPLATIN; CYCLOPHOSPHAMIDE; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; EPOTHILONE B; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; IRINOTECAN; IXABEPILONE; LAROTAXEL; METHOTREXATE; MITOMYCIN; MITOMYCIN C; NAVELBINE; OXALIPLATIN; PACLITAXEL; RPR 109881; TAXANE DERIVATIVE; UFT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

EID: 59449102796     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0005-6     Document Type: Review
Times cited : (90)

References (69)
  • 1
    • 33750316800 scopus 로고    scopus 로고
    • Available via CA Cancer J Clin
    • Jemal A, Siegel R, Ward E et al (2008) Cancer Statistics, 2008. Available via CA Cancer J Clin. http://caoline.amcancersoc.org/cgi/content/full/CA.2007. 0010v1. Accessed 5 Mar 2008
    • (2008) Cancer Statistics
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 51549117737 scopus 로고    scopus 로고
    • Ries LAG, Melbert D, Krapcho M et al (eds) National Cancer Institute
    • Ries LAG, Melbert D, Krapcho M et al (eds) (2006) SEER Cancer Statistics Review, 1975-2004, National Cancer Institute. http://seer.cancer.gov/csr/1975- 2004. Accessed 11 Feb 2008
    • (2006) SEER Cancer Statistics Review , pp. 1975-2004
  • 3
    • 9144268610 scopus 로고    scopus 로고
    • Facts and controversies in systemic treatment of metastatic breast cancer
    • C Bernard-Marty F Cardoso MJ Piccart 2004 Facts and controversies in systemic treatment of metastatic breast cancer Oncologist 9 617 632
    • (2004) Oncologist , vol.9 , pp. 617-632
    • Bernard-Marty, C.1    Cardoso, F.2    Piccart, M.J.3
  • 4
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • CL Vogel MA Cobleigh D Tripathy 2002 Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer J Clin Oncol 20 719 726
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 5
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • CE Geyer J Forster D Lindquist 2006 Lapatinib plus capecitabine for HER2-positive advanced breast cancer N Engl J Med 355 2733 2743
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 7
    • 15544389499 scopus 로고    scopus 로고
    • Chemotherapy: What progress in the last 5 years?
    • A Hamilton G Hortobagyi 2005 Chemotherapy: what progress in the last 5 years? J Clin Oncol 23 1760 1775
    • (2005) J Clin Oncol , vol.23 , pp. 1760-1775
    • Hamilton, A.1    Hortobagyi, G.2
  • 8
    • 0032887408 scopus 로고    scopus 로고
    • Current status of oral anticancer drugs in Japan
    • Y Fujiwara 1999 Current status of oral anticancer drugs in Japan J Clin Oncol 17 3362 3365
    • (1999) J Clin Oncol , vol.17 , pp. 3362-3365
    • Fujiwara, Y.1
  • 10
    • 7944225913 scopus 로고    scopus 로고
    • Phase II multicentre randomised study of docetaxel plus epirubicin vs. 5-fluorouracil plus epirubicin and cyclophosphamide in metastatic breast cancer
    • J Bonneterre V Dieras M Tubiana-Hulin 2004 Phase II multicentre randomised study of docetaxel plus epirubicin vs. 5-fluorouracil plus epirubicin and cyclophosphamide in metastatic breast cancer Br J Cancer 91 1466 1471
    • (2004) Br J Cancer , vol.91 , pp. 1466-1471
    • Bonneterre, J.1    Dieras, V.2    Tubiana-Hulin, M.3
  • 11
    • 21644460994 scopus 로고    scopus 로고
    • 2 as first-line chemotherapy in patients with advanced or recurrent breast cancer
    • 2 as first-line chemotherapy in patients with advanced or recurrent breast cancer Breast Cancer 11 374 379
    • (2004) Breast Cancer , vol.11 , pp. 374-379
    • Ishikawa, T.1    Shimizu, S.2    Inaba, M.3
  • 12
    • 14844354794 scopus 로고    scopus 로고
    • First-line chemotherapy with docetaxel and cisplatin in metastatic breast cancer
    • M Vassilomanolakis G Koumakis V Barbounis 2005 First-line chemotherapy with docetaxel and cisplatin in metastatic breast cancer Breast 14 136 141
    • (2005) Breast , vol.14 , pp. 136-141
    • Vassilomanolakis, M.1    Koumakis, G.2    Barbounis, V.3
  • 13
    • 0027965381 scopus 로고
    • Salvage therapies in women who fail to respond to first-line treatment with fluorouracil, epirubicin, and cyclophosphamide for advanced breast cancer
    • K Porkka C Blomqvist P Rissanen I Elomaa S Pyrhönen 1994 Salvage therapies in women who fail to respond to first-line treatment with fluorouracil, epirubicin, and cyclophosphamide for advanced breast cancer J Clin Oncol 12 1639 1647
    • (1994) J Clin Oncol , vol.12 , pp. 1639-1647
    • Porkka, K.1    Blomqvist, C.2    Rissanen, P.3    Elomaa, I.4    Pyrhönen, S.5
  • 14
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • M Gottesman 2002 Mechanisms of cancer drug resistance Ann Rev Med 53 615 627
    • (2002) Ann Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.1
  • 16
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • P Borst R Evers M Kool J Wijnholds 2000 A family of drug transporters: the multidrug resistance-associated proteins J Natl Cancer Inst 92 1295 1302
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 17
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • GD Leonard T Fojo SE Bates 2003 The role of ABC transporters in clinical practice Oncologist 8 411 424
    • (2003) Oncologist , vol.8 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 18
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • MM Gottesman T Fojo SE Bates 2002 Multidrug resistance in cancer: role of ATP-dependent transporters Nat Rev Cancer 2 48 58
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 19
    • 0025322402 scopus 로고
    • Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein
    • YN Chen LA Mickley AM Schwartz EM Acton J Hwang AT Fojo 1990 Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein J Biol Chem 265 10073 10080
    • (1990) J Biol Chem , vol.265 , pp. 10073-10080
    • Chen, Y.N.1    Mickley, L.A.2    Schwartz, A.M.3    Acton, E.M.4    Hwang, J.5    Fojo, A.T.6
  • 20
    • 0345688604 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    • LA Doyle DD Ross 2003 Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) Oncogene 22 7340 7358
    • (2003) Oncogene , vol.22 , pp. 7340-7358
    • Doyle, L.A.1    Ross, D.D.2
  • 22
    • 0030920342 scopus 로고    scopus 로고
    • Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance
    • BJ Trock F Leonessa R Clarke 1997 Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance J Natl Cancer Inst 89 917 931
    • (1997) J Natl Cancer Inst , vol.89 , pp. 917-931
    • Trock, B.J.1    Leonessa, F.2    Clarke, R.3
  • 23
    • 0037362355 scopus 로고    scopus 로고
    • ATP binding cassette transporters and drug resistance in breast cancer
    • F Leonessa R Clarke 2003 ATP binding cassette transporters and drug resistance in breast cancer Endocr Relat Cancer 10 43 73
    • (2003) Endocr Relat Cancer , vol.10 , pp. 43-73
    • Leonessa, F.1    Clarke, R.2
  • 24
    • 0031043119 scopus 로고    scopus 로고
    • The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance
    • M Kavallaris 1997 The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance Anti-Cancer Drugs 8 17 25
    • (1997) Anti-Cancer Drugs , vol.8 , pp. 17-25
    • Kavallaris, M.1
  • 25
    • 0035884595 scopus 로고    scopus 로고
    • Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells
    • Y Honjo CA Hrycyna QW Yan 2001 Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells Cancer Res 61 6635 6639
    • (2001) Cancer Res , vol.61 , pp. 6635-6639
    • Honjo, Y.1    Hrycyna, C.A.2    Yan, Q.W.3
  • 26
    • 18744399859 scopus 로고    scopus 로고
    • Improving the targeting of tubulin-binding agents: Lessons from drug resistance studies
    • NM Verrills M Kavallaris 2005 Improving the targeting of tubulin-binding agents: lessons from drug resistance studies Curr Pharm Des 11 1719 1733
    • (2005) Curr Pharm des , vol.11 , pp. 1719-1733
    • Verrills, N.M.1    Kavallaris, M.2
  • 27
    • 30344455579 scopus 로고    scopus 로고
    • Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer
    • suppl. 4
    • A Paradiso A Mangia A Chiriatti 2005 Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer Ann Oncol 16 suppl. 4 iv14 iv19
    • (2005) Ann Oncol , vol.16
    • Paradiso, A.1    Mangia, A.2    Chiriatti, A.3
  • 28
    • 16844365749 scopus 로고    scopus 로고
    • ßiII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
    • K Kamath L Wilson F Cabral MA Jordan 2005 ßIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability J Biol Chem 280 12902 12907
    • (2005) J Biol Chem , vol.280 , pp. 12902-12907
    • Kamath, K.1    Wilson, L.2    Cabral, F.3    Jordan, M.A.4
  • 29
    • 20144387336 scopus 로고    scopus 로고
    • Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells
    • H Zhu W Guo L Zhang 2005 Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells Mol Cancer Ther 4 451 456
    • (2005) Mol Cancer Ther , vol.4 , pp. 451-456
    • Zhu, H.1    Guo, W.2    Zhang, L.3
  • 30
    • 3242717109 scopus 로고    scopus 로고
    • Taxane-based reversal agents modulate drug resistance mediated by p-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    • T Brooks H Minderman KL O'Loughlin 2003 Taxane-based reversal agents modulate drug resistance mediated by p-glycoprotein, multidrug resistance protein, and breast cancer resistance protein Mol Cancer Ther 2 1195 1205
    • (2003) Mol Cancer Ther , vol.2 , pp. 1195-1205
    • Brooks, T.1    Minderman, H.2    O'Loughlin, K.L.3
  • 31
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
    • H Thomas HM Coley 2003 Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein Cancer Control 10 159 165
    • (2003) Cancer Control , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 32
    • 43949120781 scopus 로고    scopus 로고
    • Tariquidar (XR9576) is a potent and effective p-glycoprotein (pgp) inhibitor that can be administered safely with chemotherapy
    • Abstract 3093
    • M Menefee C Fan M Edgerly 2005 Tariquidar (XR9576) is a potent and effective p-glycoprotein (pgp) inhibitor that can be administered safely with chemotherapy J Clin Oncol 23 16S Abstract 3093
    • (2005) J Clin Oncol , vol.23
    • Menefee, M.1    Fan, C.2    Edgerly, M.3
  • 33
    • 23644452472 scopus 로고    scopus 로고
    • Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma
    • L Pusztai P Wagner N Ibrahim 2005 Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma Cancer 104 682 691
    • (2005) Cancer , vol.104 , pp. 682-691
    • Pusztai, L.1    Wagner, P.2    Ibrahim, N.3
  • 34
    • 10744229320 scopus 로고    scopus 로고
    • Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer
    • P Fumoleau R Largillier C Clippe 2004 Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer Eur J Cancer 40 536 542
    • (2004) Eur J Cancer , vol.40 , pp. 536-542
    • Fumoleau, P.1    Largillier, R.2    Clippe, C.3
  • 36
    • 0033050165 scopus 로고    scopus 로고
    • Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer
    • JL Blum SE Jones AU Buzdar 1999 Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer J Clin Oncol 17 485 493
    • (1999) J Clin Oncol , vol.17 , pp. 485-493
    • Blum, J.L.1    Jones, S.E.2    Buzdar, A.U.3
  • 37
    • 0035133449 scopus 로고    scopus 로고
    • The role of capecitabine, an oral, enzymatically activated fluoropyrimidine, in the treatment of metastatic breast cancer
    • JL Blum 2001 The role of capecitabine, an oral, enzymatically activated fluoropyrimidine, in the treatment of metastatic breast cancer Oncologist 6 56 64
    • (2001) Oncologist , vol.6 , pp. 56-64
    • Blum, J.L.1
  • 38
    • 0035476911 scopus 로고    scopus 로고
    • Multicenter, phase II study of capecitabine in taxane-pretreated metastatic breast carcinoma patients
    • JL Blum V Dieras PM Lo Russo 2001 Multicenter, phase II study of capecitabine in taxane-pretreated metastatic breast carcinoma patients Cancer 92 1759 1768
    • (2001) Cancer , vol.92 , pp. 1759-1768
    • Blum, J.L.1    Dieras, V.2    Lo Russo, P.M.3
  • 39
    • 0041508753 scopus 로고    scopus 로고
    • ®) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy
    • ®) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy Ann Oncol 14 1227 1233
    • (2003) Ann Oncol , vol.14 , pp. 1227-1233
    • Reichardt, P.1    Von Minckwitz, G.2    Thuss-Patience, P.C.3
  • 40
    • 1842627763 scopus 로고    scopus 로고
    • Oral capecitabine in anthracycline- and taxane-pretreated advanced/metastatic breast cancer
    • EA Wist HH Sommer B Stenstad T Risbert Y Bremnes I Mjaaland 2004 Oral capecitabine in anthracycline- and taxane-pretreated advanced/metastatic breast cancer Acta Oncol 43 186 189
    • (2004) Acta Oncol , vol.43 , pp. 186-189
    • Wist, E.A.1    Sommer, H.H.2    Stenstad, B.3    Risbert, T.4    Bremnes, Y.5    Mjaaland, I.6
  • 41
    • 33646095183 scopus 로고    scopus 로고
    • Phase II study of an oxaliplatin/vinorelbine combination in patients with anthracycline- and taxane-pre-treated metastatic breast cancer
    • T Petit A Benider A Yovine 2006 Phase II study of an oxaliplatin/ vinorelbine combination in patients with anthracycline- and taxane-pre-treated metastatic breast cancer Anticancer Drugs 17 337 343
    • (2006) Anticancer Drugs , vol.17 , pp. 337-343
    • Petit, T.1    Benider, A.2    Yovine, A.3
  • 42
    • 0037093273 scopus 로고    scopus 로고
    • Phase II study of oxaliplatin and fluorouracil in taxane- and anthracycline-pretreated breast cancer patients
    • L Zelek P Cottu M Tubiana-Hulin 2002 Phase II study of oxaliplatin and fluorouracil in taxane- and anthracycline-pretreated breast cancer patients J Clin Oncol 20 2551 2558
    • (2002) J Clin Oncol , vol.20 , pp. 2551-2558
    • Zelek, L.1    Cottu, P.2    Tubiana-Hulin, M.3
  • 43
    • 1642415980 scopus 로고    scopus 로고
    • Gemcitabine and platinum combinations in patients with breast cancer previously treated with anthracyclines and/or taxanes
    • EA Perez 2004 Gemcitabine and platinum combinations in patients with breast cancer previously treated with anthracyclines and/or taxanes Clin Breast Cancer 4 S113 S116
    • (2004) Clin Breast Cancer , vol.4
    • Perez, E.A.1
  • 44
    • 17044405011 scopus 로고    scopus 로고
    • Phase II study of gemcitabine plus cisplatin in patients with metastatic breast cancer: A North Central Cancer Treatment Group trial
    • PA Burch JA Mailliard DW Hillman 2005 Phase II study of gemcitabine plus cisplatin in patients with metastatic breast cancer: a North Central Cancer Treatment Group trial Am J Clin Oncol 28 195 200
    • (2005) Am J Clin Oncol , vol.28 , pp. 195-200
    • Burch, P.A.1    Mailliard, J.A.2    Hillman, D.W.3
  • 45
    • 33845357272 scopus 로고    scopus 로고
    • Phase II study of a gemcitabine and cisplatin combination regimen in taxane resistant metastatic breast cancer
    • JH Seo SC Oh CW Choi 2007 Phase II study of a gemcitabine and cisplatin combination regimen in taxane resistant metastatic breast cancer Cancer Chemother Pharmacol 59 269 274
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 269-274
    • Seo, J.H.1    Oh, S.C.2    Choi, C.W.3
  • 46
    • 21844447521 scopus 로고    scopus 로고
    • Long term disease control in taxane-refractory metastatic breast cancer treated with nab paclitaxel
    • Abstract 543
    • JL Blum MA Savin G Edelman 2004 Long term disease control in taxane-refractory metastatic breast cancer treated with nab paclitaxel J Clin Oncol 22 14S Abstract 543
    • (2004) J Clin Oncol , vol.22
    • Blum, J.L.1    Savin, M.A.2    Edelman, G.3
  • 47
    • 42549094789 scopus 로고    scopus 로고
    • Multicenter, non-randomized phase II study with RPR109881 in taxane-exposed metastatic breast cancer (MBC) patients (pts): Final results
    • Abstract 565
    • V Dieras V Valero S Limentani 2005 Multicenter, non-randomized phase II study with RPR109881 in taxane-exposed metastatic breast cancer (MBC) patients (pts): final results J Clin Oncol 23 16S Abstract 565
    • (2005) J Clin Oncol , vol.23
    • Dieras, V.1    Valero, V.2    Limentani, S.3
  • 48
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • WJ Gradishar S Tjulandin N Davidson 2005 Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer J Clin Oncol 23 7794 7803
    • (2005) J Clin Oncol , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 55
    • 22144437340 scopus 로고    scopus 로고
    • Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer
    • JA O'Shaughnessy RS Clark JL Blum 2005 Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer Clin Breast Cancer 6 143 149
    • (2005) Clin Breast Cancer , vol.6 , pp. 143-149
    • O'Shaughnessy, J.A.1    Clark, R.S.2    Blum, J.L.3
  • 56
    • 77951078636 scopus 로고    scopus 로고
    • Activity of oral irinotecan (IRI) in metastatic breast cancer (MBC) patients after prior anthracycline, taxane and capecitabine: Phase 2 study results
    • Abstract 562
    • S Vukelja J O'Shaughnessy S Campos 2005 Activity of oral irinotecan (IRI) in metastatic breast cancer (MBC) patients after prior anthracycline, taxane and capecitabine: phase 2 study results J Clin Oncol 23 16S Abstract 562
    • (2005) J Clin Oncol , vol.23
    • Vukelja, S.1    O'Shaughnessy, J.2    Campos, S.3
  • 57
    • 4344695312 scopus 로고    scopus 로고
    • Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both
    • EA Perez DW Hillman JA Mailliard 2004 Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both J Clin Oncol 22 2849 2855
    • (2004) J Clin Oncol , vol.22 , pp. 2849-2855
    • Perez, E.A.1    Hillman, D.W.2    Mailliard, J.A.3
  • 58
    • 34548157209 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
    • EA Perez G Lerzo X Pivot 2007 Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine J Clin Oncol 25 3407 3414
    • (2007) J Clin Oncol , vol.25 , pp. 3407-3414
    • Perez, E.A.1    Lerzo, G.2    Pivot, X.3
  • 59
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • FY Lee R Borzilleri CR Fairchild 2001 BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy Clin Cancer Res 7 1429 1437
    • (2001) Clin Cancer Res , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 60
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • DM Bollag PA McQueney J Zhu 1995 Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action Cancer Res 55 2325 2333
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 62
    • 12944277104 scopus 로고    scopus 로고
    • A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
    • P Giannakakou R Gussio E Nogales 2000 A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Proc Natl Acad Sci USA 97 2904 2909
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2904-2909
    • Giannakakou, P.1    Gussio, R.2    Nogales, E.3
  • 63
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant ß-tubulins that exhibit impaired paclitaxel-driven polymerization
    • P Giannakakou DL Sackett YK Kang 1997 Paclitaxel-resistant human ovarian cancer cells have mutant ß-tubulins that exhibit impaired paclitaxel-driven polymerization J Biol Chem 272 17118 17125
    • (1997) J Biol Chem , vol.272 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3
  • 64
    • 34147112848 scopus 로고    scopus 로고
    • Targeting the microtubules in breast cancer beyond taxanes: The epothilones
    • J Cortes J Baselga 2007 Targeting the microtubules in breast cancer beyond taxanes: the epothilones Oncologist 12 271 280
    • (2007) Oncologist , vol.12 , pp. 271-280
    • Cortes, J.1    Baselga, J.2
  • 65
    • 34147146068 scopus 로고    scopus 로고
    • KOS-1584: A rationally designed epothilone D analog with improved potency and pharmacokinetic (PK) properties
    • Abstract 2535
    • Zhou Y, Zhong Z, Liu F et al (2005) KOS-1584: a rationally designed epothilone D analog with improved potency and pharmacokinetic (PK) properties. Proc Amer Assoc Cancer Res 46: Abstract 2535
    • (2005) Proc Amer Assoc Cancer Res , vol.46
    • Zhou, Y.1    Zhong, Z.2    Al Et, L.F.3
  • 66
    • 34247170561 scopus 로고    scopus 로고
    • ® resistance recapitulates the phenotype of its origin has altered beta-tubulin expression and is sensitive to ixabepilone.
    • Washington DC, April 1-5, 2006 Abstract LB-280
    • ® resistance recapitulates the phenotype of its origin has altered beta-tubulin expression and is sensitive to ixabepilone. The 97th AACR Annual Meeting, Washington DC, April 1-5, 2006 Abstract LB-280
    • (2006) The 97th AACR Annual Meeting
    • Jordan, M.A.1    Miller, H.2    Al Et, N.L.3
  • 67
    • 34548187738 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
    • E Thomas J Tabernero M Fornier 2007 Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer J Clin Oncol 25 3399 3406
    • (2007) J Clin Oncol , vol.25 , pp. 3399-3406
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3
  • 68
    • 0031758794 scopus 로고    scopus 로고
    • A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer
    • V Valero SE Jones DD Von Hoff 1998 A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer J Clin Oncol 16 3362 3368
    • (1998) J Clin Oncol , vol.16 , pp. 3362-3368
    • Valero, V.1    Jones, S.E.2    Von Hoff, D.D.3
  • 69
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • ES Thomas HL Gomez RK Li 2007 Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment J Clin Oncol 25 5210 5217
    • (2007) J Clin Oncol , vol.25 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3


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