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Volumn 7, Issue 3, 2016, Pages 314-323

Survivin and tumorigenesis: Molecular mechanisms and therapeutic strategies

Author keywords

Apoptosis; Cancer; Cell cycle; Survivin; Therapy

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BETA CATENIN; CANCER VACCINE; GENE THERAPY AGENT; IMMUNOMODULATING AGENT; INHIBITOR OF APOPTOSIS PROTEIN; NOTCH RECEPTOR; OLIGONUCLEOTIDE; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STAT3 PROTEIN; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 84971552299     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.13332     Document Type: Review
Times cited : (262)

References (101)
  • 1
    • 84924266024 scopus 로고    scopus 로고
    • Apoptosis, autophagy, necroptosis, and cancer metastasis
    • Su Z, Yang Z, Xu Y, et al. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer. 2015; 14(1): 48.
    • (2015) Mol Cancer , vol.14 , Issue.1 , pp. 48
    • Su, Z.1    Yang, Z.2    Xu, Y.3
  • 2
    • 84921358091 scopus 로고    scopus 로고
    • Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells
    • Sun L, Peng Q, Qu L, et al. Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells. Mol Med Rep. 2015; 11: 3094-100.
    • (2015) Mol Med Rep , vol.11 , pp. 3094-3100
    • Sun, L.1    Peng, Q.2    Qu, L.3
  • 3
    • 84930762344 scopus 로고    scopus 로고
    • Targeting cancer with sesterterpenoids: the new potential antitumor drugs
    • Zhang C, Liu Y. Targeting cancer with sesterterpenoids: the new potential antitumor drugs. J Nat Med. 2015; 69: 255-66.
    • (2015) J Nat Med , vol.69 , pp. 255-266
    • Zhang, C.1    Liu, Y.2
  • 4
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007; 35: 495-516.
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 5
    • 84949812842 scopus 로고    scopus 로고
    • The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression
    • Zhang C, Zhang F. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics. 2015; 3: 40-50.
    • (2015) J Genomics , vol.3 , pp. 40-50
    • Zhang, C.1    Zhang, F.2
  • 6
    • 84939978235 scopus 로고    scopus 로고
    • Caspases: therapeutic targets in neurologic disease
    • Troy CM, Jean YY. Caspases: therapeutic targets in neurologic disease. Neurotherapeutics. 2015; 12: 42-8.
    • (2015) Neurotherapeutics , vol.12 , pp. 42-48
    • Troy, C.M.1    Jean, Y.Y.2
  • 8
    • 84926331582 scopus 로고    scopus 로고
    • PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition
    • Brady SW, Zhang J, Tsai MH, et al. PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition. Cancer Biol Ther. 2015; 16: 402-11.
    • (2015) Cancer Biol Ther , vol.16 , pp. 402-411
    • Brady, S.W.1    Zhang, J.2    Tsai, M.H.3
  • 9
    • 84937251445 scopus 로고    scopus 로고
    • MicroRNA regulation and therapeutic targeting of survivin in cancer
    • Huang J, Lyu H, Wang J, et al. MicroRNA regulation and therapeutic targeting of survivin in cancer. Am J Cancer Res. 2015; 5: 20-31.
    • (2015) Am J Cancer Res , vol.5 , pp. 20-31
    • Huang, J.1    Lyu, H.2    Wang, J.3
  • 10
    • 84893930312 scopus 로고    scopus 로고
    • Survivin as a preferential target for cancer therapy
    • Mobahat M, Narendran A, Riabowol K. Survivin as a preferential target for cancer therapy. Int J Mol Sci. 2014; 15: 2494-516
    • (2014) Int J Mol Sci , vol.15 , pp. 2494-2516
    • Mobahat, M.1    Narendran, A.2    Riabowol, K.3
  • 11
    • 84882740725 scopus 로고    scopus 로고
    • Inhibitors of apoptotic proteins: new targets for anticancer therapy
    • Saleem M, Qadir MI, Perveen N, et al. Inhibitors of apoptotic proteins: new targets for anticancer therapy. Chem Biol Drug Des. 2013; 82: 243-51.
    • (2013) Chem Biol Drug Des , vol.82 , pp. 243-251
    • Saleem, M.1    Qadir, M.I.2    Perveen, N.3
  • 12
    • 84870471218 scopus 로고    scopus 로고
    • Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation
    • Jarrin M, Mansergh FC, Boulton ME, et al. Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation. Mol Vis. 2012; 18: 2758-69.
    • (2012) Mol Vis , vol.18 , pp. 2758-2769
    • Jarrin, M.1    Mansergh, F.C.2    Boulton, M.E.3
  • 13
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini G, Adida C & Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997; 3: 917-21.
    • (1997) Nat Med , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 14
    • 0034672506 scopus 로고    scopus 로고
    • Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines
    • Fong WG, Liston P, Rajcan-Separovic E, et al. Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics. 2000; 70: 113-22.
    • (2000) Genomics , vol.70 , pp. 113-122
    • Fong, W.G.1    Liston, P.2    Rajcan-Separovic, E.3
  • 15
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • LaCasse EC, Baird S, Korneluk RG, et al. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1998; 17: 3247-59.
    • (1998) Oncogene , vol.17 , pp. 3247-3259
    • LaCasse, E.C.1    Baird, S.2    Korneluk, R.G.3
  • 16
    • 17744379360 scopus 로고    scopus 로고
    • Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins
    • Li J, Feng Q, Kim JM, et al. Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins. Endocrinology. 2001; 142: 370-80.
    • (2001) Endocrinology , vol.142 , pp. 370-380
    • Li, J.1    Feng, Q.2    Kim, J.M.3
  • 17
    • 0034731359 scopus 로고    scopus 로고
    • KIAP, a novel member of the inhibitor of apoptosis protein family
    • Lin JH, Deng G, Huang Q, et al. KIAP, a novel member of the inhibitor of apoptosis protein family. Biochem Biophys Res Commun. 2000; 279: 820-31.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 820-831
    • Lin, J.H.1    Deng, G.2    Huang, Q.3
  • 18
    • 17144438370 scopus 로고    scopus 로고
    • Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
    • Tamm I, Kornblau SM, Segall H et al. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000; 6:1796-803.
    • (2000) Clin Cancer Res , vol.6 , pp. 1796-1803
    • Tamm, I.1    Kornblau, S.M.2    Segall, H.3
  • 19
    • 34547126428 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) as cancer targets
    • Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis. 2007; 12: 1543-68.
    • (2007) Apoptosis , vol.12 , pp. 1543-1568
    • Hunter, A.M.1    LaCasse, E.C.2    Korneluk, R.G.3
  • 20
    • 84907077069 scopus 로고    scopus 로고
    • The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosis
    • Luk SU, Xue H, Cheng H, et al. The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosis. Oncotarget. 2014; 5: 6896-908.
    • (2014) Oncotarget , vol.5 , pp. 6896-6908
    • Luk, S.U.1    Xue, H.2    Cheng, H.3
  • 21
    • 84904701212 scopus 로고    scopus 로고
    • Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study
    • Kusner LL, Ciesielski MJ, Marx A, et al. Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study. PLoS One. 2014; 9: e102231.
    • (2014) PLoS One , vol.9
    • Kusner, L.L.1    Ciesielski, M.J.2    Marx, A.3
  • 22
    • 84901592022 scopus 로고    scopus 로고
    • Clinicopathological significance of PI3K, Akt and survivin expression in gastric cancer
    • Gu Y, Jin S, Wang F, et al. Clinicopathological significance of PI3K, Akt and survivin expression in gastric cancer. Biomed Pharmacother. 2014; 68: 471-5.
    • (2014) Biomed Pharmacother , vol.68 , pp. 471-475
    • Gu, Y.1    Jin, S.2    Wang, F.3
  • 23
    • 77950678272 scopus 로고    scopus 로고
    • Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
    • Sierra JR, Cepero V, Giordano S. Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer. 2010; 9: 75.
    • (2010) Mol Cancer , vol.9 , pp. 75
    • Sierra, J.R.1    Cepero, V.2    Giordano, S.3
  • 24
    • 32644441128 scopus 로고    scopus 로고
    • Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells
    • Carter BZ, Mak DH, Schober WD, et al. Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells. Blood. 2006; 107: 1555-63.
    • (2006) Blood , vol.107 , pp. 1555-1563
    • Carter, B.Z.1    Mak, D.H.2    Schober, W.D.3
  • 25
    • 79953217107 scopus 로고    scopus 로고
    • Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy
    • Anandharaj A, Cinghu S, Park WY. Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy. Acta Biochim Biophys Sin (Shanghai). 2011; 43: 292-300.
    • (2011) Acta Biochim Biophys Sin (Shanghai) , vol.43 , pp. 292-300
    • Anandharaj, A.1    Cinghu, S.2    Park, W.Y.3
  • 26
    • 84880582768 scopus 로고    scopus 로고
    • Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia
    • Sehara Y, Sawicka K, Hwang JY, et al. Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia. J Neurosci. 2013; 33: 12364-74.
    • (2013) J Neurosci , vol.33 , pp. 12364-12374
    • Sehara, Y.1    Sawicka, K.2    Hwang, J.Y.3
  • 27
    • 63449089496 scopus 로고    scopus 로고
    • Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
    • Tang C, Lu YH, Xie JH, et al. Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs. 2009; 20: 249-58.
    • (2009) Anticancer Drugs , vol.20 , pp. 249-258
    • Tang, C.1    Lu, Y.H.2    Xie, J.H.3
  • 28
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • Tamm I, Wang Y, Sausville E, et al. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998; 58: 5315-20.
    • (1998) Cancer Res , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3
  • 29
    • 0035136743 scopus 로고    scopus 로고
    • Cytokinesis, apoptosis and survivin: three for tango?
    • Altieri DC. Cytokinesis, apoptosis and survivin: three for tango? Cell Death Differ. 2001; 8: 4-5.
    • (2001) Cell Death Differ , vol.8 , pp. 4-5
    • Altieri, D.C.1
  • 30
    • 4544334875 scopus 로고    scopus 로고
    • Survivin regulates the p53 tumor suppressor gene family
    • Wang Z, Fukuda S, Pelus LM. Survivin regulates the p53 tumor suppressor gene family. Oncogene. 2004; 23: 8146-53.
    • (2004) Oncogene , vol.23 , pp. 8146-8153
    • Wang, Z.1    Fukuda, S.2    Pelus, L.M.3
  • 31
    • 84883341009 scopus 로고    scopus 로고
    • Survivin, a key component of the Wnt/beta-catenin signaling pathway, contributes to traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus
    • Zhang L, Yan R, Zhang Q, et al. Survivin, a key component of the Wnt/beta-catenin signaling pathway, contributes to traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus. Int J Mol Med. 2013; 32: 867-75.
    • (2013) Int J Mol Med , vol.32 , pp. 867-875
    • Zhang, L.1    Yan, R.2    Zhang, Q.3
  • 32
    • 84875256838 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha-mediated activation of survivin in cervical cancer cells
    • Bai H, Ge S, Lu J, et al. Hypoxia inducible factor-1alpha-mediated activation of survivin in cervical cancer cells. J Obstet Gynaecol Res. 2013; 39: 555-63.
    • (2013) J Obstet Gynaecol Res , vol.39 , pp. 555-563
    • Bai, H.1    Ge, S.2    Lu, J.3
  • 33
    • 78751503434 scopus 로고    scopus 로고
    • Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
    • Chen Y, Li D, Liu H, et al. Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells. Cancer Biol Ther. 2011; 11: 14-21.
    • (2011) Cancer Biol Ther , vol.11 , pp. 14-21
    • Chen, Y.1    Li, D.2    Liu, H.3
  • 34
    • 84961126508 scopus 로고    scopus 로고
    • TGF-beta Regulates Survivin to Affect Cell Cycle and the Expression of EGFR and MMP9 in Glioblastoma
    • Chen W, Zhong X, Wei Y, et al. TGF-beta Regulates Survivin to Affect Cell Cycle and the Expression of EGFR and MMP9 in Glioblastoma. Mol Neurobiol. 2015; DOI 10.1007/s12035-015-9121-6.
    • (2015) Mol Neurobiol
    • Chen, W.1    Zhong, X.2    Wei, Y.3
  • 35
    • 84923653290 scopus 로고    scopus 로고
    • Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms
    • Chen Z, Sui J, Zhang F, et al. Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms. J Cancer. 2015; 6: 233-42.
    • (2015) J Cancer , vol.6 , pp. 233-242
    • Chen, Z.1    Sui, J.2    Zhang, F.3
  • 36
    • 84930278675 scopus 로고    scopus 로고
    • Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
    • Zhang C. Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell. 2014; 5: 750-60.
    • (2014) Protein Cell , vol.5 , pp. 750-760
    • Zhang, C.1
  • 37
    • 28244490602 scopus 로고    scopus 로고
    • Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells
    • Asanuma H, Torigoe T, Kamiguchi K, et al. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res. 2005; 65: 11018-25.
    • (2005) Cancer Res , vol.65 , pp. 11018-11025
    • Asanuma, H.1    Torigoe, T.2    Kamiguchi, K.3
  • 38
    • 77953190805 scopus 로고    scopus 로고
    • Inhibition of ErbB2 by Herceptin reduces survivin expression via the ErbB2-beta-catenin/TCF4-survivin pathway in ErbB2-overexpressed breast cancer cells
    • Zhu H, Zhang G, Wang Y, et al. Inhibition of ErbB2 by Herceptin reduces survivin expression via the ErbB2-beta-catenin/TCF4-survivin pathway in ErbB2-overexpressed breast cancer cells. Cancer Sci. 2010; 101: 1156-62.
    • (2010) Cancer Sci , vol.101 , pp. 1156-1162
    • Zhu, H.1    Zhang, G.2    Wang, Y.3
  • 39
    • 34247474846 scopus 로고    scopus 로고
    • Regulation of survivin expression by IGF-1/mTOR signaling
    • Vaira V, Lee CW, Goel HL, et al. Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. 2007; 26: 2678-2684.
    • (2007) Oncogene , vol.26 , pp. 2678-2684
    • Vaira, V.1    Lee, C.W.2    Goel, H.L.3
  • 40
    • 79959694876 scopus 로고    scopus 로고
    • HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats
    • Li Y, Xia ZL, Chen LB. HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats. Neurol Res. 2011; 33: 583-92.
    • (2011) Neurol Res , vol.33 , pp. 583-592
    • Li, Y.1    Xia, Z.L.2    Chen, L.B.3
  • 41
    • 76149102204 scopus 로고    scopus 로고
    • The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription
    • Muller GA, Engeland K. The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription. FEBS J. 2010; 277: 877-93.
    • (2010) FEBS J , vol.277 , pp. 877-893
    • Muller, G.A.1    Engeland, K.2
  • 42
    • 0037267333 scopus 로고    scopus 로고
    • Validating survivin as a cancer therapeutic target
    • Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer. 2003; 3: 46-54.
    • (2003) Nat Rev Cancer , vol.3 , pp. 46-54
    • Altieri, D.C.1
  • 44
    • 0036655052 scopus 로고    scopus 로고
    • A p34(cdc2) survival checkpoint in cancer
    • O'Connor DS, Wall NR, Porter AC, et al. A p34(cdc2) survival checkpoint in cancer. Cancer Cell. 2002; 2: 43-54.
    • (2002) Cancer Cell , vol.2 , pp. 43-54
    • O'Connor, D.S.1    Wall, N.R.2    Porter, A.C.3
  • 45
    • 0034532701 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner
    • Zhao J, Tenev T, Martins LM, et al. The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner. J Cell Sci. 2000; 113 (Pt 23): 4363-71.
    • (2000) J Cell Sci , vol.113 , pp. 4363-4371
    • Zhao, J.1    Tenev, T.2    Martins, L.M.3
  • 46
    • 84898885011 scopus 로고    scopus 로고
    • EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy
    • Hakonen E, Ustinov J, Palgi J, et al. EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy. PLoS One. 2014; 9: e93651.
    • (2014) PLoS One , vol.9
    • Hakonen, E.1    Ustinov, J.2    Palgi, J.3
  • 47
    • 84858079914 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR Pathway in Angiogenesis
    • Karar J, Maity A. PI3K/AKT/mTOR Pathway in Angiogenesis. Front Mol Neurosci. 2011; 4: 51.
    • (2011) Front Mol Neurosci , vol.4 , pp. 51
    • Karar, J.1    Maity, A.2
  • 48
    • 84910079551 scopus 로고    scopus 로고
    • Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription
    • Fernandez JG, Rodriguez DA, Valenzuela M et al. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription. Mol Cancer. 2014; 13: 209.
    • (2014) Mol Cancer , vol.13 , pp. 209
    • Fernandez, J.G.1    Rodriguez, D.A.2    Valenzuela, M.3
  • 49
    • 77956483084 scopus 로고    scopus 로고
    • EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic beta-cells
    • Wang H, Gambosova K, Cooper ZA, et al. EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic beta-cells. BMC Mol Biol. 2010; 11: 66.
    • (2010) BMC Mol Biol , vol.11 , pp. 66
    • Wang, H.1    Gambosova, K.2    Cooper, Z.A.3
  • 50
    • 0035353163 scopus 로고    scopus 로고
    • Cytokine-regulated expression of survivin in myeloid leukemia
    • Carter BZ, Milella M, Altieri DC, et al. Cytokine-regulated expression of survivin in myeloid leukemia. Blood. 2001; 97: 2784-90.
    • (2001) Blood , vol.97 , pp. 2784-2790
    • Carter, B.Z.1    Milella, M.2    Altieri, D.C.3
  • 51
    • 84925517973 scopus 로고    scopus 로고
    • Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities
    • Zhang C, Zhang F. Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities. Protein Cell. 2015; 6: 88-100.
    • (2015) Protein Cell , vol.6 , pp. 88-100
    • Zhang, C.1    Zhang, F.2
  • 52
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • Aoki Y, Feldman GM, Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. 2003; 101: 1535-42.
    • (2003) Blood , vol.101 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 53
    • 80053348989 scopus 로고    scopus 로고
    • Apoptosis in cancer: from pathogenesis to treatment
    • Wong RS. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res. 2011; 30: 87.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 87
    • Wong, R.S.1
  • 54
    • 28544443984 scopus 로고    scopus 로고
    • Promoting apoptosis as a strategy for cancer drug discovery
    • Fesik SW. Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer. 2005; 5: 876-85.
    • (2005) Nat Rev Cancer , vol.5 , pp. 876-885
    • Fesik, S.W.1
  • 55
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 2006; 25: 4798-811.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 56
    • 0037022352 scopus 로고    scopus 로고
    • Cytochrome c release from mitochondria proceeds by a two-step process
    • Ott M, Robertson JD, Gogvadze V, et al. Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A. 2002; 99: 1259-63.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1259-1263
    • Ott, M.1    Robertson, J.D.2    Gogvadze, V.3
  • 57
    • 84880009385 scopus 로고    scopus 로고
    • Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
    • Brentnall M, Rodriguez-Menocal L, De Guevara RL, et al. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 2013; 14: 32.
    • (2013) BMC Cell Biol , vol.14 , pp. 32
    • Brentnall, M.1    Rodriguez-Menocal, L.2    De Guevara, R.L.3
  • 58
    • 78149468447 scopus 로고    scopus 로고
    • Overexpression of survivin initiates hematologic malignancies in vivo
    • Small S, Keerthivasan G, Huang Z, et al. Overexpression of survivin initiates hematologic malignancies in vivo. Leukemia. 2010; 24: 1920-6.
    • (2010) Leukemia , vol.24 , pp. 1920-1926
    • Small, S.1    Keerthivasan, G.2    Huang, Z.3
  • 59
    • 1642275029 scopus 로고    scopus 로고
    • Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis
    • Chandele A, Prasad V, Jagtap JC, et al. Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis. Neoplasia. 2004; 6: 29-40.
    • (2004) Neoplasia , vol.6 , pp. 29-40
    • Chandele, A.1    Prasad, V.2    Jagtap, J.C.3
  • 60
    • 0034623308 scopus 로고    scopus 로고
    • Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells
    • Wright ME, Han DK, Hockenbery DM. Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells. FEBS Lett. 2000; 481: 13-8.
    • (2000) FEBS Lett , vol.481 , pp. 13-18
    • Wright, M.E.1    Han, D.K.2    Hockenbery, D.M.3
  • 61
    • 0037663452 scopus 로고    scopus 로고
    • Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis
    • Song Z, Yao X, Wu M. Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem. 2003; 278: 23130-40.
    • (2003) J Biol Chem , vol.278 , pp. 23130-23140
    • Song, Z.1    Yao, X.2    Wu, M.3
  • 62
    • 84877280543 scopus 로고    scopus 로고
    • Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance
    • Singh M, Chaudhry P, Fabi F, et al. Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC Cancer. 2013; 13: 233.
    • (2013) BMC Cancer , vol.13 , pp. 233
    • Singh, M.1    Chaudhry, P.2    Fabi, F.3
  • 63
    • 0942290423 scopus 로고    scopus 로고
    • Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells
    • Liu T, Brouha B, Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene. 2004; 23: 39-48.
    • (2004) Oncogene , vol.23 , pp. 39-48
    • Liu, T.1    Brouha, B.2    Grossman, D.3
  • 64
    • 52649172153 scopus 로고    scopus 로고
    • Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics
    • Mita AC, Mita MM, Nawrocki ST, et al. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res. 2008; 14: 5000-5.
    • (2008) Clin Cancer Res , vol.14 , pp. 5000-5005
    • Mita, A.C.1    Mita, M.M.2    Nawrocki, S.T.3
  • 65
    • 4944250023 scopus 로고    scopus 로고
    • Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity
    • Beardmore VA, Ahonen LJ, Gorbsky GJ, et al. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 2004; 117: 4033-42.
    • (2004) J Cell Sci , vol.117 , pp. 4033-4042
    • Beardmore, V.A.1    Ahonen, L.J.2    Gorbsky, G.J.3
  • 66
    • 84863014312 scopus 로고    scopus 로고
    • Survivin deficiency induces apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells
    • Dai D, Liang Y, Xie Z, et al. Survivin deficiency induces apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Oncol Rep. 2012; 27: 621-7.
    • (2012) Oncol Rep , vol.27 , pp. 621-627
    • Dai, D.1    Liang, Y.2    Xie, Z.3
  • 67
    • 0034612594 scopus 로고    scopus 로고
    • Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation
    • Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene. 2000; 19: 3225-34.
    • (2000) Oncogene , vol.19 , pp. 3225-3234
    • Suzuki, A.1    Hayashida, M.2    Ito, T.3
  • 68
    • 0033628438 scopus 로고    scopus 로고
    • Function of the p53 gene: choice between life and death
    • Chumakov PM. Function of the p53 gene: choice between life and death. Biochemistry (Mosc). 2000; 65: 28-40.
    • (2000) Biochemistry (Mosc) , vol.65 , pp. 28-40
    • Chumakov, P.M.1
  • 69
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene. 2003; 22: 9030-40.
    • (2003) Oncogene , vol.22 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 70
    • 84897546355 scopus 로고    scopus 로고
    • Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition
    • Zhang C, Liu G, Huang M. Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition. Front Biol. 2014; 9: 104-13.
    • (2014) Front Biol , vol.9 , pp. 104-113
    • Zhang, C.1    Liu, G.2    Huang, M.3
  • 71
    • 84941145065 scopus 로고    scopus 로고
    • Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells
    • Lai YJ, Lin CI, Wang CL, et al. Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. J Cell Biochem. 2014; 115: 1888-99.
    • (2014) J Cell Biochem , vol.115 , pp. 1888-1899
    • Lai, Y.J.1    Lin, C.I.2    Wang, C.L.3
  • 72
    • 0036479115 scopus 로고    scopus 로고
    • Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
    • Hoffman WH, Biade S, Zilfou JT, et al. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem. 2002; 277:3247-57.
    • (2002) J Biol Chem , vol.277 , pp. 3247-3257
    • Hoffman, W.H.1    Biade, S.2    Zilfou, J.T.3
  • 73
    • 18344369169 scopus 로고    scopus 로고
    • Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
    • Mirza A, McGuirk M, Hockenberry TN, et al. Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene. 2002; 21: 2613-22.
    • (2002) Oncogene , vol.21 , pp. 2613-2622
    • Mirza, A.1    McGuirk, M.2    Hockenberry, T.N.3
  • 74
    • 64549130057 scopus 로고    scopus 로고
    • Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy
    • Ulasov IV, Tyler MA, Zhu ZB, et al. Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy. Int J Oncol. 2009; 34: 729-42.
    • (2009) Int J Oncol , vol.34 , pp. 729-742
    • Ulasov, I.V.1    Tyler, M.A.2    Zhu, Z.B.3
  • 75
    • 18344369169 scopus 로고    scopus 로고
    • Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
    • Mirza A, McGuirk M, Hockenberry TN, et al. Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene. 2002; 21: 2613-22.
    • (2002) Oncogene , vol.21 , pp. 2613-2622
    • Mirza, A.1    McGuirk, M.2    Hockenberry, T.N.3
  • 76
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013; 13: 11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 77
    • 45849117967 scopus 로고    scopus 로고
    • Wnt signal transduction pathways
    • Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis. 2008; 4: 68-75.
    • (2008) Organogenesis , vol.4 , pp. 68-75
    • Komiya, Y.1    Habas, R.2
  • 78
    • 84906997728 scopus 로고    scopus 로고
    • Wnt signaling pathway in non-small cell lung cancer
    • Stewart DJ. Wnt signaling pathway in non-small cell lung cancer. J Natl Cancer Inst. 2014; 106: djt356.
    • (2014) J Natl Cancer Inst , vol.106
    • Stewart, D.J.1
  • 79
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer. 2011; 11: 393-410.
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 80
    • 48549088705 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in eye disease
    • Penn JS, Madan A, Caldwell RB, et al. Vascular endothelial growth factor in eye disease. Prog Retin Eye Res. 2008; 27: 331-71.
    • (2008) Prog Retin Eye Res , vol.27 , pp. 331-371
    • Penn, J.S.1    Madan, A.2    Caldwell, R.B.3
  • 81
    • 38449121857 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia
    • Ziello JE, Jovin IS, Huang Y. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J Biol Med. 2007; 80: 51-60.
    • (2007) Yale J Biol Med , vol.80 , pp. 51-60
    • Ziello, J.E.1    Jovin, I.S.2    Huang, Y.3
  • 82
    • 84915785657 scopus 로고    scopus 로고
    • Inhibition of survivin reduces HIF-1alpha, TGF-beta1 and TFE3 in salivary adenoid cystic carcinoma
    • Wang YF, Ma SR, Wang WM, et al. Inhibition of survivin reduces HIF-1alpha, TGF-beta1 and TFE3 in salivary adenoid cystic carcinoma. PLoS One. 2014; 9: e114051.
    • (2014) PLoS One , vol.9
    • Wang, Y.F.1    Ma, S.R.2    Wang, W.M.3
  • 83
    • 63849178889 scopus 로고    scopus 로고
    • Effect of hypoxia-inducible factor-1alpha on transcription of survivin in non-small cell lung cancer
    • Chen YQ, Zhao CL, Li W. Effect of hypoxia-inducible factor-1alpha on transcription of survivin in non-small cell lung cancer. J Exp Clin Cancer Res. 2009; 28: 9.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 9
    • Chen, Y.Q.1    Zhao, C.L.2    Li, W.3
  • 84
    • 78549245097 scopus 로고    scopus 로고
    • NF-kappaB mediates aberrant activation of HIF-1 in malignant lymphoma
    • Qiao Q, Nozaki Y, Sakoe K, et al. NF-kappaB mediates aberrant activation of HIF-1 in malignant lymphoma. Exp Hematol. 2010; 38: 1199-208.
    • (2010) Exp Hematol , vol.38 , pp. 1199-1208
    • Qiao, Q.1    Nozaki, Y.2    Sakoe, K.3
  • 85
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M, Baer MR, Baumann H, et al. Signal transducer and activator of transcription proteins in leukemias. Blood. 2003; 101: 2940-54.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3
  • 86
    • 84898921083 scopus 로고    scopus 로고
    • STAT3 Target Genes Relevant to Human Cancers
    • Carpenter RL, Lo HW. STAT3 Target Genes Relevant to Human Cancers. Cancers (Basel). 2014; 6: 897-925.
    • (2014) Cancers (Basel) , vol.6 , pp. 897-925
    • Carpenter, R.L.1    Lo, H.W.2
  • 87
    • 78149238747 scopus 로고    scopus 로고
    • Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity
    • Wang H, Holloway MP, Ma L, et al. Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J Biol Chem. 2010; 285: 36129-37.
    • (2010) J Biol Chem , vol.285 , pp. 36129-36137
    • Wang, H.1    Holloway, M.P.2    Ma, L.3
  • 89
    • 80555129351 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
    • Lobry C, Oh P, Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med. 2011; 208: 1931-35.
    • (2011) J Exp Med , vol.208 , pp. 1931-1935
    • Lobry, C.1    Oh, P.2    Aifantis, I.3
  • 90
    • 78751503434 scopus 로고    scopus 로고
    • Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
    • Chen Y, Li D, Liu H, et al. Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells. Cancer Biol Ther. 2011; 11: 14-21.
    • (2011) Cancer Biol Ther , vol.11 , pp. 14-21
    • Chen, Y.1    Li, D.2    Liu, H.3
  • 91
    • 48549085976 scopus 로고    scopus 로고
    • Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis
    • Lee CW, Raskett CM, Prudovsky I, et al. Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res. 2008; 68: 5273-81.
    • (2008) Cancer Res , vol.68 , pp. 5273-5281
    • Lee, C.W.1    Raskett, C.M.2    Prudovsky, I.3
  • 92
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001; 29: 117-29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 93
    • 78549294898 scopus 로고    scopus 로고
    • Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling
    • Wahdan-Alaswad RS, Song K, Krebs TL, et al. Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. Cancer Res. 2010; 70: 9106-17.
    • (2010) Cancer Res , vol.70 , pp. 9106-9117
    • Wahdan-Alaswad, R.S.1    Song, K.2    Krebs, T.L.3
  • 94
    • 84877064816 scopus 로고    scopus 로고
    • Critical role of a survivin/TGF-beta/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells
    • Song K, Shankar E, Yang J, et al. Critical role of a survivin/TGF-beta/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells. PLoS One. 2013; 8: e61896.
    • (2013) PLoS One , vol.8
    • Song, K.1    Shankar, E.2    Yang, J.3
  • 95
    • 51649119264 scopus 로고    scopus 로고
    • Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression
    • Yang J, Song K, Krebs TL, et al. Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression. Oncogene. 2008; 27: 5326-38.
    • (2008) Oncogene , vol.27 , pp. 5326-5338
    • Yang, J.1    Song, K.2    Krebs, T.L.3
  • 96
    • 84882683386 scopus 로고    scopus 로고
    • Manipulating the apoptotic pathway: potential therapeutics for cancer patients
    • Bates DJ, Lewis LD. Manipulating the apoptotic pathway: potential therapeutics for cancer patients. Br J Clin Pharmacol. 2013; 76: 381-95.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 381-395
    • Bates, D.J.1    Lewis, L.D.2
  • 97
    • 34447315861 scopus 로고    scopus 로고
    • Targeting survivin in cancer therapy: fulfilled promises and open questions
    • Pennati M, Folini M, Zaffaroni N. Targeting survivin in cancer therapy: fulfilled promises and open questions. Carcinogenesis. 2007; 28: 1133-9.
    • (2007) Carcinogenesis , vol.28 , pp. 1133-1139
    • Pennati, M.1    Folini, M.2    Zaffaroni, N.3
  • 98
    • 0036155862 scopus 로고    scopus 로고
    • Ribozyme-mediated attenuation of survivin expression sensitizes human melanoma cells to cisplatin-induced apoptosis
    • Pennati M, Colella G, Folini M, et al. Ribozyme-mediated attenuation of survivin expression sensitizes human melanoma cells to cisplatin-induced apoptosis. J Clin Invest. 2002; 109: 285-6.
    • (2002) J Clin Invest , vol.109 , pp. 285-286
    • Pennati, M.1    Colella, G.2    Folini, M.3
  • 99
    • 80053357507 scopus 로고    scopus 로고
    • Molecular basis for the actions of Hsp90 inhibitors and cancer therapy
    • Yamaki H, Nakajima M, Shimotohno KW, et al. Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. J Antibiot (Tokyo). 2011; 64: 635-44.
    • (2011) J Antibiot (Tokyo) , vol.64 , pp. 635-644
    • Yamaki, H.1    Nakajima, M.2    Shimotohno, K.W.3
  • 100
    • 0037818503 scopus 로고    scopus 로고
    • Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells
    • Schmidt SM, Schag K, Muller MR, et al. Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. Blood. 2003; 102: 571-6.
    • (2003) Blood , vol.102 , pp. 571-576
    • Schmidt, S.M.1    Schag, K.2    Muller, M.R.3
  • 101
    • 84920390437 scopus 로고    scopus 로고
    • Survivin-specific T cell receptor targets tumor but not T cells
    • Arber C, Feng X, Abhyankar H, et al. Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest. 2015; 125: 157-68.
    • (2015) J Clin Invest , vol.125 , pp. 157-168
    • Arber, C.1    Feng, X.2    Abhyankar, H.3


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