-
1
-
-
77950365906
-
Nonresolving inflammation
-
Nathan, C., & Ding, A. Nonresolving inflammation. Cell. 140 (6), 871-882 (2010).
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 871-882
-
-
Nathan, C.1
Ding, A.2
-
2
-
-
77958108729
-
Critical care and the global burden of critical illness in adults
-
Adhikari, N. K., Fowler, R. A., Bhagwanjee, S., & Rubenfeld, G. D. Critical care and the global burden of critical illness in adults. Lancet. 376 (9749), 1339-1346 (2010).
-
(2010)
Lancet
, vol.376
, Issue.9749
, pp. 1339-1346
-
-
Adhikari, N.K.1
Fowler, R.A.2
Bhagwanjee, S.3
Rubenfeld, G.D.4
-
3
-
-
70449107044
-
Extracellular histones are major mediators of death in sepsis
-
Xu, J. et al. Extracellular histones are major mediators of death in sepsis. Nature medicine. 15 (11), 1318-1321 (2009).
-
(2009)
Nature Medicine
, vol.15
, Issue.11
, pp. 1318-1321
-
-
Xu, J.1
-
4
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 464 (7285), 104-107 (2010).
-
(2010)
Nature
, vol.464
, Issue.7285
, pp. 104-107
-
-
Zhang, Q.1
-
5
-
-
78650418074
-
Toll-like receptors 2 and 4: Initiators of non-septic inflammation in critical care medicine?
-
Lorne, E., Dupont, H., & Abraham, E. Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive care medicine. 36 (11), 1826-1835 (2010).
-
(2010)
Intensive Care Medicine
, vol.36
, Issue.11
, pp. 1826-1835
-
-
Lorne, E.1
Dupont, H.2
Abraham, E.3
-
6
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
-
Brightbill, H. D. et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 285 (5428), 732-736 (1999).
-
(1999)
Science
, vol.285
, Issue.5428
, pp. 732-736
-
-
Brightbill, H.D.1
-
7
-
-
0035164415
-
Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity
-
Zhang, G., & Ghosh, S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest. 107 (1), 13-19 (2001).
-
(2001)
J Clin Invest
, vol.107
, Issue.1
, pp. 13-19
-
-
Zhang, G.1
Ghosh, S.2
-
9
-
-
84885102672
-
Pathways mediating resolution of inflammation: When enough is too much
-
Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. Pathways mediating resolution of inflammation: when enough is too much. The Journal of pathology. 231 8-20 (2013).
-
(2013)
The Journal of Pathology
, vol.231
, pp. 8-20
-
-
Fullerton, J.N.1
O'brien, A.J.2
Gilroy, D.W.3
-
10
-
-
84891373581
-
Lipid mediators in immune dysfunction after severe inflammation
-
Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. Lipid mediators in immune dysfunction after severe inflammation. Trends in Immunology. 35 (1), 12-21 (2014).
-
(2014)
Trends in Immunology
, vol.35
, Issue.1
, pp. 12-21
-
-
Fullerton, J.N.1
O'brien, A.J.2
Gilroy, D.W.3
-
12
-
-
84924236658
-
The metabolic phenotype of rodent sepsis: Cause for concern?
-
Zolfaghari, P. S., Pinto, B. B., Dyson, A., Singer, M. The metabolic phenotype of rodent sepsis: cause for concern? Intensive Care Medicine Experimental. 1 (6), (2013).
-
(2013)
Intensive Care Medicine Experimental
, vol.1
, Issue.6
-
-
Zolfaghari, P.S.1
Pinto, B.B.2
Dyson, A.3
Singer, M.4
-
13
-
-
58849093274
-
Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?
-
Dyson, A., & Singer, M. Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Critical care medicine. 37 (1 Suppl), S30-37 (2009).
-
(2009)
Critical Care Medicine
, vol.37
, Issue.1
, pp. S30-S37
-
-
Dyson, A.1
Singer, M.2
-
14
-
-
33845905763
-
The disconnect between animal models of sepsis and human sepsis
-
Rittirsch, D., Hoesel, L. M., & Ward, P. A. The disconnect between animal models of sepsis and human sepsis. Journal of leukocyte biology. 81 (1), 137-143 (2007).
-
(2007)
Journal of Leukocyte Biology
, vol.81
, Issue.1
, pp. 137-143
-
-
Rittirsch, D.1
Hoesel, L.M.2
Ward, P.A.3
-
15
-
-
77950679333
-
Can animal models of disease reliably inform human studies?
-
van der Worp, H. B. et al. Can animal models of disease reliably inform human studies? PLoS Med. 7 (3), e1000245 (2010).
-
(2010)
Plos Med
, vol.7
, Issue.3
-
-
Van Der Worp, H.B.1
-
16
-
-
84869750897
-
Experimental human endotoxemia: A model of the systemic inflammatory response syndrome?
-
Calvano, S. E., & Coyle, S. M. Experimental human endotoxemia: a model of the systemic inflammatory response syndrome? Surgical infections. 13 (5), 293-299 (2012).
-
(2012)
Surgical Infections
, vol.13
, Issue.5
, pp. 293-299
-
-
Calvano, S.E.1
Coyle, S.M.2
-
17
-
-
84921629240
-
Human endotoxin administration as an experimental model in drug development
-
Suffredini, A. F., & Noveck, R. J. Human endotoxin administration as an experimental model in drug development. Clin Pharmacol Ther. 96 (4), 418-422 (2014).
-
(2014)
Clin Pharmacol Ther
, vol.96
, Issue.4
, pp. 418-422
-
-
Suffredini, A.F.1
Noveck, R.J.2
-
18
-
-
33646817775
-
Human endotoxemia: A model for mechanistic insight and therapeutic targeting
-
Lowry, S. F. Human endotoxemia: a model for mechanistic insight and therapeutic targeting. Shock. 24 Suppl 1 94-100 (2005).
-
(2005)
Shock. 24 Suppl
, vol.1
, pp. 94-100
-
-
Lowry, S.F.1
-
19
-
-
52449098209
-
Human endotoxemia as a model of systemic inflammation
-
Andreasen, A. S. et al. Human endotoxemia as a model of systemic inflammation. Current Medicinal Chemistry. 15 (17), 1697-1705 (2008).
-
(2008)
Current Medicinal Chemistry
, vol.15
, Issue.17
, pp. 1697-1705
-
-
Andreasen, A.S.1
-
20
-
-
0035010628
-
The inflammatory response in humans after inhalation of bacterial endotoxin: A review
-
Thorn, J. The inflammatory response in humans after inhalation of bacterial endotoxin: a review. Inflamm Res. 50 (5), 254-261 (2001).
-
(2001)
Inflamm Res
, vol.50
, Issue.5
, pp. 254-261
-
-
Thorn, J.1
-
21
-
-
84871964058
-
Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
-
Basran, A. et al. Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines. Journal of leukocyte biology. 93 (1), 7-19 (2013).
-
(2013)
Journal of Leukocyte Biology
, vol.93
, Issue.1
, pp. 7-19
-
-
Basran, A.1
-
22
-
-
84902544868
-
Transcompartmental inflammatory responses in humans: IV versus endobronchial administration of endotoxin*
-
Plovsing, R. R. et al. Transcompartmental inflammatory responses in humans: IV versus endobronchial administration of endotoxin*. Crit Care Med. 42 (7), 1658-1665 (2014).
-
(2014)
Crit Care Med
, vol.42
, Issue.7
, pp. 1658-1665
-
-
Plovsing, R.R.1
-
23
-
-
34249283440
-
Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
-
van Eijk, L. T. et al. Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med. 35 (6), 1464-1469 (2007).
-
(2007)
Crit Care Med
, vol.35
, Issue.6
, pp. 1464-1469
-
-
Van Eijk, L.T.1
-
24
-
-
0035100672
-
Ageing is associated with a prolonged fever response in human endotoxemia
-
Krabbe, K. S. et al. Ageing is associated with a prolonged fever response in human endotoxemia. Clin Diagn Lab Immunol. 8 (2), 333-338 (2001).
-
(2001)
Clin Diagn Lab Immunol
, vol.8
, Issue.2
, pp. 333-338
-
-
Krabbe, K.S.1
-
25
-
-
0035740790
-
Hypotension during endotoxemia in aged humans
-
Krabbe, K. S. et al. Hypotension during endotoxemia in aged humans. Eur J Anaesthesiol. 18 (9), 572-575 (2001).
-
(2001)
Eur J Anaesthesiol
, vol.18
, Issue.9
, pp. 572-575
-
-
Krabbe, K.S.1
-
26
-
-
0025185274
-
Biological response to intravenously administered endotoxin in patients with advanced cancer
-
Engelhardt, R., Mackensen, A., Galanos, C., & Andreesen, R. Biological response to intravenously administered endotoxin in patients with advanced cancer. J Biol Response Mod. 9 (5), 480-491 (1990).
-
(1990)
J Biol Response Mod
, vol.9
, Issue.5
, pp. 480-491
-
-
Engelhardt, R.1
Mackensen, A.2
Galanos, C.3
Andreesen, R.4
-
27
-
-
84920396283
-
Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases
-
Patel, P. N., Shah, R. Y., Ferguson, J. F., & Reilly, M. P. Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases. Arterioscler Thromb Vasc Biol. 35 (3), 525-534 (2015).
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, Issue.3
, pp. 525-534
-
-
Patel, P.N.1
Shah, R.Y.2
Ferguson, J.F.3
Reilly, M.P.4
-
28
-
-
0023734898
-
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings
-
Michie, H. R. et al. Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery. 104 (2), 280-286 (1988).
-
(1988)
Surgery
, vol.104
, Issue.2
, pp. 280-286
-
-
Michie, H.R.1
-
29
-
-
0025647250
-
Experimental endotoxemia in humans: Analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
-
van Deventer, S. J. et al. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood. 76 (12), 2520-2526 (1990).
-
(1990)
Blood
, vol.76
, Issue.12
, pp. 2520-2526
-
-
Van Deventer, S.J.1
-
30
-
-
0025358130
-
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans
-
Fong, Y. M. et al. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. The Journal of clinical investigation. 85 (6), 1896-1904 (1990).
-
(1990)
The Journal of Clinical Investigation
, vol.85
, Issue.6
, pp. 1896-1904
-
-
Fong, Y.M.1
-
31
-
-
25444485164
-
Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers
-
Stephens, R. C., O'Malley, C. M., Frumento, R. J., Mythen, M. G., & Bennett-Guerrero, E. Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers. Journal of endotoxin research. 11 (4), 207-212 (2005).
-
(2005)
Journal of Endotoxin Research
, vol.11
, Issue.4
, pp. 207-212
-
-
Stephens, R.C.1
O'malley, C.M.2
Frumento, R.J.3
Mythen, M.G.4
Bennett-Guerrero, E.5
-
32
-
-
34147128114
-
Human models of low-grade inflammation: Bolus versus continuous infusion of endotoxin
-
Taudorf, S., Krabbe, K. S., Berg, R. M., Pedersen, B. K., & Moller, K. Human models of low-grade inflammation: bolus versus continuous infusion of endotoxin. Clin Vaccine Immunol. 14 (3), 250-255 (2007).
-
(2007)
Clin Vaccine Immunol
, vol.14
, Issue.3
, pp. 250-255
-
-
Taudorf, S.1
Krabbe, K.S.2
Berg, R.M.3
Pedersen, B.K.4
Moller, K.5
-
33
-
-
84868300033
-
Reversal of immunoparalysis in humans in vivo: A double-blind, placebo-controlled, randomized pilot study
-
Leentjens, J. et al. Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study. Am J Respir Crit Care Med. 186 (9), 838-845 (2012).
-
(2012)
Am J Respir Crit Care Med
, vol.186
, Issue.9
, pp. 838-845
-
-
Leentjens, J.1
-
34
-
-
84930007712
-
Sepsis-induced immunoparalysis: Mechanisms, markers, and treatment options
-
Hamers, L., Kox, M., & Pickkers, P. Sepsis-induced immunoparalysis: mechanisms, markers, and treatment options. Minerva Anestesiol. 81 (4), 426-439 (2015).
-
(2015)
Minerva Anestesiol
, vol.81
, Issue.4
, pp. 426-439
-
-
Hamers, L.1
Kox, M.2
Pickkers, P.3
-
35
-
-
84862908403
-
A genomic storm in critically injured humans
-
Xiao, W. et al. A genomic storm in critically injured humans. The Journal of experimental medicine. 208 (13), 2581-2590 (2011).
-
(2011)
The Journal of Experimental Medicine
, vol.208
, Issue.13
, pp. 2581-2590
-
-
Xiao, W.1
-
36
-
-
0034484580
-
Asystole following endotoxin administration
-
Williams, W. V. et al. Asystole following endotoxin administration. J Endotoxin Res. 6 (4), 303-306 (2000).
-
(2000)
J Endotoxin Res
, vol.6
, Issue.4
, pp. 303-306
-
-
Williams, W.V.1
-
37
-
-
12944306903
-
Severe vagal response after endotoxin administration in humans
-
van Eijk, L. T., Pickkers, P., Smits, P., Bouw, M. P., & van der Hoeven, J. G. Severe vagal response after endotoxin administration in humans. Intensive Care Med. 30 (12), 2279-2281 (2004).
-
(2004)
Intensive Care Med
, vol.30
, Issue.12
, pp. 2279-2281
-
-
Van Eijk, L.T.1
Pickkers, P.2
Smits, P.3
Bouw, M.P.4
Van Der Hoeven, J.G.5
-
38
-
-
79961054751
-
Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia
-
Kox, M. et al. Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia. Critical care medicine. 39 (8), 1866-1870 (2011).
-
(2011)
Critical Care Medicine
, vol.39
, Issue.8
, pp. 1866-1870
-
-
Kox, M.1
-
39
-
-
67650433962
-
Development of endotoxin tolerance in humans in vivo
-
Draisma, A., Pickkers, P., Bouw, M. P., & van der Hoeven, J. G. Development of endotoxin tolerance in humans in vivo. Critical care medicine. 37 (4), 1261-1267 (2009).
-
(2009)
Critical Care Medicine
, vol.37
, Issue.4
, pp. 1261-1267
-
-
Draisma, A.1
Pickkers, P.2
Bouw, M.P.3
Van Der Hoeven, J.G.4
-
40
-
-
15844365645
-
Human endotoxemia and human sepsis: Limits to the model
-
Anel, R., & Kumar, A. Human endotoxemia and human sepsis: limits to the model. Critical care. 9 (2), 151-152 (2005).
-
(2005)
Critical Care
, vol.9
, Issue.2
, pp. 151-152
-
-
Anel, R.1
Kumar, A.2
|