메뉴 건너뛰기




Volumn , Issue , 2008, Pages 397-416

Galectins as Novel Regulators of Immune Cell Homeostasis and Infl ammation

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84971491763     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420006971-38     Document Type: Chapter
Times cited : (1)

References (125)
  • 1
    • 0028261522 scopus 로고
    • Galectins: A family of animal beta-galactoside-binding lectins
    • Barondes, S.H., et al., Galectins: A family of animal beta-galactoside-binding lectins, Cell, 76, 597, 1994.
    • (1994) Cell , vol.76 , pp. 597
    • Barondes, S.H.1
  • 2
    • 1542313842 scopus 로고    scopus 로고
    • Introduction to galectins
    • Leffler, H., et al., Introduction to galectins, Glycoconj J, 19, 433, 2004.
    • (2004) Glycoconj J , vol.19 , pp. 433
    • Leffler, H.1
  • 3
    • 0002458793 scopus 로고
    • Vertebrate lectins: Properties and functions
    • Liener, I.E., Sharon, N. and Goldstein, I.J. Eds., Academic Press, Orlando, FL
    • Barondes, S.H., Vertebrate lectins: Properties and functions, in The Lectins: Properties, Functions and Applications in Biology and Medicine, Liener, I.E., Sharon, N. and Goldstein, I.J. Eds., Academic Press, Orlando, FL, 1986, p. 467.
    • (1986) The Lectins: Properties, Functions and Applications in Biology and Medicine , pp. 467
    • Barondes, S.H.1
  • 4
    • 0041289900 scopus 로고
    • A beta-d-galactoside binding protein from electric organ tissue of Electrophorus electricus
    • Teichberg, V.I., et al., A beta-d-galactoside binding protein from electric organ tissue of Electrophorus electricus, Proc Natl Acad Sci USA, 72, 1383, 1975.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 1383
    • Teichberg, V.I.1
  • 5
    • 0036606914 scopus 로고    scopus 로고
    • Galectins and their ligands: Amplifi ers, silencers or tuners of the infl ammatory response?
    • Rabinovich, G.A., et al., Galectins and their ligands: Amplifi ers, silencers or tuners of the infl ammatory response?, Trends Immunol, 23, 313, 2002.
    • (2002) Trends Immunol , vol.23 , pp. 313
    • Rabinovich, G.A.1
  • 6
    • 0037136416 scopus 로고    scopus 로고
    • Galectinomics: Finding themes in complexity
    • Cooper, D.N., Galectinomics: Finding themes in complexity, Biochim Biophys Acta, 1572, 209, 2002.
    • (2002) Biochim Biophys Acta , vol.1572 , pp. 209
    • Cooper, D.N.1
  • 7
    • 11144241063 scopus 로고    scopus 로고
    • Galectins as modulators of tumour progression
    • Liu, F.T. and Rabinovich, G.A., Galectins as modulators of tumour progression, Nat Rev Cancer, 5, 29, 2005.
    • (2005) Nat Rev Cancer , vol.5 , pp. 29
    • Liu, F.T.1    Rabinovich, G.A.2
  • 8
    • 0037136412 scopus 로고    scopus 로고
    • Binding and cross-linking properties of galectins
    • Brewer, C., Binding and cross-linking properties of galectins, Biochim Biophys Acta, 1572, 255, 2002.
    • (2002) Biochim Biophys Acta , vol.1572 , pp. 255
    • Brewer, C.1
  • 10
    • 0037136406 scopus 로고    scopus 로고
    • Oligosaccharide specifi city of galectins: A search by frontal affi nity chromatography
    • Hirabayashi, J., et al., Oligosaccharide specifi city of galectins: A search by frontal affi nity chromatography, Biochim Biophys Acta, 1572, 232, 2002.
    • (2002) Biochim Biophys Acta , vol.1572 , pp. 232
    • Hirabayashi, J.1
  • 11
    • 27444437451 scopus 로고    scopus 로고
    • The coming of age of galectins as immunomodulatory agents: Impact of these carbohydrate binding proteins in T cell physiology and chronic infl ammatory disorders
    • Ilarregui, J.M., et al., The coming of age of galectins as immunomodulatory agents: Impact of these carbohydrate binding proteins in T cell physiology and chronic infl ammatory disorders, Ann Rheum Dis, 64 Suppl 4, iv96, 2005.
    • (2005) Ann Rheum Dis , vol.64
    • Ilarregui, J.M.1
  • 12
    • 0031928667 scopus 로고    scopus 로고
    • Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells
    • Blaser, C., et al., Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells, Eur J Immunol, 28, 2311, 1998.
    • (1998) Eur J Immunol , vol.28 , pp. 2311
    • Blaser, C.1
  • 13
    • 0032525046 scopus 로고    scopus 로고
    • Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization
    • Rabinovich, G.A., et al., Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization, J Immunol, 160, 4831, 1998.
    • (1998) J Immunol , vol.160 , pp. 4831
    • Rabinovich, G.A.1
  • 14
    • 0034974155 scopus 로고    scopus 로고
    • Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis
    • Zuniga, E., et al., Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis, J Leukoc Biol, 70, 73, 2001.
    • (2001) J Leukoc Biol , vol.70 , pp. 73
    • Zuniga, E.1
  • 15
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: A key effector of regulation mediated by CD4+ CD25+ T cells
    • Garin, M.I., et al., Galectin-1: A key effector of regulation mediated by CD4+ CD25+ T cells, Blood, 109, 2058, 2007.
    • (2007) Blood , vol.109 , pp. 2058
    • Garin, M.I.1
  • 16
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specifi c for CD25+ CD4+ natural regulatory T cells revealed by DNA microarray analysis
    • Sugimoto, N., et al., Foxp3-dependent and -independent molecules specifi c for CD25+ CD4+ natural regulatory T cells revealed by DNA microarray analysis, Int Immunol, 18, 1197, 2006.
    • (2006) Int Immunol , vol.18 , pp. 1197
    • Sugimoto, N.1
  • 17
    • 0037136408 scopus 로고    scopus 로고
    • Role of galectins in infl ammatory and immunomodulatory processes
    • Rabinovich, G.A., Rubinstein, N., and Toscano, M.A., Role of galectins in infl ammatory and immunomodulatory processes, Biochim Biophys Acta, 1572, 274, 2002.
    • (2002) Biochim Biophys Acta , vol.1572 , pp. 274
    • Rabinovich, G.A.1    Rubinstein, N.2    Toscano, M.A.3
  • 18
    • 0035852973 scopus 로고    scopus 로고
    • Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction
    • Sacchettini, J.C., Baum, L.G., and Brewer, C.F., Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction, Biochemistry, 40, 3009, 2001.
    • (2001) Biochemistry , vol.40 , pp. 3009
    • Sacchettini, J.C.1    Baum, L.G.2    Brewer, C.F.3
  • 19
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • Van Parijs, L. and Abbas, A.K., Homeostasis and self-tolerance in the immune system: Turning lymphocytes off, Science, 280, 243, 1998.
    • (1998) Science , vol.280 , pp. 243
    • Van Parijs, L.1    Abbas, A.K.2
  • 20
    • 9944222484 scopus 로고    scopus 로고
    • Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death
    • Hahn, H.P., et al., Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death, Cell Death Differ, 11, 1277, 2004.
    • (2004) Cell Death Differ , vol.11 , pp. 1277
    • Hahn, H.P.1
  • 21
    • 14844334137 scopus 로고    scopus 로고
    • Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fi ssion
    • Matarrese, P., et al., Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fi ssion, J Biol Chem, 280, 6969, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 6969
    • Matarrese, P.1
  • 22
    • 0034267915 scopus 로고    scopus 로고
    • CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death
    • Pace, K.E., et al., CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death, J Immunol, 165, 2331, 2000.
    • (2000) J Immunol , vol.165 , pp. 2331
    • Pace, K.E.1
  • 23
    • 0029589620 scopus 로고
    • Apoptosis of T cells mediated by galectin-1
    • Perillo, N.L., et al., Apoptosis of T cells mediated by galectin-1, Nature, 378, 736, 1995.
    • (1995) Nature , vol.378 , pp. 736
    • Perillo, N.L.1
  • 24
    • 0030940913 scopus 로고    scopus 로고
    • Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes
    • Perillo, N.L., et al., Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes, J Exp Med, 185, 1851, 1997.
    • (1997) J Exp Med , vol.185 , pp. 1851
    • Perillo, N.L.1
  • 25
    • 0030799196 scopus 로고    scopus 로고
    • Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a beta-galactoside-binding lectin
    • Rabinovich, G.A., et al., Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a beta-galactoside-binding lectin, J Biochem, 122, 365, 1997.
    • (1997) J Biochem , vol.122 , pp. 365
    • Rabinovich, G.A.1
  • 26
    • 85047696445 scopus 로고    scopus 로고
    • Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms
    • Rabinovich, G.A., et al., Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms, Cell Death Differ, 9, 661, 2002.
    • (2002) Cell Death Differ , vol.9 , pp. 661
    • Rabinovich, G.A.1
  • 27
    • 0035889895 scopus 로고    scopus 로고
    • CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans
    • Nguyen, J.T., et al., CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans, J Immunol, 167, 5697, 2001.
    • (2001) J Immunol , vol.167 , pp. 5697
    • Nguyen, J.T.1
  • 28
    • 0033215424 scopus 로고    scopus 로고
    • Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1
    • Pace, K.E., et al., Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1, J Immunol, 163, 3801, 1999.
    • (1999) J Immunol , vol.163 , pp. 3801
    • Pace, K.E.1
  • 29
    • 0034077257 scopus 로고    scopus 로고
    • Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells
    • Walzel, H., et al., Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells, Glycobiology, 10, 131, 2000.
    • (2000) Glycobiology , vol.10 , pp. 131
    • Walzel, H.1
  • 30
    • 0034595685 scopus 로고    scopus 로고
    • Expression of a specifi c glycosyltransferase enzyme regulates T cell death mediated by galectin-1
    • Galvan, M., et al., Expression of a specifi c glycosyltransferase enzyme regulates T cell death mediated by galectin-1, J Biol Chem, 275, 16730, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 16730
    • Galvan, M.1
  • 31
    • 0037470066 scopus 로고    scopus 로고
    • The ST6Gal I sialyltransferase selectively modifi es N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death
    • Amano, M., et al., The ST6Gal I sialyltransferase selectively modifi es N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death, J Biol Chem, 278, 7469, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 7469
    • Amano, M.1
  • 32
    • 35548938481 scopus 로고    scopus 로고
    • Functions of cell surface galectin-glycoprotein lattices
    • Rabinovich, et al., Functions of cell surface galectin-glycoprotein lattices, Curr Opin Struct Biol, 17, 513, 2007.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 513
    • Rabinovich1
  • 33
    • 18444408692 scopus 로고    scopus 로고
    • CD4+ CD7-leukemic T cells from patients with Sezary syndrome are protected from galectin-1-triggered T cell death
    • Rappl, G., et al., CD4+ CD7-leukemic T cells from patients with Sezary syndrome are protected from galectin-1-triggered T cell death, Leukemia, 16, 840, 2002.
    • (2002) Leukemia , vol.16 , pp. 840
    • Rappl, G.1
  • 34
    • 0038118507 scopus 로고    scopus 로고
    • Galectin-1-mediated apoptosis in mycosis fungoides: The roles of CD7 and cell surface glycosylation
    • Roberts, A.A., et al., Galectin-1-mediated apoptosis in mycosis fungoides: The roles of CD7 and cell surface glycosylation, Mod Pathol, 16, 543, 2003.
    • (2003) Mod Pathol , vol.16 , pp. 543
    • Roberts, A.A.1
  • 35
    • 33749363387 scopus 로고    scopus 로고
    • Haploinsuffi ciency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death
    • Cabrera, P.V., et al., Haploinsuffi ciency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death, Blood, 108, 2399, 2006.
    • (2006) Blood , vol.108 , pp. 2399
    • Cabrera, P.V.1
  • 36
    • 0033895228 scopus 로고    scopus 로고
    • Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2
    • Rabinovich, G.A., et al., Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2, Cell Death Differ, 7, 747, 2000.
    • (2000) Cell Death Differ , vol.7 , pp. 747
    • Rabinovich, G.A.1
  • 37
    • 23044475898 scopus 로고    scopus 로고
    • Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death
    • Ion, G., et al., Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death, Cell Death Differ, 12, 1145, 2005.
    • (2005) Cell Death Differ , vol.12 , pp. 1145
    • Ion, G.1
  • 38
    • 33749247232 scopus 로고    scopus 로고
    • Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1
    • Ion, G., et al., Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1, Cell Signal, 18, 1887, 2006.
    • (2006) Cell Signal , vol.18 , pp. 1887
    • Ion, G.1
  • 39
    • 0032169277 scopus 로고    scopus 로고
    • Beta-galactoside-binding protein (beta GBP) alters the cell cycle, up-regulates expression of the alpha- and beta-chains of the IFN-receptor, and triggers IFN-mediated apoptosis of activated human T lymphocytes
    • Allione, A., et al., Beta-galactoside-binding protein (beta GBP) alters the cell cycle, up-regulates expression of the alpha- and beta-chains of the IFN-receptor, and triggers IFN--mediated apoptosis of activated human T lymphocytes, J Immunol, 161, 2114, 1998.
    • (1998) J Immunol , vol.161 , pp. 2114
    • Allione, A.1
  • 40
    • 12344315867 scopus 로고    scopus 로고
    • Galectin-1 supports survival of naive T cells without promoting cell proliferation
    • Endharti, A.T., et al., Galectin-1 supports survival of naive T cells without promoting cell proliferation, Eur J Immunol, 35, 86, 2005.
    • (2005) Eur J Immunol , vol.35 , pp. 86
    • Endharti, A.T.1
  • 41
    • 33845976972 scopus 로고    scopus 로고
    • Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells
    • Stowell, S.R., et al., Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells, Blood, 109, 219, 2007.
    • (2007) Blood , vol.109 , pp. 219
    • Stowell, S.R.1
  • 42
    • 4644305974 scopus 로고    scopus 로고
    • Human galectin-2: Novel inducer of T cell apoptosis with distinct profi le of caspase activation
    • Sturm, A., et al., Human galectin-2: Novel inducer of T cell apoptosis with distinct profi le of caspase activation, J Immunol, 173, 3825, 2004.
    • (2004) J Immunol , vol.173 , pp. 3825
    • Sturm, A.1
  • 43
    • 0030707480 scopus 로고    scopus 로고
    • Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family
    • Akahani, S., et al., Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family, Cancer Res, 57, 5272, 1997.
    • (1997) Cancer Res , vol.57 , pp. 5272
    • Akahani, S.1
  • 44
    • 0029900083 scopus 로고    scopus 로고
    • Expression of galectin-3 modulates T-cell growth and apoptosis
    • Yang, R.Y., Hsu, D.K., and Liu, F.T., Expression of galectin-3 modulates T-cell growth and apoptosis, Proc Natl Acad Sci USA, 93, 6737, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6737
    • Yang, R.Y.1    Hsu, D.K.2    Liu, F.T.3
  • 45
    • 0345734273 scopus 로고    scopus 로고
    • CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis
    • Fukumori, T., et al., CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis, Cancer Res, 63, 8302, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8302
    • Fukumori, T.1
  • 46
    • 30744445427 scopus 로고    scopus 로고
    • Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death
    • Stillman, B.N., et al., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death, J Immunol, 176, 778, 2006.
    • (2006) J Immunol , vol.176 , pp. 778
    • Stillman, B.N.1
  • 47
    • 33947190764 scopus 로고    scopus 로고
    • Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes
    • Silva-Monteiro, E., et al., Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes. Am J Pathol, 170, 546, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 546
    • Silva-Monteiro, E.1
  • 48
    • 0030989330 scopus 로고    scopus 로고
    • Developmental regulation, expression, and apoptotic potential of galectin-9, a betagalactoside binding lectin
    • Wada, J., et al., Developmental regulation, expression, and apoptotic potential of galectin-9, a betagalactoside binding lectin, J Clin Invest, 99, 2452, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 2452
    • Wada, J.1
  • 49
    • 0037377942 scopus 로고    scopus 로고
    • Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway
    • Kashio, Y., et al., Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway, J Immunol, 170, 3631, 2003.
    • (2003) J Immunol , vol.170 , pp. 3631
    • Kashio, Y.1
  • 50
    • 34248638796 scopus 로고    scopus 로고
    • Characterization of galectin-9-induced death of Jurkat T-cells
    • Lu, L.H., et al., Characterization of galectin-9-induced death of Jurkat T-cells, J Biochem, 141, 157, 2007.
    • (2007) J Biochem , vol.141 , pp. 157
    • Lu, L.H.1
  • 51
    • 30044434075 scopus 로고    scopus 로고
    • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    • Zhu, C., et al., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity, Nat Immunol, 6, 1245, 2005.
    • (2005) Nat Immunol , vol.6 , pp. 1245
    • Zhu, C.1
  • 52
    • 0033613211 scopus 로고    scopus 로고
    • Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
    • Bernerd, F., Sarasin, A., and Magnaldo, T., Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes, Proc Natl Acad Sci USA, 96, 11329, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11329
    • Bernerd, F.1    Sarasin, A.2    Magnaldo, T.3
  • 53
    • 0036479302 scopus 로고    scopus 로고
    • Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    • Kuwabara, I., et al., Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release, J Biol Chem, 277, 3487, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 3487
    • Kuwabara, I.1
  • 54
    • 0033894586 scopus 로고    scopus 로고
    • Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
    • Hadari, Y.R., et al., Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis, J Cell Sci, 113, 2385, 2000.
    • (2000) J Cell Sci , vol.113 , pp. 2385
    • Hadari, Y.R.1
  • 55
    • 0035827555 scopus 로고    scopus 로고
    • Cell cycle regulation by galectin-12, a new member of the galectin superfamily
    • Yang, R.Y., et al., Cell cycle regulation by galectin-12, a new member of the galectin superfamily, J Biol Chem, 276, 20252, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 20252
    • Yang, R.Y.1
  • 56
    • 0033555408 scopus 로고    scopus 로고
    • Galectin-1 specifi cally modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation
    • Vespa, G.N., et al., Galectin-1 specifi cally modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation, J Immunol, 162, 799, 1999.
    • (1999) J Immunol , vol.162 , pp. 799
    • Vespa, G.N.1
  • 57
    • 0034292424 scopus 로고    scopus 로고
    • Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction
    • Chung, C.D., et al., Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction, J Immunol, 165, 3722, 2000.
    • (2000) J Immunol , vol.165 , pp. 3722
    • Chung, C.D.1
  • 58
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • Demetriou, M., et al., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation, Nature, 409, 733, 2001.
    • (2001) Nature , vol.409 , pp. 733
    • Demetriou, M.1
  • 59
    • 2942617342 scopus 로고    scopus 로고
    • Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal infl ammation
    • Hokama, A., et al., Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal infl ammation, Immunity, 20, 681, 2004.
    • (2004) Immunity , vol.20 , pp. 681
    • Hokama, A.1
  • 60
    • 0001853244 scopus 로고    scopus 로고
    • Specific inhibition of T-cell adhesion to extracellular matrix and proinfl ammatory cytokine secretion by human recombinant galectin-1
    • Rabinovich, G.A., et al., Specific inhibition of T-cell adhesion to extracellular matrix and proinfl ammatory cytokine secretion by human recombinant galectin-1, Immunology, 97, 100, 1999.
    • (1999) Immunology , vol.97 , pp. 100
    • Rabinovich, G.A.1
  • 61
    • 9744222923 scopus 로고    scopus 로고
    • Dimeric galectin-1 induces IL-10 production in T-lymphocytes: An important tool in the regulation of the immune response
    • van der Leij, J., et al., Dimeric galectin-1 induces IL-10 production in T-lymphocytes: An important tool in the regulation of the immune response, J Pathol, 204, 511, 2004.
    • (2004) J Pathol , vol.204 , pp. 511
    • van der Leij, J.1
  • 62
    • 9144248269 scopus 로고    scopus 로고
    • Amelioration of graft versus host disease by galectin-1
    • Baum, L.G., et al., Amelioration of graft versus host disease by galectin-1, Clin Immunol, 109, 295, 2003.
    • (2003) Clin Immunol , vol.109 , pp. 295
    • Baum, L.G.1
  • 63
    • 33749530902 scopus 로고    scopus 로고
    • Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice
    • Perone, M.J., et al., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice, J Immunol, 177, 5278, 2006.
    • (2006) J Immunol , vol.177 , pp. 5278
    • Perone, M.J.1
  • 64
    • 0033517113 scopus 로고    scopus 로고
    • Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis
    • Rabinovich, G.A., et al., Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis, J Exp Med, 190, 385, 1999.
    • (1999) J Exp Med , vol.190 , pp. 385
    • Rabinovich, G.A.1
  • 65
    • 12144285871 scopus 로고    scopus 로고
    • Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege
    • Rubinstein, N., et al., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege, Cancer Cell, 5, 241, 2004.
    • (2004) Cancer Cell , vol.5 , pp. 241
    • Rubinstein, N.1
  • 66
    • 34547099820 scopus 로고    scopus 로고
    • Differential glycosylation of Th1, Th2 and Th-17 effector cells selectively regulates susceptibility to cell death
    • Toscano, M.A., et al., Differential glycosylation of Th1, Th2 and Th-17 effector cells selectively regulates susceptibility to cell death, Nat Immunol, 8, 825, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 825
    • Toscano, M.A.1
  • 67
    • 0038297458 scopus 로고    scopus 로고
    • Galectin-1 suppresses experimental colitis in mice
    • Santucci, L., et al., Galectin-1 suppresses experimental colitis in mice, Gastroenterology, 124, 1381, 2003.
    • (2003) Gastroenterology , vol.124 , pp. 1381
    • Santucci, L.1
  • 68
    • 33646491737 scopus 로고    scopus 로고
    • Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-infl ammatory responses
    • Toscano, M.A., et al., Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-infl ammatory responses, J Immunol, 176, 6323, 2006.
    • (2006) J Immunol , vol.176 , pp. 6323
    • Toscano, M.A.1
  • 69
    • 7144226602 scopus 로고    scopus 로고
    • Galectin-3 down-regulates IL-5 gene expression on different cell types
    • Cortegano, I., et al., Galectin-3 down-regulates IL-5 gene expression on different cell types, J Immunol, 161, 385, 1998.
    • (1998) J Immunol , vol.161 , pp. 385
    • Cortegano, I.1
  • 70
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • Shevach, E.M., CD4+ CD25+ suppressor T cells: More questions than answers, Nat Rev Immunol, 2, 389, 2002.
    • (2002) Nat Rev Immunol , vol.2 , pp. 389
    • Shevach, E.M.1
  • 71
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher, E.C. and Picker, L.J., Lymphocyte homing and homeostasis, Science, 272, 60, 1996.
    • (1996) Science , vol.272 , pp. 60
    • Butcher, E.C.1    Picker, L.J.2
  • 72
    • 33646857224 scopus 로고    scopus 로고
    • Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration
    • He, J. and Baum, L.G., Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration, Lab Iinvest, 86, 578, 2006.
    • (2006) Lab Iinvest , vol.86 , pp. 578
    • He, J.1    Baum, L.G.2
  • 73
    • 0036790940 scopus 로고    scopus 로고
    • Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering
    • Gauthier, L., et al., Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering, Proc Natl Acad Sci USA, 99, 13014, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13014
    • Gauthier, L.1
  • 74
    • 33745848466 scopus 로고    scopus 로고
    • Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation
    • Rossi, B., et al., Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation, J Immunol, 177, 796, 2006.
    • (2006) J Immunol , vol.177 , pp. 796
    • Rossi, B.1
  • 75
    • 33748781721 scopus 로고    scopus 로고
    • Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells
    • Clark, A.G., et al., Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells, Mol Immunol, 44, 1274, 2007.
    • (2007) Mol Immunol , vol.44 , pp. 1274
    • Clark, A.G.1
  • 76
    • 0347364686 scopus 로고    scopus 로고
    • Galectin-3 mediates IL-4-induced survival and differentiation of B cells:Functional cross-talk and implications during Trypanosoma cruzi infection
    • Acosta-Rodriguez, E.V., et al., Galectin-3 mediates IL-4-induced survival and differentiation of B cells:Functional cross-talk and implications during Trypanosoma cruzi infection, J Immunol, 172, 493, 2004.
    • (2004) J Immunol , vol.172 , pp. 493
    • Acosta-Rodriguez, E.V.1
  • 77
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S., Alternative activation of macrophages, Nat Rev Immunol, 3, 23, 2003.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23
    • Gordon, S.1
  • 78
    • 0037320747 scopus 로고    scopus 로고
    • Opposite effects of galectin-1 on alternative metabolic pathways of l-arginine in resident, infl ammatory, and activated macrophages
    • Correa, S.G., et al., Opposite effects of galectin-1 on alternative metabolic pathways of l-arginine in resident, infl ammatory, and activated macrophages, Glycobiology, 13, 119, 2003.
    • (2003) Glycobiology , vol.13 , pp. 119
    • Correa, S.G.1
  • 79
    • 33845958124 scopus 로고    scopus 로고
    • A novel function for galectin-1 at the crossroad of innate and adaptive immunity:Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway
    • Barrionuevo, P., et al., A novel function for galectin-1 at the crossroad of innate and adaptive immunity:Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway, J Immunol, 178, 436, 2007.
    • (2007) J Immunol , vol.178 , pp. 436
    • Barrionuevo, P.1
  • 80
    • 0034778551 scopus 로고    scopus 로고
    • Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages:Modulation of microbicidal activity and survival
    • Zuniga, E., et al., Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages:Modulation of microbicidal activity and survival, Infect Immun, 69, 6804, 2001.
    • (2001) Infect Immun , vol.69 , pp. 6804
    • Zuniga, E.1
  • 81
    • 2342480580 scopus 로고    scopus 로고
    • Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro
    • Ozaki, K., et al., Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro, Nature, 429, 72, 2004.
    • (2004) Nature , vol.429 , pp. 72
    • Ozaki, K.1
  • 82
    • 0033870111 scopus 로고    scopus 로고
    • Targeted disruption of the galectin-3 gene results in attenuated peritoneal infl ammatory responses
    • Hsu, D.K., et al., Targeted disruption of the galectin-3 gene results in attenuated peritoneal infl ammatory responses, Am J Pathol, 156, 1073, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 1073
    • Hsu, D.K.1
  • 83
    • 0042388118 scopus 로고    scopus 로고
    • Critical role of galectin-3 in phagocytosis by macrophages
    • Sano, H., et al., Critical role of galectin-3 in phagocytosis by macrophages, J Clin Invest, 112, 389, 2003.
    • (2003) J Clin Invest , vol.112 , pp. 389
    • Sano, H.1
  • 84
    • 0034663945 scopus 로고    scopus 로고
    • Human galectin-3 is a novel chemoattractant for monocytes and macrophages
    • Sano, H., et al., Human galectin-3 is a novel chemoattractant for monocytes and macrophages, J Immunol, 165, 2156, 2000.
    • (2000) J Immunol , vol.165 , pp. 2156
    • Sano, H.1
  • 85
    • 33744777206 scopus 로고    scopus 로고
    • Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity
    • Bernardes, E.S., et al., Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity, Am J Pathol, 168, 1910, 2006.
    • (2006) Am J Pathol , vol.168 , pp. 1910
    • Bernardes, E.S.1
  • 86
    • 33749143645 scopus 로고    scopus 로고
    • Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling
    • Jouault, T., et al., Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling, J Immunol, 177, 4679, 2006.
    • (2006) J Immunol , vol.177 , pp. 4679
    • Jouault, T.1
  • 87
    • 0037124095 scopus 로고    scopus 로고
    • Specific recognition and cleavage of galectin-3 by Leishmania major through species-specifi c polygalactose epitope
    • Pelletier, I. and Sato, S., Specific recognition and cleavage of galectin-3 by Leishmania major through species-specifi c polygalactose epitope, J Biol Chem, 277, 17663, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 17663
    • Pelletier, I.1    Sato, S.2
  • 88
    • 0036800448 scopus 로고    scopus 로고
    • Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected
    • John, C.M., et al., Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected, Cell Microbiol, 4, 649, 2002.
    • (2002) Cell Microbiol , vol.4 , pp. 649
    • John, C.M.1
  • 89
    • 33745301484 scopus 로고    scopus 로고
    • Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix
    • Fulcher, J.A., et al., Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix, J Immunol, 177, 216, 2006.
    • (2006) J Immunol , vol.177 , pp. 216
    • Fulcher, J.A.1
  • 90
    • 21244502470 scopus 로고    scopus 로고
    • Novel innate immune functions for galectin-1: Galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinfl ammatory cytokines
    • Levroney, E.L., et al., Novel innate immune functions for galectin-1: Galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinfl ammatory cytokines, J Immunol, 175, 413, 2005.
    • (2005) J Immunol , vol.175 , pp. 413
    • Levroney, E.L.1
  • 91
    • 33744960641 scopus 로고    scopus 로고
    • Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells
    • Perone, M.J., et al., Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells, J Immunol, 176, 7207, 2006.
    • (2006) J Immunol , vol.176 , pp. 7207
    • Perone, M.J.1
  • 92
    • 23844545174 scopus 로고    scopus 로고
    • Galectin-9 induces maturation of human monocyte-derived dendritic cells
    • Dai, S.Y., et al., Galectin-9 induces maturation of human monocyte-derived dendritic cells, J Immunol, 175, 2974, 2005.
    • (2005) J Immunol , vol.175 , pp. 2974
    • Dai, S.Y.1
  • 93
    • 3142735119 scopus 로고    scopus 로고
    • Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells
    • Vray, B., et al., Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells, Glycobiology, 14, 647, 2004.
    • (2004) Glycobiology , vol.14 , pp. 647
    • Vray, B.1
  • 94
    • 0141648409 scopus 로고    scopus 로고
    • A novel biological activity for galectin-1: Inhibition of leukocyte-endothelial cell interactions in experimental infl ammation
    • La, M., et al., A novel biological activity for galectin-1: Inhibition of leukocyte-endothelial cell interactions in experimental infl ammation, Am J Pathol, 163, 1505, 2003.
    • (2003) Am J Pathol , vol.163 , pp. 1505
    • La, M.1
  • 95
    • 0034109238 scopus 로고    scopus 로고
    • Evidence of a role for galectin-1 in acute infl ammation
    • Rabinovich, G.A., et al., Evidence of a role for galectin-1 in acute infl ammation, Eur J Immunol, 30, 1331, 2000.
    • (2000) Eur J Immunol , vol.30 , pp. 1331
    • Rabinovich, G.A.1
  • 96
    • 0031850611 scopus 로고    scopus 로고
    • Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice
    • Colnot, C., et al., Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice, Immunology, 94, 290, 1998.
    • (1998) Immunology , vol.94 , pp. 290
    • Colnot, C.1
  • 97
    • 0037090251 scopus 로고    scopus 로고
    • Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1
    • Almkvist, J., et al., Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1, J Immunol, 168, 4034, 2002.
    • (2002) J Immunol , vol.168 , pp. 4034
    • Almkvist, J.1
  • 98
    • 0032080224 scopus 로고    scopus 로고
    • Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutro phils
    • Karlsson, A., et al., Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutro phils, Blood, 91, 3430, 1998.
    • (1998) Blood , vol.91 , pp. 3430
    • Karlsson, A.1
  • 99
    • 0029942555 scopus 로고    scopus 로고
    • Galectin-3 promotes adhesion of human neutrophils to laminin
    • Kuwabara, I. and Liu, F.T., Galectin-3 promotes adhesion of human neutrophils to laminin, J Immunol, 156, 3939, 1996.
    • (1996) J Immunol , vol.156 , pp. 3939
    • Kuwabara, I.1    Liu, F.T.2
  • 100
    • 0037083447 scopus 로고    scopus 로고
    • Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia
    • Sato, S., et al., Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia, J Immunol, 168, 1813, 2002.
    • (2002) J Immunol , vol.168 , pp. 1813
    • Sato, S.1
  • 101
    • 27644480032 scopus 로고    scopus 로고
    • Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses
    • Nieminen, J., St-Pierre, C., and Sato, S., Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses, J Leukoc Biol, 78, 1127, 2005.
    • (2005) J Leukoc Biol , vol.78 , pp. 1127
    • Nieminen, J.1    St-Pierre, C.2    Sato, S.3
  • 102
    • 20444366717 scopus 로고    scopus 로고
    • Galectin-3 and soluble fi brinogen act in concert to modulate neutrophil activation and survival: Involvement of alternative MAPK pathways
    • Fernandez, G.C., et al., Galectin-3 and soluble fi brinogen act in concert to modulate neutrophil activation and survival: Involvement of alternative MAPK pathways, Glycobiology, 15, 519, 2005.
    • (2005) Glycobiology , vol.15 , pp. 519
    • Fernandez, G.C.1
  • 103
    • 33645995573 scopus 로고    scopus 로고
    • Infl ammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis
    • Gil, C.D., et al., Infl ammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis, Infl amm Res, 55, 99, 2006.
    • (2006) Infl amm Res , vol.55 , pp. 99
    • Gil, C.D.1
  • 104
    • 0242693279 scopus 로고    scopus 로고
    • Galectin-8 modulates neutrophil function via interaction with integrin alphaM
    • Nishi, N., et al., Galectin-8 modulates neutrophil function via interaction with integrin alphaM, Glycobiology, 13, 755, 2003.
    • (2003) Glycobiology , vol.13 , pp. 755
    • Nishi, N.1
  • 105
    • 0036172104 scopus 로고    scopus 로고
    • Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration
    • Delbrouck, C., et al., Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration, Lab Invest, 82, 147, 2002.
    • (2002) Lab Invest , vol.82 , pp. 147
    • Delbrouck, C.1
  • 106
    • 0037083599 scopus 로고    scopus 로고
    • Biological activities of ecalectin: A novel eosinophil-activating factor
    • Matsumoto, R., et al., Biological activities of ecalectin: A novel eosinophil-activating factor, J Immunol, 168, 1961, 2002.
    • (2002) J Immunol , vol.168 , pp. 1961
    • Matsumoto, R.1
  • 107
    • 18444398329 scopus 로고    scopus 로고
    • Association of galectin-9 with eosinophil apoptosis
    • Saita, N., et al., Association of galectin-9 with eosinophil apoptosis, Int Arch Allergy Immunol, 128, 42, 2002.
    • (2002) Int Arch Allergy Immunol , vol.128 , pp. 42
    • Saita, N.1
  • 108
    • 0028237187 scopus 로고
    • Activation of rat basophilic leukemia cells by epsilon BP, an IgE-binding endogenous lectin
    • Zuberi, R.I., Frigeri, L.G., and Liu, F.T., Activation of rat basophilic leukemia cells by epsilon BP, an IgE-binding endogenous lectin, Cell Immunol, 156, 1, 1994.
    • (1994) Cell Immunol , vol.156 , pp. 1
    • Zuberi, R.I.1    Frigeri, L.G.2    Liu, F.T.3
  • 109
    • 33749530044 scopus 로고    scopus 로고
    • Role of galectin-3 in mast cell functions: Galectin-3-defi cient mast cells exhibit impaired mediator release and defective JNK expression
    • Chen, H.Y., et al., Role of galectin-3 in mast cell functions: Galectin-3-defi cient mast cells exhibit impaired mediator release and defective JNK expression, J Immunol, 177, 4991, 2006.
    • (2006) J Immunol , vol.177 , pp. 4991
    • Chen, H.Y.1
  • 110
    • 0020606576 scopus 로고
    • Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits
    • Levi, G., Tarrab-Hazdai, R., and Teichberg, V.I., Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits, Eur J Immunol, 13, 500, 1983.
    • (1983) Eur J Immunol , vol.13 , pp. 500
    • Levi, G.1    Tarrab-Hazdai, R.2    Teichberg, V.I.3
  • 111
    • 0025309457 scopus 로고
    • Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis
    • Offner, H., et al., Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis, J Neuroimmunol, 28, 177, 1990.
    • (1990) J Neuroimmunol , vol.28 , pp. 177
    • Offner, H.1
  • 112
    • 0033964385 scopus 로고    scopus 로고
    • Galectin-1 exerts immunomodulatory and protective effects on concanavalin-Ainduced hepatitis in mice
    • Santucci, L., et al., Galectin-1 exerts immunomodulatory and protective effects on concanavalin-Ainduced hepatitis in mice, Hepatology, 31, 399, 2000.
    • (2000) Hepatology , vol.31 , pp. 399
    • Santucci, L.1
  • 113
    • 0033736331 scopus 로고    scopus 로고
    • Effi cacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats
    • Tsuchiyama, Y., et al., Effi cacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats, Kidney Int, 58, 1941, 2000.
    • (2000) Kidney Int , vol.58 , pp. 1941
    • Tsuchiyama, Y.1
  • 114
    • 33645968127 scopus 로고    scopus 로고
    • Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis
    • Romero, M.D., et al., Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis, Invest Ophthalmol Vis Sci, 47, 1550, 2006.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 1550
    • Romero, M.D.1
  • 115
    • 33750474852 scopus 로고    scopus 로고
    • Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
    • Thijssen, V.L., et al., Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy, Proc Natl Acad Sci USA, 103, 15975, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15975
    • Thijssen, V.L.1
  • 116
    • 33644876868 scopus 로고    scopus 로고
    • Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycledependent mechanisms
    • Baba, M., et al., Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycledependent mechanisms, J Am Soc Nephrol, 16, 3222, 2005.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3222
    • Baba, M.1
  • 117
    • 31144445789 scopus 로고    scopus 로고
    • Inhibition of chronic airway infl ammation and remodeling by galectin-3 gene therapy in a murine model
    • Lopez, E., et al., Inhibition of chronic airway infl ammation and remodeling by galectin-3 gene therapy in a murine model, J Immunol, 176, 1943, 2006.
    • (2006) J Immunol , vol.176 , pp. 1943
    • Lopez, E.1
  • 118
    • 9644275601 scopus 로고    scopus 로고
    • Critical role for galectin-3 in airway infl ammation and bronchial hyperresponsiveness in a murine model of asthma
    • Zuberi, R.I., et al., Critical role for galectin-3 in airway infl ammation and bronchial hyperresponsiveness in a murine model of asthma, Am J Pathol, 165, 2045, 2004.
    • (2004) Am J Pathol , vol.165 , pp. 2045
    • Zuberi, R.I.1
  • 119
    • 33947259319 scopus 로고    scopus 로고
    • Immunosuppressive strategies that are mediated by tumor cells
    • Rabinovich, G.A., Gabrilovich, D., and Sotomayor, E.M., Immunosuppressive strategies that are mediated by tumor cells, Annu Rev Immunol, 25, 267, 2007.
    • (2007) Annu Rev Immunol , vol.25 , pp. 267
    • Rabinovich, G.A.1    Gabrilovich, D.2    Sotomayor, E.M.3
  • 120
    • 33749556658 scopus 로고    scopus 로고
    • Galectin-1: A small protein with major functions
    • Camby, I., et al., Galectin-1: A small protein with major functions, Glycobiology, 16, 137R, 2006.
    • (2006) Glycobiology , vol.16 , pp. 137
    • Camby, I.1
  • 121
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: A link between tumor hypoxia and tumor immune privilege
    • Le, Q.T., et al., Galectin-1: A link between tumor hypoxia and tumor immune privilege, J Clin Oncol, 23, 8932, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 8932
    • Le, Q.T.1
  • 122
    • 33846811722 scopus 로고    scopus 로고
    • Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: Implications for tumor-immune escape
    • Daroqui, C.M., et al., Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: Implications for tumor-immune escape, Cancer Immunol Immunother, 56, 491, 2007.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 491
    • Daroqui, C.M.1
  • 123
    • 33751517749 scopus 로고    scopus 로고
    • Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model
    • Zacarias Fluck, M.F., et al., Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model, Cancer Immunol Immunother, 56, 237, 2007.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 237
    • Zacarias Fluck, M.F.1
  • 124
    • 84887222182 scopus 로고    scopus 로고
    • Roles of galectins in chronic infl ammatory microenvironments
    • Parsonage, G., et al., Roles of galectins in chronic infl ammatory microenvironments, Future Rheumatol, 1, 441, 2006.
    • (2006) Future Rheumatol , vol.1 , pp. 441
    • Parsonage, G.1
  • 125
    • 33845310480 scopus 로고    scopus 로고
    • Anti-galectin compounds as potential anti-cancer drugs
    • Ingrassia, L., et al., Anti-galectin compounds as potential anti-cancer drugs, Curr Med Chem, 13, 3513, 2006.
    • (2006) Curr Med Chem , vol.13 , pp. 3513
    • Ingrassia, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.