Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 12, 2016, Pages 2931-2935

  Zhang, Zhimin ^a   Hou, Shaohua ^a   Chen, Hongli ^a   Ran, Ting ^a   Jiang, Fei ^a   Bian, Yuanyuan ^a   Zhang, Dewei ^a   Zhi, Yanle ^a   Wang, Lu ^a   Zhang, Li ^a   Li, Hongmei ^a   Zhang, Yanmin ^a   Tang, Weifang ^a   Lu, Tao ^a,b   Chen, Yadong ^a  

^a School of Science   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiproliferative activity; Bromodomain; Epigenetic; HDAC; Protein protein interactions

Indexed keywords

3,5 DIMETHYLISOXAZOLE DERIVATIVE; 4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; ANTINEOPLASTIC AGENT; BROMODOMAIN INHIBITOR; ENTINOSTAT; HISTONE DEACETYLASE INHIBITOR; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT; BRD4 PROTEIN, HUMAN; HISTONE DEACETYLASE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; EVALUATION STUDY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; K562 CELL LINE; LEUKEMIA CELL LINE; MV4 11 CELL LINE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETIC EPIGENESIS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; EPIGENESIS, GENETIC; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; ISOXAZOLES; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84971320446     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.04.034     Document Type: Article

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