-
1
-
-
49349107518
-
Lysine acetylation: Codified crosstalk with other posttranslational modifications
-
Yang, X. J.; Seto, E. Lysine acetylation: codified crosstalk with other posttranslational modifications Mol. Cell 2008, 31, 449-61
-
(2008)
Mol. Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
2
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim, S. C.; Sprung, R.; Chen, Y.; Xu, Y.; Ball, H.; Pei, J.; Cheng, T.; Kho, Y.; Xiao, H.; Xiao, L.; Grishin, N. V.; White, M.; Yang, X. J.; Zhao, Y. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey Mol. Cell 2006, 23, 607-18
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
Grishin, N.V.11
White, M.12
Yang, X.J.13
Zhao, Y.14
-
3
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides, T. Chromatin modifications and their function Cell 2007, 128, 693-705
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
4
-
-
0035313803
-
Histone acetyltransferases: Function, structure, and catalysis
-
Marmorstein, R.; Roth, S. Y. Histone acetyltransferases: function, structure, and catalysis Curr. Opin. Genet. Dev. 2001, 11, 155-61
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 155-161
-
-
Marmorstein, R.1
Roth, S.Y.2
-
5
-
-
84878629414
-
Histone deacetylases as targets for multiple diseases
-
Sangshetti, J. N.; Sakle, N. S.; Dehghan, M. H.; Shinde, D. B. Histone deacetylases as targets for multiple diseases Mini-Rev. Med. Chem. 2013, 13, 1005-26
-
(2013)
Mini-Rev. Med. Chem.
, vol.13
, pp. 1005-1026
-
-
Sangshetti, J.N.1
Sakle, N.S.2
Dehghan, M.H.3
Shinde, D.B.4
-
6
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone, R. W. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer Nat. Rev. Drug Discovery 2002, 1, 287-99
-
(2002)
Nat. Rev. Drug Discovery
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
7
-
-
84899973908
-
Targeting bromodomains: Epigenetic readers of lysine acetylation
-
Filippakopoulos, P.; Knapp, S. Targeting bromodomains: epigenetic readers of lysine acetylation Nat. Rev. Drug Discovery 2014, 13, 337-56
-
(2014)
Nat. Rev. Drug Discovery
, vol.13
, pp. 337-356
-
-
Filippakopoulos, P.1
Knapp, S.2
-
8
-
-
84867587620
-
Lysine acetylation: Enzymes, bromodomains and links to different diseases
-
You, L.; Nie, J.; Sun, W. J.; Zheng, Z. Q.; Yang, X. J. Lysine acetylation: enzymes, bromodomains and links to different diseases Essays Biochem. 2012, 52, 1-12
-
(2012)
Essays Biochem.
, vol.52
, pp. 1-12
-
-
You, L.1
Nie, J.2
Sun, W.J.3
Zheng, Z.Q.4
Yang, X.J.5
-
9
-
-
0026580006
-
Brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
-
Tamkun, J. W.; Deuring, R.; Scott, M. P.; Kissinger, M.; Pattatucci, A. M.; Kaufman, T. C.; Kennison, J. A. brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2 Cell 1992, 68, 561-72
-
(1992)
Cell
, vol.68
, pp. 561-572
-
-
Tamkun, J.W.1
Deuring, R.2
Scott, M.P.3
Kissinger, M.4
Pattatucci, A.M.5
Kaufman, T.C.6
Kennison, J.A.7
-
10
-
-
84859181036
-
Histone recognition and large-scale structural analysis of the human bromodomain family
-
Filippakopoulos, P.; Picaud, S.; Mangos, M.; Keates, T.; Lambert, J. P.; Barsyte-Lovejoy, D.; Felletar, I.; Volkmer, R.; Muller, S.; Pawson, T.; Gingras, A. C.; Arrowsmith, C. H.; Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family Cell 2012, 149, 214-31
-
(2012)
Cell
, vol.149
, pp. 214-231
-
-
Filippakopoulos, P.1
Picaud, S.2
Mangos, M.3
Keates, T.4
Lambert, J.P.5
Barsyte-Lovejoy, D.6
Felletar, I.7
Volkmer, R.8
Muller, S.9
Pawson, T.10
Gingras, A.C.11
Arrowsmith, C.H.12
Knapp, S.13
-
11
-
-
84856394571
-
Bromodomains as therapeutic targets
-
Muller, S.; Filippakopoulos, P.; Knapp, S. Bromodomains as therapeutic targets Expert Rev. Mol. Med. 2011, 13, e29
-
(2011)
Expert Rev. Mol. Med.
, vol.13
, pp. 29
-
-
Muller, S.1
Filippakopoulos, P.2
Knapp, S.3
-
12
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos, P.; Qi, J.; Picaud, S.; Shen, Y.; Smith, W. B.; Fedorov, O.; Morse, E. M.; Keates, T.; Hickman, T. T.; Felletar, I.; Philpott, M.; Munro, S.; McKeown, M. R.; Wang, Y.; Christie, A. L.; West, N.; Cameron, M. J.; Schwartz, B.; Heightman, T. D.; La Thangue, N.; French, C. A.; Wiest, O.; Kung, A. L.; Knapp, S.; Bradner, J. E. Selective inhibition of BET bromodomains Nature 2010, 468, 1067-73
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
Philpott, M.11
Munro, S.12
McKeown, M.R.13
Wang, Y.14
Christie, A.L.15
West, N.16
Cameron, M.J.17
Schwartz, B.18
Heightman, T.D.19
La Thangue, N.20
French, C.A.21
Wiest, O.22
Kung, A.L.23
Knapp, S.24
Bradner, J.E.25
more..
-
13
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore, J. E.; Issa, G. C.; Lemieux, M. E.; Rahl, P. B.; Shi, J.; Jacobs, H. M.; Kastritis, E.; Gilpatrick, T.; Paranal, R. M.; Qi, J.; Chesi, M.; Schinzel, A. C.; McKeown, M. R.; Heffernan, T. P.; Vakoc, C. R.; Bergsagel, P. L.; Ghobrial, I. M.; Richardson, P. G.; Young, R. A.; Hahn, W. C.; Anderson, K. C.; Kung, A. L.; Bradner, J. E.; Mitsiades, C. S. BET bromodomain inhibition as a therapeutic strategy to target c-Myc Cell 2011, 146, 904-17
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
Chesi, M.11
Schinzel, A.C.12
McKeown, M.R.13
Heffernan, T.P.14
Vakoc, C.R.15
Bergsagel, P.L.16
Ghobrial, I.M.17
Richardson, P.G.18
Young, R.A.19
Hahn, W.C.20
Anderson, K.C.21
Kung, A.L.22
Bradner, J.E.23
Mitsiades, C.S.24
more..
-
14
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
Nicodeme, E.; Jeffrey, K. L.; Schaefer, U.; Beinke, S.; Dewell, S.; Chung, C. W.; Chandwani, R.; Marazzi, I.; Wilson, P.; Coste, H.; White, J.; Kirilovsky, J.; Rice, C. M.; Lora, J. M.; Prinjha, R. K.; Lee, K.; Tarakhovsky, A. Suppression of inflammation by a synthetic histone mimic Nature 2010, 468, 1119-1123
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
Chandwani, R.7
Marazzi, I.8
Wilson, P.9
Coste, H.10
White, J.11
Kirilovsky, J.12
Rice, C.M.13
Lora, J.M.14
Prinjha, R.K.15
Lee, K.16
Tarakhovsky, A.17
-
15
-
-
84862809749
-
Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)
-
Seal, J.; Lamotte, Y.; Donche, F.; Bouillot, A.; Mirguet, O.; Gellibert, F.; Nicodeme, E.; Krysa, G.; Kirilovsky, J.; Beinke, S.; McCleary, S.; Rioja, I.; Bamborough, P.; Chung, C. W.; Gordon, L.; Lewis, T.; Walker, A. L.; Cutler, L.; Lugo, D.; Wilson, D. M.; Witherington, J.; Lee, K.; Prinjha, R. K. Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A) Bioorg. Med. Chem. Lett. 2012, 22, 2968-72
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 2968-2972
-
-
Seal, J.1
Lamotte, Y.2
Donche, F.3
Bouillot, A.4
Mirguet, O.5
Gellibert, F.6
Nicodeme, E.7
Krysa, G.8
Kirilovsky, J.9
Beinke, S.10
McCleary, S.11
Rioja, I.12
Bamborough, P.13
Chung, C.W.14
Gordon, L.15
Lewis, T.16
Walker, A.L.17
Cutler, L.18
Lugo, D.19
Wilson, D.M.20
Witherington, J.21
Lee, K.22
Prinjha, R.K.23
more..
-
16
-
-
84870046749
-
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
-
Fish, P. V.; Filippakopoulos, P.; Bish, G.; Brennan, P. E.; Bunnage, M. E.; Cook, A. S.; Federov, O.; Gerstenberger, B. S.; Jones, H.; Knapp, S.; Marsden, B.; Nocka, K.; Owen, D. R.; Philpott, M.; Picaud, S.; Primiano, M. J.; Ralph, M. J.; Sciammetta, N.; Trzupek, J. D. Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit J. Med. Chem. 2012, 55, 9831-7
-
(2012)
J. Med. Chem.
, vol.55
, pp. 9831-9837
-
-
Fish, P.V.1
Filippakopoulos, P.2
Bish, G.3
Brennan, P.E.4
Bunnage, M.E.5
Cook, A.S.6
Federov, O.7
Gerstenberger, B.S.8
Jones, H.9
Knapp, S.10
Marsden, B.11
Nocka, K.12
Owen, D.R.13
Philpott, M.14
Picaud, S.15
Primiano, M.J.16
Ralph, M.J.17
Sciammetta, N.18
Trzupek, J.D.19
-
17
-
-
80053924872
-
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
-
Hewings, D. S.; Wang, M.; Philpott, M.; Fedorov, O.; Uttarkar, S.; Filippakopoulos, P.; Picaud, S.; Vuppusetty, C.; Marsden, B.; Knapp, S.; Conway, S. J.; Heightman, T. D. 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands J. Med. Chem. 2011, 54, 6761-70
-
(2011)
J. Med. Chem.
, vol.54
, pp. 6761-6770
-
-
Hewings, D.S.1
Wang, M.2
Philpott, M.3
Fedorov, O.4
Uttarkar, S.5
Filippakopoulos, P.6
Picaud, S.7
Vuppusetty, C.8
Marsden, B.9
Knapp, S.10
Conway, S.J.11
Heightman, T.D.12
-
18
-
-
84893130847
-
[1,2,4]triazolo[4,3-a]phthalazines: Inhibitors of diverse bromodomains
-
Fedorov, O.; Lingard, H.; Wells, C.; Monteiro, O. P.; Picaud, S.; Keates, T.; Yapp, C.; Philpott, M.; Martin, S. J.; Felletar, I.; Marsden, B. D.; Filippakopoulos, P.; Muller, S.; Knapp, S.; Brennan, P. E. [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains J. Med. Chem. 2014, 57, 462-76
-
(2014)
J. Med. Chem.
, vol.57
, pp. 462-476
-
-
Fedorov, O.1
Lingard, H.2
Wells, C.3
Monteiro, O.P.4
Picaud, S.5
Keates, T.6
Yapp, C.7
Philpott, M.8
Martin, S.J.9
Felletar, I.10
Marsden, B.D.11
Filippakopoulos, P.12
Muller, S.13
Knapp, S.14
Brennan, P.E.15
-
19
-
-
84878029292
-
Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain
-
Zhao, L.; Cao, D.; Chen, T.; Wang, Y.; Miao, Z.; Xu, Y.; Chen, W.; Wang, X.; Li, Y.; Du, Z.; Xiong, B.; Li, J.; Xu, C.; Zhang, N.; He, J.; Shen, J. Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain J. Med. Chem. 2013, 56, 3833-51
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3833-3851
-
-
Zhao, L.1
Cao, D.2
Chen, T.3
Wang, Y.4
Miao, Z.5
Xu, Y.6
Chen, W.7
Wang, X.8
Li, Y.9
Du, Z.10
Xiong, B.11
Li, J.12
Xu, C.13
Zhang, N.14
He, J.15
Shen, J.16
-
20
-
-
84884238437
-
Discovery, design, and optimization of isoxazole azepine BET inhibitors
-
Gehling, V. S.; Hewitt, M. C.; Vaswani, R. G.; Leblanc, Y.; Cote, A.; Nasveschuk, C. G.; Taylor, A. M.; Harmange, J. C.; Audia, J. E.; Pardo, E.; Joshi, S.; Sandy, P.; Mertz, J. A.; Sims, R. J.; Bergeron, L.; Bryant, B. M.; Bellon, S.; Poy, F.; Jayaram, H.; Sankaranarayanan, R.; Yellapantula, S.; Srinivasamurthy, N. B.; Birudukota, S.; Albrecht, B. K. Discovery, design, and optimization of isoxazole azepine BET inhibitors ACS Med. Chem. Lett. 2013, 4, 835-840
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 835-840
-
-
Gehling, V.S.1
Hewitt, M.C.2
Vaswani, R.G.3
Leblanc, Y.4
Cote, A.5
Nasveschuk, C.G.6
Taylor, A.M.7
Harmange, J.C.8
Audia, J.E.9
Pardo, E.10
Joshi, S.11
Sandy, P.12
Mertz, J.A.13
Sims, R.J.14
Bergeron, L.15
Bryant, B.M.16
Bellon, S.17
Poy, F.18
Jayaram, H.19
Sankaranarayanan, R.20
Yellapantula, S.21
Srinivasamurthy, N.B.22
Birudukota, S.23
Albrecht, B.K.24
more..
-
21
-
-
84907894098
-
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor
-
Gosmini, R.; Nguyen, V. L.; Toum, J.; Simon, C.; Brusq, J. M. G.; Krysa, G.; Mirguet, O.; Riou-Eymard, A. M.; Boursier, E. V.; Trottet, L.; Bamborough, P.; Clark, H.; Chung, C. W.; Cutler, L.; Demont, E. H.; Kaur, R.; Lewis, A. J.; Schilling, M. B.; Soden, P. E.; Taylor, S.; Walker, A. L.; Walker, M. D.; Prinjha, R. K.; Nicodeme, E. The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor J. Med. Chem. 2014, 57, 8111-8131
-
(2014)
J. Med. Chem.
, vol.57
, pp. 8111-8131
-
-
Gosmini, R.1
Nguyen, V.L.2
Toum, J.3
Simon, C.4
Brusq, J.M.G.5
Krysa, G.6
Mirguet, O.7
Riou-Eymard, A.M.8
Boursier, E.V.9
Trottet, L.10
Bamborough, P.11
Clark, H.12
Chung, C.W.13
Cutler, L.14
Demont, E.H.15
Kaur, R.16
Lewis, A.J.17
Schilling, M.B.18
Soden, P.E.19
Taylor, S.20
Walker, A.L.21
Walker, M.D.22
Prinjha, R.K.23
Nicodeme, E.24
more..
-
22
-
-
84922814425
-
Biased multicomponent reactions to develop novel bromodomain inhibitors
-
McKeown, M. R.; Shaw, D. L.; Fu, H.; Liu, S.; Xu, X.; Marineau, J. J.; Huang, Y.; Zhang, X.; Buckley, D. L.; Kadam, A.; Zhang, Z.; Blacklow, S. C.; Qi, J.; Zhang, W.; Bradner, J. E. Biased multicomponent reactions to develop novel bromodomain inhibitors J. Med. Chem. 2014, 57, 9019-27
-
(2014)
J. Med. Chem.
, vol.57
, pp. 9019-9027
-
-
McKeown, M.R.1
Shaw, D.L.2
Fu, H.3
Liu, S.4
Xu, X.5
Marineau, J.J.6
Huang, Y.7
Zhang, X.8
Buckley, D.L.9
Kadam, A.10
Zhang, Z.11
Blacklow, S.C.12
Qi, J.13
Zhang, W.14
Bradner, J.E.15
-
23
-
-
84885675970
-
Discovery of epigenetic regulator I-BET762: Lead optimization to afford a clinical candidate inhibitor of the BET bromodomains
-
Mirguet, O.; Gosmini, R.; Toum, J.; Clement, C. A.; Barnathan, M.; Brusq, J. M.; Mordaunt, J. E.; Grimes, R. M.; Crowe, M.; Pineau, O.; Ajakane, M.; Daugan, A.; Jeffrey, P.; Cutler, L.; Haynes, A. C.; Smithers, N. N.; Chung, C. W.; Bamborough, P.; Uings, I. J.; Lewis, A.; Witherington, J.; Parr, N.; Prinjha, R. K.; Nicodeme, E. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains J. Med. Chem. 2013, 56, 7501-7515
-
(2013)
J. Med. Chem.
, vol.56
, pp. 7501-7515
-
-
Mirguet, O.1
Gosmini, R.2
Toum, J.3
Clement, C.A.4
Barnathan, M.5
Brusq, J.M.6
Mordaunt, J.E.7
Grimes, R.M.8
Crowe, M.9
Pineau, O.10
Ajakane, M.11
Daugan, A.12
Jeffrey, P.13
Cutler, L.14
Haynes, A.C.15
Smithers, N.N.16
Chung, C.W.17
Bamborough, P.18
Uings, I.J.19
Lewis, A.20
Witherington, J.21
Parr, N.22
Prinjha, R.K.23
Nicodeme, E.24
more..
-
24
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson, M. A.; Prinjha, R. K.; Dittmann, A.; Giotopoulos, G.; Bantscheff, M.; Chan, W. I.; Robson, S. C.; Chung, C. W.; Hopf, C.; Savitski, M. M.; Huthmacher, C.; Gudgin, E.; Lugo, D.; Beinke, S.; Chapman, T. D.; Roberts, E. J.; Soden, P. E.; Auger, K. R.; Mirguet, O.; Doehner, K.; Delwel, R.; Burnett, A. K.; Jeffrey, P.; Drewes, G.; Lee, K.; Huntly, B. J. P.; Kouzarides, T. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Nature 2011, 478, 529-533
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
Robson, S.C.7
Chung, C.W.8
Hopf, C.9
Savitski, M.M.10
Huthmacher, C.11
Gudgin, E.12
Lugo, D.13
Beinke, S.14
Chapman, T.D.15
Roberts, E.J.16
Soden, P.E.17
Auger, K.R.18
Mirguet, O.19
Doehner, K.20
Delwel, R.21
Burnett, A.K.22
Jeffrey, P.23
Drewes, G.24
Lee, K.25
Huntly, B.J.P.26
Kouzarides, T.27
more..
-
25
-
-
0013470041
-
M -Trifluoromethylbenzenesulfonyl chloride
-
m -Trifluoromethylbenzenesulfonyl chloride. Org. Synth. 1981, 60, 121.
-
(1981)
Org. Synth.
, vol.60
, pp. 121
-
-
-
26
-
-
79961096106
-
Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid
-
Xiang, Z.; Wang, L. Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid J. Org. Chem. 2011, 76, 6367-6371
-
(2011)
J. Org. Chem.
, vol.76
, pp. 6367-6371
-
-
Xiang, Z.1
Wang, L.2
-
27
-
-
70449359296
-
Solid-phase organic synthesis of difluoroalkyl entities using a novel fluorinating cleavage strategy: Part 1. Linker development: Scope and limitations
-
Wiehn, M. S.; Lindell, S. D.; Bräse, S. Solid-phase organic synthesis of difluoroalkyl entities using a novel fluorinating cleavage strategy: Part 1. linker development: scope and limitations J. Comb. Chem. 2009, 11, 960-981
-
(2009)
J. Comb. Chem.
, vol.11
, pp. 960-981
-
-
Wiehn, M.S.1
Lindell, S.D.2
Bräse, S.3
-
28
-
-
77957682613
-
Ligand efficiency indices for an effective mapping of chemico-biological space: The concept of an atlas-like representation
-
Abad-Zapatero, C.; Perišić, O.; Wass, J.; Bento, A. P.; Overington, J.; Al-Lazikani, B.; Johnson, M. E. Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation Drug Discovery Today 2010, 15, 804-811
-
(2010)
Drug Discovery Today
, vol.15
, pp. 804-811
-
-
Abad-Zapatero, C.1
Perišić, O.2
Wass, J.3
Bento, A.P.4
Overington, J.5
Al-Lazikani, B.6
Johnson, M.E.7
-
29
-
-
84903739739
-
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
-
Hay, D. A.; Fedorov, O.; Martin, S.; Singleton, D. C.; Tallant, C.; Wells, C.; Picaud, S.; Philpott, M.; Monteiro, O. P.; Rogers, C. M.; Conway, S. J.; Rooney, T. P. C.; Tumber, A.; Yapp, C.; Filippakopoulos, P.; Bunnage, M. E.; Muller, S.; Knapp, S.; Schofield, C. J.; Brennan, P. E. Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains J. Am. Chem. Soc. 2014, 136, 9308-9319
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 9308-9319
-
-
Hay, D.A.1
Fedorov, O.2
Martin, S.3
Singleton, D.C.4
Tallant, C.5
Wells, C.6
Picaud, S.7
Philpott, M.8
Monteiro, O.P.9
Rogers, C.M.10
Conway, S.J.11
Rooney, T.P.C.12
Tumber, A.13
Yapp, C.14
Filippakopoulos, P.15
Bunnage, M.E.16
Muller, S.17
Knapp, S.18
Schofield, C.J.19
Brennan, P.E.20
more..
-
30
-
-
84856399470
-
Fragment-based discovery of bromodomain inhibitors part 2: Optimization of phenylisoxazole sulfonamides
-
Bamborough, P.; Diallo, H.; Goodacre, J. D.; Gordon, L.; Lewis, A.; Seal, J. T.; Wilson, D. M.; Woodrow, M. D.; Chung, C. W. Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides J. Med. Chem. 2012, 55, 587-596
-
(2012)
J. Med. Chem.
, vol.55
, pp. 587-596
-
-
Bamborough, P.1
Diallo, H.2
Goodacre, J.D.3
Gordon, L.4
Lewis, A.5
Seal, J.T.6
Wilson, D.M.7
Woodrow, M.D.8
Chung, C.W.9
-
31
-
-
37249005205
-
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
-
Niesen, F. H.; Berglund, H.; Vedadi, M. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability Nat. Protoc. 2007, 2, 2212-2221
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2212-2221
-
-
Niesen, F.H.1
Berglund, H.2
Vedadi, M.3
-
32
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z.; Minor, W. Processing of X-ray diffraction data collected in oscillation mode Macromol. Crystallogr., Part A 1997, 276, 307-326
-
(1997)
Macromol. Crystallogr., Part A
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
33
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method Acta Crystallogr., Sect. D: Biol. Crystallogr. 1997, 53, 240-255
-
(1997)
Acta Crystallogr., Sect. D: Biol. Crystallogr.
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
34
-
-
14244272868
-
PHENIX: Building new software for automated crystallographic structure determination
-
Adams, P. D.; Grosse-Kunstleve, R. W.; Hung, L. W.; Ioerger, T. R.; McCoy, A. J.; Moriarty, N. W.; Read, R. J.; Sacchettini, J. C.; Sauter, N. K.; Terwilliger, T. C. PHENIX: building new software for automated crystallographic structure determination Acta Crystallogr., Sect. D: Biol. Crystallogr. 2002, 58, 1948-1954
-
(2002)
Acta Crystallogr., Sect. D: Biol. Crystallogr.
, vol.58
, pp. 1948-1954
-
-
Adams, P.D.1
Grosse-Kunstleve, R.W.2
Hung, L.W.3
Ioerger, T.R.4
McCoy, A.J.5
Moriarty, N.W.6
Read, R.J.7
Sacchettini, J.C.8
Sauter, N.K.9
Terwilliger, T.C.10
-
35
-
-
77949535720
-
Features and development of Coot
-
Emsley, P.; Lohkamp, B.; Scott, W. G.; Cowtan, K. Features and development of Coot Acta Crystallogr., Sect. D: Biol. Crystallogr. 2010, 66, 486-501
-
(2010)
Acta Crystallogr., Sect. D: Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
36
-
-
84903791583
-
The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury
-
Li, J. X.; Feng, J. M.; Wang, Y.; Li, X. H.; Chen, X. X.; Su, Y.; Shen, Y. Y.; Chen, Y.; Xiong, B.; Yang, C. H.; Ding, J.; Miao, Z. H. The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury Cell Death Dis. 2014, 5, e1278
-
(2014)
Cell Death Dis.
, vol.5
, pp. 1278
-
-
Li, J.X.1
Feng, J.M.2
Wang, Y.3
Li, X.H.4
Chen, X.X.5
Su, Y.6
Shen, Y.Y.7
Chen, Y.8
Xiong, B.9
Yang, C.H.10
Ding, J.11
Miao, Z.H.12
|