Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson's Disease

Cell Reports

Volumn 15, Issue 9, 2016, Pages 1866-1875

  Sepe, Sara ^a   Milanese, Chiara ^a,b   Gabriels, Sylvia ^a   Derks, Kasper W J ^a   Payan Gomez, Cesar ^a,c   van IJcken, Wilfred F J ^a   Rijksen, Yvonne M A ^a   Nigg, Alex L ^a   Moreno, Sandra ^d   Cerri, Silvia ^e   Blandini, Fabio ^e   Hoeijmakers, Jan H J ^a   Mastroberardino, Pier G ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RiMED Foundation   (Italy)

^c UNIVERSIDAD DEL ROSARIO   (Colombia)

^d ROMA TRE UNIVERSITY   (Italy)

^e C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CRE RECOMBINASE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; HISTONE H2AX; HISTONE H2AX GAMMA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, MOUSE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC INNERVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; DNA REPAIR; DOPAMINERGIC SYSTEM; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; ENZYME ACTIVITY; ERCC1 GENE; EXCISION REPAIR; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; OXIDATION REDUCTION STATE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; RNA SEQUENCE; SKIN FIBROBLAST; UPREGULATION; ANIMAL; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FIBROBLAST; METABOLISM; PATHOLOGY; ULTRASTRUCTURE;

AGING; ANIMALS; CORPUS STRIATUM; DNA REPAIR; DNA-BINDING PROTEINS; DOPAMINERGIC NEURONS; ENDONUCLEASES; FIBROBLASTS; HUMANS; MICE; PARKINSON DISEASE;

EID: 84971229247     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.04.071     Document Type: Article

References (34)

1. Ahmad A., Robinson A.R., Duensing A., van Drunen E., Beverloo H.B., Weisberg D.B., Hasty P., Hoeijmakers J.H., Niedernhofer L.J. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol. Cell. Biol. 2008, 28:5082-5092.
2. Ambrosi G., Ghezzi C., Sepe S., Milanese C., Payan-Gomez C., Bombardieri C.R., Armentero M.T., Zangaglia R., Pacchetti C., Mastroberardino P.G., Blandini F. Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease. Biochim. Biophys. Acta 2014, 1842:1385-1394.
3. Anderson J.P., Walker D.E., Goldstein J.M., de Laat R., Banducci K., Caccavello R.J., Barbour R., Huang J., Kling K., Lee M., et al. Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J. Biol. Chem. 2006, 281:29739-29752.
4. Brouwer R.W., van den Hout M.C., Grosveld F.G., van Ijcken W.F. NARWHAL, a primary analysis pipeline for NGS data. Bioinformatics 2012, 28:284-285.
5. Chinta S.J., Lieu C.A., Demaria M., Laberge R.M., Campisi J., Andersen J.K. Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?. J. Intern. Med. 2013, 273:429-436.
6. Collier T.J., Kanaan N.M., Kordower J.H. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nat. Rev. Neurosci. 2011, 12:359-366.
7. Cornetta T., Patrono C., Terrenato I., De Nigris F., Bentivoglio A.R., Testa A., Palma V., Poggioli T., Padua L., Cozzi R. Epidemiological, clinical, and molecular study of a cohort of Italian Parkinson disease patients: association with glutathione-S-transferase and DNA repair gene polymorphisms. Cell. Mol. Neurobiol. 2013, 33:673-680.
8. D'Errico M., Parlanti E., Teson M., de Jesus B.M., Degan P., Calcagnile A., Jaruga P., Bjørås M., Crescenzi M., Pedrini A.M., et al. New functions of XPC in the protection of human skin cells from oxidative damage. EMBO J. 2006, 25:4305-4315.
9. Deleidi M., Gasser T. The role of inflammation in sporadic and familial Parkinson's disease. Cell. Mol. Life Sci. 2013, 70:4259-4273.
10. DelleDonne A., Klos K.J., Fujishiro H., Ahmed Z., Parisi J.E., Josephs K.A., Frigerio R., Burnett M., Wszolek Z.K., Uitti R.J., et al. Incidental Lewy body disease and preclinical Parkinson disease. Arch. Neurol. 2008, 65:1074-1080.
11. Gencer M., Dasdemir S., Cakmakoglu B., Cetinkaya Y., Varlibas F., Tireli H., Kucukali C.I., Ozkok E., Aydin M. DNA repair genes in Parkinson's disease. Genet. Test. Mol. Biomarkers 2012, 16:504-507.
12. Greenamyre J.T., Hastings T.G. Biomedicine. Parkinson's--divergent causes, convergent mechanisms. Science 2004, 304:1120-1122.
13. Greenwood C.E., Tatton W.G., Seniuk N.A., Biddle F.G. Increased dopamine synthesis in aging substantia nigra neurons. Neurobiol. Aging 1991, 12:557-565.
14. Guzman J.N., Sanchez-Padilla J., Wokosin D., Kondapalli J., Ilijic E., Schumacker P.T., Surmeier D.J. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 2010, 468:696-700.
15. Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
16. Horowitz M.P., Milanese C., Di Maio R., Hu X., Montero L.M., Sanders L.H., Tapias V., Sepe S., van Cappellen W.A., Burton E.A., Greenamyre J.T., Mastroberardino P.G. Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults. Antioxid. Redox Signal. 2011, 15:855-871.
17. Kamel F., Tanner C., Umbach D., Hoppin J., Alavanja M., Blair A., Comyns K., Goldman S., Korell M., Langston J., et al. Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am. J. Epidemiol. 2007, 165:364-374.
18. Lin E., Cavanaugh J.E., Leak R.K., Perez R.G., Zigmond M.J. Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells. J. Neurosci. Res. 2008, 86:108-117.
19. Liu L., Hsu S.S., Kalia S.K., Lozano A.M. Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP. Brain Res. 2003, 994:243-252.
20. Mastroberardino P.G., Orr A.L., Hu X., Na H.M., Greenamyre J.T. A FRET-based method to study protein thiol oxidation in histological preparations. Free Radic. Biol. Med. 2008, 45:971-981.
21. Mastroberardino P.G., Hoffman E.K., Horowitz M.P., Betarbet R., Taylor G., Cheng D., Na H.M., Gutekunst C.A., Gearing M., Trojanowski J.Q., et al. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol. Dis. 2009, 34:417-431.
22. Mutez E., Nkiliza A., Belarbi K., de Broucker A., Vanbesien-Mailliot C., Bleuse S., Duflot A., Comptdaer T., Semaille P., Blervaque R., et al. Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease. Neurobiol. Dis. 2014, 63:165-170.
23. Niedernhofer L.J. Nucleotide excision repair deficient mouse models and neurological disease. DNA Repair (Amst.) 2008, 7:1180-1189.
24. Nouspikel T. Nucleotide excision repair and neurological diseases. DNA Repair (Amst.) 2008, 7:1155-1167.
25. Pascucci B., D'Errico M., Parlanti E., Giovannini S., Dogliotti E. Role of nucleotide excision repair proteins in oxidative DNA damage repair: an updating. Biochemistry (Mosc) 2011, 76:4-15.
26. Robbins J.H., Otsuka F., Tarone R.E., Polinsky R.J., Brumback R.A., Nee L.E. Parkinson's disease and Alzheimer's disease: hypersensitivity to X rays in cultured cell lines. J. Neurol. Neurosurg. Psychiatry 1985, 48:916-923.
27. Robinson M.D., McCarthy D.J., Smyth G.K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010, 26:139-140.
28. Salic A., Mitchison T.J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl. Acad. Sci. USA 2008, 105:2415-2420.
29. Sanders L.H., Laganière J., Cooper O., Mak S.K., Vu B.J., Huang Y.A., Paschon D.E., Vangipuram M., Sundararajan R., Urnov F.D., et al. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol. Dis. 2014, 62:381-386.
30. Sanders L.H., McCoy J., Hu X., Mastroberardino P.G., Dickinson B.C., Chang C.J., Chu C.T., Van Houten B., Greenamyre J.T. Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiol. Dis. 2014, 70:214-223.
31. Schapira A.H., Cooper J.M., Dexter D., Jenner P., Clark J.B., Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1989, 1:1269.
32. Sepe S., Payan-Gomez C., Milanese C., Hoeijmakers J.H., Mastroberardino P.G. Nucleotide excision repair in chronic neurodegenerative diseases. DNA Repair (Amst.) 2013, 12:568-577.
33. Weeda G., Donker I., de Wit J., Morreau H., Janssens R., Vissers C.J., Nigg A., van Steeg H., Bootsma D., Hoeijmakers J.H. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 1997, 7:427-439.
34. Xu G., Deng N., Zhao Z., Judeh T., Flemington E., Zhu D. SAMMate: a GUI tool for processing short read alignments in SAM/BAM format. Source Code Biol. Med. 2011, 6:2.