Vitamin K2 ameliorates damage of blood vessels by glucocorticoid: A potential mechanism for its protective effects in glucocorticoid-induced osteonecrosis of the femoral head in a rat model

International Journal of Biological Sciences

Volumn 12, Issue 7, 2016, Pages 776-785

  Zhang, Yuelei ^a   Yin, Junhui ^a   Ding, Hao ^a   Zhang, Changqing ^a   Gao, You Shui ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Angiogenesis; Eahy926; Osteoblast; Osteonecrosis of femoral heads; Vitamin K2

Indexed keywords

FARNOQUINONE; GLUCOCORTICOID;

ANIMAL; APOPTOSIS; BLOOD VESSEL; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; FEMUR HEAD NECROSIS; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOOD VESSELS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; FEMUR HEAD NECROSIS; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VITAMIN K 2; X-RAY MICROTOMOGRAPHY;

EID: 84970990745     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.15248     Document Type: Article

References (49)

1. Kerachian MA, Seguin C, Harvey EJ. Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol. 2009; 114: 121-8.
2. Weinstein RS. Glucocorticoid-induced osteonecrosis. Endocrine. 2012; 41: 183-90.
3. Kerachian MA, Harvey EJ, Cournoyer D, Chow TY, Seguin C. Avascular necrosis of the femoral head: vascular hypotheses. Endothelium. 2006; 13: 237-44.
4. Harada S, Rodan SB, Rodan GA. Expression and regulation of vascular endothelial growth factor in osteoblasts. Clin Orthop Relat Res. 1995; 313: 76-80.
5. Li X, Jin L, Cui Q, Wang GJ, Balian G. Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int. 2005; 16: 101-8.
6. Harada I. The effects of glucocorticoids on angiogenesis in vitro. Nihon Seikeigeka Gakkai zasshi. 1992; 66: 763-70.
7. Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O'Brien CA, et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging cell. 2010; 9: 147-61.
8. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, et al. Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci. 2010; 1192: 322-6.
9. Coolbaugh CC. Effects of reduced blood supply on bone. Am J Physiol. 1952; 169: 26-33.
10. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999; 5: 623-8.
11. Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Endothelial cells direct human mesenchymal stem cells for osteo-and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther. 2015; 6: 88.
12. Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G. Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem Biophys Res Commun. 2004; 322: 684-92.
13. Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014; 507: 323-8.
14. Eshkar-Oren I, Viukov SV, Salameh S, Krief S, Oh CD, Akiyama H, et al. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development. 2009; 136: 1263-72.
15. Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth factors. 2004; 22: 233-41.
16. Li H, Xue K, Kong N, Liu K, Chang J. Silicate bioceramics enhanced vascularization and osteogenesis through stimulating interactions between endothelia cells and bone marrow stromal cells. Biomaterials. 2014; 35: 3803-18.
17. Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, et al. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology. 2002; 143: 1545-53.
18. Atkins GJ, Welldon KJ, Wijenayaka AR, Bonewald LF, Findlay DM. Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and-independent mechanisms. Am J Physiol Cell Physiol. 2009; 297: C1358-67.
19. Azuma K, Ouchi Y, Inoue S. Vitamin K: novel molecular mechanisms of action and its roles in osteoporosis. Geriatr Gerontol Int. 2014; 14: 1-7.
20. Iwamoto J, Seki A, Sato Y, Matsumoto H, Tadeda T, Yeh JK. Vitamin K-2 Promotes Bone Healing in a Rat Femoral Osteotomy Model with or without Glucocorticoid Treatment. Calcif Tissue Int. 2010; 86: 234-41.
21. Sasaki N, Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E, et al. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab. 2005; 23: 41-7.
22. Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012; 3: 158-65.
23. Hasanbasic I, Rajotte I, Blostein M. The role of gamma-carboxylation in the anti-apoptotic function of gas6. J Thromb Haemost. 2005; 3: 2790-7.
24. Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, et al. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 2012; 336: 1306-10.
25. Hegarty JM, Yang H, Chi NC. UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. Development. 2013; 140: 1713-9.
26. Yoshiji H, Kuriyama S, Noguchi R, Yoshii J, Ikenaka Y, Yanase K, et al. Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression. J Hepatol. 2005; 42: 687-93.
27. Xia Q, Yang S, Zhang SQ, Chen B, Wang DB, Zhu QX, et al. The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine. Clin Exp Dermatol. 2005; 30: 165-70.
28. Park SK, Kim HI, Yang YI. Roles of vascular endothelial growth factor, Angiopoietin 1, and Angiopoietin 2 in nasal polyp. Laryngoscope. 2009; 119: 409-13.
29. Abud AP, Zych J, Reus TL, Kuligovski C, de Moraes E, Dallagiovanna B, et al. The use of human adipose-derived stem cells based cytotoxicity assay for acute toxicity test. Regul Toxicol Pharmacol. 2015; 73: 992-8.
30. Burstyn-Cohen T, Heeb MJ, Lemke G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009; 119: 2942-53.
31. Vogt CJ, Schmid-Schonbein GW. Microvascular endothelial cell death and rarefaction in the glucocorticoid-induced hypertensive rat. Microcirculation. 2001; 8: 129-39.
32. Jang YH, Shin HS, Sun Choi H, Ryu ES, Jin Kim M, Ki Min S, et al. Effects of dexamethasone on the TGF-beta1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells. Lab Invest. 2013; 93: 194-206.
33. Shikatani EA, Trifonova A, Mandel ER, Liu ST, Roudier E, Krylova A, et al. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PloS one. 2012; 7: e46625.
34. Zarrinpashneh E, Poggioli T, Sarathchandra P, Lexow J, Monassier L, Terracciano C, et al. Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction. PloS one. 2013; 8: e80268.
35. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol. 1993; 13: 2031-40.
36. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996; 380: 435-9.
37. Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, et al. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J. 2010; 29: 424-41.
38. Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, Rabie AB. The role of vascular endothelial growth factor in ossification. Int J Oral Sci. 2012; 4: 64-8.
39. Dai J, Rabie AB. VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res. 2007; 86: 937-50.
40. Jabalee J, Franz-Odendaal TA. Vascular endothelial growth factor signaling affects both angiogenesis and osteogenesis during the development of scleral ossicles. Dev Biol. 2015; 406: 52-62.
41. Hamidi MS, Gajic-Veljanoski O, Cheung AM. Vitamin K and bone health. J Clin Densitom. 2013; 16: 409-13.
42. Muraoka N, Shum L, Fukumoto S, Nomura T, Ohishi M, Nonaka K. Transforming growth factor-beta3 promotes mesenchymal cell proliferation and angiogenesis mediated by the enhancement of cyclin D1, Flk-1, and CD31 gene expression during CL/Fr mouse lip fusion. Birth Defects Res A Clin Mol Teratol. 2005; 73: 956-65.
43. Uras N, Oguz SS, Zergeroglu S, Akdag A, Polat B, Dizdar EA, et al. CD31 and Factor VIII in angiogenesis of normal and pre-eclamptic human placentas. J Obstet Gynaecol. 2012; 32: 533-6.
44. Hannink M, Donoghue DJ. Structure and function of platelet-derived growth factor (PDGF) and related proteins. Biochim Biophys Acta. 1989; 989: 1-10.
45. Mittermayr R, Slezak P, Haffner N, Smolen D, Hartinger J, Hofmann A, et al. Controlled release of fibrin matrix-conjugated platelet derived growth factor improves ischemic tissue regeneration by functional angiogenesis. Acta Biomater. 2016; 29: 11-20.
46. Herzog DP, Dohle E, Bischoff I, Kirkpatrick CJ. Cell communication in a coculture system consisting of outgrowth endothelial cells and primary osteoblasts. Biomed Res Int. 2014; 2014: 320123.
47. Fang Y, Hu C, Tao X, Wan Y, Tao F. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials. J Bone Miner Metab. 2012; 30: 60-8.
48. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res. 2000; 15: 515-21.
49. Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone. 2000; 27: 769-76.