Controlled release of fibrin matrix-conjugated platelet derived growth factor improves ischemic tissue regeneration by functional angiogenesis

Acta Biomaterialia

Volumn 29, Issue , 2016, Pages 11-20

  Mittermayr, Rainer ^a,b   Slezak, Paul ^a   Haffner, Nicolas ^a   Smolen, Daniel ^a,b   Hartinger, Joachim ^a   Hofmann, Anna ^a   Schense, Jason ^c   Spazierer, Daniel ^d   Gampfer, Jörg ^d   Goppelt, Andreas ^a   Redl, Heinz ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^b AUVA Soziale Unfallversicherung   (Austria)

^c Kuros Biosurgery AG   (Switzerland)

^d BAXTER INNOVATIONS GMBH   (Austria)

Author keywords

Angiogenesis; Controlled drug release; Fibrin; Ischemia; Matrix; PDGF; Platelet derived growth factor; Tissue regeneration

Indexed keywords

BLOOD VESSELS; PLATELETS; PROTEINS; SCAFFOLDS (BIOLOGY); TARGETED DRUG DELIVERY; TISSUE; TISSUE REGENERATION;

ANGIOGENESIS; CONTROLLED DRUG RELEASE; FIBRIN; FIBRIN MATRIX; GROWTH FACTOR; ISCHAEMIA; MATRIX; PLATELET-DERIVED GROWTH FACTORS; TRANSGLUTAMINASES;

CONTROLLED DRUG DELIVERY;

FIBRIN GLUE; PLATELET DERIVED GROWTH FACTOR AB; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; SMOOTH MUSCLE ACTIN; VON WILLEBRAND FACTOR; DELAYED RELEASE FORMULATION; FIBRIN; PLATELET DERIVED GROWTH FACTOR; PLATELET-DERIVED GROWTH FACTOR A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONJUGATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIA; LASER DOPPLER FLOWMETRY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE FLAP; TISSUE NECROSIS; TISSUE PERFUSION; TISSUE REGENERATION; ANIMAL; DELAYED RELEASE FORMULATION; DRUG EFFECTS; HUMAN; PHARMACOKINETICS; PHARMACOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; DELAYED-ACTION PREPARATIONS; FIBRIN; HUMANS; ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84952637604     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.10.028     Document Type: Article

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