Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment

Calcified Tissue International

Volumn 86, Issue 3, 2010, Pages 234-241

  Iwamoto, Jun ^a   Seki, Azusa ^b   Sato, Yoshihiro ^c   Matsumoto, Hideo ^a   Tadeda, Tsuyoshi ^a   Yeh, James K ^d  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Hamri Co Ltd   (Japan)

^c Mitate Hospital   (Japan)

^d WINTHROP UNIVERSITY HOSPITAL   (United States)

Author keywords

Bone healing; Callus; Glucocorticoid; Rat; Vitamin K2

Indexed keywords

MENATETRENONE; PREDNISOLONE; SODIUM CHLORIDE; ANTIFIBRINOLYTIC AGENT; FARNOQUINONE; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE TURNOVER; CALLUS; CONTROLLED STUDY; DIAPHYSIS; DOWN REGULATION; DRUG EFFICACY; EXPERIMENTAL MODEL; FEMALE; FEMUR OSTEOTOMY; FRACTURE HEALING; INTRAMEDULLARY NAILING; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT; TREATMENT DURATION; ANIMAL; BONE REGENERATION; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; DRUG POTENTIATION; FEMUR; FRACTURE; INJURY; INTERNAL FIXATOR; METABOLISM; OSTEOTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME; WOUND HEALING;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; BONE REGENERATION; BONE RESORPTION; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; FEMUR; FRACTURES, BONE; GLUCOCORTICOIDS; INTERNAL FIXATORS; OSTEOBLASTS; OSTEOCLASTS; OSTEOTOMY; PREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; VITAMIN K 2; WOUND HEALING;

EID: 77950866917     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9333-8     Document Type: Article

References (24)

1. Buckwalter JA, Cruess RL (1991) Healing of the musculoskeletal tissues. In: Rockwood CA, Green DP, Bucholz RW (eds) Rockwood and Green's fractures in adults, 3rd ed. edn. Lippincott, Philadelphia, pp 181-222
2. Manolagas SC, Weinstein RS (1999) New developments in the pathogenesis and treatment of steroid-induced osteoporosis. J Bone Miner Res 14:1061-1066
3. Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M (2000) Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model. Acta Orthop Scand 71: 316-321
4. Luppen CA, Blake CA, Ammirati KM, Stevens ML, Seeherman HJ, Wozney JM, Bouxsein ML (2002) Recombinant human bone morphogenetic protein-2 enhances osteotomy healing in glucocorticoid- treated rabbits. J Bone Miner Res 17:301-310
5. Bostrom MP, Gamradt SC, Asnis P, Vickery BH, Hill E, Avnur Z, Waters RV (2000) Parathyroid hormone-related protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy. Bone 26:437-442
6. Høgevold HE, Grøgaard B, Reikerås O (1992) Effects of shortterm treatment with corticosteroids and indomethacin on bone healing. A mechanical study of osteotomies in rats. Acta Orthop Scand 63:607-611
7. Aslan M, Simşek G, Yildirim U (2005) Effects of short-term treatment with systemic prednisone on bone healing: an experimental study in rats. Dent Traumatol 21:222-225
8. Gilley RS, Wallace LJ, Bourgeault CA, Kidder LS, Bechtold JE (2009) OP-1 augments glucocorticoid-inhibited fracture healing in a rat fracture model. Clin Orthop Relat Res 467:3104-3112
9. Hauschka PV, Lian JB, Cole DEC, Gundberg CM (1989) Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69:990-1047
10. 2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. J Bone Miner Res 12:431-438
11. Shearer MJ (1995) Vitamin K. Lancet 345:229-234
12. Vermeer C, Jie KSG, Knapen MHJ (1995) Role of vitamin K in bone metabolism. Annu Rev Nutr 15:1-22
13. 2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. J Biol Chem 278:43919-43927
14. 2 (menatetrenone) on bone resorption may be related to its side chain. Bone 16:179-184
15. 2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. J Bone Miner Res 18:776-783 (Pubitemid 36899327)
16. 2 combine to improve the femoral neck strength of ovariectomized rats. Calcif Tissue Int 77:119-126
17. Erben RG (1997) Embedding of bone samples in methylmethacrylate: an improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry. J Histochem Cytochem 45:307-313
18. Chen MM, Yeh JK, Aloia JF, Tierney JM, Sprintz S (1994) Effect of treadmill exercise on tibial cortical bone in aged female rats: a histomorphometry and dual energy X-ray absorptiometry study. Bone 15:313-319
19. Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Norimatsu H (1999) Effect of bisphosphonate (incadronate) on fracture healing of long bones in rats. J Bone Miner Res 14:969-979
20. Cao Y, Mori S, Mashiba T, Westmore MS, Ma L, Sato M, Akiyama T, Shi L, Komatsubara S, Miyamoto K, Norimatsu H (2002) Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res 17:2237-2246
21. 2 on osteoporosis. Curr Pharm Des 10:2557-2576
22. 2 on the development of osteopenia in rats as the models of osteoporosis. Yonsei Med J 47:157-166
23. Shen V, Birchman R, Liang XG, Wu DD, Lindsay R, Dempster DW (1997) Prednisolone alone, or in combination with estrogen or dietary calcium deficiency or immobilization, inhibits bone formation but does not induce bone loss in mature rats. Bone 21:345-351
24. 2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. Bone 31: 575-581