-
1
-
-
0032538973
-
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
-
Abo, A., J. Qu, M.S. Cammarano, C. Dan, A. Fritsch, V. Baud, B. Belisle, and A. Minden. 1998. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J. 17:6527-6540. http://dx.doi.org/10.1093/emboj/17.22.6527
-
(1998)
EMBO J
, vol.17
, pp. 6527-6540
-
-
Abo, A.1
Qu, J.2
Cammarano, M.S.3
Dan, C.4
Fritsch, A.5
Baud, V.6
Belisle, B.7
Minden, A.8
-
2
-
-
43049167377
-
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF
-
Ahmed, T., K. Shea, J.R. Masters, G.E. Jones, and C.M. Wells. 2008. A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF. Cell. Signal. 20:1320-1328. http://dx.doi.org/10.1016/j.cellsig.2008.02.021
-
(2008)
Cell. Signal
, vol.20
, pp. 1320-1328
-
-
Ahmed, T.1
Shea, K.2
Masters, J.R.3
Jones, G.E.4
Wells, C.M.5
-
3
-
-
84863299837
-
Group I and II mammalian PAKs have different modes of activation by Cdc42
-
Baskaran, Y., Y.W. Ng, W. Selamat, F.T. Ling, and E. Manser. 2012. Group I and II mammalian PAKs have different modes of activation by Cdc42. EMBO Rep. 13:653-659. http://dx.doi.org/10.1038/embor.2012.75
-
(2012)
EMBO Rep
, vol.13
, pp. 653-659
-
-
Baskaran, Y.1
Ng, Y.W.2
Selamat, W.3
Ling, F.T.4
Manser, E.5
-
4
-
-
84872175646
-
Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration
-
Bhavsar, P.J., E. Infante, A. Khwaja, and A.J. Ridley. 2013. Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration. Oncogene. 32:198-208. http://dx.doi.org/10.1038/onc.2012.42
-
(2013)
Oncogene
, vol.32
, pp. 198-208
-
-
Bhavsar, P.J.1
Infante, E.2
Khwaja, A.3
Ridley, A.J.4
-
5
-
-
77956389302
-
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis
-
Bompard, G., G. Rabeharivelo, M. Frank, J. Cau, C. Delsert, and N. Morin. 2010. Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. J. Cell Biol. 190:807-822. http://dx.doi.org/10.1083/jcb.200912056
-
(2010)
J. Cell Biol
, vol.190
, pp. 807-822
-
-
Bompard, G.1
Rabeharivelo, G.2
Frank, M.3
Cau, J.4
Delsert, C.5
Morin, N.6
-
6
-
-
0037016748
-
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines
-
Callow, M.G., F. Clairvoyant, S. Zhu, B. Schryver, D.B. Whyte, J.R. Bischoff, B. Jallal, and T. Smeal. 2002. Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J. Biol. Chem. 277:550-558. http://dx.doi.org/10.1074/jbc.M105732200
-
(2002)
J. Biol. Chem
, vol.277
, pp. 550-558
-
-
Callow, M.G.1
Clairvoyant, F.2
Zhu, S.3
Schryver, B.4
Whyte, D.B.5
Bischoff, J.R.6
Jallal, B.7
Smeal, T.8
-
7
-
-
34250830244
-
The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration
-
Chuang, Y.Y., A. Valster, S.J. Coniglio, J.M. Backer, and M. Symons. 2007. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. J. Cell Sci. 120:1927-1934. http://dx.doi.org/10.1242/jcs.03456
-
(2007)
J. Cell Sci
, vol.120
, pp. 1927-1934
-
-
Chuang, Y.Y.1
Valster, A.2
Coniglio, S.J.3
Backer, J.M.4
Symons, M.5
-
8
-
-
84877588213
-
P21-activated kinase 4-not just one of the PAK
-
Dart, A.E., and C.M. Wells. 2013. P21-activated kinase 4-not just one of the PAK. Eur. J. Cell Biol. 92:129-138. http://dx.doi.org/10.1016/j.ejcb.2013.03.002
-
(2013)
Eur. J. Cell Biol
, vol.92
, pp. 129-138
-
-
Dart, A.E.1
Wells, C.M.2
-
9
-
-
80053299062
-
Ubiquitination: Added complexity in Ras and Rho family GTPase function
-
de la Vega, M., J.F. Burrows, and J.A. Johnston. 2011. Ubiquitination: Added complexity in Ras and Rho family GTPase function. Small GTPases. 2:192-201. http://dx.doi.org/10.4161/sgtp.2.4.16707
-
(2011)
Small GTPases
, vol.2
, pp. 192-201
-
-
de la Vega, M.1
Burrows, J.F.2
Johnston, J.A.3
-
10
-
-
84897566387
-
The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis
-
Dickover, M., J.M. Hegarty, K. Ly, D. Lopez, H. Yang, R. Zhang, N. Tedeschi, T.K. Hsiai, and N.C. Chi. 2014. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev. Biol. 389:182-191. http://dx.doi.org/10.1016/j.ydbio.2014.02.014
-
(2014)
Dev. Biol
, vol.389
, pp. 182-191
-
-
Dickover, M.1
Hegarty, J.M.2
Ly, K.3
Lopez, D.4
Yang, H.5
Zhang, R.6
Tedeschi, N.7
Hsiai, T.K.8
Chi, N.C.9
-
11
-
-
59849115232
-
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation
-
Dong, J.M., L.S. Lau, Y.W. Ng, L. Lim, and E. Manser. 2009. Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation. Biochem. J. 418:173-184. http://dx.doi.org/10.1042/BJ20080170
-
(2009)
Biochem. J
, vol.418
, pp. 173-184
-
-
Dong, J.M.1
Lau, L.S.2
Ng, Y.W.3
Lim, L.4
Manser, E.5
-
12
-
-
48349123894
-
UnPAKing the class differences among p21-activated kinases
-
Eswaran, J., M. Soundararajan, R. Kumar, and S. Knapp. 2008. UnPAKing the class differences among p21-activated kinases. Trends Biochem. Sci. 33:394-403. http://dx.doi.org/10.1016/j.tibs.2008.06.002
-
(2008)
Trends Biochem. Sci
, vol.33
, pp. 394-403
-
-
Eswaran, J.1
Soundararajan, M.2
Kumar, R.3
Knapp, S.4
-
13
-
-
2942584851
-
Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues
-
Fay, M.J., K.A. Longo, G.A. Karathanasis, D.M. Shope, C.J. Mandernach, J.R. Leong, A. Hicks, K. Pherson, and A. Husain. 2003. Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues. Mol. Cancer. 2:40. http://dx.doi.org/10.1186/1476-4598-2-40
-
(2003)
Mol. Cancer
, vol.2
, pp. 40
-
-
Fay, M.J.1
Longo, K.A.2
Karathanasis, G.A.3
Shope, D.M.4
Mandernach, C.J.5
Leong, J.R.6
Hicks, A.7
Pherson, K.8
Husain, A.9
-
14
-
-
33845455068
-
EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells
-
Garcia, R., R.A. Franklin, and J.A. McCubrey. 2006. EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells. Cell Cycle. 5:2820-2826. http://dx.doi.org/10.4161/cc.5.23.3535
-
(2006)
Cell Cycle
, vol.5
, pp. 2820-2826
-
-
Garcia, R.1
Franklin, R.A.2
McCubrey, J.A.3
-
15
-
-
0035957986
-
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta, N., J. Qu, and A. Minden. 2001. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 276:14414-14419
-
(2001)
J. Biol. Chem
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
Qu, J.2
Minden, A.3
-
16
-
-
84867043259
-
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
-
Ha, B.H., M.J. Davis, C. Chen, H.J. Lou, J. Gao, R. Zhang, M. Krauthammer, R. Halaban, J. Schlessinger, B.E. Turk, and T.J. Boggon. 2012. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc. Natl. Acad. Sci. USA. 109:16107-16112. http://dx.doi.org/10.1073/pnas.1214447109
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 16107-16112
-
-
Ha, B.H.1
Davis, M.J.2
Chen, C.3
Lou, H.J.4
Gao, J.5
Zhang, R.6
Krauthammer, M.7
Halaban, R.8
Schlessinger, J.9
Turk, B.E.10
Boggon, T.J.11
-
17
-
-
84862726617
-
Coordination between RAB GTPase and phosphoinositide regulation and functions
-
Jean, S., and A.A. Kiger. 2012. Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat. Rev. Mol. Cell Biol. 13:463-470. http://dx.doi.org/10.1038/nrm3379
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 463-470
-
-
Jean, S.1
Kiger, A.A.2
-
18
-
-
84875259201
-
Ubiquitin- omics reveals novel networks and associations with human disease
-
Kessler, B.M. 2013. Ubiquitin- omics reveals novel networks and associations with human disease. Curr. Opin. Chem. Biol. 17:59-65. http://dx.doi.org/10.1016/j.cbpa.2012.12.024
-
(2013)
Curr. Opin. Chem. Biol
, vol.17
, pp. 59-65
-
-
Kessler, B.M.1
-
19
-
-
0036558025
-
The SOCS box: a tale of destruction and degradation
-
Kile, B.T., B.A. Schulman, W.S. Alexander, N.A. Nicola, H.M. Martin, and D.J. Hilton. 2002. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27:235-241. http://dx.doi.org/10.1016/S0968-0004(02)02085-6
-
(2002)
Trends Biochem. Sci
, vol.27
, pp. 235-241
-
-
Kile, B.T.1
Schulman, B.A.2
Alexander, W.S.3
Nicola, N.A.4
Martin, H.M.5
Hilton, D.J.6
-
20
-
-
0034810488
-
WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells
-
Kirikoshi, H., H. Sekihara, and M. Katoh. 2001. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem. Biophys. Res. Commun. 283:798-805. http://dx.doi.org/10.1006/bbrc.2001.4855
-
(2001)
Biochem. Biophys. Res. Commun
, vol.283
, pp. 798-805
-
-
Kirikoshi, H.1
Sekihara, H.2
Katoh, M.3
-
21
-
-
34547798463
-
XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway
-
Lee, R.H., H. Iioka, M. Ohashi, S. Iemura, T. Natsume, and N. Kinoshita. 2007. XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J. 26:3592-3606. http://dx.doi.org/10.1038/sj.emboj.7601781
-
(2007)
EMBO J
, vol.26
, pp. 3592-3606
-
-
Lee, R.H.1
Iioka, H.2
Ohashi, M.3
Iemura, S.4
Natsume, T.5
Kinoshita, N.6
-
22
-
-
29244439927
-
PAK4 functions in tumor necrosis factor (TNF)α-induced survival pathways by facilitating TRA DD binding to the TNF receptor
-
Li, X., and A. Minden. 2005. PAK4 functions in tumor necrosis factor (TNF)α-induced survival pathways by facilitating TRA DD binding to the TNF receptor. J. Biol. Chem. 280:41192-41200. http://dx.doi.org/10.1074/jbc.M506884200
-
(2005)
J. Biol. Chem
, vol.280
, pp. 41192-41200
-
-
Li, X.1
Minden, A.2
-
23
-
-
84862816551
-
Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling
-
Li, Y., Y. Shao, Y. Tong, T. Shen, J. Zhang, Y. Li, H. Gu, and F. Li. 2012. Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling. Biochim. Biophys. Acta. 1823:465-475. http://dx.doi.org/10.1016/j.bbamcr.2011.11.013
-
(2012)
Biochim. Biophys. Acta
, vol.1823
, pp. 465-475
-
-
Li, Y.1
Shao, Y.2
Tong, Y.3
Shen, T.4
Zhang, J.5
Li, Y.6
Gu, H.7
Li, F.8
-
24
-
-
51649119414
-
The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice
-
Liu, Y., H. Xiao, Y. Tian, T. Nekrasova, X. Hao, H.J. Lee, N. Suh, C.S. Yang, and A. Minden. 2008. The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol. Cancer Res. 6:1215-1224. http://dx.doi.org/10.1158/1541-7786.MCR-08-0087
-
(2008)
Mol. Cancer Res
, vol.6
, pp. 1215-1224
-
-
Liu, Y.1
Xiao, H.2
Tian, Y.3
Nekrasova, T.4
Hao, X.5
Lee, H.J.6
Suh, N.7
Yang, C.S.8
Minden, A.9
-
25
-
-
78149466325
-
The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis
-
Liu, Y., N. Chen, X. Cui, X. Zheng, L. Deng, S. Price, V. Karantza, and A. Minden. 2010. The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene. 29:5883-5894. http://dx.doi.org/10.1038/onc.2010.329
-
(2010)
Oncogene
, vol.29
, pp. 5883-5894
-
-
Liu, Y.1
Chen, N.2
Cui, X.3
Zheng, X.4
Deng, L.5
Price, S.6
Karantza, V.7
Minden, A.8
-
26
-
-
77952720804
-
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
-
Murray, B.W., C. Guo, J. Piraino, J.K. Westwick, C. Zhang, J. Lamerdin, E. Dagostino, D. Knighton, C.M. Loi, M. Zager, et al. 2010. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc. Natl. Acad. Sci. USA. 107:9446-9451. http://dx.doi.org/10.1073/pnas.0911863107
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9446-9451
-
-
Murray, B.W.1
Guo, C.2
Piraino, J.3
Westwick, J.K.4
Zhang, C.5
Lamerdin, J.6
Dagostino, E.7
Knighton, D.8
Loi, C.M.9
Zager, M.10
-
27
-
-
33646776346
-
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics
-
Nayal, A., D.J. Webb, C.M. Brown, E.M. Schaefer, M. Vicente-Manzanares, and A.R. Horwitz. 2006. Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. J. Cell Biol. 173:587-589. http://dx.doi.org/10.1083/jcb.200509075
-
(2006)
J. Cell Biol
, vol.173
, pp. 587-589
-
-
Nayal, A.1
Webb, D.J.2
Brown, C.M.3
Schaefer, E.M.4
Vicente-Manzanares, M.5
Horwitz, A.R.6
-
28
-
-
78649729521
-
The role of ubiquitylation and degradation in RhoGTPase signalling
-
Nethe, M., and P.L. Hordijk. 2010. The role of ubiquitylation and degradation in RhoGTPase signalling. J. Cell Sci. 123:4011-4018. http://dx.doi.org/10.1242/jcs.078360
-
(2010)
J. Cell Sci
, vol.123
, pp. 4011-4018
-
-
Nethe, M.1
Hordijk, P.L.2
-
29
-
-
77953162073
-
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway
-
Nethe, M., E.C. Anthony, M. Fernandez-Borja, R. Dee, D. Geerts, P.J. Hensbergen, A.M. Deelder, G. Schmidt, and P.L. Hordijk. 2010. Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J. Cell Sci. 123:1948-1958. http://dx.doi.org/10.1242/jcs.062919
-
(2010)
J. Cell Sci
, vol.123
, pp. 1948-1958
-
-
Nethe, M.1
Anthony, E.C.2
Fernandez-Borja, M.3
Dee, R.4
Geerts, D.5
Hensbergen, P.J.6
Deelder, A.M.7
Schmidt, G.8
Hordijk, P.L.9
-
30
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
Neve, R.M., K. Chin, J. Fridlyand, J. Yeh, F.L. Baehner, T. Fevr, L. Clark, N. Bayani, J.P. Coppe, F. Tong, et al. 2006. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 10:515-527. http://dx.doi.org/10.1016/j.ccr.2006.10.008
-
(2006)
Cancer Cell
, vol.10
, pp. 515-527
-
-
Neve, R.M.1
Chin, K.2
Fridlyand, J.3
Yeh, J.4
Baehner, F.L.5
Fevr, T.6
Clark, L.7
Bayani, N.8
Coppe, J.P.9
Tong, F.10
-
31
-
-
0029114101
-
Staurosporine, a potentially important gift from a microorganism
-
Omura, S., Y. Sasaki, Y. Iwai, and H. Takeshima. 1995. Staurosporine, a potentially important gift from a microorganism. J. Antibiot. 48:535-548. http://dx.doi.org/10.7164/antibiotics.48.535
-
(1995)
J. Antibiot
, vol.48
, pp. 535-548
-
-
Omura, S.1
Sasaki, Y.2
Iwai, Y.3
Takeshima, H.4
-
32
-
-
36749082817
-
Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration
-
Ory, S., H. Brazier, and A. Blangy. 2007. Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration. Biol. Cell. 99:701-716. http://dx.doi.org/10.1042/BC20070058
-
(2007)
Biol. Cell
, vol.99
, pp. 701-716
-
-
Ory, S.1
Brazier, H.2
Blangy, A.3
-
33
-
-
84877633978
-
p21-Activated kinase 4 promotes prostate cancer progression through CREB
-
Park, M.H., H.S. Lee, C.S. Lee, S.T. You, D.J. Kim, B.H. Park, M.J. Kang, W.D. Heo, E.Y. Shin, M.A. Schwartz, and E.G. Kim. 2013. p21-Activated kinase 4 promotes prostate cancer progression through CREB. Oncogene. 32:2475-2482. http://dx.doi.org/10.1038/onc.2012.255
-
(2013)
Oncogene
, vol.32
, pp. 2475-2482
-
-
Park, M.H.1
Lee, H.S.2
Lee, C.S.3
You, S.T.4
Kim, D.J.5
Park, B.H.6
Kang, M.J.7
Heo, W.D.8
Shin, E.Y.9
Schwartz, M.A.10
Kim, E.G.11
-
34
-
-
0141819123
-
PAK4 kinase is essential for embryonic viability and for proper neuronal development
-
Qu, J., X. Li, B.G. Novitch, Y. Zheng, M. Kohn, J.M. Xie, S. Kozinn, R. Bronson, A.A. Beg, and A. Minden. 2003. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol. Cell. Biol. 23:7122-7133. http://dx.doi.org/10.1128/MCB.23.20.7122-7133.2003
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 7122-7133
-
-
Qu, J.1
Li, X.2
Novitch, B.G.3
Zheng, Y.4
Kohn, M.5
Xie, J.M.6
Kozinn, S.7
Bronson, R.8
Beg, A.A.9
Minden, A.10
-
35
-
-
84859085199
-
ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression
-
Rafn, B., C.F. Nielsen, S.H. Andersen, P. Szyniarowski, E. Corcelle-Termeau, E. Valo, N. Fehrenbacher, C.J. Olsen, M. Daugaard, C. Egebjerg, et al. 2012. ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. Mol. Cell. 45:764-776. http://dx.doi.org/10.1016/j.molcel.2012.01.029
-
(2012)
Mol. Cell
, vol.45
, pp. 764-776
-
-
Rafn, B.1
Nielsen, C.F.2
Andersen, S.H.3
Szyniarowski, P.4
Corcelle-Termeau, E.5
Valo, E.6
Fehrenbacher, N.7
Olsen, C.J.8
Daugaard, M.9
Egebjerg, C.10
-
36
-
-
80455143827
-
SHA RPIN is an endogenous inhibitor of β1-integrin activation
-
Rantala, J.K., J. Pouwels, T. Pellinen, S. Veltel, P. Laasola, E. Mattila, C.S. Potter, T. Duffy, J.P. Sundberg, O. Kallioniemi, et al. 2011. SHA RPIN is an endogenous inhibitor of β1-integrin activation. Nat. Cell Biol. 13:1315-1324. http://dx.doi.org/10.1038/ncb2340
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 1315-1324
-
-
Rantala, J.K.1
Pouwels, J.2
Pellinen, T.3
Veltel, S.4
Laasola, P.5
Mattila, E.6
Potter, C.S.7
Duffy, T.8
Sundberg, J.P.9
Kallioniemi, O.10
-
37
-
-
0033767235
-
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
-
Rodriguez, M.S., J.M. Desterro, S. Lain, D.P. Lane, and R.T. Hay. 2000. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol. Cell. Biol. 20:8458-8467. http://dx.doi.org/10.1128/MCB.20.22.8458-8467.2000
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 8458-8467
-
-
Rodriguez, M.S.1
Desterro, J.M.2
Lain, S.3
Lane, D.P.4
Hay, R.T.5
-
38
-
-
20444480169
-
Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells
-
Rolli-Derkinderen, M., V. Sauzeau, L. Boyer, E. Lemichez, C. Baron, D. Henrion, G. Loirand, and P. Pacaud. 2005. Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Circ. Res. 96:1152-1160. http://dx.doi.org/10.1161/01.RES.0000170084.88780.ea
-
(2005)
Circ. Res
, vol.96
, pp. 1152-1160
-
-
Rolli-Derkinderen, M.1
Sauzeau, V.2
Boyer, L.3
Lemichez, E.4
Baron, C.5
Henrion, D.6
Loirand, G.7
Pacaud, P.8
-
39
-
-
4444240175
-
Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects
-
Saras, J., P. Wollberg, and P. Aspenström. 2004. Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects. Exp. Cell Res. 299:356-369. http://dx.doi.org/10.1016/j.yexcr.2004.05.029
-
(2004)
Exp. Cell Res
, vol.299
, pp. 356-369
-
-
Saras, J.1
Wollberg, P.2
Aspenström, P.3
-
40
-
-
67650908700
-
The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways
-
Schiavone, D., S. Dewilde, F. Vallania, J. Turkson, F. Di Cunto, and V. Poli. 2009. The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways. Biochem. J. 421:283-292. http://dx.doi.org/10.1042/BJ20090061
-
(2009)
Biochem. J
, vol.421
, pp. 283-292
-
-
Schiavone, D.1
Dewilde, S.2
Vallania, F.3
Turkson, J.4
Di Cunto, F.5
Poli, V.6
-
41
-
-
84856618073
-
Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV
-
Shepelev, M.V., and I.V. Korobko. 2012. Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. Biochemistry Mosc. 77:26-32. http://dx.doi.org/10.1134/S0006297912010038
-
(2012)
Biochemistry Mosc
, vol.77
, pp. 26-32
-
-
Shepelev, M.V.1
Korobko, I.V.2
-
42
-
-
9244239247
-
Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase
-
Shutes, A., A.C. Berzat, A.D. Cox, and C.J. Der. 2004. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Curr. Biol. 14:2052-2056. http://dx.doi.org/10.1016/j.cub.2004.11.011
-
(2004)
Curr. Biol
, vol.14
, pp. 2052-2056
-
-
Shutes, A.1
Berzat, A.C.2
Cox, A.D.3
Der, C.J.4
-
43
-
-
78649880786
-
p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
-
Siu, M.K., H.Y. Chan, D.S. Kong, E.S. Wong, O.G. Wong, H.Y. Ngan, K.F. Tam, H. Zhang, Z. Li, Q.K. Chan, et al. 2010. p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients. Proc. Natl. Acad. Sci. USA. 107:18622-18627. http://dx.doi.org/10.1073/pnas.0907481107
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18622-18627
-
-
Siu, M.K.1
Chan, H.Y.2
Kong, D.S.3
Wong, E.S.4
Wong, O.G.5
Ngan, H.Y.6
Tam, K.F.7
Zhang, H.8
Li, Z.9
Chan, Q.K.10
-
44
-
-
84874424655
-
Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling
-
Tabusa, H., T. Brooks, and A.J. Massey. 2013. Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. Mol. Cancer Res. 11:109-121. http://dx.doi.org/10.1158/1541-7786.MCR-12-0466
-
(2013)
Mol. Cancer Res
, vol.11
, pp. 109-121
-
-
Tabusa, H.1
Brooks, T.2
Massey, A.J.3
-
45
-
-
0035878110
-
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1
-
Tao, W., D. Pennica, L. Xu, R.F. Kalejta, and A.J. Levine. 2001. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 15:1796-1807. http://dx.doi.org/10.1101/gad.894301
-
(2001)
Genes Dev
, vol.15
, pp. 1796-1807
-
-
Tao, W.1
Pennica, D.2
Xu, L.3
Kalejta, R.F.4
Levine, A.J.5
-
46
-
-
84894096603
-
Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation
-
Teckchandani, A., G.S. Laszlo, S. Simó, K. Shah, C. Pilling, A.A. Strait, and J.A. Cooper. 2014. Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation. J. Cell Sci. 127:509-520. http://dx.doi.org/10.1242/jcs.127829
-
(2014)
J. Cell Sci
, vol.127
, pp. 509-520
-
-
Teckchandani, A.1
Laszlo, G.S.2
Simó, S.3
Shah, K.4
Pilling, C.5
Strait, A.A.6
Cooper, J.A.7
-
47
-
-
0032884277
-
Association of in vitro invasiveness and gene expression of estrogen receptor, progesterone receptor, pS2 and plasminogen activator inhibitor-1 in human breast cancer cell lines
-
Tong, D., K. Czerwenka, J. Sedlak, C. Schneeberger, I. Schiebel, N. Concin, S. Leodolter, and R. Zeillinger. 1999. Association of in vitro invasiveness and gene expression of estrogen receptor, progesterone receptor, pS2 and plasminogen activator inhibitor-1 in human breast cancer cell lines. Breast Cancer Res. Treat. 56:91-97. http://dx.doi.org/10.1023/A:1006262501062
-
(1999)
Breast Cancer Res. Treat
, vol.56
, pp. 91-97
-
-
Tong, D.1
Czerwenka, K.2
Sedlak, J.3
Schneeberger, C.4
Schiebel, I.5
Concin, N.6
Leodolter, S.7
Zeillinger, R.8
-
48
-
-
0034680895
-
Characterization of TCL, a new GTPase of the rho family related to TC10 and Cdc42
-
Vignal, E., M. De Toledo, F. Comunale, A. Ladopoulou, C. Gauthier-Rouvière, A. Blangy, and P. Fort. 2000. Characterization of TCL, a new GTPase of the rho family related to TC10 and Cdc42. J. Biol. Chem. 275:36457-36464. http://dx.doi.org/10.1074/jbc.M003487200
-
(2000)
J. Biol. Chem
, vol.275
, pp. 36457-36464
-
-
Vignal, E.1
De Toledo, M.2
Comunale, F.3
Ladopoulou, A.4
Gauthier-Rouvière, C.5
Blangy, A.6
Fort, P.7
-
49
-
-
37849050182
-
Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process
-
Visvikis, O., P. Lorès, L. Boyer, P. Chardin, E. Lemichez, and G. Gacon. 2008. Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process. FEBS J. 275:386-396. http://dx.doi.org/10.1111/j.1742-4658.2007.06209.x
-
(2008)
FEBS J
, vol.275
, pp. 386-396
-
-
Visvikis, O.1
Lorès, P.2
Boyer, L.3
Chardin, P.4
Lemichez, E.5
Gacon, G.6
-
50
-
-
84867103151
-
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues
-
Wagner, S.A., P. Beli, B.T. Weinert, C. Schölz, C.D. Kelstrup, C. Young, M.L. Nielsen, J.V. Olsen, C. Brakebusch, and C. Choudhary. 2012. Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol. Cell. Proteomics. 11:1578-1585. http://dx.doi.org/10.1074/mcp.M112.017905
-
(2012)
Mol. Cell. Proteomics
, vol.11
, pp. 1578-1585
-
-
Wagner, S.A.1
Beli, P.2
Weinert, B.T.3
Schölz, C.4
Kelstrup, C.D.5
Young, C.6
Nielsen, M.L.7
Olsen, J.V.8
Brakebusch, C.9
Choudhary, C.10
-
51
-
-
77956247092
-
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B
-
Wallace, S.W., J. Durgan, D. Jin, and A. Hall. 2010. Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol. Biol. Cell. 21:2996-3006. http://dx.doi.org/10.1091/mbc.E10-05-0429
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2996-3006
-
-
Wallace, S.W.1
Durgan, J.2
Jin, D.3
Hall, A.4
-
52
-
-
84878972377
-
K63-linked ubiquitination in kinase activation and cancer
-
Wang, G., Y. Gao, L. Li, G. Jin, Z. Cai, J.I. Chao, and H.K. Lin. 2012. K63-linked ubiquitination in kinase activation and cancer. Front Oncol. 2:5. http://dx.doi.org/10.3389/fonc.2012.00005
-
(2012)
Front Oncol
, vol.2
, pp. 5
-
-
Wang, G.1
Gao, Y.2
Li, L.3
Jin, G.4
Cai, Z.5
Chao, J.I.6
Lin, H.K.7
-
53
-
-
84881554400
-
NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1
-
Wang, W., L. Lim, Y. Baskaran, E. Manser, and J. Song. 2013. NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1. Biochem. Biophys. Res. Commun. 438:169-174. http://dx.doi.org/10.1016/j.bbrc.2013.07.047
-
(2013)
Biochem. Biophys. Res. Commun
, vol.438
, pp. 169-174
-
-
Wang, W.1
Lim, L.2
Baskaran, Y.3
Manser, E.4
Song, J.5
-
54
-
-
84857686971
-
Structure and function of focal adhesions
-
Wehrle-Haller, B. 2012. Structure and function of focal adhesions. Curr. Opin. Cell Biol. 24:116-124. http://dx.doi.org/10.1016/j.ceb.2011.11.001
-
(2012)
Curr. Opin. Cell Biol
, vol.24
, pp. 116-124
-
-
Wehrle-Haller, B.1
-
55
-
-
0035292759
-
Themes and variations on ubiquitylation
-
Weissman, A.M. 2001. Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Biol. 2:169-178. http://dx.doi.org/10.1038/35056563
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 169-178
-
-
Weissman, A.M.1
-
56
-
-
0037107548
-
PAK4 is activated via PI3K in HGF-stimulated epithelial cells
-
Wells, C.M., A. Abo, and A.J. Ridley. 2002. PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J. Cell Sci. 115:3947-3956. http://dx.doi.org/10.1242/jcs.00080
-
(2002)
J. Cell Sci
, vol.115
, pp. 3947-3956
-
-
Wells, C.M.1
Abo, A.2
Ridley, A.J.3
-
57
-
-
77952361543
-
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion
-
Wells, C.M., A.D. Whale, M. Parsons, J.R. Masters, and G.E. Jones. 2010. PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J. Cell Sci. 123:1663-1673. http://dx.doi.org/10.1242/jcs.055707
-
(2010)
J. Cell Sci
, vol.123
, pp. 1663-1673
-
-
Wells, C.M.1
Whale, A.D.2
Parsons, M.3
Masters, J.R.4
Jones, G.E.5
-
58
-
-
84876695177
-
PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity
-
Whale, A.D., A. Dart, M. Holt, G.E. Jones, and C.M. Wells. 2013. PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity. Oncogene. 32:2114-2120. http://dx.doi.org/10.1038/onc.2012.233
-
(2013)
Oncogene
, vol.32
, pp. 2114-2120
-
-
Whale, A.D.1
Dart, A.2
Holt, M.3
Jones, G.E.4
Wells, C.M.5
-
59
-
-
84904279179
-
RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly
-
Wilson, E., K. Leszczynska, N.S. Poulter, F. Edelmann, V.A. Salisbury, P.J. Noy, A. Bacon, J.Z. Rappoport, J.K. Heath, R. Bicknell, and V.L. Heath. 2014. RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly. J. Cell Sci. 127:3039-3051. http://dx.doi.org/10.1242/jcs.140434
-
(2014)
J. Cell Sci
, vol.127
, pp. 3039-3051
-
-
Wilson, E.1
Leszczynska, K.2
Poulter, N.S.3
Edelmann, F.4
Salisbury, V.A.5
Noy, P.J.6
Bacon, A.7
Rappoport, J.Z.8
Heath, J.K.9
Bicknell, R.10
Heath, V.L.11
-
60
-
-
33750509850
-
Multiple Rho proteins regulate the subcellular targeting of PAK5
-
Wu, X., and J.A. Frost. 2006. Multiple Rho proteins regulate the subcellular targeting of PAK5. Biochem. Biophys. Res. Commun. 351:328-335. http://dx.doi.org/10.1016/j.bbrc.2006.09.172
-
(2006)
Biochem. Biophys. Res. Commun
, vol.351
, pp. 328-335
-
-
Wu, X.1
Frost, J.A.2
-
61
-
-
67651083565
-
Chromosomal changes in aggressive breast cancers with basal-like features
-
Yu, W., Y. Kanaan, Y.K. Bae, and E. Gabrielson. 2009. Chromosomal changes in aggressive breast cancers with basal-like features. Cancer Genet. Cytogenet. 193:29-37. http://dx.doi.org/10.1016/j.cancergencyto.2009.03.017
-
(2009)
Cancer Genet. Cytogenet
, vol.193
, pp. 29-37
-
-
Yu, W.1
Kanaan, Y.2
Bae, Y.K.3
Gabrielson, E.4
-
62
-
-
79955766598
-
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma
-
Zhang, H.J., M.K. Siu, M.C. Yeung, L.L. Jiang, V.C. Mak, H.Y. Ngan, O.G. Wong, H.Q. Zhang, and A.N. Cheung. 2011. Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma. Carcinogenesis. 32:765-771. http://dx.doi.org/10.1093/carcin/bgr033
-
(2011)
Carcinogenesis
, vol.32
, pp. 765-771
-
-
Zhang, H.J.1
Siu, M.K.2
Yeung, M.C.3
Jiang, L.L.4
Mak, V.C.5
Ngan, H.Y.6
Wong, O.G.7
Zhang, H.Q.8
Cheung, A.N.9
-
63
-
-
84856352028
-
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
-
Zhang, J., J. Wang, Q. Guo, Y. Wang, Y. Zhou, H. Peng, M. Cheng, D. Zhao, and F. Li. 2012. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 317:24-32. http://dx.doi.org/10.1016/j.canlet.2011.11.007
-
(2012)
Cancer Lett
, vol.317
, pp. 24-32
-
-
Zhang, J.1
Wang, J.2
Guo, Q.3
Wang, Y.4
Zhou, Y.5
Peng, H.6
Cheng, M.7
Zhao, D.8
Li, F.9
|