LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

Cancer Letters

Volumn 317, Issue 1, 2012, Pages 24-32

  Zhang, Jian ^a   Wang, Jian ^b   Guo, Qiqiang ^a   Wang, Yu ^b   Zhou, Ying ^a   Peng, Huizhi ^a   Cheng, Maosheng ^b   Zhao, Dongmei ^b   Li, Feng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Gastric cancer; Inhibitor; Invasion; PAK4; Proliferation

Indexed keywords

ANTINEOPLASTIC AGENT; LCH 7749944; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N2 (3 METHOXYPHENYL) N4 [(TETRAHYDROFURAN 2 YL)METHYL]QUINAZOLINE 2,4 DIAMINE; P21 ACTIVATED KINASE 4; PROTEIN KINASE P60; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; CELL CYCLE ARREST; CELL ELONGATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FLOW CYTOMETRY; GENETIC ALGORITHM; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STOMACH CANCER;

ACTIN DEPOLYMERIZING FACTORS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIM KINASES; MAP KINASE KINASE 1; MATRIX METALLOPROTEINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASM INVASIVENESS; P21-ACTIVATED KINASES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PSEUDOPODIA; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84856352028     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.11.007     Document Type: Article

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