Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

Journal of Hepatology

Volumn 65, Issue 2, 2016, Pages 354-362

  Ni, Hong Min ^a   McGill, Mitchell R ^a   Chao, Xiaojuan ^a   Du, Kuo ^a   Williams, Jessica A ^a   Xie, Yuchao ^a   Jaeschke, Hartmut ^a   Ding, Wen Xing ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Acetaminophen protein adducts; Autophagy; Liver injury; p62 SQSTM1

Indexed keywords

ACETAMINOPHEN PROTEIN ADDUCT; ALANINE AMINOTRANSFERASE; CELL PROTEIN; CHLOROQUINE; GLUTATHIONE; LEUPEPTIN; LIVER PROTECTIVE AGENT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PARACETAMOL; PROTEIN P62; SHORT HAIRPIN RNA; TORIN 1; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; C57BL 6 MOUSE; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ELECTROCHEMISTRY; GENE SILENCING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER CELL DAMAGE; LIVER NECROSIS; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SELECTIVE AUTOPHAGY; TOXIC HEPATITIS; WESTERN BLOTTING; ANIMAL; AUTOPHAGY; C57BL MOUSE; LIVER;

ACETAMINOPHEN; ANIMALS; AUTOPHAGY; CHEMICAL AND DRUG INDUCED LIVER INJURY; HEPATOCYTES; LIVER; MICE; MICE, INBRED C57BL;

EID: 84969944929     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.04.025     Document Type: Article

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