BMP4 signaling is able to induce an epithelial-mesenchymal transition-like phenotype in Barrett's esophagus and esophageal adenocarcinoma through induction of SNAIL2

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Kestens, Christine ^a   Siersema, Peter D ^a,b   Offerhaus, G Johan A ^a   Van Baal, Jantine W P M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 4; CDH2 PROTEIN; NOGGIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; BMP4 PROTEIN, HUMAN; SNAI1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SNAIL;

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CELL MIGRATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGEAL ADENOCARCINOMA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MIDDLE AGED; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS EPITHELIUM CELL; UPREGULATION; VERY ELDERLY; ADENOCARCINOMA; CELL CULTURE; CELL LINE; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; ESOPHAGUS TUMOR; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; BONE MORPHOGENETIC PROTEIN 4; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; SIGNAL TRANSDUCTION; SNAIL FAMILY TRANSCRIPTION FACTORS;

EID: 84969902718     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0155754     Document Type: Article

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