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Volumn 32, Issue 3, 2014, Pages 636-648

BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2

Author keywords

BMP; EMT; Human ESCs; Mesodermal differentiation; MSX2; SLUG

Indexed keywords

BMP; EMT; HUMAN ESCS; MESODERMAL DIFFERENTIATION; MSX2; SLUG;

EID: 84894283160     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1592     Document Type: Article
Times cited : (75)

References (58)
  • 1
    • 33645469939 scopus 로고    scopus 로고
    • Functions of the TGFbeta superfamily in human embryonic stem cells
    • Valdimarsdottir G, and, Mummery C,. Functions of the TGFbeta superfamily in human embryonic stem cells. APMIS 2005; 113: 773-789.
    • (2005) APMIS , vol.113 , pp. 773-789
    • Valdimarsdottir, G.1    Mummery, C.2
  • 2
    • 70349173392 scopus 로고    scopus 로고
    • Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery
    • Braam SR, Passier R, Mummery CL,. Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery. Trends Pharmacol Sci 2009; 30: 536-545.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 536-545
    • Braam, S.R.1    Passier, R.2    Mummery, C.L.3
  • 3
    • 0033625416 scopus 로고    scopus 로고
    • Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
    • Goumans MJ, Mummery C,. Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Int J Dev Biol 2000; 44: 253-265.
    • (2000) Int J Dev Biol , vol.44 , pp. 253-265
    • Goumans, M.J.1    Mummery, C.2
  • 4
    • 77449161605 scopus 로고    scopus 로고
    • Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells
    • Greber B, Wu G, Bernemann C, et al. Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 2010; 6: 215-226.
    • (2010) Cell Stem Cell , vol.6 , pp. 215-226
    • Greber, B.1    Wu, G.2    Bernemann, C.3
  • 5
    • 84857991080 scopus 로고    scopus 로고
    • Tracking the progression of the human inner cell mass during embryonic stem cell derivation
    • O'Leary T, Heindryckx B, Lierman S, et al. Tracking the progression of the human inner cell mass during embryonic stem cell derivation. Nat Biotechnol 2012; 30: 278-282.
    • (2012) Nat Biotechnol , vol.30 , pp. 278-282
    • O'Leary, T.1    Heindryckx, B.2    Lierman, S.3
  • 6
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying QL, Nichols J, Chambers I, et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003; 115: 281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3
  • 7
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • James D, Levine AJ, Besser D, et al. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005; 132: 1273-1282.
    • (2005) Development , vol.132 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3
  • 8
    • 20144380595 scopus 로고    scopus 로고
    • Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium
    • Xu C, Rosler E, Jiang J, et al. Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium. Stem Cells 2005; 23: 315-323.
    • (2005) Stem Cells , vol.23 , pp. 315-323
    • Xu, C.1    Rosler, E.2    Jiang, J.3
  • 9
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J,. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 10
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFbeta signal transduction
    • Moustakas A, Heldin CH,. The regulation of TGFbeta signal transduction. Development 2009; 136: 3699-3714.
    • (2009) Development , vol.136 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.H.2
  • 12
    • 0036910425 scopus 로고    scopus 로고
    • Two major Smad pathways in TGF-beta superfamily signalling
    • Miyazawa K, Shinozaki M, Hara T, et al. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 2002; 7: 1191-1204.
    • (2002) Genes Cells , vol.7 , pp. 1191-1204
    • Miyazawa, K.1    Shinozaki, M.2    Hara, T.3
  • 13
    • 0028970392 scopus 로고
    • Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development
    • Johansson BM, Wiles MV,. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 1995; 15: 141-151.
    • (1995) Mol Cell Biol , vol.15 , pp. 141-151
    • Johansson, B.M.1    Wiles, M.V.2
  • 14
    • 3543053797 scopus 로고    scopus 로고
    • Spatio-temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins
    • Monteiro RM, de Sousa Lopes SM, Korchynskyi O, et al. Spatio-temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins. J Cell Sci 2004; 117: 4653-4663.
    • (2004) J Cell Sci , vol.117 , pp. 4653-4663
    • Monteiro, R.M.1    De Sousa Lopes, S.M.2    Korchynskyi, O.3
  • 15
    • 1842426937 scopus 로고    scopus 로고
    • Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
    • Pera MF, Andrade J, Houssami S, et al. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci 2004; 117: 1269-1280.
    • (2004) J Cell Sci , vol.117 , pp. 1269-1280
    • Pera, M.F.1    Andrade, J.2    Houssami, S.3
  • 16
    • 74949122105 scopus 로고    scopus 로고
    • BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway
    • Bai H, Gao Y, Arzigian M, et al. BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway. J Cell Biochem 2010; 109: 363-374.
    • (2010) J Cell Biochem , vol.109 , pp. 363-374
    • Bai, H.1    Gao, Y.2    Arzigian, M.3
  • 17
    • 0033538447 scopus 로고    scopus 로고
    • Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
    • Hollnagel A, Oehlmann V, Heymer J, et al. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 1999; 274: 19838-19845.
    • (1999) J Biol Chem , vol.274 , pp. 19838-19845
    • Hollnagel, A.1    Oehlmann, V.2    Heymer, J.3
  • 18
    • 1842853507 scopus 로고    scopus 로고
    • BMP4 initiates human embryonic stem cell differentiation to trophoblast
    • Xu RH, Chen X, Li DS, et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 2002; 20: 1261-1264.
    • (2002) Nat Biotechnol , vol.20 , pp. 1261-1264
    • Xu, R.H.1    Chen, X.2    Li, D.S.3
  • 19
    • 0037871588 scopus 로고    scopus 로고
    • Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    • Chadwick K, Wang L, Li L, et al. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003; 102: 906-915.
    • (2003) Blood , vol.102 , pp. 906-915
    • Chadwick, K.1    Wang, L.2    Li, L.3
  • 20
    • 33947587879 scopus 로고    scopus 로고
    • Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures
    • Kennedy M, D'Souza SL, Lynch-Kattman M, et al. Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 2007; 109: 2679-2687.
    • (2007) Blood , vol.109 , pp. 2679-2687
    • Kennedy, M.1    D'Souza, S.L.2    Lynch-Kattman, M.3
  • 21
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    • Laflamme MA, Chen KY, Naumova AV, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007; 25: 1015-1024.
    • (2007) Nat Biotechnol , vol.25 , pp. 1015-1024
    • Laflamme, M.A.1    Chen, K.Y.2    Naumova, A.V.3
  • 22
    • 76349087336 scopus 로고    scopus 로고
    • Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent
    • James D, Nam HS, Seandel M, et al. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol 2010; 28: 161-166.
    • (2010) Nat Biotechnol , vol.28 , pp. 161-166
    • James, D.1    Nam, H.S.2    Seandel, M.3
  • 23
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    • Yang L, Soonpaa MH, Adler ED, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 2008; 453: 524-528.
    • (2008) Nature , vol.453 , pp. 524-528
    • Yang, L.1    Soonpaa, M.H.2    Adler, E.D.3
  • 24
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • Micalizzi DS, Farabaugh SM, Ford HL,. Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15: 117-134.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 25
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes
    • Fuxe J, Vincent T, Garcia de Herreros A,. Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes. Cell Cycle 2010; 9: 2363-2374.
    • (2010) Cell Cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    Garcia De Herreros, A.3
  • 26
    • 12144288049 scopus 로고    scopus 로고
    • Derivation of embryonic stem-cell lines from human blastocysts
    • Cowan CA, Klimanskaya I, McMahon J, et al. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 2004; 350: 1353-1356.
    • (2004) N Engl J Med , vol.350 , pp. 1353-1356
    • Cowan, C.A.1    Klimanskaya, I.2    McMahon, J.3
  • 27
    • 43149101280 scopus 로고    scopus 로고
    • A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies
    • Ng ES, Davis R, Stanley EG, et al. A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nat Protoc 2008; 3: 768-776.
    • (2008) Nat Protoc , vol.3 , pp. 768-776
    • Ng, E.S.1    Davis, R.2    Stanley, E.G.3
  • 28
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman LB, De Jesus-Escobar JM, Harland RM,. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 1996; 86: 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3
  • 29
    • 48149098004 scopus 로고    scopus 로고
    • NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs
    • Xu RH, Sampsell-Barron TL, Gu F, et al. NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 2008; 3: 196-206.
    • (2008) Cell Stem Cell , vol.3 , pp. 196-206
    • Xu, R.H.1    Sampsell-Barron, T.L.2    Gu, F.3
  • 30
    • 7244240749 scopus 로고    scopus 로고
    • Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3
    • Besser D,. Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. J Biol Chem 2004; 279: 45076-45084.
    • (2004) J Biol Chem , vol.279 , pp. 45076-45084
    • Besser, D.1
  • 31
    • 36849053911 scopus 로고    scopus 로고
    • Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling
    • Morita T, Mayanagi T, Sobue K,. Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. J Cell Biol 2007; 179: 1027-1042.
    • (2007) J Cell Biol , vol.179 , pp. 1027-1042
    • Morita, T.1    Mayanagi, T.2    Sobue, K.3
  • 32
    • 39349097787 scopus 로고    scopus 로고
    • Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors
    • Davis RP, Ng ES, Costa M, et al. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 2008; 111: 1876-1884.
    • (2008) Blood , vol.111 , pp. 1876-1884
    • Davis, R.P.1    Ng, E.S.2    Costa, M.3
  • 33
    • 66949175935 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development
    • Takei S, Ichikawa H, Johkura K, et al. Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development. Am J Physiol Heart Circ Physiol 2009; 296: H1793-1803.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Takei, S.1    Ichikawa, H.2    Johkura, K.3
  • 34
    • 79961130865 scopus 로고    scopus 로고
    • Combinatorial activin receptor-like kinase/Smad and basic fibroblast growth factor signals stimulate the differentiation of human embryonic stem cells into the cardiac lineage
    • Yook JY, Kim MJ, Son MJ, et al. Combinatorial activin receptor-like kinase/Smad and basic fibroblast growth factor signals stimulate the differentiation of human embryonic stem cells into the cardiac lineage. Stem Cells Dev 2011; 20: 1479-1490.
    • (2011) Stem Cells Dev , vol.20 , pp. 1479-1490
    • Yook, J.Y.1    Kim, M.J.2    Son, M.J.3
  • 35
    • 39349091570 scopus 로고    scopus 로고
    • Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells
    • Zhang P, Li J, Tan Z, et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood 2008; 111: 1933-1941.
    • (2008) Blood , vol.111 , pp. 1933-1941
    • Zhang, P.1    Li, J.2    Tan, Z.3
  • 36
    • 67849106825 scopus 로고    scopus 로고
    • Phosphorylation dynamics during early differentiation of human embryonic stem cells
    • Van Hoof D, Munoz J, Braam SR, et al. Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 2009; 5: 214-226.
    • (2009) Cell Stem Cell , vol.5 , pp. 214-226
    • Van Hoof, D.1    Munoz, J.2    Braam, S.R.3
  • 37
    • 33845619576 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions
    • Ullmann U, In't Veld P, Gilles C, et al. Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions. Mol Hum Reprod 2007; 13: 21-32.
    • (2007) Mol Hum Reprod , vol.13 , pp. 21-32
    • Ullmann, U.1    In'T Veld, P.2    Gilles, C.3
  • 38
    • 37049007672 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition events during human embryonic stem cell differentiation
    • Eastham AM, Spencer H, Soncin F, et al. Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res 2007; 67: 11254-11262.
    • (2007) Cancer Res , vol.67 , pp. 11254-11262
    • Eastham, A.M.1    Spencer, H.2    Soncin, F.3
  • 39
    • 77958117982 scopus 로고    scopus 로고
    • MiR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells
    • Lee MR, Kim JS, Kim KS,. miR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells. Stem Cells 2010; 28: 1550-1559.
    • (2010) Stem Cells , vol.28 , pp. 1550-1559
    • Lee, M.R.1    Kim, J.S.2    Kim, K.S.3
  • 40
    • 56249096559 scopus 로고    scopus 로고
    • Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile
    • Van Hoof D, Braam SR, Dormeyer W, et al. Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells 2008; 26: 2777-2781.
    • (2008) Stem Cells , vol.26 , pp. 2777-2781
    • Van Hoof, D.1    Braam, S.R.2    Dormeyer, W.3
  • 41
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • Grunert S, Jechlinger M, Beug H,. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 2003; 4: 657-665.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 657-665
    • Grunert, S.1    Jechlinger, M.2    Beug, H.3
  • 42
    • 70350144395 scopus 로고    scopus 로고
    • BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways
    • Morikawa Y, Zehir A, Maska E, et al. BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 2009; 136: 3575-3584.
    • (2009) Development , vol.136 , pp. 3575-3584
    • Morikawa, Y.1    Zehir, A.2    Maska, E.3
  • 43
    • 79961149681 scopus 로고    scopus 로고
    • BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages
    • Bernardo AS, Faial T, Gardner L, et al. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell 2011; 9: 144-155.
    • (2011) Cell Stem Cell , vol.9 , pp. 144-155
    • Bernardo, A.S.1    Faial, T.2    Gardner, L.3
  • 44
    • 84875522268 scopus 로고    scopus 로고
    • Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4
    • Amita M, Adachi K, Alexenko AP, et al.: Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proc Natl Acad Sci USA 2013.
    • (2013) Proc Natl Acad Sci USA
    • Amita, M.1    Adachi, K.2    Alexenko, A.P.3
  • 45
    • 0034029571 scopus 로고    scopus 로고
    • Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    • Satokata I, Ma L, Ohshima H, et al. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 2000; 24: 391-395.
    • (2000) Nat Genet , vol.24 , pp. 391-395
    • Satokata, I.1    Ma, L.2    Ohshima, H.3
  • 46
    • 0027467238 scopus 로고
    • Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth
    • Jowett AK, Vainio S, Ferguson MW, et al. Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development 1993; 117: 461-470.
    • (1993) Development , vol.117 , pp. 461-470
    • Jowett, A.K.1    Vainio, S.2    Ferguson, M.W.3
  • 47
    • 31144440253 scopus 로고    scopus 로고
    • Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    • Ma L, Lu MF, Schwartz RJ, et al. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 2005; 132: 5601-5611.
    • (2005) Development , vol.132 , pp. 5601-5611
    • Ma, L.1    Lu, M.F.2    Schwartz, R.J.3
  • 48
    • 33745266407 scopus 로고    scopus 로고
    • Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field
    • Rivera-Feliciano J, Tabin CJ,. Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field. Dev Biol 2006; 295: 580-588.
    • (2006) Dev Biol , vol.295 , pp. 580-588
    • Rivera-Feliciano, J.1    Tabin, C.J.2
  • 49
    • 8444245525 scopus 로고    scopus 로고
    • A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos
    • Brugger SM, Merrill AE, Torres-Vazquez J, et al. A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development 2004; 131: 5153-5165.
    • (2004) Development , vol.131 , pp. 5153-5165
    • Brugger, S.M.1    Merrill, A.E.2    Torres-Vazquez, J.3
  • 50
    • 78149292472 scopus 로고    scopus 로고
    • High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors
    • Zhou J, Su P, Li D, et al. High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells 2010; 28: 1741-1750.
    • (2010) Stem Cells , vol.28 , pp. 1741-1750
    • Zhou, J.1    Su, P.2    Li, D.3
  • 51
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry CE, Keller G,. Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 2008; 132: 661-680.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 52
    • 79551597211 scopus 로고    scopus 로고
    • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • Kattman SJ, Witty AD, Gagliardi M, et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 2011; 8: 228-240.
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1    Witty, A.D.2    Gagliardi, M.3
  • 53
    • 1442299193 scopus 로고    scopus 로고
    • Lateral signaling enhances TGF-beta response complexity
    • Byfield SD, Roberts AB,. Lateral signaling enhances TGF-beta response complexity. Trends Cell Biol 2004; 14: 107-111.
    • (2004) Trends Cell Biol , vol.14 , pp. 107-111
    • Byfield, S.D.1    Roberts, A.B.2
  • 54
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R, Liang J, Ni S, et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010; 7: 51-63.
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 55
    • 70350536767 scopus 로고    scopus 로고
    • A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog
    • Ichida JK, Blanchard J, Lam K, et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009; 5: 491-503.
    • (2009) Cell Stem Cell , vol.5 , pp. 491-503
    • Ichida, J.K.1    Blanchard, J.2    Lam, K.3
  • 56
    • 70350732790 scopus 로고    scopus 로고
    • A chemical platform for improved induction of human iPSCs
    • Lin T, Ambasudhan R, Yuan X, et al. A chemical platform for improved induction of human iPSCs. Nat Methods 2009; 6: 805-808.
    • (2009) Nat Methods , vol.6 , pp. 805-808
    • Lin, T.1    Ambasudhan, R.2    Yuan, X.3
  • 57
    • 84867903696 scopus 로고    scopus 로고
    • Pathogenic mutation of ALK2 inhibits induced pluripotent stem cell reprogramming and maintenance: Mechanisms of reprogramming and strategy for drug identification
    • Hamasaki M, Hashizume Y, Yamada Y, et al. Pathogenic mutation of ALK2 inhibits induced pluripotent stem cell reprogramming and maintenance: Mechanisms of reprogramming and strategy for drug identification. Stem Cells 2012; 30: 2437-2449.
    • (2012) Stem Cells , vol.30 , pp. 2437-2449
    • Hamasaki, M.1    Hashizume, Y.2    Yamada, Y.3
  • 58
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani P, Golipour A, David L, et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010; 7: 64-77.
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1    Golipour, A.2    David, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.