메뉴 건너뛰기




Volumn 2, Issue 2, 2016, Pages 180-188

PTEN Loss as Determined by Clinical-grade Immunohistochemistry Assay Is Associated with Worse Recurrence-free Survival in Prostate Cancer

(18)  Lotan, Tamara L a   Wei, Wei b   Morais, Carlos L a   Hawley, Sarah T c   Fazli, Ladan d   Hurtado Coll, Antonio d   Troyer, Dean e   McKenney, Jesse K f   Simko, Jeffrey g   Carroll, Peter R g   Gleave, Martin d   Lance, Raymond e   Lin, Daniel W h   Nelson, Peter S h   Thompson, Ian M i   True, Lawrence D g   Feng, Ziding b   Brooks, James D j  


Author keywords

Biomarker; ERG; Immunohistochemistry; Prostatic carcinoma; PTEN; Radical prostatectomy

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR ERG;

EID: 84969776648     PISSN: None     EISSN: 24054569     Source Type: Journal    
DOI: 10.1016/j.euf.2015.07.005     Document Type: Article
Times cited : (61)

References (44)
  • 1
    • 77954255681 scopus 로고    scopus 로고
    • Integrative genomic profiling of human prostate cancer
    • Taylor B.S., Schultz N., Hieronymus H., et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010, 18:11-22.
    • (2010) Cancer Cell , vol.18 , pp. 11-22
    • Taylor, B.S.1    Schultz, N.2    Hieronymus, H.3
  • 2
    • 79951497419 scopus 로고    scopus 로고
    • The genomic complexity of primary human prostate cancer
    • Berger M.F., Lawrence M.S., Demichelis F., et al. The genomic complexity of primary human prostate cancer. Nature 2011, 470:214-220.
    • (2011) Nature , vol.470 , pp. 214-220
    • Berger, M.F.1    Lawrence, M.S.2    Demichelis, F.3
  • 3
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso C.S., Wu Y.M., Robinson D.R., et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 2012, 487:239-243.
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1    Wu, Y.M.2    Robinson, D.R.3
  • 4
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    • Barbieri C.E., Baca S.C., Lawrence M.S., et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet 2012, 44:685-689.
    • (2012) Nat Genet , vol.44 , pp. 685-689
    • Barbieri, C.E.1    Baca, S.C.2    Lawrence, M.S.3
  • 5
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J., Yen C., Liaw D., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 6
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck P.A., Pershouse M.A., Jasser S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997, 15:356-362.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 7
    • 15444349266 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
    • Cairns P., Okami K., Halachmi S., et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 1997, 57:4997-5000.
    • (1997) Cancer Res , vol.57 , pp. 4997-5000
    • Cairns, P.1    Okami, K.2    Halachmi, S.3
  • 8
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
    • McMenamin M.E., Soung P., Perera S., Kaplan I., Loda M., Sellers W.R. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999, 59:4291-4296.
    • (1999) Cancer Res , vol.59 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3    Kaplan, I.4    Loda, M.5    Sellers, W.R.6
  • 9
    • 0037388601 scopus 로고    scopus 로고
    • Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer
    • Halvorsen O.J., Haukaas S.A., Akslen L.A. Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer. Clin Cancer Res 2003, 9:1474-1479.
    • (2003) Clin Cancer Res , vol.9 , pp. 1474-1479
    • Halvorsen, O.J.1    Haukaas, S.A.2    Akslen, L.A.3
  • 10
    • 33645231294 scopus 로고    scopus 로고
    • The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion
    • Verhagen P.C., van Duijn P.W., Hermans K.G., et al. The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. J Pathol 2006, 208:699-707.
    • (2006) J Pathol , vol.208 , pp. 699-707
    • Verhagen, P.C.1    van Duijn, P.W.2    Hermans, K.G.3
  • 11
    • 34447133479 scopus 로고    scopus 로고
    • Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    • Bedolla R., Prihoda T.J., Kreisberg J.I., et al. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin Cancer Res 2007, 13:3860-3867.
    • (2007) Clin Cancer Res , vol.13 , pp. 3860-3867
    • Bedolla, R.1    Prihoda, T.J.2    Kreisberg, J.I.3
  • 12
    • 33846968797 scopus 로고    scopus 로고
    • Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis
    • Schmitz M., Grignard G., Margue C., et al. Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis. Int J Cancer 2007, 120:1284-1292.
    • (2007) Int J Cancer , vol.120 , pp. 1284-1292
    • Schmitz, M.1    Grignard, G.2    Margue, C.3
  • 13
    • 34548299547 scopus 로고    scopus 로고
    • FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
    • Yoshimoto M., Cunha I.W., Coudry R.A., et al. FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer 2007, 97:678-685.
    • (2007) Br J Cancer , vol.97 , pp. 678-685
    • Yoshimoto, M.1    Cunha, I.W.2    Coudry, R.A.3
  • 14
    • 67650917081 scopus 로고    scopus 로고
    • PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
    • Sircar K., Yoshimoto M., Monzon F.A., et al. PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J Pathol 2009, 218:505-513.
    • (2009) J Pathol , vol.218 , pp. 505-513
    • Sircar, K.1    Yoshimoto, M.2    Monzon, F.A.3
  • 15
    • 68249083702 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression
    • Han B., Mehra R., Lonigro R.J., et al. Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression. Mod Pathol 2009, 22:1083-1093.
    • (2009) Mod Pathol , vol.22 , pp. 1083-1093
    • Han, B.1    Mehra, R.2    Lonigro, R.J.3
  • 16
    • 76949106361 scopus 로고    scopus 로고
    • Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer
    • Reid A.H., Attard G., Ambroisine L., et al. Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. Br J Cancer 2010, 102:678-684.
    • (2010) Br J Cancer , vol.102 , pp. 678-684
    • Reid, A.H.1    Attard, G.2    Ambroisine, L.3
  • 17
    • 84864141538 scopus 로고    scopus 로고
    • Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
    • Krohn A., Diedler T., Burkhardt L., et al. Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer. Am J Pathol 2012, 181:401-412.
    • (2012) Am J Pathol , vol.181 , pp. 401-412
    • Krohn, A.1    Diedler, T.2    Burkhardt, L.3
  • 18
    • 80054111295 scopus 로고    scopus 로고
    • PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
    • Lotan T.L., Gurel B., Sutcliffe S., et al. PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients. Clin Cancer Res 2011, 17:6563-6573.
    • (2011) Clin Cancer Res , vol.17 , pp. 6563-6573
    • Lotan, T.L.1    Gurel, B.2    Sutcliffe, S.3
  • 19
    • 84870659824 scopus 로고    scopus 로고
    • An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy
    • Antonarakis E.S., Keizman D., Zhang Z., et al. An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy. Cancer 2012, 118:6063-6071.
    • (2012) Cancer , vol.118 , pp. 6063-6071
    • Antonarakis, E.S.1    Keizman, D.2    Zhang, Z.3
  • 20
    • 84868446982 scopus 로고    scopus 로고
    • Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
    • Chaux A., Peskoe S.B., Gonzalez-Roibon N., et al. Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer. Mod Pathol 2012, 25:1543-1549.
    • (2012) Mod Pathol , vol.25 , pp. 1543-1549
    • Chaux, A.1    Peskoe, S.B.2    Gonzalez-Roibon, N.3
  • 21
    • 56649091295 scopus 로고    scopus 로고
    • Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
    • Yoshimoto M., Joshua A.M., Cunha I.W., et al. Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome. Mod Pathol 2008, 21:1451-1460.
    • (2008) Mod Pathol , vol.21 , pp. 1451-1460
    • Yoshimoto, M.1    Joshua, A.M.2    Cunha, I.W.3
  • 22
    • 84932195056 scopus 로고    scopus 로고
    • A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer
    • Troyer D.A., Jamaspishvili T., Wei W., et al. A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer. Prostate 2015, 75:1206-1215.
    • (2015) Prostate , vol.75 , pp. 1206-1215
    • Troyer, D.A.1    Jamaspishvili, T.2    Wei, W.3
  • 23
    • 84927176341 scopus 로고    scopus 로고
    • Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer
    • Krohn A., Freudenthaler F., Harasimowicz S., et al. Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer. Mod Pathol 2014, 27:1612-1620.
    • (2014) Mod Pathol , vol.27 , pp. 1612-1620
    • Krohn, A.1    Freudenthaler, F.2    Harasimowicz, S.3
  • 24
    • 84882450258 scopus 로고    scopus 로고
    • Assessing the order of critical alterations in prostate cancer development and progression by IHC: further evidence that PTEN loss occurs subsequent to ERG gene fusion
    • Gumuskaya B., Gurel B., Fedor H., et al. Assessing the order of critical alterations in prostate cancer development and progression by IHC: further evidence that PTEN loss occurs subsequent to ERG gene fusion. Prostate Cancer Prostatic Dis 2013, 16:209-215.
    • (2013) Prostate Cancer Prostatic Dis , vol.16 , pp. 209-215
    • Gumuskaya, B.1    Gurel, B.2    Fedor, H.3
  • 25
    • 84862817081 scopus 로고    scopus 로고
    • Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer
    • Bismar T.A., Yoshimoto M., Duan Q., Liu S., Sircar K., Squire J.A. Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer. Histopathology 2012, 60:645-652.
    • (2012) Histopathology , vol.60 , pp. 645-652
    • Bismar, T.A.1    Yoshimoto, M.2    Duan, Q.3    Liu, S.4    Sircar, K.5    Squire, J.A.6
  • 26
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins S.A., Rhodes D.R., Perner S., et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005, 310:644-648.
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3
  • 27
    • 84866172302 scopus 로고    scopus 로고
    • The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis
    • Pettersson A., Graff R.E., Bauer S.R., et al. The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev 2012, 21:1497-1509.
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 1497-1509
    • Pettersson, A.1    Graff, R.E.2    Bauer, S.R.3
  • 28
    • 84891437243 scopus 로고    scopus 로고
    • Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG
    • Pettersson A., Lis R.T., Meisner A., et al. Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG. J Natl Cancer Inst 2013, 105:1881-1890.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1881-1890
    • Pettersson, A.1    Lis, R.T.2    Meisner, A.3
  • 29
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver B.S., Tran J., Gopalan A., et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet 2009, 41:619-624.
    • (2009) Nat Genet , vol.41 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3
  • 30
    • 66749100105 scopus 로고    scopus 로고
    • Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    • King J.C., Xu J., Wongvipat J., et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 2009, 41:524-526.
    • (2009) Nat Genet , vol.41 , pp. 524-526
    • King, J.C.1    Xu, J.2    Wongvipat, J.3
  • 31
    • 79251536870 scopus 로고    scopus 로고
    • PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer
    • Bismar T.A., Yoshimoto M., Vollmer R.T., et al. PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer. BJU Int 2011, 107:477-485.
    • (2011) BJU Int , vol.107 , pp. 477-485
    • Bismar, T.A.1    Yoshimoto, M.2    Vollmer, R.T.3
  • 32
    • 84861904278 scopus 로고    scopus 로고
    • Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer
    • Reid A.H., Attard G., Brewer D., et al. Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer. Mod Pathol 2012, 25:902-910.
    • (2012) Mod Pathol , vol.25 , pp. 902-910
    • Reid, A.H.1    Attard, G.2    Brewer, D.3
  • 33
    • 84882285291 scopus 로고    scopus 로고
    • ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
    • Chen Y., Chi P., Rockowitz S., et al. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med 2013, 19:1023-1029.
    • (2013) Nat Med , vol.19 , pp. 1023-1029
    • Chen, Y.1    Chi, P.2    Rockowitz, S.3
  • 34
    • 84871741950 scopus 로고    scopus 로고
    • A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray
    • Hawley S., Fazli L., McKenney J.K., et al. A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray. Adv Anat Pathol 2013, 20:39-44.
    • (2013) Adv Anat Pathol , vol.20 , pp. 39-44
    • Hawley, S.1    Fazli, L.2    McKenney, J.K.3
  • 35
    • 79959660044 scopus 로고    scopus 로고
    • Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas
    • Chaux A., Albadine R., Toubaji A., et al. Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas. Am J Surg Pathol 2011, 35:1014-1020.
    • (2011) Am J Surg Pathol , vol.35 , pp. 1014-1020
    • Chaux, A.1    Albadine, R.2    Toubaji, A.3
  • 36
    • 77954997528 scopus 로고    scopus 로고
    • Antibody-based detection of ERG rearrangement-positive prostate cancer
    • Park K., Tomlins S.A., Mudaliar K.M., et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia 2010, 12:590-598.
    • (2010) Neoplasia , vol.12 , pp. 590-598
    • Park, K.1    Tomlins, S.A.2    Mudaliar, K.M.3
  • 37
    • 84940751168 scopus 로고    scopus 로고
    • Evaluation of ERG and SPINK1 by immunohistochemical staining and clinicopathological outcomes in a multi-institutional radical prostatectomy cohort of 1067 patients
    • Brooks J.D., Wei W., Hawley S., et al. Evaluation of ERG and SPINK1 by immunohistochemical staining and clinicopathological outcomes in a multi-institutional radical prostatectomy cohort of 1067 patients. PLoS One 2015, 10:e0132343.
    • (2015) PLoS One , vol.10 , pp. e0132343
    • Brooks, J.D.1    Wei, W.2    Hawley, S.3
  • 38
    • 84969827724 scopus 로고    scopus 로고
    • PTEN status determination in prostate cancer: comparison of IHC and FISH in a large multi-center cohort
    • Lotan T., Morais C., Wei W., et al. PTEN status determination in prostate cancer: comparison of IHC and FISH in a large multi-center cohort. Mod Pathol 2015, 28:241A.
    • (2015) Mod Pathol , vol.28 , pp. 241A
    • Lotan, T.1    Morais, C.2    Wei, W.3
  • 39
    • 84922438928 scopus 로고    scopus 로고
    • Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis
    • Heselmeyer-Haddad K.M., Berroa Garcia L.Y., Bradley A., et al. Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis. Am J Pathol 2014, 184:2671-2686.
    • (2014) Am J Pathol , vol.184 , pp. 2671-2686
    • Heselmeyer-Haddad, K.M.1    Berroa Garcia, L.Y.2    Bradley, A.3
  • 40
    • 84909974951 scopus 로고    scopus 로고
    • TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer
    • Steurer S., Mayer P.S., Adam M., et al. TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer. Eur Urol 2014, 66:978-981.
    • (2014) Eur Urol , vol.66 , pp. 978-981
    • Steurer, S.1    Mayer, P.S.2    Adam, M.3
  • 41
    • 84890061009 scopus 로고    scopus 로고
    • Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer
    • Leinonen K.A., Saramaki O.R., Furusato B., et al. Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer. Cancer Epidemiol Biomarkers Prev 2013, 22:2333-2344.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 2333-2344
    • Leinonen, K.A.1    Saramaki, O.R.2    Furusato, B.3
  • 42
    • 84898747431 scopus 로고    scopus 로고
    • Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment
    • Fontugne J., Lee D., Cantaloni C., et al. Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment. Cancer Epidemiol Biomarkers Prev 2014, 23:594-600.
    • (2014) Cancer Epidemiol Biomarkers Prev , vol.23 , pp. 594-600
    • Fontugne, J.1    Lee, D.2    Cantaloni, C.3
  • 43
    • 84879690468 scopus 로고    scopus 로고
    • Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    • Cuzick J., Yang Z.H., Fisher G., et al. Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer. Br J Cancer 2013, 108:2582-2589.
    • (2013) Br J Cancer , vol.108 , pp. 2582-2589
    • Cuzick, J.1    Yang, Z.H.2    Fisher, G.3
  • 44
    • 84920719733 scopus 로고    scopus 로고
    • Combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort
    • Cooperberg M.R., Davicioni E., Crisan A., Jenkins R.B., Ghadessi M., Karnes R.J. combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort. Eur Urol 2015, 67:326-333.
    • (2015) Eur Urol , vol.67 , pp. 326-333
    • Cooperberg, M.R.1    Davicioni, E.2    Crisan, A.3    Jenkins, R.B.4    Ghadessi, M.5    Karnes, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.