Role of matrix metalloproteinases in dental caries, pulp and periapical inflammation: An overview

Journal of Oral Biology and Craniofacial Research

Volumn 5, Issue 3, 2015, Pages 212-218

  Jain, Atul ^a   Bahuguna, Rachana ^a  

^a Rungta College of Dental Sciences and Research   (India)

Author keywords

Chronic apical periodontitis; Extra cellular matrix; Matrix metalloproteinase; Pulp exudate; Tissue inhibitor of MMP

Indexed keywords

EID: 84969262247     PISSN: 22124268     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jobcr.2015.06.015     Document Type: Review

References (73)

1. Kahari V., Saariallo-Kere U. Matrix metalloproteinase in skin. Exp Dermatol 1997, 6:199-213.
2. Nagase H., Woessmer J.F. Matrix metalloproteinases. J Biol Chem 1999, 274:21491-21494.
3. Le N.T., Xue M., Castelnoble L.A., Jackson C.J. The dual personalities of matrix metalloproteinases in inflammation. Front Biosci 2007, 12:1475-1487.
4. Sternlicht M., Werb Z. How matrix metalloproteinases regulate cell behaviour. Annu Rev Cell Dev Biol 2001, 17:463-516.
5. Goldberg M., Smith A.J. Cells and extracellular matrix of dentin and pulp: a biological basis for repair & tissue engineering. Crit Rev Oral Biol Med 2004, 15:13-27. 10.1177/154411130401500103.
6. Opshal Vital S., Gaucher C., Bardet C., et al. Tooth dentin defects reflect genetic disorders affecting bone mineralization. Bone 2012, 50:989-997. 10.1016/j.bone.2012.01.010.
7. Kawashaki K., Featherstone J.D. Effects of collagenase on root demineralization. J Dent Res 1997, 76:588-595. 10.1177/00220345970760011001.
8. Palosarri H., Ding Y., Larmas M., et al. Regulation & interactions of MT1-MMP & MMP-20 in human odontoblasts & pulp tissue in vitro. J Dent Res 2002, 81:354-359. 10.1177/154405910208100513.
9. Sulkala M., Larmas M., Sorsa T., Salo T., Tjaderhane L. The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth. J Dent Res 2002, 81:603-607. 10.1177/154405910208100905.
10. Sulkala M., Paakkonen V., Larmas M., Salo T., Tjaderhane L. Matrix metalloproteinase-13 (MMP-13, collagenase-3) is highly expressed in human tooth pulp. Connect Tissue Res 2004, 45:231-237. 10.1080/03008200490885788.
11. Sulkala M., Tervahartiala T., Sorsa T., Larmas M., Salo T., Tjaderhane L. Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin. Arch Oral Biol 2007, 52:121-127.
12. Mazzoni A., Pashley D.H., Tay F.R., Gobbi P., Orsini G., Ruggeri A. Immunohistochemical identification of MMP-2 and MMP-9 in human dentin: correlative FEI-SEM/TEM analysis. J Biomed Mater Res A 2009, 88A:697-703. 10.1002/jbm.a.31920.
13. Mazzoni A., Papa V., Nato F., Carrilho M., Tjaderhane L., Ruggeri A. Immunohistochemical and bio-chemical assay of MMP-3 in human dentine. J Dent 2011, 39:231-237. 10.1016/j.jdent.2011.01.001.
14. Lee T.Y., Jin E.J., Choi B. MMP-13 expression in coronal and radicular dentin according to caries progression - a pilot study. Tiss Eng Reg Med 2013, 10.6:317-321.
15. Lorento C., Galanti C., Musumeci G., Rusu M.C., Leonardi R. Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin. Eur J Histochem 2014, 58(2318):47-51.
16. Shimada Y., Ichinose S., Sadr A., Burrow M.F., Tagami J. Localization of matrix metalloproteinases (MMPs-2, 8, 9 and 20) in normal and carious dentine. Aust Dent J 2009, 54:347-354.
17. Moon P.C., Weaver J., Brooks C.N. Review of matrix metalloproteinases. Effect on the hybrid dentin bond layer stability and chlorhexidine clinical use. Open Dent J 2010, 4:147-152.
18. Nascimento F.D., Miniciotti C.L., Tersariol I.L.S. Cysteine cathepsins in human carious dentin. J Dent Res 2011, 90(4):506-511.
19. Tjaderhane L., Larjava H., Sorsa T., Uitto V.J., Larmas M., Salo T. The activation and function of host matrix metalloproteinases in dentin matrix break down in caries lesions. J Dent Res 1998, 77:1622-1629. 10.1177/00220345980770081001.
20. Camps J., Pashley D.H. Buffering action of human dentin in vitro. J Adhes Dent 2000, 2:39-50.
21. Haapasalo M., Qian W., Portenier I., Waltimo T. Effects of dentin on the antimicrobial properties of endodontic medicaments. J Endod 2007, 33:917-925. 10.1016/j.joen.2007.04.008.
22. Fedarko N.S., Jain A., Karadag A., Fisher L.W. Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases. FASEB J 2004, 18:734-736. 10.1096/fj.03-0966fje.
23. Leonardi R., Matthew J.B., Caltabiano R., et al. MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocyst. Oral Dis 2010, 16:795-800.
24. Loreto C., Leonardi R., Musumeci G., Pannone G., Castorina S. An ex-vivo study on immunohistochemical localization of MMP-7 and MMP-9 in temporomandibular joint disc with internal derangement. Eur J Histochem 2013, 57:e12.
25. Van Strijp A.J., Jansen D.C., Degroot J., TenCate J.M., Everts V. Host-derived proteinases and degradation of dentine collagen in situ. Caries Res 2003, 37:58-65. 10.1159/000068223.
26. Tjaderhane L., Nascimento F.D., Breschi L., et al. Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. Dent Mater 2013, 29:116-135.
27. Vidal C.M., Tjaderhane L., Saffa P.M., et al. Abundance of MMPs and cysteine cathepsins in caries-affected dentin. J Dent Res 2014, 93:269-274.
28. Toledano M., Nieto-Aguilar R., Osorio R., Campos A., Osorio E., Tay F.R. Differential expression of matrix metalloproteinase-2 in human coronal and radicular sound and carious dentine. J Dent 2010, 38:635-640. 10.1016/j.jdent.2010.05.001.
29. Boushell L.W., Kaku M., Mochida Y., Bagnell R., Yamauchi M. Immuno-histochemical localization of matrix metalloproteinase-2 in human coronal dentin. Arch Oral Biol 2008, 53:109-116. 10.1016/j. archoralbio.2007.09.012.
30. Palosaari H. Matrix Metalloproteinases and their Specific Tissue Inhibitors in Mature Human Odontoblasts and Pulp Tissue. The Regulation of Expression of Fibrillar Collagens, MMPs and TIMPs by Growth Factors, Transforming Growth Factor B1 and Bone Morphogenetic Protein 2 2003, [Academic Dissertation], Institute of Dentistry, University of Oulu.
31. Palosaari H., Tasanen K., Risteli J., Larmas M., Salo T., Tjäderhane L. Baseline expression and effect of TGF-beta 1 on type I and III collagen mRNA and protein synthesis in human odontoblast and pulp cells in vitro. Calcif Tissue Int 2001, 68:122-129.
32. Nakata K., Yamasaki M., Iwata T., Suzuki K., Nakane A., Nakamura H. Anaerobic bacterial extracts influence production of matrix metalloproteinases and their inhibitors by human dental pulp cells. J Endod 2000, 26:410-413.
33. Chang Y.C., Yang S.F., Lai C.C., Liu J.Y., Hsieh Y.S. Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures. J Periodontal Res 2002, 37(3):196-203.
34. Lesot H., Smith A.J., Tziafas D., Begue-Kirn C., Cassidy N., Ruch J.V. Biologically active molecules and dental tissue repair: a comparative review of reactionary and reparative dentinogenesis with the induction of odontoblast differentiation in vitro. Cells Mater 1994, 4:199-218.
35. Shin S.J., Lee J.I., Baek S.H., Lim S.S. Tissue levels of matrix metalloproteinases in pulps and periapical lesions. J Endod 2002, 28:313-315.
36. Suzuki K., Enghild J.J., Morodomi T., Salvesen G., Nagase H. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 1990, 29:10261-10270.
37. Khoufache K., Kibangou Bondza P., Harir N. Soluble human interleukin 1 receptor type 2 inhibits ectopic endometrial tissue implantation and growth: identification of a novel potential target for endometriosis treatment. Am J Pathol 2012, 181:1197-1205.
38. Manka S.W., Carafoli F., Visse R. Structural insights into triple-helical collagen cleavage by matrix metalloproteinase. Proc Natl Acad Sci USA 2012, 109:12461-12466.
39. Zheng L., Amano K., Iohara K. Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury. Am J Pathol 2009, 175:1905-19014.
40. Muromachi K., Kamino N., Fukushima M.H., et al. Metalloproteinases and CCN 2/CTGF in dentin-pulp complex repair. J Oral Biosci 2014, 10.1016/j.job.2014.12.001.
41. Goda S., Kato Y., Domane E., et al. Effects of JNK1/2 on the inflammation cytokine TNF-α-enhanced production of MMP-3 in human dental pulp fibroblast like cells. Int Endod J 2014, 10.1111/iej.12411.
42. Evrosimoska B., Dimova C., Kovacevska I., Panov S. Concentration of collagenases (MMP-1, -8, -13) in patients with chronically inflamed dental pulp tissue. Sec Bio Med Sci 2012, MASA XXXIII(2):191-204.
43. D'Souza R., Brown L.R., Newland J.R., Levy B.M., Lachman L.B. Detection and characterization of interleukin-1 in human dental pulps. Arch Oral Biol 1989, 34:307-313.
44. Pezelj-Ribaric S., Anic I., Brekalo I., Miletic I., Hasan M., Simunovic-Soskic M. Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps. Arch Med Res 2002, 33:482-484.
45. Chang Y.C., Yang S.F., Hsieh Y.S. Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures. J Endod 2001, 27:679-682.
46. Lin S.K., Wang C.C., Huang S., et al. Induction of dental pulp fibroblast matrixmetalloproteinases-1 and tissue inhibitor of metalloproteinases-1 gene expression by interleukin-1α and tumor necrosis factor-α through a prostaglandin-dependent pathway. J Endod 2001, 27:185-189.
47. Ding Y., Uitto V.J., Haapasalo M., et al. Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res 1996, 75:1986-1993.
48. Ding Y., Haapasalo M., Kerosuo E., Lounatmaa K., Kotiranta A., Sorsa T. Release and activation of human neutrophil matrix metallo- and serine proteinases during phagocytosis of Fusobacterium nucleatum, Porphyromonas gingivalis and Treponema denticola. J Clin Periodontol 1997, 24:237-248.
49. Tamura M., Nagaoka S., Kawagoe M. Interleukin-1 alpha stimulates interstitial collagenase gene expression in human dental pulp fibroblast. J Endod 1996, 22:240-243.
50. O'Boskey F.J, Panagakos F. Cytokines stimulate matrix metalloproteinase production by human pulp cells during long-term culture. J Endod 1998, 24:7-10.
51. Bergenholtz G. Evidence for bacterial causation of adverse pulpal responses in resin-based dental restorations. Crit Rev Oral Biol Med 2000, 11:467-480.
52. Lin S.K., Kok S.H., Kuo M.Y.P., et al. Sequential expressions of MMP-1, TIMP-1, IL-6 and COX-2 genes in induced periapical lesions in rats. Eur J Oral Sci 2002, 110:246-253.
53. Wahlgren J., Salo T., Teronen O., Luoto H., Sorsa T., Tjäderhane L. Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates. Int Endod J 2002, 35(11):897-904.
54. Apajalahti S. Short Root Anomaly (SRA) Prevalence and Phenotypic Features in Families with Emphasis on Matrix Metalloporteinases in Gingival Cervicular Fluid of SRA and Orthodontic Patients 2004, [Academic dissertation], University of Helsinki, Helsinki.
55. Ding Y., Uitto V.J., Firth J., et al. Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases. Oral Dis 1995, 1(4):279-286.
56. Lindy O., Konttinen Y.T., Sorsa T., et al. Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium. Arthritis Rheum 1997, 40(8):1391-1399.
57. Kiili M., Cox S.W., Chen H.Y., et al. Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. J Clin Periodontol 2002, 29(3):224-232. Erratum in: J Clin Periodontol 2004;31(2):149.
58. Wahlgren J., Väänänen A., Teronen O., et al. Laminin-5 gamma 2 chain is colocalized with gelatinase A (MMP-2) and collagenase-3 (MMP-13) in odontogenic keratocysts. J Oral Pathol Med 2003, 32(2):100-107.
59. Hong C.Y., Lin S.K., Kok S.H., et al. The role of lipopolysaccharide in infectious bone resorption of periapical lesion. J Oral Pathol Med 2004, 33(3):162-169.
60. Lin S.K., Chiang C.P., Hong C.Y., et al. Immunolocalization of interstitial collagenase (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in radicular cysts. J Oral Pathol Med 1997, 26:458-463.
61. Wahlgren J., Salo T., Teronen O., Luoto H., Sorsa T., Tjäderhane L. Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates. Int Endod J 2002, 35:897-904.
62. Leonardi R., Caltabiano R., Loreto C. Collagenase-3 (MMP-13) is expressed in periapical lesions: an immunohistochemical study. Int Endod J 2005, 38:297-301.
63. Paula-Silva F.W.G., D'Silva N.J., Silva L.A.B., Kapila Y.L. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod 2009, 35(9):1234-1242.
64. Barkhordar R.A., Hussain M.Z., Hayashi C. Detection of interleukin 1-beta in human periapical lesions. Oral Surg Oral Med Oral Pathol 1992, 73:334-336.
65. Prikk K., Maisi P., Pirilä E., et al. In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. J Pathol 2001, 194:232-238.
66. Kiili M., Cox S.W., Chen H.W., et al. Collagenase-8 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalization in gingival tissue. J Clin Periodontol 2002, 29:224-232.
67. Anan H., Akamine A., Hara Y., Maeda K., Hashiguchi I., Aono M. A histochemical study of bone remodelling during experimental apical periodontitis in rats. J Endod 1991, 17:332-337.
68. Reponen P., Sahlberg C., Munaut C., Thessleff I., Tryggvason K. High expression of 92 -kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Biol 1994, 124:1091-1102.
69. Wucherpfennig A.L., Li Y.P., Stetler-Stevenson W.G., Rosenberg A.E., Stashenko P. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J Bone Miner Res 1994, 9:549-555.
70. Sorsa T., Suomalainen K., Helenius J., et al. Periodontal disease. N Engl J Med 1990, 323:133-135.
71. Gendron R., Grenier D., Sorsa T., Mayrand D. Inhibition of the activities of matrix metalloproteinases -2, -8 and -9 by chlorhexidine. Clin Diagn Lab Immunol 1999, 6:437-439.
72. Azmak N., Atilla G., Luoto H., Sorsa T. The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid. J Periodontol 2002, 73:608-615.
73. Mäntylä P., Stenman M., Kinane D., et al. Gingival grevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. J Periodontal Res 2003, 38:436-439.