Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease

Science Signaling

Volumn 9, Issue 427, 2016, Pages

  Alfonso, Stephanie I ^a   Callender, Julia A ^b,c   Hooli, Basavaraj ^d   Antal, Corina E ^b,c,g   Mullin, Kristina ^d   Sherman, Mathew A ^e   Lesné, Sylvain E ^e   Leitges, Michael ^f   Newton, Alexandra C ^b   Tanzi, Rudolph E ^d   Malinow, Roberto ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF OSLO   (Norway)

^g SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' TRIPHOSPHATE COMPETITIVE INHIBITOR; ADENOSINE TRIPHOSPHATE; AMYLOID PRECURSOR PROTEIN; BISINDOLYLMALEIMIDE; ENZYME INHIBITOR; PHOSPHOSPECIFIC ANTIBODY; PROTEIN KINASE C ALPHA; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; PRKCA PROTEIN, HUMAN; PRKCA PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL LYSATE; CODON; CONTROL; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; GAIN OF FUNCTION MUTATION; GENE DELETION; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; HIPPOCAMPAL SLICE; HUMAN; MAJOR CLINICAL STUDY; MOUSE; NERVE CELL; NONHUMAN; PDZ DOMAIN; PENETRANCE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SECOND MESSENGER; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; DEGENERATIVE DISEASE; FAMILY HEALTH; GENETICS; GENOME; HIPPOCAMPUS; HUMAN GENOME; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; PROTEIN DOMAIN;

ALZHEIMER DISEASE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; FAMILY HEALTH; GENOME; GENOME, HUMAN; HIPPOCAMPUS; HUMANS; MICE; MUTATION; NEOPLASMS; NEURODEGENERATIVE DISEASES; PROTEIN DOMAINS; PROTEIN KINASE C-ALPHA; SYNAPSES;

EID: 84969253465     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaf6209     Document Type: Article

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