Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane

ACS Infectious Diseases

Volumn 2, Issue 3, 2016, Pages 207-220

  Molohon, Katie J ^a,b   Blair, Patricia M ^b   Park, Seongjin ^c   Doroghazi, James R ^b   Maxson, Tucker ^b   Hershfield, Jeremy R ^d   Flatt, Kristen M ^b   Schroeder, Nathan E ^b   Ha, Taekjip ^b,c,e   Mitchell, Douglas A ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c University of Illinois at Urbana Champaign   (United States)

^d UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

anthrax; antibiotic; Bacillus anthracis; membrane depolarization; mode of action; oxazole; pathogen specific antibiotic; ribosomally synthesized and post translationally modified natural product; thiazole

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA; BACTERIAL RNA; CARDIOLIPIN; GENOMIC DNA; NATURAL PRODUCT; PLANTAZOLICIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIOPHAGE; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOLYSIS; DRUG POTENCY; GENE EXPRESSION; GENE SEQUENCE; MACROMOLECULE; MEMBRANE DEPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; RNA ISOLATION; UPREGULATION;

EID: 84969246780     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.5b00115     Document Type: Article

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