mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

Oncotarget

Volumn 7, Issue 18, 2016, Pages 25224-25240

  Chen, Yaqing ^a   Qian, Jianchang ^a   He, Qun ^a   Zhao, Hui ^a   Toral Barza, Lourdes ^b   Shi, Celine ^b   Zhang, Xuesai ^a   Wu, Jiang ^b   Yu, Ker ^a  

^a FUDAN UNIVERSITY   (China)

^b PFIZER INC   (United States)

Author keywords

ATP citrate lyase; Breast cancer; Cancer metabolism; Lipid synthesis; mTORC2

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUCOSE; LIPID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CA; RAPAMYCIN; SERINE; SOMATOMEDIN C; UNCLASSIFIED DRUG; ERBB2 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CA PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BREAST CANCER; BREAST TUMOR; CELL SURVIVAL; CONTROLLED STUDY; GROWTH INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPOLARIZATION; IN VITRO STUDY; LIPID METABOLISM; LIPOGENESIS; MITOCHONDRION; NONHUMAN; PROTEIN FUNCTION; PROTEIN TARGETING; PROTEOMICS; TUMOR CELL LINE; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY;

ACETYL COENZYME A; ATP CITRATE (PRO-S)-LYASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; FEMALE; HUMANS; LIPOGENESIS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 2; RECEPTOR, ERBB-2; TOR SERINE-THREONINE KINASES;

EID: 84967205798     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8279     Document Type: Article

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