Ptdins(3,4,5) P3 -dependent activation of the mTORC2 kinase complex

Cancer Discovery

Volumn 5, Issue 11, 2015, Pages 1194-11209

  Liu, Pengda ^a   Gan, Wenjian ^a   Chin, Y Rebecca ^a   Ogura, Kohei ^a   Guo, Jianping ^a   Zhang, Jinfang ^a   Wang, Bin ^a   Blenis, John ^b   Cantley, Lewis C ^b   Toker, Alex ^a   Su, Bing ^c,d   Wei, Wenyi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ETOPOSIDE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE; STRESS ACTIVATED MAP KINASE INTERACTING PROTEIN 1; UNCLASSIFIED DRUG; KRAS PROTEIN, HUMAN; MAPKAP1 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; PROTEIN BINDING; PROTEIN KINASE B; PROTEIN P21; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

AKT KINASE ASSAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CARCINOGENESIS; CATALYSIS; CELL GROWTH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LIPID ANALYSIS; MOUSE; NONHUMAN; PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; BINDING SITE; CHEMISTRY; CONFORMATION; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; NEOPLASM; PATHOLOGY; PROTEIN DOMAIN; PROTEIN MOTIF; TUMOR CELL LINE; XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CATALYSIS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FEMALE; HETEROGRAFTS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MULTIPROTEIN COMPLEXES; MUTATION; NEOPLASMS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); TOR SERINE-THREONINE KINASES;

EID: 84946216201     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-15-0460     Document Type: Article

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