Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE-and LDLR-mediated mechanisms

Cardiovascular Research

Volumn 110, Issue 2, 2016, Pages 268-278

  Tavori, Hagai ^a   Giunzioni, Ilaria ^a   Predazzi, Irene M ^a   Plubell, Deanna ^a   Shivinsky, Anna ^a   Miles, Joshua ^a   DeVay, Rachel M ^b   Liang, Hong ^b   Rashid, Shirya ^c   Linton, MacRae F ^d   Fazio, Sergio ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c DALHOUSIE UNIVERSITY   (Canada)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Hepatocytes; Lipoproteins; Murine models; PCSK9

Indexed keywords

APOLIPOPROTEIN E; LIGAND; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; LOW DENSITY LIPOPROTEIN RECEPTOR; PCSK9 PROTEIN, HUMAN; PCSK9 PROTEIN, MOUSE; PROPROTEIN CONVERTASE 9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HEART INJURY; LIPID BLOOD LEVEL; LIPOGENESIS; MONOCYTE; MOUSE; NONHUMAN; PCSK9 MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; PHYSIOLOGY;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL, LDL; HEPATOCYTES; HUMANS; LIPOGENESIS; LIVER; MICE, INBRED C57BL; MICE, KNOCKOUT; PROPROTEIN CONVERTASE 9; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 84966587947     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvw053     Document Type: Article

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