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Volumn 73, Issue 5, 2016, Pages 520-528

Immunologic effects of metformin and pioglitazone treatment on metabolic syndrome and multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; ADIPONECTIN; ANTIHYPERTENSIVE AGENT; BETA INTERFERON; GADOLINIUM; GAMMA INTERFERON; GLATIRAMER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; LEPTIN; METFORMIN; MYELIN BASIC PROTEIN; NATALIZUMAB; PENTETIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; TUMOR NECROSIS FACTOR; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ANTIINFLAMMATORY AGENT; CYTOKINE; MESSENGER RNA;

EID: 84966570157     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2015.4807     Document Type: Article
Times cited : (139)

References (44)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502-1517.
    • (2008) Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 84926336855 scopus 로고    scopus 로고
    • Role of the innate and adaptive immune responses in the course of multiple sclerosis
    • Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015;14 (4):406-419.
    • (2015) Lancet Neurol. , vol.14 , Issue.4 , pp. 406-419
    • Hemmer, B.1    Kerschensteiner, M.2    Korn, T.3
  • 3
    • 84890084194 scopus 로고    scopus 로고
    • Environmental factors in multiple sclerosis
    • Ascherio A. Environmental factors in multiple sclerosis. Expert Rev Neurother. 2013;13(12)(suppl): 3-9.
    • (2013) Expert Rev Neurother , vol.13 , Issue.12 , pp. 3-9
    • Ascherio, A.1
  • 4
    • 84930408700 scopus 로고    scopus 로고
    • Multiple sclerosis and environmental factors
    • Correale J, Gaitán MI. Multiple sclerosis and environmental factors. Acta Neurol Scand. 2015;132 (199):46-55.
    • (2015) Acta Neurol Scand , vol.132 , Issue.199 , pp. 46-55
    • Correale, J.1    Gaitán, M.I.2
  • 5
    • 84878883338 scopus 로고    scopus 로고
    • Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls
    • International Multiple Sclerosis Genetics Consortium. Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet. 2013; 92(6):854-865.
    • (2013) Am J Hum Genet , vol.92 , Issue.6 , pp. 854-865
  • 6
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347(12):911-920.
    • (2002) N Engl J Med. , vol.347 , Issue.12 , pp. 911-920
    • Bach, J.F.1
  • 7
    • 84906793835 scopus 로고    scopus 로고
    • Is it time for a new global classification of multiple sclerosis?
    • Melcon MO, Correale J, Melcon CM. Is it time for a new global classification of multiple sclerosis? J Neurol Sci. 2014;344(1-2):171-181.
    • (2014) J Neurol Sci. , vol.344 , Issue.1-2 , pp. 171-181
    • Melcon, M.O.1    Correale, J.2    Melcon, C.M.3
  • 8
    • 84933678058 scopus 로고    scopus 로고
    • The epidemiology of obesity: A big picture
    • Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33(7): 673-689.
    • (2015) Pharmacoeconomics , vol.33 , Issue.7 , pp. 673-689
    • Hruby, A.1    Hu, F.B.2
  • 9
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications, part 1
    • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications, part 1. Diabet Med. 1998;15(7): 539-553.
    • (1998) Diabet Med. , vol.15 , Issue.7 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 10
    • 72049092916 scopus 로고    scopus 로고
    • Body size and risk of MS in two cohorts of US women
    • Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology. 2009;73(19):1543-1550.
    • (2009) Neurology , vol.73 , Issue.19 , pp. 1543-1550
    • Munger, K.L.1    Chitnis, T.2    Ascherio, A.3
  • 12
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004;4(5):371-379.
    • (2004) Nat Rev Immunol. , vol.4 , Issue.5 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 13
    • 33745630063 scopus 로고    scopus 로고
    • Leptin is a link between adipose tissue and inflammation
    • Härle P, Straub RH. Leptin is a link between adipose tissue and inflammation. Ann N Y Acad Sci. 2006;1069:454-462.
    • (2006) Ann N y Acad Sci. , vol.1069 , pp. 454-462
    • Härle, P.1    Straub, R.H.2
  • 14
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha. Science. 1993;259(5091):87-91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 15
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821-1830.
    • (2003) J Clin Invest. , vol.112 , Issue.12 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 16
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis
    • Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis. Ann Neurol. 2011;69(2):292-302.
    • (2011) Ann Neurol. , vol.69 , Issue.2 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3
  • 17
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology. 1983;33(11):1444-1452.
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 18
    • 17044391471 scopus 로고    scopus 로고
    • Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-β
    • Correale J, Rush C, Amengual A, Goicochea MT. Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-β. J Neuroimmunol. 2005;162(1-2):173-183.
    • (2005) J Neuroimmunol. , vol.162 , Issue.1-2 , pp. 173-183
    • Correale, J.1    Rush, C.2    Amengual, A.3    Goicochea, M.T.4
  • 19
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet. 2002;3(10):737-747.
    • (2002) Nat Rev Genet. , vol.3 , Issue.10 , pp. 737-747
    • McManus, M.T.1    Sharp, P.A.2
  • 20
    • 67649196932 scopus 로고    scopus 로고
    • Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis
    • [published correction appears in J Immunol. 2009;183(5):3551]
    • Nath N, Khan M, Paintlia MK, Singh I, Hoda MN, Giri S. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis [published correction appears in J Immunol. 2009;183(5):3551]. J Immunol. 2009;182(12):8005-8014.
    • (2009) J Immunol. , vol.182 , Issue.12 , pp. 8005-8014
    • Nath, N.1    Khan, M.2    Paintlia, M.K.3    Singh, I.4    Hoda, M.N.5    Giri, S.6
  • 21
    • 84880628985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model
    • Paintlia AS, Paintlia MK, Mohan S, Singh AK, Singh I. AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model. Am J Pathol. 2013;183(2):526-541.
    • (2013) Am J Pathol. , vol.183 , Issue.2 , pp. 526-541
    • Paintlia, A.S.1    Paintlia, M.K.2    Mohan, S.3    Singh, A.K.4    Singh, I.5
  • 22
    • 84875999344 scopus 로고    scopus 로고
    • Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis
    • Kang KY, Kim YK, Yi H, et al. Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis. Int Immunopharmacol. 2013;16(1):85-92.
    • (2013) Int Immunopharmacol. , vol.16 , Issue.1 , pp. 85-92
    • Kang, K.Y.1    Kim, Y.K.2    Yi, H.3
  • 23
    • 84897643844 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer
    • Koh SJ, Kim JM, Kim IK, Ko SH, Kim JS. Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. J Gastroenterol Hepatol. 2014;29(3):502-510.
    • (2014) J Gastroenterol Hepatol. , vol.29 , Issue.3 , pp. 502-510
    • Koh, S.J.1    Kim, J.M.2    Kim, I.K.3    Ko, S.H.4    Kim, J.S.5
  • 24
    • 0036260784 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists prevent experimental autoimmune encephalomyelitis
    • Feinstein DL, Galea E, Gavrilyuk V, et al. Peroxisome proliferator-activated receptor-γ agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol. 2002;51(6):694-702.
    • (2002) Ann Neurol. , vol.51 , Issue.6 , pp. 694-702
    • Feinstein, D.L.1    Galea, E.2    Gavrilyuk, V.3
  • 25
    • 84859349600 scopus 로고    scopus 로고
    • The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
    • Gray E, Ginty M, Kemp K, Scolding N, Wilkins A. The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function. J Neuroinflammation. 2012;9:63.
    • (2012) J Neuroinflammation , vol.9 , pp. 63
    • Gray, E.1    Ginty, M.2    Kemp, K.3    Scolding, N.4    Wilkins, A.5
  • 26
    • 84860623244 scopus 로고    scopus 로고
    • Licensing ofmyeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ
    • Hucke S, Floßdorf J, Grützke B, et al. Licensing ofmyeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ. Brain. 2012;135 (pt 5):1586-1605.
    • (2012) Brain , vol.135 , pp. 1586-1605
    • Hucke, S.1    Floßdorf, J.2    Grützke, B.3
  • 27
    • 84896922432 scopus 로고    scopus 로고
    • Adipokines, metabolic syndrome and rheumatic diseases
    • Abella V, Scotece M, Conde J, et al. Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res. 2014;2014:343746.
    • (2014) J Immunol Res. , vol.2014 , pp. 343746
    • Abella, V.1    Scotece, M.2    Conde, J.3
  • 28
    • 14844282813 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes
    • Storer PD, Xu J, Chavis J, Drew PD. Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes. J Neuroimmunol. 2005;161(1-2):113-122.
    • (2005) J Neuroimmunol. , vol.161 , Issue.1-2 , pp. 113-122
    • Storer, P.D.1    Xu, J.2    Chavis, J.3    Drew, P.D.4
  • 30
    • 0037241113 scopus 로고    scopus 로고
    • Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
    • Sanna V, Di Giacomo A, La Cava A, et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest. 2003;111(2):241-250.
    • (2003) J Clin Invest. , vol.111 , Issue.2 , pp. 241-250
    • Sanna, V.1    Di Giacomo, A.2    La Cava, A.3
  • 31
    • 84858839512 scopus 로고    scopus 로고
    • Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis
    • Kraszula L, Jasińska A, Eusebio M, Kuna P, Głąbiński A, Pietruczuk M. Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurol Neurochir Pol. 2012;46(1): 22-28.
    • (2012) Neurol Neurochir Pol. , vol.46 , Issue.1 , pp. 22-28
    • Kraszula, L.1    Jasińska, A.2    Eusebio, M.3    Kuna, P.4    Głąbiński, A.5    Pietruczuk, M.6
  • 32
    • 84914703145 scopus 로고    scopus 로고
    • Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis
    • Evangelopoulos ME, Koutsis G, Markianos M. Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis. Autoimmune Dis. 2014;2014: 486282.
    • (2014) Autoimmune Dis. , vol.2014 , pp. 486282
    • Evangelopoulos, M.E.1    Koutsis, G.2    Markianos, M.3
  • 33
    • 84887150106 scopus 로고    scopus 로고
    • Increased leptin and A-FABP levels in relapsing and progressive forms of MS
    • Messina S, Vargas-Lowy D, Musallam A, et al. Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol. 2013;13:172.
    • (2013) BMC Neurol. , vol.13 , pp. 172
    • Messina, S.1    Vargas-Lowy, D.2    Musallam, A.3
  • 35
    • 84881510394 scopus 로고    scopus 로고
    • Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis
    • Piccio L, Cantoni C, Henderson JG, et al. Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis. Eur J Immunol. 2013;43(8):2089-2100.
    • (2013) Eur J Immunol. , vol.43 , Issue.8 , pp. 2089-2100
    • Piccio, L.1    Cantoni, C.2    Henderson, J.G.3
  • 36
    • 77955540342 scopus 로고    scopus 로고
    • Serum adiponectin, TNF-α, IL-12p70, and IL-13 levels in multiple sclerosis and the effects of different therapy regimens
    • Musabak U, Demirkaya S, Genç G, Ilikci RS, Odabasi Z. Serum adiponectin, TNF-α, IL-12p70, and IL-13 levels in multiple sclerosis and the effects of different therapy regimens. Neuroimmunomodulation. 2011;18(1):57-66.
    • (2011) Neuroimmunomodulation , vol.18 , Issue.1 , pp. 57-66
    • Musabak, U.1    Demirkaya, S.2    Genç, G.3    Ilikci, R.S.4    Odabasi, Z.5
  • 37
    • 1542313910 scopus 로고    scopus 로고
    • Anti-inflammatory and antiproliferative actions of PPAR-γ agonists on T lymphocytes derived from MS patients
    • Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT. Anti-inflammatory and antiproliferative actions of PPAR-γ agonists on T lymphocytes derived from MS patients. J Leukoc Biol. 2004;75(3):478-485.
    • (2004) J Leukoc Biol. , vol.75 , Issue.3 , pp. 478-485
    • Schmidt, S.1    Moric, E.2    Schmidt, M.3    Sastre, M.4    Feinstein, D.L.5    Heneka, M.T.6
  • 38
    • 77649270079 scopus 로고    scopus 로고
    • Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients
    • Shukla DK, Kaiser CC, Stebbins GT, Feinstein DL. Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients. Neurosci Lett. 2010;472(3):153-156.
    • (2010) Neurosci Lett. , vol.472 , Issue.3 , pp. 153-156
    • Shukla, D.K.1    Kaiser, C.C.2    Stebbins, G.T.3    Feinstein, D.L.4
  • 39
    • 67349169962 scopus 로고    scopus 로고
    • A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis
    • Kaiser CC, Shukla DK, Stebbins GT, et al. A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis. J Neuroimmunol. 2009;211(1-2):124-130.
    • (2009) J Neuroimmunol. , vol.211 , Issue.1-2 , pp. 124-130
    • Kaiser, C.C.1    Shukla, D.K.2    Stebbins, G.T.3
  • 40
    • 84948398534 scopus 로고    scopus 로고
    • Neutrophil extracellular trap mitochondrial DNA and its autoantibody in systemic lupus erythematosus and a proof-of-concept trial of metformin
    • Wang H, Li T, Chen S, Gu Y, Ye S. Neutrophil extracellular trap mitochondrial DNA and its autoantibody in systemic lupus erythematosus and a proof-of-concept trial of metformin. Arthritis Rheumatol. 2015;67(12):3190-3200.
    • (2015) Arthritis Rheumatol. , vol.67 , Issue.12 , pp. 3190-3200
    • Wang, H.1    Li, T.2    Chen, S.3    Gu, Y.4    Ye, S.5
  • 41
    • 84902300618 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptor-γ pioglitazone improves vascular function and decreases disease activity in patients with rheumatoid arthritis
    • Marder W, Khalatbari S, Myles JD, et al. The peroxisome proliferator activated receptor-γ pioglitazone improves vascular function and decreases disease activity in patients with rheumatoid arthritis. J AmHeart Assoc. 2013;2(6): e000441.
    • (2013) J AmHeart Assoc. , vol.2 , Issue.6 , pp. e000441
    • Marder, W.1    Khalatbari, S.2    Myles, J.D.3
  • 42
    • 17444404606 scopus 로고    scopus 로고
    • Pilot trial: Pioglitazone versus placebo in patients with plaque psoriasis (the P6)
    • [published correction appears in Int J Dermatol. 2005;44(7):622]
    • Shafiq N, Malhotra S, Pandhi P, Gupta M, Kumar B, Sandhu K. Pilot trial: Pioglitazone versus placebo in patients with plaque psoriasis (the P6) [published correction appears in Int J Dermatol. 2005;44(7):622]. Int J Dermatol. 2005;44(4): 328-333.
    • (2005) Int J Dermatol. , vol.44 , Issue.4 , pp. 328-333
    • Shafiq, N.1    Malhotra, S.2    Pandhi, P.3    Gupta, M.4    Kumar, B.5    Sandhu, K.6
  • 43
    • 84897935033 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmune neuroinflammation
    • Kleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunol Rev. 2014;259(1):231-244.
    • (2014) Immunol Rev. , vol.259 , Issue.1 , pp. 231-244
    • Kleinewietfeld, M.1    Hafler, D.A.2
  • 44
    • 84876461373 scopus 로고    scopus 로고
    • Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
    • Wagner NM, Brandhorst G, Czepluch F, et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk. Obesity (Silver Spring). 2013;21(3):461-468.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.3 , pp. 461-468
    • Wagner, N.M.1    Brandhorst, G.2    Czepluch, F.3


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