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Volumn 18, Issue 1, 2010, Pages 57-66

Serum adiponectin, TNF-α, IL-12p70, and IL-13 levels in multiple sclerosis and the effects of different therapy regimens

Author keywords

Adiponectin; Glatiramer acetate; Interferon; Interleukin; Multiple sclerosis; Pathogenesis

Indexed keywords

ADIPONECTIN; AZATHIOPRINE; BETA1A INTERFERON; GLATIRAMER; INTERFERON BETA SERINE; INTERLEUKIN 12P70; INTERLEUKIN 13; METHOTREXATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77955540342     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000317393     Document Type: Article
Times cited : (50)

References (45)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of mul-tiple sclerosis
    • Sospedra M, Martin R: Immunology of mul-tiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 0034025811 scopus 로고    scopus 로고
    • Multiple sclerosis is as-sociated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)-and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment
    • Ozenci V, Kouwenhoven M, Huang YM, Kivisäkk P, Link H: Multiple sclerosis is as-sociated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)-and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment. Clin Exp Immunol 2000; 120:147-153.
    • (2000) Clin Exp Immunol , vol.120 , pp. 147-153
    • Ozenci, V.1    Kouwenhoven, M.2    Huang, Y.M.3    Kivisäkk, P.4    Link, H.5
  • 4
    • 0035352990 scopus 로고    scopus 로고
    • T cells, cytokines, and autoantigens in multiple sclerosis
    • Gran B, Rostami A: T cells, cytokines, and autoantigens in multiple sclerosis. Curr Neu-rol Neurosci Rep 2001; 1: 263-270.
    • (2001) Curr Neurol Neurosci Rep , vol.1 , pp. 263-270
    • Gran, B.1    Rostami, A.2
  • 5
    • 3142556134 scopus 로고    scopus 로고
    • Development of bio-markers in multiple sclerosis
    • Bielekova B, Martin R: Development of bio-markers in multiple sclerosis. Brain 2004; 127:1463-1478.
    • (2004) Brain , vol.127 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 6
    • 0029743819 scopus 로고    scopus 로고
    • Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99)
    • Hemmer B, Vergelli M, Calabresi P, Huang T, McFarland HF, Martin R: Cytokine phe-notype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99). J Neurosci Res 1996; 45: 852-862. (Pubitemid 26332573)
    • (1996) Journal of Neuroscience Research , vol.45 , Issue.6 , pp. 852-862
    • Hemmer, B.1    Vergelli, M.2    Calabresi, P.3    Huang, T.4    McFarland, H.F.5    Martin, R.6
  • 7
    • 2142733093 scopus 로고    scopus 로고
    • Cytokines
    • Ab-bas AK, Lichtman AH (eds) ed 5, Philadelphia, Saunders
    • Abbas AK, Lichtman AH: Cytokines; in Ab-bas AK, Lichtman AH (eds): Cellular and Molecular Immunology, ed 5, Philadelphia, Saunders, 2003, pp 243-274.
    • (2003) Cellular and Molecular Immunology , pp. 243-274
    • Abbas, A.K.1    Lichtman, A.H.2
  • 9
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, in-flammation, and cardiovascular disease
    • Berg AH, Scherer PE: Adipose tissue, in-flammation, and cardiovascular disease. Circ Res 2005; 96:939-949.
    • (2005) Circ Res , vol.96 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 15
    • 74549218763 scopus 로고    scopus 로고
    • El-evated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple scle-rosis: A Finnish co-twin study
    • DOI: 10.1111/j.1468-1331.2009.02701.x
    • Hietaharju A, Kuusisto H, Nieminen R, Vuolteenaho K, Elovaara I, Moilanen E: El-evated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple scle-rosis: a Finnish co-twin study. Eur J Neurol DOI: 10.1111/j.1468-1331.2009.02701.x.
    • Eur J Neurol
    • Hietaharju, A.1    Kuusisto, H.2    Nieminen, R.3    Vuolteenaho, K.4    Elovaara, I.5    Moilanen, E.6
  • 19
    • 0033401730 scopus 로고    scopus 로고
    • Interleukin-12 is detectable in sera of patients with multiple sclerosis-associa-tion with chronic progressive disease course?
    • Heesen C, Sieverding F, Schoser BG, Hadji B, Kunze K: Interleukin-12 is detectable in sera of patients with multiple sclerosis-associa-tion with chronic progressive disease course? Eur J Neurol 1999; 6: 591-596.
    • (1999) Eur J Neurol , vol.6 , pp. 591-596
    • Heesen, C.1    Sieverding, F.2    Schoser, B.G.3    Hadji, B.4    Kunze, K.5
  • 20
  • 22
    • 0347968011 scopus 로고    scopus 로고
    • Multiple sclerosis: Expression of CD1a and production of IL-12p70 and IFN-gamma by blood mononuclear cells in pa-tients on combination therapy with IFN-beta and glatiramer acetate compared to monotherapy with IFN-beta
    • Hussien Y, Sanna A, Söderström M, Link H, Huang YM: Multiple sclerosis: expression of CD1a and production of IL-12p70 and IFN-gamma by blood mononuclear cells in pa-tients on combination therapy with IFN-beta and glatiramer acetate compared to monotherapy with IFN-beta. Mult Scler 2004; 10:16-25.
    • (2004) Mult Scler , vol.10 , pp. 16-25
    • Hussien, Y.1    Sanna, A.2    Söderström, M.3    Link, H.4    Huang, Y.M.5
  • 24
    • 33748791731 scopus 로고    scopus 로고
    • The inter-leukin-10 levels as a potential indicator of positive response to interferon beta treat-ment of multiple sclerosis patients
    • Bartosik-Psujek H, Stelmasiak Z: The inter-leukin-10 levels as a potential indicator of positive response to interferon beta treat-ment of multiple sclerosis patients. Clin Neu-rol Neurosurg 2006; 108:644-647.
    • (2006) Clin Neu-rol Neurosurg , vol.108 , pp. 644-647
    • Bartosik-Psujek, H.1    Stelmasiak, Z.2
  • 25
    • 0346964327 scopus 로고    scopus 로고
    • A retrospective, observational study compar-ing the four available immunomodulatory treatments for relapsing-remitting multiple sclerosis
    • Carrá A, Onaha P, Sinay V, Alvarez F, Luetic G, Bettinelli R, San Pedro E, Rodríguez L: A retrospective, observational study compar-ing the four available immunomodulatory treatments for relapsing-remitting multiple sclerosis. Eur J Neurol 2003; 10:671-676.
    • (2003) Eur J Neurol , vol.10 , pp. 671-676
    • Carrá, A.1    Onaha, P.2    Sinay, V.3    Alvarez, F.4    Luetic, G.5    Bettinelli, R.6    San Pedro, E.7    Rodríguez, L.8
  • 27
    • 0037181634 scopus 로고    scopus 로고
    • Independent Comparison of Interferon (INCOMIN) Trial Study Group: Every-oth-er-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: Results of a 2-year prospective randomised multicentre study (INCOMIN)
    • Durelli L, Verdun E, Barbero P, Bergui M, Versino E, Ghezzi A, Montanari E, Zaffaroni M, Independent Comparison of Interferon (INCOMIN) Trial Study Group: Every-oth-er-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 2002; 359:1453-1460.
    • (2002) Lancet , vol.359 , pp. 1453-1460
    • Durelli, L.1    Verdun, E.2    Barbero, P.3    Bergui, M.4    Versino, E.5    Ghezzi, A.6    Montanari, E.7    Zaffaroni, M.8
  • 28
    • 0037180479 scopus 로고    scopus 로고
    • Evidence of Interferon Dose-response: Euro-pean North American Comparative Effica-cy, University of British Columbia MS/MRI Research Group: Randomized, comparative study of interferon beta-1a treatment regi-mens in MS: The EVIDENCE Trial
    • Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O'Connor P, Monaghan E, Li D, Weinshenker B, EVIDENCE Study Group, Evidence of Interferon Dose-response: Euro-pean North American Comparative Effica-cy, University of British Columbia MS/MRI Research Group: Randomized, comparative study of interferon beta-1a treatment regi-mens in MS: the EVIDENCE Trial. Neurology 2002; 59: 1496-1506.
    • (2002) Neurology , vol.59 , pp. 1496-1506
    • Panitch, H.1    Goodin, D.S.2    Francis, G.3    Chang, P.4    Coyle, P.K.5    O'Connor, P.6    Monaghan, E.7    Li, D.8    Weinshenker, B.9    Study Group, E.10
  • 29
    • 20044388168 scopus 로고    scopus 로고
    • Twenty-four-month com-parison of immunomodulatory treatments - A retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (Copaxone)
    • Haas J, Firzlaff M: Twenty-four-month com-parison of immunomodulatory treatments-a retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (Copaxone). Eur J Neu-rol 2005; 12:425-431.
    • (2005) Eur J Neurol , vol.12 , pp. 425-431
    • Haas, J.1    Firzlaff, M.2
  • 30
    • 0034520544 scopus 로고    scopus 로고
    • The antiinflammatory cytokine interleu-kin-13 is not detectable in the circulation of multiple sclerosis patients and is not in-ducible by interferon-beta1b treatment, that neither modifies its ex vivo secretion from peripheral blood mononuclear cells
    • Nicoletti F, Marco RD, Patti F, Nicoletti A, Leonardi C, Reggio E, Meroni P, Reggio A: The antiinflammatory cytokine interleu-kin-13 is not detectable in the circulation of multiple sclerosis patients and is not in-ducible by interferon-beta1b treatment, that neither modifies its ex vivo secretion from peripheral blood mononuclear cells. Auto-immunity 2000; 32: 265-270.
    • (2000) Autoimmunity , vol.32 , pp. 265-270
    • Nicoletti, F.1    Marco, R.D.2    Patti, F.3    Nicoletti, A.4    Leonardi, C.5    Reggio, E.6    Meroni, P.7    Reggio, A.8
  • 31
    • 0042827531 scopus 로고    scopus 로고
    • Correlation of serum IL-13 and IL-5 levels with clinical response to Glatiramer acetate in patients with mul-tiple sclerosis
    • Wiesemann E, Klatt J, Wenzel C, Heiden-reich F, Windhagen A: Correlation of serum IL-13 and IL-5 levels with clinical response to Glatiramer acetate in patients with mul-tiple sclerosis. Clin Exp Immunol 2003; 133: 454-460.
    • (2003) Clin Exp Immunol , vol.133 , pp. 454-460
    • Wiesemann, E.1    Klatt, J.2    Wenzel, C.3    Heiden-Reich, F.4    Windhagen, A.5
  • 32
    • 0037105990 scopus 로고    scopus 로고
    • Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase
    • Ochi H, Osoegawa M, Wu XM, Minohara M, Horiuchi I, Murai H, Furuya H, Kira J: In-creased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase. J Neurol Sci 2002; 201:45-51.
    • (2002) J Neurol Sci , vol.201 , pp. 45-51
    • Ochi, H.1    Osoegawa, M.2    Wu, X.M.3    Minohara, M.4    Horiuchi, I.5    Murai, H.6    Furuya, H.7    Kira, J.8
  • 33
    • 49149116386 scopus 로고    scopus 로고
    • Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis
    • Wiesemann E, Deb M, Hemmer B, Radeke HH, Windhagen A: Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis. Clin Immunol 2008; 128: 306-313.
    • (2008) Clin Immunol , vol.128 , pp. 306-313
    • Wiesemann, E.1    Deb, M.2    Hemmer, B.3    Radeke, H.H.4    Windhagen, A.5
  • 34
    • 33744535722 scopus 로고    scopus 로고
    • Longterm favorable response to interferon beta-1b is linked to cytokine deviation to-ward the Th2 and Tc2 sides in Japanese pa-tients with multiple sclerosis
    • Mei FJ, Osoegawa M, Ochi H, Minohara M, Nan S, Murai H, Ishizu T, Taniwaki T, Kira J: Long-term favorable response to interferon beta-1b is linked to cytokine deviation to-ward the Th2 and Tc2 sides in Japanese pa-tients with multiple sclerosis. J Neurol Sci 2006; 246: 71-77.
    • (2006) J Neurol Sci , vol.246 , pp. 71-77
    • Mei, F.J.1    Osoegawa, M.2    Ochi, H.3    Minohara, M.4    Nan, S.5    Murai, H.6    Ishizu, T.7    Taniwaki, T.8    Kira, J.9
  • 35
    • 0029311748 scopus 로고
    • A phase III trial of intramuscular recombinant interferon beta as treatment for exacerbat-ing-remitting multiple sclerosis: Design and conduct of study and baseline characteristics of patients
    • Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, Hern-don RM, Richert JR Salazar AM, Fischer JS, Goodkin DE, Granger CV, Simon JH: A phase III trial of intramuscular recombinant interferon beta as treatment for exacerbat-ing-remitting multiple sclerosis: design and conduct of study and baseline characteristics of patients. Multiple Sclerosis Collaborative Research Group (MSCRG). Mult Scler 1995; 1:118-135
    • (1995) Mult Scler , vol.1 , pp. 118-135
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3    Hern-Don, R.M.4    Richert, J.R.5    Salazar, A.M.6    Fischer, J.S.7    Goodkin, D.E.8    Granger, C.V.9    Simon, J.H.10
  • 36
    • 0027418515 scopus 로고
    • Clinical re-sults of a multicenter, randomized, double blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group: Interferon beta 1-b is effective in relapsing-remitting multiple sclerosis. I.
    • The IFNB Multiple Sclerosis Study Group: Interferon beta 1-b is effective in relapsing-remitting multiple sclerosis. I. Clinical re-sults of a multicenter, randomized, double blind, placebo-controlled trial. Neurology 1993; 43:655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 37
    • 0345601517 scopus 로고    scopus 로고
    • PRISMS (Prevention of Relapses and Dis-ability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group: Ran-domised double-blind placebo-controlled study of interferon beta-1a in relapsing/re-mitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Dis-ability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group: Ran-domised double-blind placebo-controlled study of interferon beta-1a in relapsing/re-mitting multiple sclerosis. Lancet 1998; 352: 1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 38
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in re-lapsing-remitting multiple sclerosis: Results of a phase III multicenter, double blind pla-cebo-controlled trial
    • The Copolymer 1 Mul-tiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB: Copolymer 1 reduces relapse rate and improves disability in re-lapsing-remitting multiple sclerosis: results of a phase III multicenter, double blind pla-cebo-controlled trial. The Copolymer 1 Mul-tiple Sclerosis Study Group. Neurology 1995; 45:1268-1276.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3    Ford, C.C.4    Goldstein, J.5    Lisak, R.P.6    Myers, L.W.7    Panitch, H.S.8    Rose, J.W.9    Schiffer, R.B.10
  • 39
    • 0025976467 scopus 로고
    • Serum and CSF levels of IL-2, sIL-2R TNF-al-pha, and IL-1 beta in chronic progressive multiple sclerosis: Expected lack of clinical utility
    • Peter JB, Boctor FN, Tourtellotte WW: Se-rum and CSF levels of IL-2, sIL-2R TNF-al-pha, and IL-1 beta in chronic progressive multiple sclerosis: expected lack of clinical utility. Neurology 1991; 41:121-123.
    • (1991) Neurology , vol.41 , pp. 121-123
    • Peter, J.B.1    Boctor, F.N.2    Tourtellotte, W.W.3
  • 40
    • 0026066932 scopus 로고
    • Cytokine levels in the cerebrospinal flu-id and serum of patients with multiple scle-rosis
    • Maimone D, Gregory S, Arnason BG, Reder AT: Cytokine levels in the cerebrospinal flu-id and serum of patients with multiple scle-rosis. J Neuroimmunol 1991; 32:67-74.
    • (1991) J Neuroimmunol , vol.32 , pp. 67-74
    • Maimone, D.1    Gregory, S.2    Arnason, B.G.3    Reder, A.T.4
  • 41
    • 0025856580 scopus 로고
    • Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis
    • Tsukada N, Miyagi K, Matsuda M, Yanagi-sawa N, Yone K: Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis. J Neurol Sci 1991; 104: 230-234.
    • (1991) J Neurol Sci , vol.104 , pp. 230-234
    • Tsukada, N.1    Miyagi, K.2    Matsuda, M.3    Yanagi-Sawa, N.4    Yone, K.5
  • 42
    • 0026596353 scopus 로고
    • In vivo relation-ship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis
    • Sharief MK, Thompson EJ: In vivo relation-ship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol 1992; 38: 27-33.
    • (1992) J Neuroimmunol , vol.38 , pp. 27-33
    • Sharief, M.K.1    Thompson, E.J.2
  • 43
    • 33845904623 scopus 로고    scopus 로고
    • Association among serous and cerebrospinal fluid TNF-alpha level, gene polymorphisms of TNF-alpha and multiple sclerosis in Han nationality of southern China (in Chinese)
    • Dong YX, Xu ZR, Lin PY: Association among serous and cerebrospinal fluid TNF-alpha level, gene polymorphisms of TNF-alpha and multiple sclerosis in Han nationality of southern China (in Chinese). Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006; 23: 677-679.
    • (2006) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.23 , pp. 677-679
    • Dong, Y.X.1    Xu, Z.R.2    Lin, P.Y.3
  • 45
    • 33646592531 scopus 로고    scopus 로고
    • Sex hormones: A role in the control of multiple sclerosis?
    • Tomassini V, Pozzilli C: Sex hormones: a role in the control of multiple sclerosis? Expert Opin Pharmacother 2006; 7: 857-868.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 857-868
    • Tomassini, V.1    Pozzilli, C.2


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