Leptin as a metabolic link to multiple sclerosis

Nature Reviews Neurology

Volumn 6, Issue 8, 2010, Pages 455-461

  Matarese, Giuseppe ^a   Carrieri, Pietro Biagio ^b   Montella, Silvana ^b   De Rosa, Veronica ^a   La Cava, Antonio ^c  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCANNABINOID; GLITAZONE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEPTIN; LEPTIN RECEPTOR; METFORMIN; NEUROPEPTIDE Y; RECOMBINANT LEPTIN;

ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CALORIC RESTRICTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG MECHANISM; FOOD INTAKE; HORMONAL REGULATION; HORMONE METABOLISM; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INSULIN RESISTANCE; METABOLIC REGULATION; MULTIPLE SCLEROSIS; NERVE CELL DIFFERENTIATION; NEUROPATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; LEPTIN; MULTIPLE SCLEROSIS; SELF TOLERANCE;

EID: 77956264569     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2010.89     Document Type: Review

References (46)

1. Ahima R. S., Flier J. S. Leptin. Annu. Rev. Physiol. 62:413-437 (2000).
2. La Cava, A. & Matarese, G. The weight of leptin in immunity. Nat. Rev. Immunol. 4, 371-379 (2004).
3. O'Neill, L. A role for leptin in autoimmunity? Trends Immunol. 22, 352 (2001).
4. Matarese, G. & La Cava, A. The intricate interface between immune system and metabolism. Trends Immunol. 25, 193-200 (2004).
5. Steinman, L. A molecular trio in relapse and remission in multiple sclerosis. Nat. Rev. Immunol. 9, 440-447 (2009).
6. Matarese, G. et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol. 23, 182-187 (2002).
7. De Rosa, V. et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 26, 241-255 (2007).
8. Sánchez-Margalet, V. et al. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin. Exp. Immunol. 133, 11-19 (2003).
9. Hekerman, P. et al. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J. 272, 109-119 (2005).
10. Chan, J. L. et al. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc. Natl Acad. Sci. USA 103, 8481-8486 (2006).
11. Sanna, V. et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J. Clin. Invest. 111, 241-250 (2003).
12. Howard, J. K. et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104, 1051-1059 (1999).
13. Matarese, G. et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 166, 5909-5916 (2001).
14. Sarraf, P. et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185, 171-175 (1997).
15. Lock, C. et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8, 500-508 (2002).
16. + regulatory T cells. Proc. Natl Acad. Sci. USA 102, 5150-5155 (2005).
17. De Rosa, V. et al. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J. Clin. Invest. 116, 447-455 (2006).
18. Farooqi, I. S. et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110, 1093-1103 (2002).
19. Härle, P. & Straub, R. H. Leptin is a link between adipose tissue and inflammation. Ann. NY Acad. Sci. 1069, 454-462 (2006).
20. Frisullo, G. The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. J. Neuroimmunol. 192, 174-183 (2007).
21. Munger, K. L., Chitnis, T. & Ascherio, A. Body size and risk of MS in two cohorts of US women. Neurology 73, 1543-1550 (2009).
22. Gomez, R., Lago, F., Gomez-Reino, J., Dieguez, C. & Gualillo, O. Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. J. Mol. Endocrinol. 43, 11-18 (2009).
23. Lago, F., Dieguez, C., Gómez-Reino, J. & Gualillo, O. Adipokines as emerging mediators of immune response and inflammation. Nat. Clin. Pract. Rheumatol. 3, 716-724 (2007).
24. Taleb, S. et al. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27, 2691-2698 (2007).
25. Dixit, V. D. et al. Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114, 57-66 (2004).
26. Theil, M. M. et al. Suppression of experimental autoimmune encephalomyelitis by ghrelin. J. Immunol. 183, 2859-2866 (2009).
27. 1 receptor-specific inhibition of autoreactive Th1 responses in vivo. J. Immunol. 171, 3451-3458 (2003).
28. Malfitano, A. M. et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. J. Neuroimmunol. 171, 110-119 (2006).
29. Piccio, L., Stark, J. L. & Cross, A. H. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J. Leukoc. Biol. 84, 940-948 (2008).
30. Longo, V. D. & Fontana, L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol. Sci. 31, 89-98 (2010).
31. Esquifino, A. I., Cano, P., Jimenez, V., Cutrera, R. A. & Cardinali, D. P. Experimental allergic encephalomyelitis in male Lewis rats subjected to calorie restriction. J. Physiol. Biochem. 60, 245-252 (2004).
32. Esquifino, A. I., Cano, P., Jimenez-Ortega, V., Fernandez-Mateos, M. P. & Cardinali, D. P. Immune response after experimental allergic encephalomyelitis in rats subjected to calorie restriction. J. Neuroinflammation 4, 6 (2007).
33. Hewson, D. C. Is there a role for gluten-free diets in multiple sclerosis? Hum. Nutr. Appl. Nutr. 38, 417-420 (1984).
34. Swank, R. L. & Dugan, B. B. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 336, 37-39 (1990).
35. Nath, N. et al. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J. Immunol. 182, 8005-8014 (2009).
36. 1214-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 168, 2508-2515 (2002).
37. Youssef, S. et al. The HMG-CoA reductase nhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420, 78-84 (2002).
38. Heneka, M. T., Landreth, G. E. & Hüll, M. Drug nsight: effects mediated by peroxisome proliferator-activated receptor-Y in CNS disorders. Nat. Clin. Pract. Neurol. 3, 496-504 (2007).
39. Zhang, X. & Markovic-Plese, S. Statins' mmunomodulatory potential against Th17 cell-mediated autoimmune response. Immunol. Res. 41, 165-174 (2008).
40. Udagawa, J. et al. The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147, 647-658 (2006).
41. Valerio, A. et al. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3(3. J. Biol. Chem. 281, 12950-12958 (2006).
42. Ahima, R. S., Bjorbaek, C, Osei, S. & Flier, J. S. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140, 2755-2762 (1999).
43. Levine, J. M., Reynolds, R. & Fawcett, J. W. The oligodendrocyte precursor cell in health and disease. Trends Neurosci. 24, 39-47 (2001).
44. Steinman, L, Conlon, P, Maki, R. & Foster, A. The ntricate interplay among body weight, stress, and the immune response to friend or foe. J. Clin. Invest. 111, 183-185 (2003).
45. Kuchroo, V. K. & Nicholson, L. B. Fast and feel good? Nature 422, 27-28 (2003).
46. Gao, Q. & Horvath, T L. Neurobiology of feeding and energy expenditure. Annu. Rev. Neurosci. 30, 367-398 (2007).