Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 19, 2016, Pages 5424-5428

  Nagy, Maria ^a,b   Fenton, Wayne A ^b   Li, Di ^a,b   Furtak, Krystyna ^a,b   Horwich, Arthur L ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ALS; Chaperone; Hsp110; SOD1; Survival

Indexed keywords

CHAPERONE; COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK PROTEIN 110;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; MOTONEURON; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN FOLDING; SURVIVAL; SURVIVAL RATE; TRANSGENE; ANIMAL; FEMALE; GENETICS; MALE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; FEMALE; HSP110 HEAT-SHOCK PROTEINS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR CHAPERONES; MOTOR NEURONS; PROTEIN FOLDING; SUPEROXIDE DISMUTASE-1; SURVIVAL RATE;

EID: 84966430282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604885113     Document Type: Article

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