Attenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture model

Brain Research

Volumn 1644, Issue , 2016, Pages 1-8

  Zhu, Ya Juan ^a   Peng, Ke ^a   Meng, Xiao Wen ^a   Ji, Fu Hai ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Cholinergic receptor; Dexmedetomidine; Neuroinflammation; Tibial fracture; Vagus nerve

Indexed keywords

CD11B ANTIGEN; DEXMEDETOMIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; METHYLLYCACONITINE; TUMOR NECROSIS FACTOR ALPHA; ACONITINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUNGAROTOXIN RECEPTOR; NEUROPROTECTIVE AGENT; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME ACTIVITY; HIPPOCAMPUS; IMMUNOFLUORESCENCE; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TIBIA FRACTURE; VAGOTOMY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENCEPHALITIS; METABOLISM; SPRAGUE DAWLEY RAT;

ACONITINE; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ASTROCYTES; DEXMEDETOMIDINE; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HIPPOCAMPUS; INTERLEUKIN-1BETA; MALE; MICROGLIA; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; TIBIAL FRACTURES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84966389757     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2016.04.074     Document Type: Article

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