Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering

FASEB Journal

Volumn 30, Issue 5, 2016, Pages 1941-1957

  Plecitá Hlavatá, Lydie ^a   Engstová, Hana ^a   Alán, Lukáš M ^a   Špaček, Tomáš ^a   Dlasková, Andrea ^a   Smolková, Katarína ^a   Špačková, Jitka ^a   Tauber, Jan ^a   Strádalová, Vendula ^b   Malínský, Jan ^b   Lessard, Mark ^c   Bewersdorf, Joerg ^d   Ježek, Petr ^a  

^a INSTITUTE OF MATHEMATICS   (Czech Republic)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^c JACKSON LABORATORY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DSTORM 3d immunocytochemistry; Electron microscopy; Mic60; Mitochondrial cristae morphology; Mitofilin; OPA1

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIMER; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOFILIN; MONOMER; OXYGEN; PENICILLINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX; PROTEIN SUBUNIT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ADAPTATION; ARTICLE; CELL RESPIRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME SYNTHESIS; FLUORESCENCE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC ADAPTATION; HYPOXIC CELL; IMMUNOCYTOCHEMISTRY; MICROSCOPY; MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOLECULAR IMAGING; OLIGOMERIZATION; OUTER MEMBRANE; OXIDATIVE PHOSPHORYLATION; PHOTOACTIVATION; PRIORITY JOURNAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; METABOLISM; MITOCHONDRIAL DYNAMICS; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN SUBUNIT;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; ATP SYNTHETASE COMPLEXES; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; MULTIPROTEIN COMPLEXES; OXYGEN; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN SUBUNITS;

EID: 84966373468     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201500176     Document Type: Article

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