Antibacterial Diamines Targeting Bacterial Membranes

Journal of Medicinal Chemistry

Volumn 59, Issue 7, 2016, Pages 3140-3151

  Wang, Bo ^a,c   Pachaiyappan, Boobalan ^b,d   Gruber, Jordon D ^a   Schmidt, Michael G ^a   Zhang, Yong Mei ^a   Woster, Patrick M ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,11 BIS [(3,3 DIPHENYLPROPYL)UREIDO]UNDECANE; 1,12 BIS [(1,1 DIPHENYLMETHYL)THIOUREIDO]DODECANE; 1,12 BIS [(1,1 DIPHENYLMETHYL)UREIDO]DODECANE; 1,12 BIS [(2,2 DIPHENYLETHYL)UREIDO]DODECANE; 1,13 BIS[[(2,2 DIPHENYL) 1 ETHYL]THIOUREIDO] 4,10 DIAZATRIDECANE; AMPICILLIN; ANTIBIOTIC AGENT; COLISTIN; DIAMINE; FLUOROURACIL; GENTAMICIN; KANAMYCIN; NORFLOXACIN; TETRACYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

A549 CELL LINE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEPOLARIZATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERANCE; ESCHERICHIA COLI; HEK293 CELL LINE; HEMOLYSIS; HUMAN; HUMAN CELL; INHIBITORY CONCENTRATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SELECTIVITY INDEX; STAPHYLOCOCCUS AUREUS; TOXICITY ASSAY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BIOFILM; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; CAENORHABDITIS ELEGANS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMISTRY TECHNIQUES, SYNTHETIC; DIAMINES; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; ESCHERICHIA COLI; HEK293 CELLS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84966372886     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01912     Document Type: Article

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