Effects of amoxicillin and augmentin on cystine-glutamate exchanger and glutamate transporter 1 isoforms as well as ethanol intake in alcohol-preferring rats

Frontiers in Neuroscience

Volumn 10, Issue APR, 2016, Pages

  Hakami, Alqassem Y ^a   Hammad, Alaa M ^a   Sari, Youssef ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

Amoxicillin; Augmentin; GLAST; GLT 1 isoforms; xCT

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; CYSTINE GLUTAMATE EXCHANGER; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE TRANSPORTER; ISOPROTEIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 1A; VESICULAR GLUTAMATE TRANSPORTER 1B;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TREATMENT RESPONSE; UPREGULATION;

EID: 84966349713     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2016.00171     Document Type: Article

References (42)

1. Alasmari, F., Abuhamdah, S., and Sari, Y. (2015). Effects of ampicillin on cystine/glutamate antiporter and glutamate transporter 1 isoforms as well as ethanol drinking in male P rats. Neurosci. Lett. 600, 148-152. doi: 10.1016/j.neulet.2015.06.015.
2. Alasmari, F., Rao, P. S. S., and Sari, Y. (2016). Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats. Brain Res. 1634, 150-157. doi: 10.1016/j.brainres.2016.01.007.
3. Alhaddad, H., Das, S. C., and Sari, Y. (2014a). Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats. Psychopharmacology 231, 4049-4057. doi: 10.1007/s00213-014-3545-y.
4. Alhaddad, H., Kim, N. T., Aal-Aaboda, M., Althobaiti, Y. S., Leighton, J., Boddu, S. H., et al. (2014b). Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Front. Behav. Neurosci. 8:366. doi: 10.3389/fnbeh.2014.00366.
5. Baker, D., Shen, H., and Kalivas, P. (2002). Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration. Amino Acids 23, 161-162. doi: 10.1007/s00726-001-0122-6.
6. Bauer, D. E., Jackson, J. G., Genda, E. N., Montoya, M. M., Yudkoff, M., and Robinson, M. B. (2012). The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism. Neurochem. Int. 61, 566-574. doi: 10.1016/j.neuint.2012.01.013.
7. Bell, R. L., Rodd, Z. A., Schultz, J. A., Peper, C. L., Lumeng, L., Murphy, J. M., et al. (2008). Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol 42, 407-416. doi: 10.1016/j.alcohol.2008.03.130.
8. Berger, U. V., DeSilva, T. M., Chen, W., and Rosenberg, P. A. (2005). Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization. J. Comp. Neurol. 492, 78-89. doi: 10.1002/cne.20737.
9. Capriles, N., Rodaros, D., Sorge, R. E., and Stewart, J. (2003). A role for the prefrontal cortex in stress-and cocaine-induced reinstatement of cocaine seeking in rats. Psychopharmacology 168, 66-74. doi: 10.1007/s00213-002-1283-z.
10. Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., and O'brien, C. P. (1999). Limbic activation during cue-induced cocaine craving. Am. J. Psychiatry 156, 11-18.
11. Danbolt, N. C. (2001). Glutamate uptake. Prog. Neurobiol. 65, 1-105. doi: 10.1016/S0301-0082(00)00067-8.
12. Das, S. C., Yamamoto, B. K., Hristov, A. M., and Sari, Y. (2015). Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. Neuropharmacology 97, 67-74. doi: 10.1016/j.neuropharm.2015.05.009.
13. Ding, Z. M., Rodd, Z. A., Engleman, E. A., Bailey, J. A., Lahiri, D. K., and McBride, W. J. (2013). Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. Addict. Biol. 18, 297-306. doi: 10.1111/adb.12018.
14. Goldstein, R. Z., and Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am. J. Psychiatry 159, 1642-1652. doi: 10.1176/appi.ajp.159.10.1642.
15. Goodwani, S., Rao, P. S., Bell, R. L., and Sari, Y. (2015). Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Brain Res. 1622, 397-408. doi: 10.1016/j.brainres.2015.07.008.
16. Griffin III, W. C., Haun, H. L., Hazelbaker, C. L., Ramachandra, V. S., and Becker, H. C. (2014). Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology 39, 707-717. doi: 10.1038/npp.2013.256.
17. Holmseth, S., Dehnes, Y., Huang, Y. H., Follin-Arbelet, V. V., Grutle, N. J., Mylonakou, M. N., et al. (2012). The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS. J. Neurosci. 32, 6000-6013. doi: 10.1523/JNEUROSCI.5347-11.2012.
18. Holmseth, S., Scott, H. A., Real, K., Lehre, K. P., Leergaard, T. B., Bjaalie, J. G., et al. (2009). The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation. Neuroscience 162, 1055-1071. doi: 10.1016/j.neuroscience.2009.03.048.
19. Kapasova, Z., and Szumlinski, K. K. (2008). Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake. Alcohol. Clin. Exp. Res. 32, 617-631. doi: 10.1111/j.1530-0277.2008.00620.x.
20. Kim, J., John, J., Langford, D., Walker, E., Ward, S., and Rawls, S. M. (2015). Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino Acids 48, 689-696. doi: 10.1007/s00726-015-2117-8.
21. Knackstedt, L. A., Melendez, R. I., and Kalivas, P. W. (2010). Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol. Psychiatry 67, 81-84. doi: 10.1016/j.biopsych.2009.07.018.
22. Lehre, K. P., and Danbolt, N. C. (1998). The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J. Neurosci. 18, 8751-8757.
23. Lipski, J., Wan, C. K., Bai, J. Z., Pi, R., Li, D., and Donnelly, D. (2007). Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146, 617-629. doi: 10.1016/j.neuroscience.2007.02.003.
24. Maragakis, N. J., Dykes-Hoberg, M., and Rothstein, J. D. (2004). Altered expression of the glutamate transporter EAAT2b in neurological disease. Ann. Neurol. 55, 469-477. doi: 10.1002/ana.20003.
25. McFarland, K., Lapish, C. C., and Kalivas, P. W. (2003). Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 23, 3531-3537.
26. Melendez, R. I., Hicks, M. P., Cagle, S. S., and Kalivas, P. W. (2005). Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol. Clin. Exp. Res. 29, 326-333. doi: 10.1097/01.ALC.0000156086.65665.4D.
27. Moghaddam, B., and Bolinao, M. L. (1994). Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci. Lett. 178, 99-102. doi: 10.1016/0304-3940(94)90299-2.
28. Moran, M. M., McFarland, K., Melendez, R. I., Kalivas, P. W., and Seamans, J. K. (2005). Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J. Neurosci. 25, 6389-6393. doi: 10.1523/JNEUROSCI.1007-05.2005.
29. Obara, I., Bell, R. L., Goulding, S. P., Reyes, C. M., Larson, L. A., Ary, A. W., et al. (2009). Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcohol. Clin. Exp. Res. 33, 1924-1934. doi: 10.1111/j.1530-0277.2009.01030.x.
30. Paxinos, G., and Watson, C. (1997). The Rat Brain in Stereotaxic Coordinates, Compact. San Diego: Academic Press Figure.
31. Petr, G. T., Sun, Y., Frederick, N. M., Zhou, Y., Dhamne, S. C., Hameed, M. Q., et al. (2015). Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J. Neurosci. 35, 5187-5201. doi: 10.1523/JNEUROSCI.4255-14.2015.
32. Rao, P. S., Saternos, H., Goodwani, S., and Sari, Y. (2015). Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Psychopharmacology (Berl). 232, 2333-2342. doi: 10.1007/s00213-015-3868-3.
33. Rao, P. S. S., and Sari, Y. (2014). Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats. J. Mol. Neurosci. 54, 71-77. doi: 10.1007/s12031-014-0251-5.
34. Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., et al. (1996). Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675-686. doi: 10.1016/S0896-6273(00)80086-0.
35. Sari, Y., Sakai, M., Weedman, J. M., Rebec, G. V., and Bell, R. L. (2011). Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. Alcohol Alcohol. 46, 239-246. doi: 10.1093/alcalc/agr023.
36. Sari, Y., Smith, K. D., Ali, P. K., and Rebec, G. V. (2009). Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. J. Neurosci. 29, 9239-9243. doi: 10.1523/JNEUROSCI.1746-09.2009.
37. Sari, Y., and Sreemantula, S. N. (2012). Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience 227, 327-335. doi: 10.1016/j.neuroscience.2012.10.007.
38. Sari, Y., Sreemantula, S. N., Lee, M. R., and Choi, D.-S. (2013). Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. J. Mol. Neurosci. 51, 779-787. doi: 10.1007/s12031-013-0064-y.
39. Shalev, U., Grimm, J. W., and Shaham, Y. (2002). Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54, 1-42. doi: 10.1124/pr.54.1.1.
40. Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., et al. (1997). Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276, 1699-1702. doi: 10.1126/science.276.5319.1699.
41. Volterra, A., Bezzi, P., Rizzini, B. L., Trotti, D., Ullensvang, K., Danbolt, N. C., et al. (1996). The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. Eur. J. Neurosci. 8, 2019-2028. doi: 10.1111/j.1460-9568.1996.tb01345.x.
42. Whitelaw, B. S., and Robinson, M. B. (2013). Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes. Front. Endocrinol. 4:123. doi: 10.3389/fendo.2013.00123.