Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions

Brain Research

Volumn 1622, Issue , 2015, Pages 397-408

  Goodwani, Sunil ^a   Rao, P S S ^a   Bell, Richard L ^b   Sari, Youssef ^a  

^a UNIVERSITY OF TOLEDO   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT; Amoxicillin; Augmentin; Clavulanate; GLT 1

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; PROTEIN KINASE B; VESICULAR GLUTAMATE TRANSPORTER 1; ALCOHOL; ANTIINFECTIVE AGENT; CEFTRIAXONE; CENTRAL DEPRESSANT AGENT; DRUGS USED IN THE TREATMENT OF ADDICTION; EXCITATORY AMINO ACID TRANSPORTER 2; SLC1A2 PROTEIN, RAT; SUGAR INTAKE; WATER;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; MEDIAL PREFRONTAL CORTEX; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; CEREBROSPINAL FLUID; DECISION MAKING; DISEASE MODEL; DRINKING BEHAVIOR; DRUG EFFECTS; DRUG THERAPY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PREFRONTAL CORTEX; RANDOMIZATION; SUGAR INTAKE;

ALCOHOL DETERRENTS; ALCOHOL DRINKING; AMOXICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHOICE BEHAVIOR; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; ETHANOL; EXCITATORY AMINO ACID TRANSPORTER 2; MALE; NUCLEUS ACCUMBENS; PHOSPHORYLATION; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; WATER;

EID: 84940927622     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.07.008     Document Type: Article

References (56)

1. H. Alhaddad, S.C. Das, and Y. Sari Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate concentrations in P rats Psychopharmacology (Berl) 231 2014 4049 4057
2. C.M. Anderson, and R.A. Swanson Astrocyte glutamate transport: review of properties, regulation, and physiological functions Glia 32 2000 1 14
3. A. Antonelli, and et al. Second surgery for renal relapse after nephron sparing surgery: review of seven cases Arch. Ital. Urol. Androl. 81 2009 218 222
4. J.F. Brien, and et al. A comparative study of the inhibition of hepatic aldehyde dehydrogenases in the rat by methyltetrazolethiol, calcium carbimide, and disulfiram Can J Physiol Pharmacol. 63 1985 438 443
5. A.R. Childress, and et al. Limbic activation during cue-induced cocaine craving Am J. Psychiatry. 156 1999 11 18
6. N. Clumeck, and et al. Amoxicillin entry into human cerebrospinal fluid: comparison with ampicillin Antimicrob. Agents Chemother 14 1978 531 532
7. D.K. Cozzoli, and et al. Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism J. Neurosci. 29 2009 8655 8668
8. W. Cynkar, and et al. Classification of Tempranillo wines according to geographic origin: combination of mass spectrometry based electronic nose and chemometrics Anal Chim. Acta. 660 2010 227 231
9. A. Dahchour, and et al. Effects of ethanol on extracellular amino acid levels in high-and low-alcohol sensitive rats: a microdialysis study Alcohol Alcohol. 35 2000 548 553
10. N.C. Danbolt Glutamate uptake Prog. Neurobiol. 65 2001 1 105
11. Z.M. Ding, and et al. Ethanol increases glutamate neurotransmission in the posterior ventral tegmental area of female wistar rats Alcohol. Clin Exp. Res. 36 2012 633 640
12. Z.M. Ding, and et al. Neuroprotective effects of ischemic preconditioning and postconditioning on global brain ischemia in rats through the same effect on inhibition of apoptosis Int. J. Mol. Sci. 13 2012 6089 6101
13. K.D. Fischer, A.C. Houston, and G.V. Rebec Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior J. Neurosci. 33 2013 9319 9327
14. R. Ganel, and et al. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection Neurobiol. Dis. 21 2006 556 567
15. G. Gegelashvili, and A. Schousboe High affinity glutamate transporters: regulation of expression and activity Mol. Pharmacol. 52 1997 6 15
16. R.Z. Goldstein, and N.D. Volkow Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex Am J. Psychiatry. 159 2002 1642 1652
17. S.R. Hauser, and et al. Development of an oral operant nicotine/ethanol co-use model in alcohol- preferring (p) rats Alcohol. Clin Exp. Res. 36 2012 1963 1972
18. S. Holmseth, and et al. The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS J. Neurosci. 32 2012 6000 6013
19. P.N. Karamanakos, and et al. Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines Int. J. Toxicol. 26 2007 423 432
20. D.J. Kim, and et al. Clavulanic acid: a competitive inhibitor of β-lactamases with novel anxiolytic- like activity and minimal side effects Pharmacol. Biochem. Behav. 93 2009 112 120
21. A. Kiryk, and et al. Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction Neurotox Res. 13 2008 19 30
22. L.A. Knackstedt, and et al. The role of cystine-glutamate exchange in nicotine dependence in rats and humans Biol. Psychiatry. 65 2009 841 845
23. L.A. Knackstedt, R.I. Melendez, and P.W. Kalivas Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking Biol. Psychiatry. 67 2010 81 84
24. M.R. Lee, and et al. Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice Neuropsychopharmacology 38 2013 437 445
25. L.B. Li, and et al. Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype J. Neurochem. 97 2006 759 771
26. T. Matsubara, and et al. Effects of β-lactam antibiotics and N-methyltetrazolethiol on the alcohol-metabolizing system in rats Jpn. J. Pharmacol. 45 1987 303 315
27. R.I. Melendez, and et al. Ethanol exposure decreases glutamate uptake in the nucleus accumbens Alcohol. Clin Exp. Res. 29 2005 326 333
28. S. Mingrino, M. Scanarini, and E. Magliulo Penetration of amoxicillin into the cerebrospinal fluid Arch. Sci. Med. (Torino) 138 1981 33 35
29. B. Moghaddam, and M.L. Bolinao Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens Neurosci. Lett. 178 1994 99 102
30. H. Nakagawa, and et al. Penetration of potassium clavulanate/ticarcillin sodium into cerebrospinal fluid in neurosurgical patients Jpn. J. Antibiot. 47 1994 93 101
31. T. Nakagawa, and M. Satoh Involvement of glial glutamate transporters in morphine dependence Ann N Y Acad. Sci. 1025 2004 383 388
32. J. Neasta, and et al. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors Biol. Psychiatry. 70 2011 575 582
33. I. Obara, and et al. Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats Alcohol Clin. Exp. Res. 33 2009 1924 1934
34. T.S. Otis, and M.P. Kavanaugh Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2 J. Neurosci. 20 2000 2749 2757
35. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates sixth ed. 2007 Academic Press New York, NY
36. D.R. Powell, and et al. Improved glycemic control in mice lacking Sglt1 and Sglt2 Am J. Physiol. Endocrinol. Metab. 304 2013 E117 E130
37. P.S. Rao, and Y. Sari Glutamate transporter 1: target for the treatment of alcohol dependence Curr Med Chem. 19 2012 5148 5156
38. P.S. Rao, and et al. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol Psychopharmacology (Berl) 232 2015 2333 2342
39. P.S.S. Rao, R.L. Bell, E.A. Engleman, and Y. Sari Targeting glutamate uptake to treat alcohol use disorders Front. Neurosci. Neuropharmacol 9 2015 144
40. S.M. Rawls, and et al. Beta-lactamase inhibitors display anti-seizure properties in an invertebrate assay Neuroscience 169 2010 1800 1804
41. J.D. Rothstein, and et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate Neuron 16 1996 675 686
42. J.D. Rothstein, and et al. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature 433 2005 73 77
43. Y. Sari, and et al. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats J. Neurosci. 29 2009 9239 9243
44. Y. Sari, and et al. Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats Alcohol Alcohol. 46 2011 239 246
45. Y. Sari, and S.N. Sreemantula Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats Neuroscience 227 2012 327 335
46. Y. Sari Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence OA Alcohol 1 2013 6
47. Y. Sari, and et al. Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats Neuroscience 241 2013 229 238
48. Y. Sari, and et al. Ceftriaxone treatment affects the expression of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats J. Mol. Neurosci. 51 2013 779 787
49. J.A. Schroeder, and et al. Clavulanic acid reduces rewarding, hyperthermic and locomotor-sensitizing effects of morphine in rats: a new indication for an old drug Drug Alcohol. Depend 142 2014 41 45
50. R.P. Seal, and S.G. Amara Excitatory amino acid transporters: a family in flux Annu Rev. Pharmacol. Toxicol. 39 1999 431 456
51. R.B. Stewart, R.N. Russell, L. Lumeng, T.-K. Li, and J.M. Murphy Consumption of sweet, salty, sour and bitter solutions by selectively bred alcohol-preferring P and -nonpreferring NP lines of rats Alcohol Clin Exp. Res. 18 1994 375 381
52. K.K. Szumlinski, and et al. Accumbens neurochemical adaptations produced by binge-like alcohol consumption Psychopharmacology (Berl) 190 2007 415 431
53. K. Tanaka, and et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 Science 276 1997 1699 1702
54. H. Weiner Subcellular localization of acetaldehyde oxidation in liver Ann. N.Y. Acad. Sci 492 1987 25 34
55. X. Wu, and et al. PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes Biochem. Biophys Res. Commun. 393 2010 514 518
56. N.J. Xu, and et al. Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses J. Neurosci. 23 2003 4775 4784