Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress

European Journal of Pharmacology

Volumn 783, Issue , 2016, Pages 92-102

  Yang, Ji Hye ^a   Kim, Sang Chan ^b   Kim, Kyu Min ^a   Jang, Chang Ho ^a   Cho, Sam Seok ^a   Kim, Seung Jung ^a   Ku, Sae Kwang ^b   Cho, Il Je ^b   Ki, Sung Hwan ^a  

^a Chosun University   (South Korea)

^b Daegu Haany University   (South Korea)

Author keywords

Hepatic stellatecells; Isorhamnetin; Liver fibrosis; Oxidative stress; Smad; TGF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; ISORHAMNETIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; 3-METHYLQUERCETIN; NFE2L2 PROTEIN, HUMAN; QUERCETIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BINDING AFFINITY; CELL INFILTRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG RESPONSE; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LIVER CELL; LIVER FIBROSIS; LIVER PROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TREATMENT DURATION; TREATMENT OUTCOME; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; DRUG EFFECTS; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; MALE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; QUERCETIN; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84966309580     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.04.042     Document Type: Article

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