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Volumn 2016, Issue 1, 2016, Pages

Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE PLUS FORMOTEROL; CORTICOSTEROID; FLUTICASONE PROPIONATE PLUS SALMETEROL; LONG ACTING BETA 2 AGONIST; LONG ACTING MUSCARINIC ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG;

EID: 84966280695     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD011721.pub2     Document Type: Review
Times cited : (50)

References (122)
  • 3
    • 85027426390 scopus 로고    scopus 로고
    • Tiotropium respimat add-on therapy reduces exacerbation risk in patients with symptomatic moderate to severe asthma, independent of t helper 2 status
    • 2015 May 15-20; Denver
    • Casale TB, Dahl R, Virchow JC, Engel M, Moroni-Zentgraf P, Luehmann R, et al. Tiotropium respimat add-on therapy reduces exacerbation risk in patients with symptomatic moderate to severe asthma, independent of t helper 2 status. American Thoracic Society International Conference; 2015 May 15-20; Denver. 2015:A4193.
    • (2015) American Thoracic Society International Conference , pp. A4193
    • Casale, T.B.1    Dahl, R.2    Virchow, J.C.3    Engel, M.4    Moroni-Zentgraf, P.5    Luehmann, R.6
  • 4
    • 85027426385 scopus 로고    scopus 로고
    • Tiotropium as add-on therapy to ICS+LABA in patients with symptomatic severe asthma: spirometric assessment over 24 hours [Abstract]
    • 2013 Oct 26-31; Chicago
    • Corren J, Frew A, Engel M, Schmidt H, Moroni-Zentgraf P, Kerstjens HAM. Tiotropium as add-on therapy to ICS+LABA in patients with symptomatic severe asthma: spirometric assessment over 24 hours [Abstract]. American College of Chest Physicians Annual Meeting; 2013 Oct 26-31; Chicago. 2013; Vol. 144:91A.
    • (2013) American College of Chest Physicians Annual Meeting , vol.144 , pp. 91A
    • Corren, J.1    Frew, A.2    Engel, M.3    Schmidt, H.4    Moroni-Zentgraf, P.5    Kerstjens, H.A.M.6
  • 5
    • 84973274912 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat decreases the risk of exacerbations, independent of baseline characteristics, in patients with symptomatic severe asthma without evidence of chronic obstructive pulmonary disease
    • Corren J, Murphy KR, Bensch G, Dahl R, Paggiaro P, Engel M, et al. Once-daily tiotropium Respimat decreases the risk of exacerbations, independent of baseline characteristics, in patients with symptomatic severe asthma without evidence of chronic obstructive pulmonary disease. Journal of General Internal Medicine 2014;29:S157-8.
    • (2014) Journal of General Internal Medicine , vol.29 , pp. S157-S158
    • Corren, J.1    Murphy, K.R.2    Bensch, G.3    Dahl, R.4    Paggiaro, P.5    Engel, M.6
  • 6
    • 85027426616 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat as add-on to at least medium-to high-dose ICS, with or without LABA, improves lung function in patients with symptomatic asthma, independent of allergic status
    • Dahl R, Casale T, Pizzichini E, Vandewalker M, Virchow JC, Engel M, et al. Once-daily tiotropium Respimat as add-on to at least medium-to high-dose ICS, with or without LABA, improves lung function in patients with symptomatic asthma, independent of allergic status. Thorax 2014;69(Suppl 2):A177-8.
    • (2014) Thorax , vol.69 , pp. A177-A178
    • Dahl, R.1    Casale, T.2    Pizzichini, E.3    Vandewalker, M.4    Virchow, J.C.5    Engel, M.6
  • 7
    • 84969967101 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat improves lung function in patients with severe symptomatic asthma independent of leukotriene modifier use
    • AB5
    • Dahl R, Doherty DE, Corren J, Karpel J, Kerstjens HAM, Engel M, et al. Once-daily tiotropium respimat improves lung function in patients with severe symptomatic asthma independent of leukotriene modifier use. The Journal of Allergy and Clinical Immunology 2014;133(2):AB5.
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.2
    • Dahl, R.1    Doherty, D.E.2    Corren, J.3    Karpel, J.4    Kerstjens, H.A.M.5    Engel, M.6
  • 8
    • 84969907606 scopus 로고    scopus 로고
    • Once-daily tiotropium improves lung function and reduces risk of asthma exacerbation/worsening in patients with symptomatic asthma, regardless of allergic status
    • Dahl R, Paggiaro P, Engel M, Sigmund R, Moroni-Zentgraf P, Bateman E, et al. Once-daily tiotropium improves lung function and reduces risk of asthma exacerbation/worsening in patients with symptomatic asthma, regardless of allergic status. Allergy 2013;68(s98):40-1.
    • (2013) Allergy , vol.68 , pp. 40-41
    • Dahl, R.1    Paggiaro, P.2    Engel, M.3    Sigmund, R.4    Moroni-Zentgraf, P.5    Bateman, E.6
  • 9
    • 85027426513 scopus 로고    scopus 로고
    • Tiotropium respimat add-on therapy improves lung function, as measured by peak expiratory flow, in adult patients across severities of symptomatic asthma
    • 2015 May 15-20; Denver
    • Doherty DE, Castro M, Moroni-Zentgraf P, Engel M, Luehmann R, Buhl R. Tiotropium respimat add-on therapy improves lung function, as measured by peak expiratory flow, in adult patients across severities of symptomatic asthma. American Thoracic Society International Conference; 2015 May 15-20; Denver. 2015:A4258.
    • (2015) American Thoracic Society International Conference , pp. A4258
    • Doherty, D.E.1    Castro, M.2    Moroni-Zentgraf, P.3    Engel, M.4    Luehmann, R.5    Buhl, R.6
  • 10
    • 85027426413 scopus 로고    scopus 로고
    • Improvements in lung function with tiotropium as add-on controller therapy to ICS+LABA for patients with symptomatic severe asthma
    • Doherty DE, Tashkin DP, Harrison T W, Engel M, Schmidt H, Moroni-Zentgraf P, et al. Improvements in lung function with tiotropium as add-on controller therapy to ICS+LABA for patients with symptomatic severe asthma. Chest 2013;144(4):88A.
    • (2013) Chest , vol.144 , Issue.4 , pp. 88A
    • Doherty, D.E.1    Tashkin, D.P.2    Harrison, T.W.3    Engel, M.4    Schmidt, H.5    Moroni-Zentgraf, P.6
  • 11
    • 85027426387 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat add-on therapy improves symptom control across severities of symptomatic asthma, independent of allergic status
    • 2015 May 15-20; Denver
    • FitzGerald JM, Engel M, Moroni-Zentgraf P, Luehmann R, Bleecker ER. Once-daily tiotropium respimat add-on therapy improves symptom control across severities of symptomatic asthma, independent of allergic status. American Thoracic Society Internation Conference; 2015 May 15-20; Denver. 2015:A4263.
    • (2015) American Thoracic Society Internation Conference , pp. A4263
    • FitzGerald, J.M.1    Engel, M.2    Moroni-Zentgraf, P.3    Luehmann, R.4    Bleecker, E.R.5
  • 12
    • 84969989829 scopus 로고    scopus 로고
    • Efficacy of once-daily tiotropium respimat 5 μg from five phase III trials in adults with symptomatic asthma
    • Frith P, Price D, Bateman E, Paggiaro P, Kaplan A, Engel M, et al. Efficacy of once-daily tiotropium respimat 5 μg from five phase III trials in adults with symptomatic asthma. Respirology 2015;20(Suppl S2):137.
    • (2015) Respirology , vol.20 , pp. 137
    • Frith, P.1    Price, D.2    Bateman, E.3    Paggiaro, P.4    Kaplan, A.5    Engel, M.6
  • 13
    • 85027426645 scopus 로고    scopus 로고
    • Tiotropium is effective in patients with severe asthma without evidence of chronic obstructive pulmonary disease
    • Halpin DMG, Bateman ED, Moroni-Zentgraf P, Engel M, Schmidt H, Kerstjens HAM. Tiotropium is effective in patients with severe asthma without evidence of chronic obstructive pulmonary disease. Thorax 2013;68(Suppl 3):A152.
    • (2013) Thorax , vol.68 , pp. A152
    • Halpin, D.M.G.1    Bateman, E.D.2    Moroni-Zentgraf, P.3    Engel, M.4    Schmidt, H.5    Kerstjens, H.A.M.6
  • 14
    • 85027426237 scopus 로고    scopus 로고
    • Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics including markers of allergic status
    • Halpin DMG, Bateman ED, Tashkin DP, Engel M, Dahl R, Paggiaro P, et al. Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics including markers of allergic status. Thorax 2013;68(Suppl 3):A149.
    • (2013) Thorax , vol.68 , pp. A149
    • Halpin, D.M.G.1    Bateman, E.D.2    Tashkin, D.P.3    Engel, M.4    Dahl, R.5    Paggiaro, P.6
  • 15
    • 84970037689 scopus 로고    scopus 로고
    • Once-daily tiotropium as add-on to ICS + LABA for patients with severe symptomatic asthma: baseline characteristics in Japanese patients
    • Hashimoto S, Engel M, Schmidt H, Moroni-Zentgraf P, Kerstjens HAM. Once-daily tiotropium as add-on to ICS + LABA for patients with severe symptomatic asthma: baseline characteristics in Japanese patients. Respirology 2013;18(S2):88.
    • (2013) Respirology , vol.18 , pp. 88
    • Hashimoto, S.1    Engel, M.2    Schmidt, H.3    Moroni-Zentgraf, P.4    Kerstjens, H.A.M.5
  • 16
    • 84970046907 scopus 로고    scopus 로고
    • Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics
    • Hozawa S, Kerstjens HAM, Tashkin DP, Engel M, Ronald D, Pierluigi P, et al. Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics. Respirology 2013;18(Suppl 3):A149.
    • (2013) Respirology , vol.18 , pp. A149
    • Hozawa, S.1    Kerstjens, H.A.M.2    Tashkin, D.P.3    Engel, M.4    Ronald, D.5    Pierluigi, P.6
  • 17
    • 85027426397 scopus 로고    scopus 로고
    • Tiotropium reduces asthma exacerbations in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines
    • Kerstjens H, Dahl R, Beck E, Vandewalker M, Engel M, Sigmund R, et al. Tiotropium reduces asthma exacerbations in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines. Respirology 2012;17(Suppl 2):A483.
    • (2012) Respirology , vol.17 , pp. A483
    • Kerstjens, H.1    Dahl, R.2    Beck, E.3    Vandewalker, M.4    Engel, M.5    Sigmund, R.6
  • 18
    • 85027426070 scopus 로고    scopus 로고
    • Tiotropium Respimat® add-on therapy to inhaled corticosteroids (ICS) + long-acting B2-agonists (LABAS) in patients with symptomatic severe asthma: efficacy by level of airway obstruction [Abstract]
    • Kerstjens HAM, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, et al. Tiotropium Respimat® add-on therapy to inhaled corticosteroids (ICS) + long-acting B2-agonists (LABAS) in patients with symptomatic severe asthma: efficacy by level of airway obstruction [Abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A1312.
    • (2014) American Journal of Respiratory and Critical Care Medicine , vol.189 , pp. A1312
    • Kerstjens, H.A.M.1    Engel, M.2    Dahl, R.3    Paggiaro, P.4    Beck, E.5    Vandewalker, M.6
  • 20
    • 84970033447 scopus 로고    scopus 로고
    • Tiotropium added to inhaled corticosteroids and long-acting beta(2)-agonists reduces episodes of asthma worsening, irrespective of selected patient baseline characteristics
    • Kerstjens HAM, Engel M, Moroni-Zentgraf P, Schmidt H, Bateman E. Tiotropium added to inhaled corticosteroids and long-acting beta(2)-agonists reduces episodes of asthma worsening, irrespective of selected patient baseline characteristics. Allergy 2013;68(s98):41.
    • (2013) Allergy , vol.68 , pp. 41
    • Kerstjens, H.A.M.1    Engel, M.2    Moroni-Zentgraf, P.3    Schmidt, H.4    Bateman, E.5
  • 21
    • 84970046900 scopus 로고    scopus 로고
    • Tiotropium provides sustained bronchodilation in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines [Abstract]
    • Kerstjens HAM, Paggiaro P, Vandewalker M, Beck E, Engel M, Sigmund R, et al. Tiotropium provides sustained bronchodilation in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines [Abstract]. Respirology 2012;17(Suppl 2):6 [221].
    • (2012) Respirology , vol.17 , pp. 6 [221]
    • Kerstjens, H.A.M.1    Paggiaro, P.2    Vandewalker, M.3    Beck, E.4    Engel, M.5    Sigmund, R.6
  • 22
    • 84969933022 scopus 로고    scopus 로고
    • A Phase III randomised, double-blind, placebo-controlled, parallel-group trial to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat ® inhaler (5 μg/day) over 48 weeks as add-on controller therapy on top of usual care in patients with severe persistent asthma
    • (accessed 23 June 2015)
    • NCT00772538 . A Phase III randomised, double-blind, placebo-controlled, parallel-group trial to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat ® inhaler (5 μg/day) over 48 weeks as add-on controller therapy on top of usual care in patients with severe persistent asthma. https://www.clinicaltrialsregister.eu/ctr-search/trial/2008-001413-14/results (accessed 23 June 2015).
  • 23
    • 84970033475 scopus 로고    scopus 로고
    • Evaluation of tiotropium 5 μg/day delivered via the Respimat® inhaler over 48 weeks in patients with severe persistent asthma on top of usual care (study I)
    • (accessed 22 June 2015)
    • NCT00772538 . Evaluation of tiotropium 5 μg/day delivered via the Respimat® inhaler over 48 weeks in patients with severe persistent asthma on top of usual care (study I). https://clinicaltrials.gov/ct2/show/NCT00772538 (accessed 22 June 2015).
    • https://clinicaltrials.gov/ct2/show/NCT00772538
  • 24
    • 85027426605 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat add-on to ICS + LABA improves symptom control and reduces exacerbations in patients with symptomatic asthma
    • Price D, Engel M, Moroni-Zentgraf P, Schmidt H, Dahl R, Paggiaro P, et al. Once-daily tiotropium respimat add-on to ICS + LABA improves symptom control and reduces exacerbations in patients with symptomatic asthma. Thorax 2014;69(Suppl 2):A49-50.
    • (2014) Thorax , vol.69 , pp. A49-A50
    • Price, D.1    Engel, M.2    Moroni-Zentgraf, P.3    Schmidt, H.4    Dahl, R.5    Paggiaro, P.6
  • 25
    • 85027426192 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat add-on to ICS+LABA reduces risk of severe exacerbation and asthma worsening in patients with asthma, independent of degree of airflow obstruction
    • Tashkin D, Moroni-Zentgraf P, Engel M, Schmidt H, Kerstjens H. Once-daily tiotropium respimat add-on to ICS+LABA reduces risk of severe exacerbation and asthma worsening in patients with asthma, independent of degree of airflow obstruction. Chest 2014;146(4):18A.
    • (2014) Chest , vol.146 , Issue.4 , pp. 18A
    • Tashkin, D.1    Moroni-Zentgraf, P.2    Engel, M.3    Schmidt, H.4    Kerstjens, H.5
  • 28
    • 85027426068 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on to maintenance therapy improves lung function in patients with moderate or severe symptomatic asthma, independent of T helper 2 inflammatory status
    • Vandewalker ML, Karpel J, Bensch G, Ford L, Engel M, Sigmund R, et al. Once-daily tiotropium Respimat add-on to maintenance therapy improves lung function in patients with moderate or severe symptomatic asthma, independent of T helper 2 inflammatory status. Annals of Allergy, Asthma & Immunology 2014;113(5):A105-6.
    • (2014) Annals of Allergy, Asthma & Immunology , vol.113 , Issue.5 , pp. A105-A106
    • Vandewalker, M.L.1    Karpel, J.2    Bensch, G.3    Ford, L.4    Engel, M.5    Sigmund, R.6
  • 29
    • 84969933022 scopus 로고    scopus 로고
    • A Phase III randomised, double-blind, placebo-controlled, parallel-group trial to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat ® inhaler (5 μg/day) over 48 weeks as add-on controller therapy on top of usual care in patients with severe persistent asthma
    • 2008-001414-25, (accessed 23 June 2015)
    • 2008-001414-25 . A Phase III randomised, double-blind, placebo-controlled, parallel-group trial to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat ® inhaler (5 μg/day) over 48 weeks as add-on controller therapy on top of usual care in patients with severe persistent asthma. https://www.clinicaltrialsregister.eu/ctr-search/trial/2008-001414-25/results (accessed 23 June 2015).
  • 32
    • 85027426390 scopus 로고    scopus 로고
    • Tiotropium respimat add-on therapy reduces exacerbation risk in patients with symptomatic moderate to severe asthma, independent of t helper 2 status
    • 2015 May 15-20; Denver
    • Casale TB, Dahl R, Virchow JC, Engel M, Moroni-Zentgraf P, Luehmann R, et al. Tiotropium respimat add-on therapy reduces exacerbation risk in patients with symptomatic moderate to severe asthma, independent of t helper 2 status. American Thoracic Society International Conference; 2015 May 15-20; Denver. 2015:A4193.
    • (2015) American Thoracic Society International Conference , pp. A4193
    • Casale, T.B.1    Dahl, R.2    Virchow, J.C.3    Engel, M.4    Moroni-Zentgraf, P.5    Luehmann, R.6
  • 33
    • 85027426385 scopus 로고    scopus 로고
    • Tiotropium as add-on therapy to ICS+LABA in patients with symptomatic severe asthma: spirometric assessment over 24 hours [Abstract]
    • 2013 Oct 26-31; Chicago, Illinois
    • Corren J, Frew A, Engel M, Schmidt H, Moroni-Zentgraf P, Kerstjens HAM. Tiotropium as add-on therapy to ICS+LABA in patients with symptomatic severe asthma: spirometric assessment over 24 hours [Abstract]. American College of Chest Physicians Annual Meeting; 2013 Oct 26-31; Chicago, Illinois. 2013; Vol. 144:91A.
    • (2013) American College of Chest Physicians Annual Meeting , vol.144 , pp. 91A
    • Corren, J.1    Frew, A.2    Engel, M.3    Schmidt, H.4    Moroni-Zentgraf, P.5    Kerstjens, H.A.M.6
  • 34
    • 84973274912 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat decreases the risk of exacerbations, independent of baseline characteristics, in patients with symptomatic severe asthma without evidence of chronic obstructive pulmonary disease
    • Corren J, Murphy KR, Bensch G, Dahl R, Paggiaro P, Engel M, et al. Once-daily tiotropium respimat decreases the risk of exacerbations, independent of baseline characteristics, in patients with symptomatic severe asthma without evidence of chronic obstructive pulmonary disease. Journal of General Internal Medicine 2014;29:S157-8.
    • (2014) Journal of General Internal Medicine , vol.29 , pp. S157-S158
    • Corren, J.1    Murphy, K.R.2    Bensch, G.3    Dahl, R.4    Paggiaro, P.5    Engel, M.6
  • 35
    • 85027426616 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat as add-on to at least medium-to high-dose ICS, with or without LABA, improves lung function in patients with symptomatic asthma, independent of allergic status
    • Dahl R, Casale T, Pizzichini E, Vandewalker M, Virchow JC, Engel M, et al. Once-daily tiotropium Respimat as add-on to at least medium-to high-dose ICS, with or without LABA, improves lung function in patients with symptomatic asthma, independent of allergic status. Thorax 2014;69(Suppl 2):A177-8.
    • (2014) Thorax , vol.69 , pp. A177-A178
    • Dahl, R.1    Casale, T.2    Pizzichini, E.3    Vandewalker, M.4    Virchow, J.C.5    Engel, M.6
  • 36
    • 84969967101 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat improves lung function in patients with severe symptomatic asthma independent of leukotriene modifier use
    • AB5
    • Dahl R, Doherty DE, Corren J, Karpel J, Kerstjens HAM, Engel M, et al. Once-daily tiotropium respimat improves lung function in patients with severe symptomatic asthma independent of leukotriene modifier use. The Journal of Allergy and Clinical Immunology 2014;133(2):AB5.
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.2
    • Dahl, R.1    Doherty, D.E.2    Corren, J.3    Karpel, J.4    Kerstjens, H.A.M.5    Engel, M.6
  • 37
    • 84969907606 scopus 로고    scopus 로고
    • Once-daily tiotropium improves lung function and reduces risk of asthma exacerbation/worsening in patients with symptomatic asthma, regardless of allergic status
    • Dahl R, Paggiaro P, Engel M, Sigmund R, Moroni-Zentgraf P, Bateman E, et al. Once-daily tiotropium improves lung function and reduces risk of asthma exacerbation/worsening in patients with symptomatic asthma, regardless of allergic status. Allergy 2013;68(s98):40-1.
    • (2013) Allergy , vol.68 , pp. 40-41
    • Dahl, R.1    Paggiaro, P.2    Engel, M.3    Sigmund, R.4    Moroni-Zentgraf, P.5    Bateman, E.6
  • 38
    • 85027426513 scopus 로고    scopus 로고
    • Tiotropium respimat add-on therapy improves lung function, as measured by peak expiratory flow, in adult patients across severities of symptomatic asthma
    • 2015 May 15-20; Denver
    • Doherty DE, Castro M, Moroni-Zentgraf P, Engel M, Luehmann R, Buhl R. Tiotropium respimat add-on therapy improves lung function, as measured by peak expiratory flow, in adult patients across severities of symptomatic asthma. American Thoracic Society International Conference; 2015 May 15-20; Denver. 2015:A4258.
    • (2015) American Thoracic Society International Conference , pp. A4258
    • Doherty, D.E.1    Castro, M.2    Moroni-Zentgraf, P.3    Engel, M.4    Luehmann, R.5    Buhl, R.6
  • 39
    • 85027426413 scopus 로고    scopus 로고
    • Improvements in lung function with tiotropium as add-on controller therapy to ICS+LABA for patients with symptomatic severe asthma
    • Doherty DE, Tashkin DP, Harrison T W, Engel M, Schmidt H, Moroni-Zentgraf P, et al. Improvements in lung function with tiotropium as add-on controller therapy to ICS+LABA for patients with symptomatic severe asthma. Chest 2013;144(4):88A.
    • (2013) Chest , vol.144 , Issue.4 , pp. 88A
    • Doherty, D.E.1    Tashkin, D.P.2    Harrison, T.W.3    Engel, M.4    Schmidt, H.5    Moroni-Zentgraf, P.6
  • 40
    • 85027426387 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat add-on therapy improves symptom control across severities of symptomatic asthma, independent of allergic status
    • 2015 May 15-20; Denver
    • FitzGerald JM, Engel M, Moroni-Zentgraf P, Luehmann R, Bleecker ER. Once-daily tiotropium respimat add-on therapy improves symptom control across severities of symptomatic asthma, independent of allergic status. American Thoracic Society Internation Conference; 2015 May 15-20; Denver. 2015:A4263.
    • (2015) American Thoracic Society Internation Conference , pp. A4263
    • FitzGerald, J.M.1    Engel, M.2    Moroni-Zentgraf, P.3    Luehmann, R.4    Bleecker, E.R.5
  • 41
    • 84969989829 scopus 로고    scopus 로고
    • Efficacy of once-daily tiotropium Respimat 5 μg from five phase III trials in adults with symptomatic asthma
    • Frith P, Price D, Bateman E, Paggiaro P, Kaplan A, Engel M, et al. Efficacy of once-daily tiotropium Respimat 5 μg from five phase III trials in adults with symptomatic asthma. Respirology 2015;20(Suppl S2):137.
    • (2015) Respirology , vol.20 , pp. 137
    • Frith, P.1    Price, D.2    Bateman, E.3    Paggiaro, P.4    Kaplan, A.5    Engel, M.6
  • 42
    • 85027426645 scopus 로고    scopus 로고
    • Tiotropium is effective in patients with severe asthma without evidence of chronic obstructive pulmonary disease
    • Halpin DMG, Bateman ED, Moroni-Zentgraf P, Engel M, Schmidt H, Kerstjens HAM. Tiotropium is effective in patients with severe asthma without evidence of chronic obstructive pulmonary disease. Thorax 2013;68(Suppl 3):A152.
    • (2013) Thorax , vol.68 , pp. A152
    • Halpin, D.M.G.1    Bateman, E.D.2    Moroni-Zentgraf, P.3    Engel, M.4    Schmidt, H.5    Kerstjens, H.A.M.6
  • 43
    • 85027426237 scopus 로고    scopus 로고
    • Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics including markers of allergic status
    • Halpin DMG, Bateman ED, Tashkin DP, Engel M, Dahl R, Paggiaro P, et al. Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics including markers of allergic status. Thorax 2013;68(Suppl 3):A149.
    • (2013) Thorax , vol.68 , pp. A149
    • Halpin, D.M.G.1    Bateman, E.D.2    Tashkin, D.P.3    Engel, M.4    Dahl, R.5    Paggiaro, P.6
  • 44
    • 84970037689 scopus 로고    scopus 로고
    • Once-daily tiotropium as add-on to ICS + LABA for patients with severe symptomatic asthma: Baseline characteristics in Japanese patients
    • Hashimoto S, Engel M, Schmidt H, Moroni-Zentgraf P, Kerstjens HAM. Once-daily tiotropium as add-on to ICS + LABA for patients with severe symptomatic asthma: Baseline characteristics in Japanese patients. Respirology 2013;18(S2):88.
    • (2013) Respirology , vol.18 , pp. 88
    • Hashimoto, S.1    Engel, M.2    Schmidt, H.3    Moroni-Zentgraf, P.4    Kerstjens, H.A.M.5
  • 45
    • 84970046907 scopus 로고    scopus 로고
    • Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics
    • Hozawa S, Kerstjens HAM, Tashkin DP, Engel M, Ronald D, Pierluigi P, et al. Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics. Respirology 2013;18(Suppl 3):175.
    • (2013) Respirology , vol.18 , pp. 175
    • Hozawa, S.1    Kerstjens, H.A.M.2    Tashkin, D.P.3    Engel, M.4    Ronald, D.5    Pierluigi, P.6
  • 46
    • 85027426397 scopus 로고    scopus 로고
    • Tiotropium reduces asthma exacerbations in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines
    • Kerstjens H, Dahl R, Beck E, Vandewalker M, Engel M, Sigmund R, et al. Tiotropium reduces asthma exacerbations in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines. Respirology 2012;17(Suppl 2):16.
    • (2012) Respirology , vol.17 , pp. 16
    • Kerstjens, H.1    Dahl, R.2    Beck, E.3    Vandewalker, M.4    Engel, M.5    Sigmund, R.6
  • 47
    • 85027426070 scopus 로고    scopus 로고
    • Tiotropium Respimat® add-on therapy to inhaled corticosteroids (ICS) + long-acting B2-agonists (LABAS) in patients with symptomatic severe asthma: efficacy by level of airway obstruction [Abstract]
    • Kerstjens HAM, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, et al. Tiotropium Respimat® add-on therapy to inhaled corticosteroids (ICS) + long-acting B2-agonists (LABAS) in patients with symptomatic severe asthma: efficacy by level of airway obstruction [Abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A1312.
    • (2014) American Journal of Respiratory and Critical Care Medicine , vol.189 , pp. A1312
    • Kerstjens, H.A.M.1    Engel, M.2    Dahl, R.3    Paggiaro, P.4    Beck, E.5    Vandewalker, M.6
  • 50
    • 84970033447 scopus 로고    scopus 로고
    • Tiotropium added to inhaled corticosteroids and long-acting beta(2)-agonists reduces episodes of asthma worsening, irrespective of selected patient baseline characteristics
    • Kerstjens HAM, Engel M, Moroni-Zentgraf P, Schmidt H, Bateman E. Tiotropium added to inhaled corticosteroids and long-acting beta(2)-agonists reduces episodes of asthma worsening, irrespective of selected patient baseline characteristics. Allergy 2013;68(s98):41.
    • (2013) Allergy , vol.68 , pp. 41
    • Kerstjens, H.A.M.1    Engel, M.2    Moroni-Zentgraf, P.3    Schmidt, H.4    Bateman, E.5
  • 51
    • 84970046900 scopus 로고    scopus 로고
    • Tiotropium provides sustained bronchodilation in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines [Abstract]
    • [221]
    • Kerstjens HAM, Paggiaro P, Vandewalker M, Beck E, Engel M, Sigmund R, et al. Tiotropium provides sustained bronchodilation in patients with uncontrolled asthma and persistent airflow obstruction despite treatment in accordance with guidelines [Abstract]. Respirology 2012;17(Suppl 2):6 [221].
    • (2012) Respirology , vol.17 , pp. 6
    • Kerstjens, H.A.M.1    Paggiaro, P.2    Vandewalker, M.3    Beck, E.4    Engel, M.5    Sigmund, R.6
  • 52
    • 84969910615 scopus 로고    scopus 로고
    • Evaluation of tiotropium 5 μg/day delivered via the Respimat® inhaler over 48 weeks in patients with severe persistent asthma on top of usual care (study II)
    • (accessed 22 June 2015)
    • NCT00776984 . Evaluation of tiotropium 5 μg/day delivered via the Respimat® inhaler over 48 weeks in patients with severe persistent asthma on top of usual care (study II). https://clinicaltrials.gov/ct2/show/NCT00776984 (accessed 22 June 2015).
  • 53
    • 85027426605 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on to ICS + LABA improves symptom control and reduces exacerbations in patients with symptomatic asthma
    • Price D, Engel M, Moroni-Zentgraf P, Schmidt H, Dahl R, Paggiaro P, et al. Once-daily tiotropium Respimat add-on to ICS + LABA improves symptom control and reduces exacerbations in patients with symptomatic asthma. Thorax 2014;69(Suppl 2):A49-50.
    • (2014) Thorax , vol.69 , pp. A49-A50
    • Price, D.1    Engel, M.2    Moroni-Zentgraf, P.3    Schmidt, H.4    Dahl, R.5    Paggiaro, P.6
  • 54
    • 85027426192 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on to ICS+LABA reduces risk of severe exacerbation and asthma worsening in patients with asthma, independent of degree of airflow obstruction
    • Tashkin D, Moroni-Zentgraf P, Engel M, Schmidt H, Kerstjens H. Once-daily tiotropium Respimat add-on to ICS+LABA reduces risk of severe exacerbation and asthma worsening in patients with asthma, independent of degree of airflow obstruction. Chest 2014;146(4):18A.
    • (2014) Chest , vol.146 , Issue.4 , pp. 18A
    • Tashkin, D.1    Moroni-Zentgraf, P.2    Engel, M.3    Schmidt, H.4    Kerstjens, H.5
  • 57
    • 85027426068 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on to maintenance therapy improves lung function in patients with moderate or severe symptomatic asthma, independent of T helper 2 inflammatory status
    • Vandewalker ML, Karpel J, Bensch G, Ford L, Engel M, Sigmund R, et al. Once-daily tiotropium Respimat add-on to maintenance therapy improves lung function in patients with moderate or severe symptomatic asthma, independent of T helper 2 inflammatory status. Annals of Allergy, Asthma and Immunology 2014;113(5):A105-6.
    • (2014) Annals of Allergy, Asthma and Immunology , vol.113 , Issue.5 , pp. A105-A106
    • Vandewalker, M.L.1    Karpel, J.2    Bensch, G.3    Ford, L.4    Engel, M.5    Sigmund, R.6
  • 58
    • 84970046855 scopus 로고    scopus 로고
    • Study of efficacy and safety of NVA237 in patients with poorly controlled asthma
    • (accessed 22 June 2015)
    • NCT02127697 . Study of efficacy and safety of NVA237 in patients with poorly controlled asthma. https://clinicaltrials.gov/ct2/show/NCT02127697 (accessed 22 June 2015).
  • 59
    • 84969914421 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat is well tolerated and efficacious over 52 weeks in Japanese patients with symptomatic asthma receiving inhaled corticosteroids (ICS) + long-acting B2-agonist (LABA): A randomized, double-blind, placebo-controlled study
    • Ichinose M, Ohta K, Tohda Y, Engel M, Moroni-Zentgraf P, Kunimitsu S, et al. Once-daily tiotropium respimat is well tolerated and efficacious over 52 weeks in Japanese patients with symptomatic asthma receiving inhaled corticosteroids (ICS) + long-acting B2-agonist (LABA): A randomized, double-blind, placebo-controlled study. Respirology 2014;19(Suppl 3):65.
    • (2014) Respirology , vol.19 , pp. 65
    • Ichinose, M.1    Ohta, K.2    Tohda, Y.3    Engel, M.4    Moroni-Zentgraf, P.5    Kunimitsu, S.6
  • 60
    • 84969918889 scopus 로고    scopus 로고
    • Evaluation of tiotropium 2.5 and 5 μg once daily delivered via the Respimat inhaler compared to placebo in patients with moderate to severe persistent asthma
    • (accessed 22 June 2015)
    • NCT01340209 . Evaluation of tiotropium 2.5 and 5 μg once daily delivered via the Respimat inhaler compared to placebo in patients with moderate to severe persistent asthma. https://clinicaltrials.gov/ct2/show/NCT01340209 (accessed 22 June 2015).
  • 61
    • 84928887136 scopus 로고    scopus 로고
    • Long-term once-daily tiotropium Respimat is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: A randomised, placebo-controlled study
    • e0124109
    • Ohta K, Ichinose M, Tohda Y, Engel M, Moroni-Zentgraf P, Kunimitsu S, et al. Long-term once-daily tiotropium Respimat is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: A randomised, placebo-controlled study. PLOS ONE 2015;10(4):e0124109.
    • (2015) PLOS ONE , vol.10 , Issue.4
    • Ohta, K.1    Ichinose, M.2    Tohda, Y.3    Engel, M.4    Moroni-Zentgraf, P.5    Kunimitsu, S.6
  • 62
    • 85027426650 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat® is well tolerated and efficacious over 52 weeks in Japanese patients with symptomatic asthma receiving inhaled corticosteroids (ICS ± long-acting B2-agonist (LABA): a randomized, double-blind, placebo-controlled study [Abstract]
    • Ohta K, Ichinose M, Tohda Y, Engel M, Moroni-Zentgraf P, Kunimitsu S, et al. Once-daily tiotropium respimat® is well tolerated and efficacious over 52 weeks in Japanese patients with symptomatic asthma receiving inhaled corticosteroids (ICS ± long-acting B2-agonist (LABA): a randomized, double-blind, placebo-controlled study [Abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A1311.
    • (2014) American Journal of Respiratory and Critical Care Medicine , vol.189 , pp. A1311
    • Ohta, K.1    Ichinose, M.2    Tohda, Y.3    Engel, M.4    Moroni-Zentgraf, P.5    Kunimitsu, S.6
  • 63
    • 84969910634 scopus 로고    scopus 로고
    • A phase II, randomised, double- blind, placebo controlled, cross-over efficacy and safety comparison of tiotropium 5 μg administered once daily (in the evening) and tiotropium 2.5 μg administered twice daily delivered by the Respimat® inhaler for four weeks versus placebo in patients with moderate persistent asthma
    • 2009-018006-21, (accessed 23 June 2015)
    • 2009-018006-21 . A phase II, randomised, double- blind, placebo controlled, cross-over efficacy and safety comparison of tiotropium 5 μg administered once daily (in the evening) and tiotropium 2.5 μg administered twice daily delivered by the Respimat® inhaler for four weeks versus placebo in patients with moderate persistent asthma. https://www.clinicaltrialsregister.eu/ctr-search/trial/2009-018006-21/results (accessed 23 June 2015).
  • 64
    • 84969961130 scopus 로고    scopus 로고
    • A phase II randomised, double-blind, placebo controlled, cross-over efficacy and safety comparison of three doses of tiotropium inhalation solution delivered via Respimat® inhaler (1.25, 2.5 and 5.0 μg once daily) versus placebo in patients with moderate persistent asthma
    • 2010-018471-26, (accessed 23 June 2015)
    • 2010-018471-26 . A phase II randomised, double-blind, placebo controlled, cross-over efficacy and safety comparison of three doses of tiotropium inhalation solution delivered via Respimat® inhaler (1.25, 2.5 and 5.0 μg once daily) versus placebo in patients with moderate persistent asthma. https://www.clinicaltrialsregister.eu/ctr-search/trial/2010-018471-26/results (accessed 23 June 2015).
  • 66
    • 84969980766 scopus 로고    scopus 로고
    • Once-daily add-on tiotropium: a dose-finding trial in adult patients with moderate persistent asthma
    • Beeh KM, Ablinger O, Moroni-Zentgraf P, Hollaenderova Z, Pivovarova A, Engel M, et al. Once-daily add-on tiotropium: a dose-finding trial in adult patients with moderate persistent asthma. Allergy 2013;68(s97):376-7.
    • (2013) Allergy , vol.68 , pp. 376-377
    • Beeh, K.M.1    Ablinger, O.2    Moroni-Zentgraf, P.3    Hollaenderova, Z.4    Pivovarova, A.5    Engel, M.6
  • 67
    • 84904767957 scopus 로고    scopus 로고
    • Tiotropium Respimat in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma
    • Beeh KM, Moroni-Zentgraf P, Ablinger O, Hollaenderova Z, Unseld A, Engel M, et al. Tiotropium Respimat in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma. Respiratory Research 2014;15:61.
    • (2014) Respiratory Research , vol.15 , pp. 61
    • Beeh, K.M.1    Moroni-Zentgraf, P.2    Ablinger, O.3    Hollaenderova, Z.4    Unseld, A.5    Engel, M.6
  • 68
    • 85027426403 scopus 로고    scopus 로고
    • Once-daily tiotropium respimat add-on to at least ICS in adult patients with symptomatic asthma: Pooled safety analysis
    • Dusser D, Buhl R, Castro M, Kerstjens H, Paggiaro P, Engel M, et al. Once-daily tiotropium respimat add-on to at least ICS in adult patients with symptomatic asthma: Pooled safety analysis. European Respiratory Journal 2014;44(Suppl 58):P905.
    • (2014) European Respiratory Journal , vol.44 , pp. P905
    • Dusser, D.1    Buhl, R.2    Castro, M.3    Kerstjens, H.4    Paggiaro, P.5    Engel, M.6
  • 69
    • 34247645201 scopus 로고    scopus 로고
    • A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma
    • Fardon T, Haggart K, Lee D K C, Lipworth B J. A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma. Respiratory Medicine 2007;101(6):1218-28.
    • (2007) Respiratory Medicine , vol.101 , Issue.6 , pp. 1218-1228
    • Fardon, T.1    Haggart, K.2    Lee, D.K.C.3    Lipworth, B.J.4
  • 71
    • 85011294923 scopus 로고    scopus 로고
    • Stepping down inhaled steroids in severe asthma with long acting bronchodilators: utilising effort dependent and independent measures of pulmonary function [Abstract]
    • 2004 Dec 1-3; London, United Kingdom
    • Haggart K, Fardon TC, Lee DKC, Lipworth BJ. Stepping down inhaled steroids in severe asthma with long acting bronchodilators: utilising effort dependent and independent measures of pulmonary function [Abstract]. British Thoracic Society Winter Meeting; 2004 Dec 1-3; London, United Kingdom. 2004; Vol. 59:ii72.
    • (2004) British Thoracic Society Winter Meeting , vol.59 , pp. 272
    • Haggart, K.1    Fardon, T.C.2    Lee, D.K.C.3    Lipworth, B.J.4
  • 72
    • 85027426652 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat: safety and tolerability results from five phase iii trials in adults with symptomatic asthma
    • Haughney J, Vandewalker M, Meltzer E, Paggiaro P, Engel M, Unseld A, et al. Once-daily tiotropium Respimat: safety and tolerability results from five phase iii trials in adults with symptomatic asthma. Thorax 2014;69(Suppl 2):A178-9.
    • (2014) Thorax , vol.69 , pp. A178-A179
    • Haughney, J.1    Vandewalker, M.2    Meltzer, E.3    Paggiaro, P.4    Engel, M.5    Unseld, A.6
  • 75
    • 84969991558 scopus 로고    scopus 로고
    • Phase III trials to investigate tiotropium as add-on therapy to inhaled corticosteroids for patients with symptomatic asthma: Trial design and planned statistical analyses
    • Casale T, Bleecker E, Meltzer E, Pizzichini E, Schmidt O, Bateman E, et al. Phase III trials to investigate tiotropium as add-on therapy to inhaled corticosteroids for patients with symptomatic asthma: Trial design and planned statistical analyses. Allergy 2013;68(s97):377.
    • (2013) Allergy , vol.68 , pp. 377
    • Casale, T.1    Bleecker, E.2    Meltzer, E.3    Pizzichini, E.4    Schmidt, O.5    Bateman, E.6
  • 76
    • 85027426525 scopus 로고    scopus 로고
    • 24-hour lung function response to tiotropium Respimatadd-on to maintenance therapy in symptomatic patients with moderate persistent asthma
    • Casale T, Carr WW, Greos L, Engel M, Bour LJ, Moroni-Zentgraf P, et al. 24-hour lung function response to tiotropium Respimatadd-on to maintenance therapy in symptomatic patients with moderate persistent asthma. Annals of Allergy, Asthma & Immunology 2014;113(5):A108.
    • (2014) Annals of Allergy, Asthma & Immunology , vol.113 , Issue.5 , pp. A108
    • Casale, T.1    Carr, W.W.2    Greos, L.3    Engel, M.4    Bour, L.J.5    Moroni-Zentgraf, P.6
  • 77
  • 78
    • 84929030264 scopus 로고    scopus 로고
    • Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials
    • Kerstjens HA, Casale TB, Bleecker ER, Meltzer EO, Pizzichini E, Schmidt O, et al. Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials. The Lancet Respiratory Medicine 2015;3(5):367-76.
    • (2015) The Lancet Respiratory Medicine , vol.3 , Issue.5 , pp. 367-376
    • Kerstjens, H.A.1    Casale, T.B.2    Bleecker, E.R.3    Meltzer, E.O.4    Pizzichini, E.5    Schmidt, O.6
  • 80
    • 84919711899 scopus 로고    scopus 로고
    • The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study
    • Lee LA, Yang S, Kerwin E, Trivedi R, Edwards LD, Pascoe S. The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study. Respiratory Medicine 2015;109(1):54-62.
    • (2015) Respiratory Medicine , vol.109 , Issue.1 , pp. 54-62
    • Lee, L.A.1    Yang, S.2    Kerwin, E.3    Trivedi, R.4    Edwards, L.D.5    Pascoe, S.6
  • 83
    • 84970037540 scopus 로고    scopus 로고
    • A multi-center, randomized, double-blind, dose-ranging study to evaluate GSK573719 in combination with fluticasone furoate, fluticasone furoate alone, and an active control of fluticasone furoate/vilanterol combination in subjects with asthma
    • NCT01573624, (accessed 22 June 2015)
    • NCT01573624 . A multi-center, randomized, double-blind, dose-ranging study to evaluate GSK573719 in combination with fluticasone furoate, fluticasone furoate alone, and an active control of fluticasone furoate/vilanterol combination in subjects with asthma. http://clinicaltrials.gov/show/NCT01573624 (accessed 22 June 2015).
  • 84
    • 84969914441 scopus 로고    scopus 로고
    • Proof of concept study to evaluate single and chronic dosing effects of ultra-long acting bronchodilator therapy on mannitol challenge in asthmatic patients taking inhaled corticosteroids - MAN02 Ultra-long Acting Bronchodilator Therapy in Asthmatics
    • NCT02039011, (accessed 23 June 2015)
    • NCT02039011 . Proof of concept study to evaluate single and chronic dosing effects of ultra-long acting bronchodilator therapy on mannitol challenge in asthmatic patients taking inhaled corticosteroids - MAN02 Ultra-long Acting Bronchodilator Therapy in Asthmatics. http://apps.who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2013-001953-28-GB (accessed 23 June 2015).
  • 85
    • 85027426452 scopus 로고    scopus 로고
    • Phase III trial of tiotropium as add-on therapy to low-dose inhaled corticosteroids for patients with symptomatic mild persistent asthma: design and planned analyses [Abstract]
    • [P4133]
    • Paggiaro P, Engel M, Tudoric N, Forstner B, Radeczky E, Zubek V, et al. Phase III trial of tiotropium as add-on therapy to low-dose inhaled corticosteroids for patients with symptomatic mild persistent asthma: design and planned analyses [Abstract]. European Respiratory Journal 2013;42(Suppl 57):877s [P4133].
    • (2013) European Respiratory Journal , vol.42 , pp. 877S
    • Paggiaro, P.1    Engel, M.2    Tudoric, N.3    Forstner, B.4    Radeczky, E.5    Zubek, V.6
  • 86
    • 79551624288 scopus 로고    scopus 로고
    • Tiotropium bromide in asthma patients: an alternative to inhaled long-acting beta-agonists?
    • Lane M. Tiotropium bromide in asthma patients: an alternative to inhaled long-acting beta-agonists?. Journal of the Royal College of Physicians of Edinburgh 2010;40(4):321-2.
    • (2010) Journal of the Royal College of Physicians of Edinburgh , vol.40 , Issue.4 , pp. 321-322
    • Lane, M.1
  • 89
    • 85027426526 scopus 로고    scopus 로고
    • Efficacy of once-daily tiotropium Respimat 5 mug from five phase III trials in adults with symptomatic asthma
    • Price D, Bateman ED, Paggiaro P, Kaplan A, Engel M, Schmidt H, et al. Efficacy of once-daily tiotropium Respimat 5 mug from five phase III trials in adults with symptomatic asthma. Thorax 2014;69(Suppl 2):A50.
    • (2014) Thorax , vol.69 , pp. A50
    • Price, D.1    Bateman, E.D.2    Paggiaro, P.3    Kaplan, A.4    Engel, M.5    Schmidt, H.6
  • 90
    • 84898925474 scopus 로고    scopus 로고
    • Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study
    • Rajanandh MG, Nageswari A D, Ilango K. Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study. Clinical Therapeutics 2014;36(4):526-33.
    • (2014) Clinical Therapeutics , vol.36 , Issue.4 , pp. 526-533
    • Rajanandh, M.G.1    Nageswari, A.D.2    Ilango, K.3
  • 91
    • 84923654867 scopus 로고    scopus 로고
    • Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial
    • Rajanandh MG, Nageswari AD, Ilango K. Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial. Clinical Therapeutics 2015;37(2):418-26.
    • (2015) Clinical Therapeutics , vol.37 , Issue.2 , pp. 418-426
    • Rajanandh, M.G.1    Nageswari, A.D.2    Ilango, K.3
  • 92
    • 84903883629 scopus 로고    scopus 로고
    • Assessment of various second-line medications in addition to inhaled corticosteroid in asthma patients: a randomized controlled trial
    • Rajanandh MG, Nageswari AD, Ilango K. Assessment of various second-line medications in addition to inhaled corticosteroid in asthma patients: a randomized controlled trial. Clinical and Experimental Pharmacology & Physiology 2014;41(7):509-13.
    • (2014) Clinical and Experimental Pharmacology & Physiology , vol.41 , Issue.7 , pp. 509-513
    • Rajanandh, M.G.1    Nageswari, A.D.2    Ilango, K.3
  • 93
    • 84928084942 scopus 로고    scopus 로고
    • What is the role of tiotropium in asthma?: a systematic review with meta-analysis [Review]
    • Rodrigo GJ, Castro-Rodriguez JA. What is the role of tiotropium in asthma?: a systematic review with meta-analysis [Review]. Chest 2015;147(2):388-96.
    • (2015) Chest , vol.147 , Issue.2 , pp. 388-396
    • Rodrigo, G.J.1    Castro-Rodriguez, J.A.2
  • 94
    • 85027426480 scopus 로고    scopus 로고
    • Eight weeks of treatment with tiotropium plus fluticasone (t + f ) produces an equally effective therapeutic response as salmeterol plus fluticasone (s + f) in subjects with moderate-to-severe asthma [Abstract]
    • Salvi S, Bhosle K, Brashier B, Limaye S, Mandrekar S, Gaikwad S, et al. Eight weeks of treatment with tiotropium plus fluticasone (t + f ) produces an equally effective therapeutic response as salmeterol plus fluticasone (s + f) in subjects with moderate-to-severe asthma [Abstract]. European Respiratory Journal 2009;34(Suppl 53):E276.
    • (2009) European Respiratory Journal , vol.34 , pp. E276
    • Salvi, S.1    Bhosle, K.2    Brashier, B.3    Limaye, S.4    Mandrekar, S.5    Gaikwad, S.6
  • 95
    • 84933179804 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat 5 mug is an efficacious 24-h bronchodilator in adults with symptomatic asthma
    • Timmer W, Moroni-Zentgraf P, Cornelissen P, Unseld A, Pizzichini E, Buhl R. Once-daily tiotropium Respimat 5 mug is an efficacious 24-h bronchodilator in adults with symptomatic asthma. Respiratory Medicine 2015;109(3):329-38.
    • (2015) Respiratory Medicine , vol.109 , Issue.3 , pp. 329-338
    • Timmer, W.1    Moroni-Zentgraf, P.2    Cornelissen, P.3    Unseld, A.4    Pizzichini, E.5    Buhl, R.6
  • 96
    • 85027426211 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on therapy improves lung function in adolescent patients with moderate symptomatic asthma, independent of t helper 2 inflammatory status
    • Vandewalker M, Harper III T, Moroni-Zentgraf P, Engel M, Luhmann R, Bernstein JA. Once-daily tiotropium Respimat add-on therapy improves lung function in adolescent patients with moderate symptomatic asthma, independent of t helper 2 inflammatory status. Annals of Allergy, Asthma & Immunology 2015;115(5 Suppl 1):A54-5.
    • (2015) Annals of Allergy, Asthma & Immunology , vol.115 , Issue.5 , pp. A54-A55
    • Vandewalker, M.1    Harper, T.2    Moroni-Zentgraf, P.3    Engel, M.4    Luhmann, R.5    Bernstein, J.A.6
  • 97
    • 85027426048 scopus 로고    scopus 로고
    • Once-daily tiotropium Respimat add-on to medium-dose ics is an efficacious 24-hour bronchodilator in adolescent patients with symptomatic asthma
    • Vogelberg C, Engel M, Moroni-Zentgraf P, Leonaviciute-Klimantaviciene M, Sigmund R, Downie J, et al. Once-daily tiotropium Respimat add-on to medium-dose ics is an efficacious 24-hour bronchodilator in adolescent patients with symptomatic asthma. Chest 2014;146(4):698A.
    • (2014) Chest , vol.146 , Issue.4 , pp. 698A
    • Vogelberg, C.1    Engel, M.2    Moroni-Zentgraf, P.3    Leonaviciute-Klimantaviciene, M.4    Sigmund, R.5    Downie, J.6
  • 100
    • 84969916476 scopus 로고    scopus 로고
    • A pilot study to determine the feasibility and utility of implementing of the full scale TOM trial (SAPS)
    • (accessed 22 June 2015)
    • NCT01696214 . A pilot study to determine the feasibility and utility of implementing of the full scale TOM trial (SAPS). https://clinicaltrials.gov/ct2/show/NCT01696214 (accessed 22 June 2015).
  • 103
    • 84991247096 scopus 로고    scopus 로고
    • Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma
    • Anderson DE, Kew KM, Boyter AC. Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma. Cochrane Database of Systematic Reviews 2015, Issue 8. [DOI: 10.1002/14651858.CD011397.pub2]
    • (2015) Cochrane Database of Systematic Reviews , Issue.8
    • Anderson, D.E.1    Kew, K.M.2    Boyter, A.C.3
  • 104
    • 84963651592 scopus 로고    scopus 로고
    • British guideline on the management of asthma, October 2014
    • (accessed 16 March 2015)
    • British Thoracic Society/Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma, October 2014. https://www.brit-thoracic.org.uk/guidelines-and-quality-standards/asthma-guideline/ (accessed 16 March 2015).
  • 107
    • 84969986634 scopus 로고    scopus 로고
    • License extension 19th September 2014: Spiriva Respimat 2.5 micrograms solution for inhalation
    • (accessed 16 March 2015)
    • Electronic Medicines Compendium. License extension 19th September 2014: Spiriva Respimat 2.5 micrograms solution for inhalation. https://www.medicines.org.uk/emc/history/20134 (accessed 16 March 2015).
  • 108
    • 84941077227 scopus 로고    scopus 로고
    • Global strategy for asthma management and prevention
    • (accessed 16 March 2015)
    • Global Initiative for Asthma. Global strategy for asthma management and prevention. http://www.ginasthma.org/ (accessed 16 March 2015).
  • 109
    • 84901782267 scopus 로고    scopus 로고
    • The Global Asthma Report 2011
    • (accessed 16 March 2015)
    • International Union Against Tuberculosis and Lung Disease. The Global Asthma Report 2011. http://theunion.org/what-we-do/publications/technical/global-asthma-report (accessed 16 March 2015).
  • 110
    • 84856377620 scopus 로고    scopus 로고
    • GRADEpro
    • Version 3.2 for Windows. Hamilton, Ontario: McMaster University
    • Brozek J, Oxman A, Schünemann H. GRADEpro. Version 3.2 for Windows. Hamilton, Ontario: McMaster University, 2008.
    • (2008)
    • Brozek, J.1    Oxman, A.2    Schünemann, H.3
  • 111
    • 84887346660 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions
    • Version 5.1 [updated March 2011]
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
    • (2011)
    • Higgins, J.P.T.1    Green, S.2
  • 113
    • 0033542041 scopus 로고    scopus 로고
    • Systemic adverse effects of inhaled corticosteroid therapy
    • Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy. Archives of Internal Medicine 1999;159(9):941-55.
    • (1999) Archives of Internal Medicine , vol.159 , Issue.9 , pp. 941-955
    • Lipworth, B.J.1
  • 114
    • 84891125162 scopus 로고    scopus 로고
    • Emerging role of long acting muscarinic antagonists for asthma
    • Lipworth BJ. Emerging role of long acting muscarinic antagonists for asthma. British Journal of Clinical Pharmacology 2014;77(1):55-62.
    • (2014) British Journal of Clinical Pharmacology , vol.77 , Issue.1 , pp. 55-62
    • Lipworth, B.J.1
  • 115
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • e1000097
    • Moher D, Liberati A, Tetzlaff J, Altman D. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 2009;6(7):e1000097. [DOI: 10.1371/journal.pmed.1000097]
    • (2009) PLoS Medicine , vol.6 , Issue.7
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.4
  • 116
    • 79953684895 scopus 로고    scopus 로고
    • Muscarinic receptor antagonists, from folklore to pharmacology: finding drugs that actually work in asthma and COPD
    • Moulton BC, Fryer AD. Muscarinic receptor antagonists, from folklore to pharmacology: finding drugs that actually work in asthma and COPD. British Journal of Clinical Pharmacology 2011;163(1):44-52.
    • (2011) British Journal of Clinical Pharmacology , vol.163 , Issue.1 , pp. 44-52
    • Moulton, B.C.1    Fryer, A.D.2
  • 117
    • 84924405281 scopus 로고    scopus 로고
    • Why asthma still kills: the national review of asthma deaths
    • (accessed 27 March 2015)
    • Royal College of Physicians. Why asthma still kills: the national review of asthma deaths. www.rcplondon.ac.uk/sites/default/files/why-asthma-still-kills-full-report.pdf (accessed 27 March 2015).
  • 119
    • 84964921069 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
    • (2014)
  • 120
    • 84969927970 scopus 로고    scopus 로고
    • Respiratory disorders: chronic obstructive pulmonary disease
    • In: Gray J editor(s).. 7th Edition. Ottawa: Canadian Pharmaceutical Association
    • McIvor RA. Respiratory disorders: chronic obstructive pulmonary disease. In: Gray J editor(s). Therapeutic Choices. 7th Edition. Ottawa: Canadian Pharmaceutical Association, 2014.
    • (2014) Therapeutic Choices
    • McIvor, R.A.1
  • 121
    • 84899734162 scopus 로고    scopus 로고
    • Tiotropium versus placebo for inadequately controlled asthma: a meta-analysis
    • Tian J, Chen J, Chen R, Chen X. Tiotropium versus placebo for inadequately controlled asthma: a meta-analysis. Respiratory Care 2014;59(5):654-66.
    • (2014) Respiratory Care , vol.59 , Issue.5 , pp. 654-666
    • Tian, J.1    Chen, J.2    Chen, R.3    Chen, X.4
  • 122
    • 84969974007 scopus 로고    scopus 로고
    • 2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma
    • 2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma. Cochrane Database of Systematic Reviews 2015, Issue 5. [DOI: 10.1002/14651858.CD011721]
    • (2015) Cochrane Database of Systematic Reviews , Issue.5
    • Kew, K.M.1    Dahri, K.2


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