Predictors of response to tiotropium versus salmeterol in asthmatic adults

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 5, 2013, Pages 1068-1074.e1

  Peters, Stephen P ^a   Bleecker, Eugene R ^a   Kunselman, Susan J ^b   Icitovic, Nikolina ^b   Moore, Wendy C ^a   Pascual, Rodolfo ^a   Ameredes, Bill T ^c   Boushey, Homer A ^d   Calhoun, William J ^c   Castro, Mario ^e   Cherniack, Reuben M ^f   Craig, Timothy ^b   Denlinger, Loren C ^g   Engle, Linda L ^b   Dimango, Emily A ^h   Israel, Elliot ⁱ   Kraft, Monica ^j   Lazarus, Stephen C ^d   Lemanske, Robert F ^g   Lugogo, Njira ^j   Martin, Richard J ^f   Meyers, Deborah A ^a   Ramsdell, Joe ^k   Sorkness, Christine A ^l   Sutherland, E Rand ^f   Wasserman, Stephen I ^k   Walter, Michael J ^e   Wechsler, Michael E ^f   Chinchilli, Vernon M ^b   Szefler, Stanley J ^f   more..

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^h NewYork Presbyterian Hospital   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j DUKE UNIVERSITY   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF WISCONSIN MADISON   (United States)

more..

Author keywords

Asthma; predictor of response; responder analysis; salmeterol; tiotropium

Indexed keywords

BECLOMETHASONE HYDROFLUOROALKANE; CORTICOSTEROID; IMMUNOGLOBULIN E; IPRATROPIUM BROMIDE; NITRIC OXIDE; SALBUTAMOL; SALMETEROL; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTHMA; ATOPY; BODY MASS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE DURATION; DOUBLE BLIND PROCEDURE; EOSINOPHIL COUNT; ETHNICITY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX; TREATMENT RESPONSE;

EID: 84887024692     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.08.003     Document Type: Article

References (15)

1. National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the diagnosis and management of asthma 2007 Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute Bethesda (MD)
2. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Available at: http://www.ginasthma.org. Accessed August 14, 2012.
3. S.T. Weiss New approaches to personalized medicine for asthma: where are we? J Allergy Clin Immunol 129 2012 327 334
4. R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
5. P.A. Greenberger Personalized medicine for patients with asthma J Allergy Clin Immunol 125 2010 305 306
6. S. Sharma, A.A. Litonjua, K.G. Tantisira, A.L. Fuhlbrigge, S.J. Szefler, and R.C. Strunk Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program J Allergy Clin Immunol 122 2008 921 928
7. S.J. Szefler, B.R. Phillips, F.D. Martinez, V.M. Chinchilli, R.F. Lemanske, and R.C. Strunk Characterization of within-subject responses to fluticasone and montelukast in childhood asthma J Allergy Clin Immunol 115 2005 233 242
8. R.S. Zeiger, S.J. Szefler, B.R. Phillips, M. Schatz, F.D. Martinez, and V.M. Chinchilli Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma J Allergy Clin Immunol 117 2006 45 52
9. J.E. Knuffman, C.A. Sorkness, R.F. Lemanske Jr., D.T. Mauger, S.J. Boehmer, and F.D. Martinez Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma J Allergy Clin Immunol 123 2009 411 416
10. R.J. Martin, S.J. Szefler, T.S. King, M. Kraft, H.A. Boushey, and V.M. Chinchilli The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial J Allergy Clin Immunol 119 2007 73 80
11. S.J. Szefler, and R.J. Martin Lessons learned from variation in response to therapy in clinical trials J Allergy Clin Immunol 125 2010 285 292
12. S.P. Peters, S.J. Kunselman, N. Icitovic, W.C. Moore, R. Pascual, and B.T. Ameredes Tiotropium bromide step-up therapy for adults with uncontrolled asthma N Engl J Med 363 2010 1715 1726
13. E.D. Bateman, O. Kornmann, P. Schmidt, A. Pivovarova, M. Engel, and L.M. Fabbri Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma J Allergy Clin Immunol 128 2011 315 322
14. H.A. Kerstjens, B. Disse, W. Schröder-Babo, T.A. Bantje, M. Gahlemann, and R. Sigmund Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial J Allergy Clin Immunol 128 2011 308 314
15. H.A. Kerstjens, M. Engel, R. Dahl, P. Paggiaro, E. Beck, and M. Vandewalker Tiotropium in asthma poorly controlled with standard combination therapy N Engl J Med 367 2012 1198 1207