Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects

Experimental Gerontology

Volumn 81, Issue , 2016, Pages 56-64

  Issa, Chahira Taha Mahd Ibrahim ^a   Silva, Alexandre Sérgio ^a   Toscano, Luciana Tavares ^a   Medeiros, Marcia Silva ^a   Persuhn, Darlene Camati ^a   da Silva Diniz, Alcides ^b   de Carvalho Costa, Maria José ^a   Rodrigues Gonçalves, Maria da Conceição ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Elderly; Hyperglycemia; Oxidative stress; Polymorphism; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; VITAMIN D; 25-HYDROXYVITAMIN D; CALCITRIOL RECEPTOR; GLUCOSE BLOOD LEVEL; MALONALDEHYDE; VDR PROTEIN, HUMAN;

AGED; ARTICLE; BODY MASS; BSMI GENE; CARDIOMETABOLIC RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ELDERLY CARE; FEMALE; FOOD INTAKE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HOMOZYGOSITY; HUMAN; MALE; NUTRITIONAL STATUS; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; VDR GENE; AGING; ANALOGS AND DERIVATIVES; BLOOD; BRAZIL; GENETICS; HOMOZYGOTE; HYPERGLYCEMIA; MIDDLE AGED; VITAMIN D DEFICIENCY;

AGED; AGING; BLOOD GLUCOSE; BRAZIL; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; FEMALE; GENE FREQUENCY; HOMOZYGOTE; HUMANS; HYPERGLYCEMIA; MALE; MALONDIALDEHYDE; MIDDLE AGED; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84965168150     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2016.04.020     Document Type: Article

References (71)

1. Aidar M., Line S.R.P. A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz. Dent. J. 2007, 18(2):148-152.
2. Al-Ajlan A., Krishnaswamy S., Alokail M.S., et al. Vitamin D deficiency and dyslipidemia in early pregnancy. BMC Pregnancy Childbirth 2015, 15:314.
3. Al-Daghri N.M., Rahman S., Amer O.E., et al. Gender dependent association of 25-hydroxyvitamin D and circulating leptin in saudi subjects: influence of dyslipidemia. Int. J. Clin. Exp. Med. 2015, 8:11,160-11,166.
4. Almirall J., Vaqueiro M., Baré M.L., et al. Association of low serum 25 hydroxyvitamin D levels and high arterial blood pressure in the elderly. Nephrol. Dial. Transplant. 2010, 25:503-509.
5. Arabi A., Zahed L., Mahfoud Z., et al. Vitamin D receptor gene polymorphism modulate the skeletal response to vitamin D supplementation in healthy girls. Bone 2009, 45(6):1091-1097. 10.1016/j.bone.2009.07.074.
6. Asemi Z., Hashemi T., Karamali M., et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am. J. Clin. Nutr. 2013, 10.3945/ajcn.113.072785.
7. Barchetta I., De Bernardinis M., Capoccia D., et al. Hypovitaminosis D is independently associated with metabolic syndrome in obese patients. PLoS One 2013, 8(7). 10.1371/journal.pone.0068689.
8. Bhutto A., Morley J.E. The clinical significance of gastrointestinal changes with aging. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11(5):651-660.
9. Bland R., Markovic D., Hills C.E., et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J. Steroid Biochem. Mol. Biol. 2004, 89-90(1-5):121-125.
10. Brouwer-Brolsma E.M., Feskens E.J.M., Steegenga W.T., et al. Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur. J. Nutr. 2013, 52:917-925. 10.1007/s00394-012-0399-0.
11. Cavalcante I.G.M., Silva A.S., Costa M.J.C., et al. Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency vitamin D3 megadose reduces inflammatory markers. Exp. Gerontol. 2015, 66:10-16.
12. Chang B., Schlussel Y., Sukumar D., et al. Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction. Bone 2015, 81:138-144. 10.1016/j.bone.2015.07.011.
13. Chinetti G., Lestavel S., Bocher V., et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 2001, 7(1):53-58.
14. Chinetti G., Lestavel S., Fruchart J.C., et al. Peroxisome proliferator-activated receptor reduces cholesterol esterification in macrophages. Circ. Res. 2003, 92:212-217.
15. Clark S.A., Stumpf W.E., Sar M. Effects of 1,25 dihydroxyvitamin D3 on insulin secretion. Diabetes 1981, 30:380-386.
16. Clark S.A., Stumpf W.E., Sar M., et al. Target cells for 1,25 dihydroxyvitamin D3 in the pancreas. Cell Tissue Res. 1980, 209:515-520.
17. Codoñer-Franch P., Tavárez-Alonso S., Simó-Jordá R., et al. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. J. Pediatr. 2012, 161(5):848-854. 10.1016/j.jpeds.2012.04.046.
18. Doğan M., Cesur Y., ZehraDoğan Ş., et al. Oxidant/antioxidant system markers and trace element levels in children with nutritional rickets. J. Pediatr. Endocrinol. Metab. 2012, 25(11-12):1129-1139. 10.1515/jpem-2012-0153.
19. Elmarakby A.A., Sullivan J.C., 2010. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovasc. Ther., 00, 1-11. doi: 10.1111/j.1755-5922.2010.00218.x.
20. Elnenaei M.O., Chandra R., Mangion T., et al. Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation. Br. J. Nutr. 2011, 105:71-79. 10.1017/S0007114510003065.
21. El-Shehaby A.M., El-Khatib M.M., Marzouk S., et al. Relationship of BsmI polymorphism of vitamin D receptor gene with left ventricular hypertrophy and atherosclerosis in hemodialysis patients. Scand. J. Clin. Lab. Invest. 2013, 73(1):75-81. 10.3109/00365513.2012.743163.
22. Esler M., Rumantir M., Kaye D., et al. The sympathetic neurobiology of essential hypertension: disparate influences of obesity, stress, and noradrenaline transporter dysfunction?. Am. J. Hypertens. 2001, 14(6 Pt 2):139S-146S.
23. Friis H., Range N., Changalucha J., et al. Vitamin D status among pulmonary TB patients and non-TB controls: a cross-sectional study from Mwanza, Tanzania. PLoS One 2013, 8(12). 10.1371/journal.pone.0081142.
24. Fu L.W., Vender R., 2011. Systemic role for vitamin D in the treatment of psoriasis and metabolic syndrome. Dermatol. Res. Pract., (Article ID 276,079).
25. Gepner A.D., Ramamurthy R., Krueger D.C., et al. Prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One 2012, 7(5). 10.1371/journal.pone.0036617.
26. González-Molero I., Rojo G., Morcillo S., et al. Relationship between vitamin D deficiency and metabolic syndrome. Med. Clin. (Barc.) 2013, 10.1016/j.medcli.2013.05.049.
27. Gradinaru D., Borsa C., Ionescu C., et al. Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus. Aging Clin. Exp. Res. 2012, 24(6):595-602. 10.3275/8591.
28. Holick M.F. Vitamin D: its role in cancer prevention and treatment. Prog. Biophys. Mol. Biol. 2006, 92:49-59.
29. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2011, 96(7):1911-1930.
30. Hyppönen E., Berry D., Cortina-Borja M., et al. 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British birth cohort. PLoS One 2010, 5(5). 10.1371/journal.pone.0010801.
31. Jarrett R.J., Murrells T.J., Shipley M.J., et al. Screening blood glucose values: effects of season and time of day. Diabetologia 1984, 27(6):574-577.
32. Kayaniyil S., Harris S.B., Retnakaran R., et al. Associação prospectiva de 25 (OH) D com síndrome metabólica. Clin. Endocrinol. 2013, 10.1111/cen.12190.
33. Kelishadi R., Saleka S., Saleka M., et al. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. J. Pediatr. 2013, 10.1016/j.jped.2013.06.006.
34. Laczmanski L., Milewicz A., Lwow F., et al. Vitamin D receptor gene polymorphism and cardiovascular risk variables in elderly Polish subjects. Gynecol. Endocrinol. 2013, 29(3):268-272. 10.3109/09513590.2012.736562.
35. Lanzke B., Razzaque M.S. Vitamin and aging: old concepts and news insights. J. Nutr. Biochem. 2007, 18(12):771-777. 10.1016/j.jnutbio.2007.02.002.
36. Lima F.E.L., Slater B., Latorre M.R.D.O., et al. Validade de um questionário quantitativo de frequência alimentar desenvolvido para população feminina no nordeste do Brasil. Rev. Bras. Epidemiol. 2007, 10(4):483-490.
37. Mai X.M., Chen Y., Camargo C.A., et al. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults the HUNT study. Am. J. Epidemiol. 2012, 175(10):1029-1036. 10.1093/aje/kwr456.
38. Makariou S., Liberopoulos E., Florentin M., et al. The relationship of vitamin D with non-traditional risk factors for cardiovascular disease in subjects with metabolic syndrome. Arch. Med. Sci. 2012, 8(3):437-443. 10.5114/aoms.2012.29398.
39. Naharci I., Bozoglu E., Kocak N., et al., 2012. Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose. Geriatr. Gerontol. Int., 12 (3), 454-60. doi: 10.1111/j.1447-0594.2011.00791.x.
40. Neves J.P.R., Silva A.S., Morais L.C.S.L., et al. Concentrações de 25-hidroxivitamina D e níveis pressóricos em idosos hipertensos. Arq. Bras. Endocrinol. Metabol. 2012, 56(7).
41. Nunn A.V.W., Bell J.D., Guy G.W. Life style-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?. Nutr. Metab. 2009, 6(16). 10.1186/1743-7075-6-16.
42. Ogunkolade B.W., Boucher B.J., Prahl J.M., et al. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 2002, 51:2294-2312.
43. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
44. Oosterwerff M.M., Eekhoff E.M., Heymans M.W., et al. Serum 25-hydroxyvitamin D levels and the metabolic syndrome in older persons: a population-based study. Clin. Endocrinol. 2011, 75(5):608-613.
45. Palacios C., Gil K., Pérez C.M., et al. Determinants of vitamin D status among overweight and obese Puerto Rican adults. Ann. Nutr. Metab. 2012, 60:35-43. 10.1159/000,335,282.
46. Piccirillo L.J., Gonçalves M.F.R., Clemente E.L.S., et al. Marcadores de inflamação em pacientes com diabetes mellitus tipo 1. Arq. Bras. Endocrinol. Metab. 2004, 48(2).
47. Rizvi A., Hasan S.S., Naseem I. Selective cytotoxic action and DNA damage by calcitriol-Cu(II) interaction: putative mechanism of cancer prevention. PLoS One 2013, 8(9). 10.1371/journal.pone.0076191.
48. Santos B.R., Mascarenhas L.P.G., Satler F., et al. Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. BMC Pediatr. 2012, 12:62.
49. Serrano J.C.E., De Lorenzo D., Cassanye A., et al. Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile. Genes Nutr. 2013, 8:561-569. 10.1007/s12263-013-0356-4.
50. Shab-Bidar S., Neyestani T.R., Djazayery A. Efficacy of vitamin D3-fortified-yogurt drink on anthropometric, metabolic, inflammatory and oxidative stress biomarkers according to vitamin D receptor gene polymorphisms in diabetic patients: a study protocol for a randomized controlled clinical trial. BMC Endocr. Disord. 2011, 11:12.
51. Shab-Bidar S., Neyestani T.R., Djazayery A., et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab. Res. Rev. 2012, 28(5):424-430. 10.1002/dmrr.2290.
52. Shahar D.R., Schwarzfuchs D., Fraser D., et al. Dairy calcium intake, serum vitamin D, and successful weight loss. Am. J. Clin. Nutr. 2010, 92:1017-1022.
53. Shea M.K., Booth S.L., Massaro J.M., et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham offspring study. Am. J. Epidemiol. 2008, 167:313-320.
54. Silva B.C.C., Camargos B.M., Fujii J.B., et al. Prevalência de deficiência e insuficiência de vitamina D e sua correlação com PTH, marcadores de remodelação óssea e densidade mineral óssea, em pacientes ambulatoriais. Arq. Bras. Endocrinol. Metabol. 2008, 52:482-488.
55. Silva S.H., Moresco R.N. Biomarcadores cardíacos na avaliação da síndrome coronariana aguda. Sci. Med. 2011, 21(3):132-142. (Porto Alegre).
56. Sociedade Brasileira de Cardiologia IV Diretriz brasileira sobre dislipidemias e prevenção da aterosclerose. Arq. Bras. Cardiol. 2007, 88. Suplemento I.
57. Sociedade Brasileira de Cardiologia VI Diretrizes brasileiras de hipertensão. Rev. Bras. Hipertens. 2010, 17(1).
58. Sociedade Brasileira de Diabetes Diretriz 2012-2013.
59. Speer G., Cseh K., Winkler G., et al. Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Eur. J. Endocrinol. 2001, 144:385-389.
60. Takase B., Takeishi Y., Hirai T., et al. Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension. Circ. J. 2008, 72:764-769.
61. Timms P.M., Mannan N., Hitman G.A., et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. Q. J. Med. 2002, 95:787-796.
62. Tworowska-Bardzińska U., Lwow F., Kubicka E., et al. The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women. Gynecol. Endocrinol. 2008, 24(9):514-518. 10.1080/09,513,590,802,302,985.
63. Vélayoudom-Céphise F.L., Larifla L., Donnet J.P., et al. Vitamin D deficiency, vitamin D receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes. Diabete Metab. 2011, 37(6):540-545. 10.1016/j.diabet.2011.05.005.
64. Volanakis J.E., 2001. Human C-reactive protein: expression, structure, and function. Mol. Immunol., 38 (3-2), 189-197.
65. Volp A.C.P., Bressan J., Hermsdorff H.H.M., et al. Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica. Ver. Nutr. Campinas 2010, 23(4):581-590.
66. Vuolo L., Di Somma C., Faggiano A., et al. Vitamin D and cancer. Front. Endocrinol. 2012, 3:58. (Lausanne). 10.3389/fendo.2012.00058.
67. World Health Organization Obesity: preventing and managing the global epidemic. Technical Report Series, 894 1998, WHO, Geneva.
68. World Health Organization Obesity: Preventing and managing the global epidemic. Report of a Who Consultation 2000, WHO, Geneva.
69. Ye W.Z., Reis A.F., Dubois-Laforgue D., et al. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur. J. Endocrinol. 2001, 145:181-186.
70. Yildirim I., Hur E., Kokturk F. Inflammatory markers: C-reactive protein, erythrocyte sedimentation rate, and leukocyte count in vitamin D deficient patients with and without chronic kidney disease. Int. J. Endocrinol. 2013, 802:165. 10.1155/2013/802,165.
71. Yin Y., Yu Z., Xia M., et al. Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism. Eur. J. Clin. Investig. 2012, 42(11):1189-1196. 10.1111/j.1365-2362.2012.027.