Genome-wide association analysis of blood-pressure traits in african-ancestry individuals reveals common associated genes in African and Non-African populations

American Journal of Human Genetics

Volumn 93, Issue 3, 2013, Pages 545-554

  Franceschini, Nora ^a   Fox, Ervin ^b   Zhang, Zhaogong ^c,d   Edwards, Todd L ^e   Nalls, Michael A ^f   Sung, Yun Ju ^g   Tayo, Bamidele O ^h   Sun, Yan V ⁱ   Gottesman, Omri ^j   Adeyemo, Adebawole ^k   Johnson, Andrew D ^l   Young, J Hunter ^m   Rice, Ken ⁿ   Duan, Qing ^o   Chen, Fang ^p   Li, Yun ^a,q   Tang, Hua ^r   Fornage, Myriam ^s   Keene, Keith L ^p   Andrews, Jeanette S ^t   Smith, Jennifer A ^u   Faul, Jessica D ^u   Guangfa, Zhang ^v   Guo, Wei ^c   Liu, Yu ^c   Murray, Sarah S ^w   Musani, Solomon K ^b   Srinivasan, Sathanur ^w   Velez Edwards, Digna R ^x   Wang, Heming ^c   Becker, Lewis C ^m   Bovet, Pascal ^y,z   Bochud, Murielle ^y   Broeckel, Ulrich ^aa   Burnier, Michel ^ab   Carty, Cara ^ac   Chasman, Daniel I ^ad   Ehret, Georg ^m,ae   Chen, Wei Min ^p   Chen, Guanjie ^k   Chan, Wei ^w   Ding, Jingzhong ^t   Dreisbach, Albert W ^b   Evans, Michele K ^f   Guo, Xiuqing ^af   Garcia, Melissa E ^f   Jensen, Rich ^ag   Keller, Margaux F ^f,ah   Lettre, Guillaume ^ai   Lotay, Vaneet ^j   Martin, Lisa W ^aj   Moore, Jason H ^ak   Morrison, Alanna C ^s   Mosley, Thomas H ^b   Ogunniyi, Adesola ^al   Palmas, Walter ^am   Papanicolaou, George ^l   Penman, Alan ^b   Polak, Joseph F ^an   Ridker, Paul M ^ad   Salako, Babatunde ^s   Singleton, Andrew B ^f   Shriner, Daniel ^k   Taylor, Kent D ^af   Vasan, Ramachandran ^ao   Wiggins, Kerri ^ag   Williams, Scott M ^e   Yanek, Lisa R ^m   Zhao, Wei ^u   Zonderman, Alan B ^f   Becker, Diane M ^m   Berenson, Gerald ^w   Boerwinkle, Eric ^s   Bottinger, Erwin ^j   Cushman, Mary ^ap   Eaton, Charles ^aq   Nyberg, Fredrik ^ar   Heiss, Gerardo ^a   Hirschhron, Joel N ^as,at,au   Howard, Virginia J ^av   Karczewsk, Konrad J ^r   Lanktree, Matthew B ^aw   Liu, Kiang ^ax   Liu, Yongmei ^t   Loos, Ruth ^j   Margolis, Karen ^ay   Snyder, Michael ^r   Psaty, Bruce M ^ag,az   Schork, Nicholas J ^v   Weir, David R ^u   Rotimi, Charles N ^k   Sale, Michele M ^p   Harris, Tamara ^ba   Kardia, Sharon L R ^u   Hunt, Steven C ^bb   Arnett, Donna ^av   Redline, Susan ^au   Cooper, Richard S ^h   Risch, Neil J ^bc   Rao, D C ^g   Rotter, Jerome I ^af   Chakravarti, Aravinda ^m   Reiner, Alex P ^ac   Levy, Daniel ^l   Keating, Brendan J ^bd,be   Zhu, Xiaofeng ^c   more..

^a IL   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HEILONGJIANG UNIVERSITY   (China)

^e VANDERBILT UNIVERSITY   (United States)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h LOYOLA UNIVERSITY CHICAGO   (United States)

ⁱ EMORY UNIVERSITY   (United States)

^j MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^k NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^l NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^m JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ UNIVERSITY OF WASHINGTON   (United States)

^o UNIVERSITY OF NORTH CAROLINA   (United States)

^p UNIVERSITY OF VIRGINIA   (United States)

^q UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^r STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^t WAKE FOREST SCHOOL OF MEDICINE   (United States)

^u UNIVERSITY OF MICHIGAN   (United States)

^v SCRIPPS RESEARCH INSTITUTE   (United States)

^w Tulane Center for Cardiovascular Health   (United States)

^x VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^y UNIVERSITY OF LAUSANNE   (Switzerland)

^z MINISTRY OF HEALTH   (Seychelles)

^aa MEDICAL COLLEGE OF WISCONSIN   (United States)

^ab LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ac Fred Hutchinson Cancer Research Center   (United States)

^ad BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ae GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^af CEDARS SINAI MEDICAL CENTER   (United States)

^ag UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^ah TEMPLE UNIVERSITY   (United States)

^ai MONTREAL HEART INSTITUTE   (Canada)

^aj GEORGE WASHINGTON UNIVERSITY   (United States)

^ak DARTMOUTH MEDICAL SCHOOL   (United States)

^al UNIVERSITY OF IBADAN   (Nigeria)

^am Och Spine at New York Presbyterian Hospitals   (United States)

^an TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ao BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ap UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^aq BROWN UNIVERSITY   (United States)

^ar ASTRAZENECA R AND D   (Sweden)

^as BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^at BOSTON CHILDREN S HOSPITAL   (United States)

^au HARVARD MEDICAL SCHOOL   (United States)

^av UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^aw WESTERN UNIVERSITY   (Canada)

^ax NORTHWESTERN UNIVERSITY   (United States)

^ay HENNEPIN COUNTY MEDICAL CENTER   (United States)

^az CENTER FOR HEALTH STUDIES   (United States)

^ba Gateway Building 3C309   (United States)

^bb UNIVERSITY OF UTAH   (United States)

^bc UNIVERSITY OF CALIFORNIA   (United States)

^bd CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^be UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA; ARTICLE; BLOOD PRESSURE; DIASTOLIC BLOOD PRESSURE; EVX1 GENE; EVX1 HOXA GENE; GENE; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HOXA GENE; HUMAN; PLEKHG1 GENE; PRIORITY JOURNAL; RSPO3 GENE; SIGNAL TRANSDUCTION; SOX6 GENE; SYSTOLIC BLOOD PRESSURE; ULK4 GENE;

AFRICA; AFRICAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; COHORT STUDIES; DATABASES, GENETIC; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; REPRODUCIBILITY OF RESULTS;

EID: 84883824600     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2013.07.010     Document Type: Article

References (41)

1. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, W.B. Borden, D.M. Bravata, S. Dai, E.S. Ford, C.S. Fox American Heart Association Statistics Committee and Stroke Statistics Subcommittee Executive summary: heart disease and stroke statistics - 2012 update: a report from the American Heart Association Circulation 125 2012 188 197
2. R.P. Hertz, A.N. Unger, J.A. Cornell, and E. Saunders Racial disparities in hypertension prevalence, awareness, and management Arch. Intern. Med. 165 2005 2098 2104
3. J. Stevens, K.P. Truesdale, E.G. Katz, and J. Cai Impact of body mass index on incident hypertension and diabetes in Chinese Asians, American Whites, and American Blacks: the People's Republic of China Study and the Atherosclerosis Risk in Communities Study Am. J. Epidemiol. 167 2008 1365 1374
4. A.V. Chobanian, G.L. Bakris, H.R. Black, W.C. Cushman, L.A. Green, J.L. Izzo Jr., D.W. Jones, B.J. Materson, S. Oparil, J.T. Wright Jr., E.J. Roccella National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure National High Blood Pressure Education Program Coordinating Committee The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report JAMA 289 2003 2560 2572
5. J.D. Berry, A. Dyer, X. Cai, D.B. Garside, H. Ning, A. Thomas, P. Greenland, L. Van Horn, R.P. Tracy, and D.M. Lloyd-Jones Lifetime risks of cardiovascular disease N. Engl. J. Med. 366 2012 321 329
6. J.P. Forman, M.J. Stampfer, and G.C. Curhan Diet and lifestyle risk factors associated with incident hypertension in women JAMA 302 2009 401 411
7. P.K. Whelton, J. He, L.J. Appel, J.A. Cutler, S. Havas, T.A. Kotchen, E.J. Roccella, R. Stout, C. Vallbona, M.C. Winston, J. Karimbakas National High Blood Pressure Education Program Coordinating Committee Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program JAMA 288 2002 1882 1888
8. J. Stamler, R. Stamler, J.D. Neaton, D. Wentworth, M.L. Daviglus, D. Garside, A.R. Dyer, K. Liu, and P. Greenland Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women JAMA 282 1999 2012 2018
9. L.J. Appel, M.W. Brands, S.R. Daniels, N. Karanja, P.J. Elmer, F.M. Sacks American Heart Association Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association Hypertension 47 2006 296 308
10. P. Primatesta, E. Falaschetti, S. Gupta, M.G. Marmot, and N.R. Poulter Association between smoking and blood pressure: evidence from the health survey for England Hypertension 37 2001 187 193
11. G.B. Ehret, P.B. Munroe, K.M. Rice, M. Bochud, A.D. Johnson, D.I. Chasman, A.V. Smith, M.D. Tobin, G.C. Verwoert, S.J. Hwang International Consortium for Blood Pressure Genome-Wide Association Studies CARDIoGRAM consortium CKDGen Consortium KidneyGen Consortium EchoGen consortium CHARGE-HF consortium Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Nature 478 2011 103 109
12. D. Levy, G.B. Ehret, K. Rice, G.C. Verwoert, L.J. Launer, A. Dehghan, N.L. Glazer, A.C. Morrison, A.D. Johnson, and T. Aspelund Genome-wide association study of blood pressure and hypertension Nat. Genet. 41 2009 677 687
13. C. Newton-Cheh, T. Johnson, V. Gateva, M.D. Tobin, M. Bochud, L. Coin, S.S. Najjar, J.H. Zhao, S.C. Heath, S. Eyheramendy Wellcome Trust Case Control Consortium Genome-wide association study identifies eight loci associated with blood pressure Nat. Genet. 41 2009 666 676
14. A. Adeyemo, N. Gerry, G. Chen, A. Herbert, A. Doumatey, H. Huang, J. Zhou, K. Lashley, Y. Chen, M. Christman, and C. Rotimi A genome-wide association study of hypertension and blood pressure in African Americans PLoS Genet. 5 2009 e1000564
15. E.R. Fox, J.H. Young, Y. Li, A.W. Dreisbach, B.J. Keating, S.K. Musani, K. Liu, A.C. Morrison, S. Ganesh, A. Kutlar International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS) Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study Hum. Mol. Genet. 20 2011 2273 2284
16. X. Zhu, J.H. Young, E. Fox, B.J. Keating, N. Franceschini, S. Kang, B. Tayo, A. Adeyemo, Y.V. Sun, and Y. Li Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium Hum. Mol. Genet. 20 2011 2285 2295
17. N. Kato, F. Takeuchi, Y. Tabara, T.N. Kelly, M.J. Go, X. Sim, W.T. Tay, C.H. Chen, Y. Zhang, and K. Yamamoto Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians Nat. Genet. 43 2011 531 538
18. T. Johnson, T.R. Gaunt, S.J. Newhouse, S. Padmanabhan, M. Tomaszewski, M. Kumari, R.W. Morris, I. Tzoulaki, E.T. O'Brien, N.R. Poulter Cardiogenics Consortium Global BPgen Consortium Blood pressure loci identified with a gene-centric array Am. J. Hum. Genet. 89 2011 688 700
19. M.H. Chen, and Q. Yang GWAF: an R package for genome-wide association analyses with family data Bioinformatics 26 2010 580 581
20. A.L. Price, N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, and D. Reich Principal components analysis corrects for stratification in genome-wide association studies Nat. Genet. 38 2006 904 909
21. X. Zhu, S. Zhang, H. Zhao, and R.S. Cooper Association mapping, using a mixture model for complex traits Genet. Epidemiol. 23 2002 181 196
22. X. Zhu, and R.S. Cooper Admixture mapping provides evidence of association of the VNN1 gene with hypertension PLoS ONE 2 2007 e1244
23. X. Zhu, A. Luke, R.S. Cooper, T. Quertermous, C. Hanis, T. Mosley, C.C. Gu, H. Tang, D.C. Rao, N. Risch, and A. Weder Admixture mapping for hypertension loci with genome-scan markers Nat. Genet. 37 2005 177 181
24. Y.J. Kim, M.J. Go, C. Hu, C.B. Hong, Y.K. Kim, J.Y. Lee, J.Y. Hwang, J.H. Oh, D.J. Kim, N.H. Kim MAGIC consortium Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits Nat. Genet. 43 2011 990 995
25. E.L. Duncan, P. Danoy, J.P. Kemp, P.J. Leo, E. McCloskey, G.C. Nicholson, R. Eastell, R.L. Prince, J.A. Eisman, and G. Jones Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk PLoS Genet. 7 2011 e1001372
26. I.M. Heid, A.U. Jackson, J.C. Randall, T.W. Winkler, L. Qi, V. Steinthorsdottir, G. Thorleifsson, M.C. Zillikens, E.K. Speliotes, R. Mägi MAGIC Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat. Genet. 42 2010 949 960
27. O. Kazanskaya, B. Ohkawara, M. Heroult, W. Wu, N. Maltry, H.G. Augustin, and C. Niehrs The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development Development 135 2008 3655 3664
28. J. Yang, T. Ferreira, A.P. Morris, S.E. Medland, P.A. Madden, A.C. Heath, N.G. Martin, G.W. Montgomery, M.N. Weedon, R.J. Loos Genetic Investigation of ANthropometric Traits (GIANT) Consortium DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits Nat. Genet. 44 2012 369 375 S1-S3
29. A.D. Johnson, R.E. Handsaker, S.L. Pulit, M.M. Nizzari, C.J. O'Donnell, and P.I. de Bakker SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap Bioinformatics 24 2008 2938 2939
30. D.M. Greenawalt, R. Dobrin, E. Chudin, I.J. Hatoum, C. Suver, J. Beaulaurier, B. Zhang, V. Castro, J. Zhu, and S.K. Sieberts A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort Genome Res. 21 2011 1008 1016
31. F. Innocenti, G.M. Cooper, I.B. Stanaway, E.R. Gamazon, J.D. Smith, S. Mirkov, J. Ramirez, W. Liu, Y.S. Lin, and C. Moloney Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue PLoS Genet. 7 2011 e1002078
32. R.M. Saraiva, and J.M. Hare Nitric oxide signaling in the cardiovascular system: implications for heart failure Curr. Opin. Cardiol. 21 2006 221 228
33. H. Clevers, and R. Nusse Wnt/β-catenin signaling and disease Cell 149 2012 1192 1205
34. B.E. Bernstein, E. Birney, I. Dunham, E.D. Green, C. Gunter, M. Snyder ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
35. A.P. Boyle, E.L. Hong, M. Hariharan, Y. Cheng, M.A. Schaub, M. Kasowski, K.J. Karczewski, J. Park, B.C. Hitz, and S. Weng Annotation of functional variation in personal genomes using RegulomeDB Genome Res. 22 2012 1790 1797
36. L.D. Ward, and M. Kellis HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants Nucleic Acids Res. 40 Database issue 2012 D930 D934
37. G. Bhatia, N. Patterson, B. Pasaniuc, N. Zaitlen, G. Genovese, S. Pollack, S. Mallick, S. Myers, A. Tandon, and C. Spencer Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection Am. J. Hum. Genet. 89 2011 368 381
38. F. Tajima Statistical method for testing the neutral mutation hypothesis by DNA polymorphism Genetics 123 1989 585 595
39. P.C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E.H. Byrne, S.A. McCarroll, R. Gaudet International HapMap Consortium Genome-wide detection and characterization of positive selection in human populations Nature 449 2007 913 918
40. B.F. Voight, S. Kudaravalli, X. Wen, and J.K. Pritchard A map of recent positive selection in the human genome PLoS Biol. 4 2006 e72
41. J.H. Young, Y.P. Chang, J.D. Kim, J.P. Chretien, M.J. Klag, M.A. Levine, C.B. Ruff, N.Y. Wang, and A. Chakravarti Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion PLoS Genet. 1 2005 e82