Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates

Journal of Biological Chemistry

Volumn 291, Issue 17, 2016, Pages 8908-8917

  Westwell Roper, Clara ^a   Denroche, Heather C ^a   Ehses, Jan A ^a   Verchere, C Bruce ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; GLYCOPROTEINS; MACROPHAGES; PHYSIOLOGY;

AMYLOIDOGENIC PEPTIDES; CYTOKINE PRODUCTION; FIBRILLAR AGGREGATES; ISLET AMYLOID POLYPEPTIDES; ISLET TRANSPLANTATION; SYNTHESIS AND PROCESSING; THERAPEUTIC TARGETS; TOLL-LIKE RECEPTORS;

PROTEINS;

AMYLIN; AMYLOID PROTEIN; CRYOPYRIN; HETERODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; THIOFLAVINE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR; CARRIER PROTEIN; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, HUMAN; NLRP3 PROTEIN, MOUSE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IL1B GENE; IMMUNOSTIMULATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATITIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; TNF GENE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY; PROTEINOSIS;

ANIMALS; CARRIER PROTEINS; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; ISLET AMYLOID POLYPEPTIDE; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN AGGREGATION, PATHOLOGICAL; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84965081830     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.712455     Document Type: Article

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