Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis

Annals of the Rheumatic Diseases

Volumn 76, Issue 1, 2017, Pages 244-251

  Palumbo Zerr, Katrin ^a   Soare, Alina ^a,b   Zerr, Pawel ^a   Liebl, Andrea ^a   Mancuso, Rossella ^a   Tomcik, Michal ^a,c   Sumova, Barbora ^a,c   Dees, Clara ^a   Chen, Chih Wei ^a   Wohlfahrt, Thomas ^a   Mallano, Tatjana ^a   Distler, Alfiya ^a   Ramming, Andreas ^a   Gelse, Kolja ^a   Mihai, Carina ^b   Distler, Oliver ^d   Schett, Georg ^a   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c CHARLES UNIVERSITY   (Czech Republic)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DIMER; INHIBITOR OF DIFFERENTIATION PROTEIN; MESSENGER RNA; PROTEIN E12; PROTEIN E47; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SMAD3 PROTEIN; SMALL INTERFERING RNA; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TWIST RELATED PROTEIN 1; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TWIST1 PROTEIN, HUMAN; TWIST1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; TGF BETA SIGNALING; UPREGULATION; ANIMAL; BIOSYNTHESIS; CASE CONTROL STUDY; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SKIN;

ANIMALS; CASE-CONTROL STUDIES; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROTEIN MULTIMERIZATION; RNA, MESSENGER; RNA, SMALL INTERFERING; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN; TRANSFORMING GROWTH FACTOR BETA; TWIST-RELATED PROTEIN 1;

EID: 84965078966     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208470     Document Type: Article

References (42)

1. Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med 2009;360:1989-2003.
2. Grande MT, Sánchez-Laorden B, López-Blau C, et al. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med 2015;21:989-97.
3. Ramming A, Dees C, Distler JH. From pathogenesis to therapy-perspective on treatment strategies in fibrotic diseases. Pharmacol Res 2015;100:93-100.
4. Lovisa S, LeBleu VS, Tampe B, et al. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med 2015;21:998-1009.
5. Franco HL, Casasnovas J, Rodríguez-Medina JR, et al. Redundant or separate entities?-roles of Twist1 and Twist2 as molecular switches during gene transcription. Nucleic Acids Res 2011;39:1177-86.
6. Castanon I, Baylies MK. A Twist in fate: evolutionary comparison of Twist structure and function. Gene 2002;287:11-22.
7. Murre C, McCaw PS, Vaessin H, et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989;58:537-44.
8. Gort EH, van Haaften G, Verlaan I, et al. The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha. Oncogene 2008;27:1501-10.
9. Yoo YG, Christensen J, Gu J, et al. HIF-1α mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Sci Signal 2011;4:pt4.
10. Kang Y, Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004;118:277-9.
11. Kida Y, Asahina K, Teraoka H, et al. Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem 2007;55:661-73.
12. Pozharskaya V, Torres-González E, Rojas M, et al. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PloS ONE 2009;4:e7559.
13. van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747-55.
14. Palumbo-Zerr K, Zerr P, Distler A, et al. Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat Med 2015;21:150-8.
15. Reich N, Tomcik M, Zerr P, et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis 2012;71:737-45.
16. Akhmetshina A, Palumbo K, Dees C, et al. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun 2012;3:735.
17. Beyer C, Schramm A, Akhmetshina A, et al. β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2012;71:761-7.
18. Shi-wen X, Parapuram SK, Pala D, et al. Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum 2009;60:234-41.
19. Dees C, Beyer C, Distler A, et al. Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies. Ann Rheum Dis 2015;74:1621-5.
20. Dees C, Tomcik M, Palumbo-Zerr K, et al. JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis. Arthritis Rheum 2012;64:3006-15.
21. Dees C, Schlottmann I, Funke R, et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis 2014;73:1232-9.
22. Beyer C, Huang J, Beer J, et al. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Ann Rheum Dis 2015;74:1317-24.
23. Sonnylal S, Denton CP, Zheng B, et al. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 2007;56:334-44.
24. Distler A, Ziemer C, Beyer C, et al. Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling. Ann Rheum Dis 2014;73:624-7.
25. Mallano T, Palumbo-Zerr K, Zerr P, et al. Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis. Ann Rheum Dis 2016;75:586-92.
26. Palumbo K, Zerr P, Tomcik M, et al. The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis. Ann Rheum Dis 2011;70:1320-6.
27. Tomcik M, Palumbo-Zerr K, Zerr P, et al. S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis. Ann Rheum Dis 2015;74:1748-55.
28. Tomcik M, Palumbo-Zerr K, Zerr P, et al. Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis. Ann Rheum Dis 2016;75:609-16.
29. Tomcik M, Zerr P, Pitkowski J, et al. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. Ann Rheum Dis 2014;73:1215-22.
30. Uhl M, Aulwurm S, Wischhusen J, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 2004;64:7954-61.
31. Castanon I, Von Stetina S, Kass J, et al. Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development 2001;128:3145-59.
32. Connerney J, Andreeva V, Leshem Y, et al. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 2006;235:1345-57.
33. Ruzankina Y, Pinzon-Guzman C, Asare A, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell stem cell 2007;1:113-26.
34. LeRoy EC. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest 1974;54:880-9.
35. Cho KH, Jeong KJ, Shin SC, et al. STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion. Cancer Lett 2013;336:167-73.
36. Shiota M, Zardan A, Takeuchi A, et al. Clusterin mediates TGF-β-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells. Cancer Res 2012;72:5261-72.
37. Beyer C, Schett G, Gay S, et al. Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis. Arthritis Res Ther 2009;11:220.
38. Distler JH, Jüngel A, Pileckyte M, et al. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheum 2007;56:4203-15.
39. Distler O, Distler JH, Scheid A, et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004;95:109-16.
40. Qin Q, Xu Y, He T, et al. Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res 2012;22:90-106.
41. Connerney J, Andreeva V, Leshem Y, et al. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure. Dev Biol 2008;318:323-34.
42. Puisieux A, Valsesia-Wittmann S, Ansieau S. A twist for survival and cancer progression. Br J Cancer 2006;94:13-17.