Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

Biochemical and Biophysical Research Communications

Volumn 473, Issue 4, 2016, Pages 867-873

  Yao, Jingyun ^a,b   Wei, Xing ^a,b   Lu, Yanhua ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI COLLABORATIVE INNOVATION CENTER FOR BIOMANUFACTURING TECHNOLOGY   (China)

Author keywords

Chaetominine; Chemoresistance; K562 Adr; MRP1; Reversal effect

Indexed keywords

ANTINEOPLASTIC ALKALOID; CHAETOMININE; DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; INDOLE ALKALOID; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; NFE2L2 PROTEIN, HUMAN; ONCOPROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; K-562 CELL LINE; LEUKEMIA, EXPERIMENTAL; METABOLISM; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HUMANS; INDOLE ALKALOIDS; K562 CELLS; LEUKEMIA, EXPERIMENTAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NF-E2-RELATED FACTOR 2; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84964988256     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.03.141     Document Type: Article

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