BME, a novel compound of anthraquinone, down regulated P-glycoprotein expression in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells via generation of reactive oxygen species

Chemico-Biological Interactions

Volumn 239, Issue , 2015, Pages 139-145

  Wang, Jianhong ^a   Liu, Lu ^a   Cen, Juan ^a   Ji, Biansheng ^a  

^a HENAN UNIVERSITY   (China)

Author keywords

BME; P glycoprotein; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANTHRAQUINONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BME; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; U 0216; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; RHODAMINE 123;

ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG DEVELOPMENT; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; K562 CELL LINE; MULTIDRUG RESISTANCE; MYELOID LEUKEMIA CELL LINE; PROTEIN EXPRESSION; TUMOR CELL; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL CYCLE; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; P-GLYCOPROTEINS; REACTIVE OXYGEN SPECIES; RHODAMINE 123;

EID: 84937125302     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.07.003     Document Type: Article

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